Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress... by Ágnes Szabó, Zsolt Galla, Eleonóra Spekker, Mónika Szűcs, Diána Martos, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka

“…This may lead to the development of a double-hit preclinical model in despair-based depression, a better understanding of these complex conditions, and more effective therapeutic strategies by elucidating the relationship between Trp metabolism and PTSD pathogenesis.…”
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Zoonotic diseases awareness and food safety practices among livestock farmers in Nepal by Deepak Subedi, Alok Dhakal, Sumit Jyoti, Sanjay Paudel, Sanjay Paudel, Ganesh Ranabhat, Ananda Tiwari, Ahmad I. Al-Mustapha, Ahmad I. Al-Mustapha, Ahmad I. Al-Mustapha

“…It emphasizes the importance of understanding risks, effective behavioral change strategies, and engaging farmers in developing zoonotic disease and foodborne illness prevention programs.…”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study... by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…However, the optimal strategies to harness the CRST for motor recovery remain unknown. …”
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Adaptive coping mechanisms use and associated factors among adult glaucoma patients attending the University of Gondar Comprehensive Specialized Hospital, Tertiary Eye Care and Tra... by Bisrat Misganaw Geremew, Biruk Fanta Alemayehu, Getenet Shumet Birhan, Biruk Lelisa Eticha, Mahtot Leykun Sisay, Woretaw Endalew Melese, Abebe Tilahun Mekonenne

“…Implementing an integrated approach that incorporates biopsychosocial strategies aimed at reducing ACM and promoting the adaptive one is essential.…”
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Association between daily sitting time and sarcopenia in the US population: a cross-sectional study by Alei Zhang, Yanlei Li, Jinlei Zhou, Yuan Zhang, Shanggao Xie, Haiyu Shao, Tingxiao Zhao, Tao Tang

“…Therefore, reducing sedentary behavior and increasing moderate exercise may be effective prevention strategies.…”
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The Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysis by Nadiye Sever, Sedat Yıldırım, Ali Fuat Gurbuz, Delyadil Karakaş Kılıç, Esra Zeynelgil, Yunus Emre Altintaş, Berivan Deniz Çimik, Yeşim Ağyol, Ali Kaan Güren, Pınar Erel, Erkam Kocaaslan, Burak Paçacı, Mustafa Alperen Tunç, Abdussamet Çelebi, Nazım Can Demircan, Selver Işık, Rukiye Arıkan, Murat Araz, Serdar Karakaya, Murat Sarı, Osman Köstek, İbrahim Vedat Bayoğlu

“…Identifying reliable prognostic factors is crucial for risk stratification and optimizing treatment strategies. This study aimed to evaluate the impact of clinicopathologic factors and systemic inflammatory markers on survival outcomes in patients with MPM. …”
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MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment by Di Cao, Shi-Juan Mai, Hui-yun Wang, Ge Ren, Yue-Ning Wang, Chao-Yue Sun, Haojiang Li, Yu-Feng Zhou, Mei-Yin Zhang, Shuo-Cheng Wang

“…Understanding the underlying mechanisms by which MAF1 enhances anti-tumor immunity in HCC is crucial for developing novel immunotherapy strategies and enhancing clinical responses to treatment for patients with HCC.Methods Mice were subjected to hydrodynamic tail vein injections of transposon vectors to overexpress AKT/NRas, or c-Myc, with or without wild-type (WT) or mutant-activated (−4A) MAF1, or short-hairpin MAF1 (shMAF1). …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…Advancements in these innovative approaches pave the way for more accurate, scalable, and environmentally compatible detection solutions, contributing to improved monitoring and remediation strategies. This review highlights the potential of biosensors as advanced analytical methods, including a section on prospects that address the challenges that could lead to significant advancements in environmental monitoring, highlighting the necessity of testing the new sensing developments under real conditions (composition/matrix of the samples), which are often overlooked, as well as the study of peptides as a novel recognition element in microplastic sensing.…”
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Fatty acids from soybeans: compatibility with Panonychus citri (Acari: Tetranychidae) and its two predators☆ by Qayyoum Muhammad Asif, Khan Bilal Saeed, Song Zi-Wei, Yi Tian-Ci, Inayat Rehan, Akram Muhammad Irfan, Mobarak Syed Husne, Li Dun-Song

“…Soybean oil, with its lower mortality rates and sublethal effects on reproduction and behavior, is a strong candidate for integrated pest management strategies. Oleic and palmitic acids, though effective, have repellency to beneficial predators.…”
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Preconditioning of Rat Bone Marrow-Derived Mesenchymal Stromal Cells with Toll-Like Receptor Agonists by Fabiana Evaristo-Mendonça, Gabriela Sardella-Silva, Tais Hanae Kasai-Brunswick, Raquel Maria Pereira Campos, Pablo Domizi, Marcelo Felippe Santiago, Ricardo Augusto de Melo Reis, Rosalia Mendez-Otero, Victor Túlio Ribeiro-Resende, Pedro Moreno Pimentel-Coelho

“…Accordingly, the therapeutic potential of BM-MSCs can be modulated by preconditioning strategies aimed at modifying their paracrine action. …”
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Clinical features and genetic analysis of 15 Chinese children with dent disease by Qian Li, Zhenle Yang, Ruixian Zang, Suwen Liu, Lichun Yu, Jing Wang, Cong Wang, Xiaoyuan Wang, Shuzhen Sun

“…Objective  The clinical characteristics, genetic mutation spectrum, treatment strategies and prognoses of 15 children with Dent disease were retrospectively analyzed to improve pediatricians’ awareness of and attention to this disease.Methods  We analyzed the clinical and laboratory data of 15 Chinese children with Dent disease who were diagnosed and treated at our hospital between January 2017 and May 2023 and evaluated the expression of the CLCN5 and OCRL1 genes.Results  All 15 patients were male and complained of proteinuria, and the incidence of low-molecular-weight proteinuria (LMWP) was 100.0% in both Dent disease 1 (DD1) and Dent disease 2 (DD2) patients. …”
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Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort by Thorarinn Gislason, Torben Sigsgaard, Vivi Schlünssen, Joachim Heinrich, Jesús Martínez-Moratalla, Øistein Svanes, Mathias Holm, Bertil Forsberg, Dan Norbäck, Rain Jogi, Kjell Torén, Deborah Jarvis, Magnus Ekström, Adrian Lowe, Caroline J Lodge, Michael Abramson, Shyamali Dharmage, Kathrine Pape, Cecilie Svanes, Gita Mishra, Caroline Lodge, Lyle Gurrin, Bruce Thompson, Eva Lindberg, Christer Janson, Simone Accordini, Ane Johannessen, Bryndis Benediktsdottir, Karl Franklin, Andrei Malinovschi, Anna Oudin, Francisco Gómez Real, José Luis Sánchez-Ramos, Lennart Bråbäck, Torgeir Storaas, Shanshan Xu, Julia Dratva, John Holloway, Jorunn Kirkeleit, Christine Cramer, Gro Tjalvin, Anne Mette Lund Würtz, Randi Jacobsen Bertelsen, Oskar Jõgi, Signe Timm, Francisco Javier Callejas, Raúl Godoy, Trude Duelien Skorge, Christine Drengenes, Nils Oskar Jõgi, Maryia Khomich, Toril Mørkve Knudsen, Ingrid Kuiper, Juan Pablo López-Cervantes, Marianne Lønnebotn, Shokouh Makvandi-Nejad, Antonio Pérez, Anders Røsland, Rajesh Shigdel, Svein Magne Skulstad, Kai Triebner, Hilde Vindenes, Jose Luis Sanchez, Jose Maldonado, David Martino, Jennifer Perret, Lucia Calciano, William Horsnell, Susanne Krauss-Etchmann

“…The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations.Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). …”
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Development and validation of a novel artificial intelligence algorithm for precise prediction the postoperative prognosis of esophageal squamous cell carcinoma by Zichen Wang, Zhihan Xiao, Tongyu Zhang, Meiyou Lu, Hai Li, Jing Cao, Jianan Zheng, Yichan Zhou, Juncheng Dai, Cheng Wang, Liang Chen, Jing Xu

“…Conclusion The study highlights the clinical utility of PPMESCC algorithm in prognostic prediction that may facilitate to establish the personalized screening and management strategies for postoperative ESCC patients.…”
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Ultrasensitive interferons quantification reveals different cytokine profile secretion in inflammatory myopathies and can serve as biomarkers of activity in dermatomyositis by Loïs Bolko, Loïs Bolko, Loïs Bolko, Céline Anquetil, Céline Anquetil, Alba Llibre, Solène Maillard, Damien Amelin, Karim Dorgham, Vincent Bondet, Océane Landon-Cardinal, Océane Landon-Cardinal, Océane Landon-Cardinal, Ségolène Toquet, Ségolène Toquet, Kuberaka Mariampillai, Samuel Malatre, Alexandrine Mahoudeau, Baptiste Hervier, Mathieu Rodero, Guy Gorochov, Darragh Duffy, Olivier Benveniste, Olivier Benveniste, Yves Allenbach, Yves Allenbach

“…This data needs to be confirmed in order to select the good therapeutics strategies in DM.…”
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Unsupervised machine learning clustering approach for hospitalized COVID-19 pneumonia patients by Nuttinan Nalinthasnai, Ratchainant Thammasudjarit, Tanapat Tassaneyasin, Dararat Eksombatchai, Somnuek Sungkanuparph, Viboon Boonsarngsuk, Yuda Sutherasan, Detajin Junhasavasdikul, Pongdhep Theerawit, Tananchai Petnak

“…These findings may guide tailored clinical management strategies.…”
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AAV2 serotype demonstrates the highest transduction efficiency in porcine lung-derived cells by Won Seok Ju, Seokho Kim, Areum Choi, Jae-Yeong Lee, Haesun Lee, Jingu No, Seunghoon Lee, Keonbong Oh, Jae Gyu Yoo

“…Understanding cell type-specific preferences of AAV serotypes offer crucial insight for tailoring AAV vectors to specific tissue and optimizing genome editing strategies, with potential implications for the advancement of personalized medicine and development of treatments for human and livestock.…”
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Data recording and use of data tools for pig health management: perspectives of stakeholders in pig farming by Xiao Zhou, Andrea Knörr, Beatriz Garcia Morante, Beatriz Garcia Morante, Beatriz Garcia Morante, Carla Correia-Gomes, Lucia Dieste Pérez, Joaquim Segalés, Joaquim Segalés, Joaquim Segalés, Marina Sibila, Marina Sibila, Marina Sibila, Carles Vilalta, Carles Vilalta, Carles Vilalta, Alison Burrell, Tijs Tobias, Michael Siegrist, Angela Bearth

“…IntroductionData-driven strategies might combat the spreading of infectious pig disease and improve the early detection of potential pig health problems. …”
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Assessment of the general population knowledge about the emergence of Nipah virus outbreak in Bangladesh: A nationwide cross-sectional study by Mobin Ibne Mokbul, Shuvajit Saha, Samiha Nahar Tuli, Fatema Binte Nur, A.M. Khairul Islam, Tariful Islam, Shirsho Shreyan, Alok Bijoy Bhadra, Golam Dastageer Prince, Irfath Sharmin Eva, Mustari Nailah Tabassum, Ferdous Wahid, Md Irfan Bin Kayes, Nazim Hassan Ziad, Mohammad Delwer Hossain Hawlader

“…The current study underscores the importance of evidence-based educational strategies, and may guide government and policymakers to design future targeted interventions to enhance public health literacy and mitigate the spread of NiV in Bangladesh as well as in its neighbouring countries.…”
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Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study by Xunying Zhao, Xueyao Wu, Tianpei Ma, Jinyu Xiao, Xin Chen, Mingshuang Tang, Li Zhang, Tao Zhang, Mengyu Fan, Jiaqiang Liao, Ben Zhang, Xia Jiang, Jiayuan Li

“…Conclusions Our findings underscore the multifaceted benefits of PA in mitigating cognitive impairment risk among older Chinese adults. Public health strategies should focus on promoting overall late-life PA levels, especially moderate-intensity PA, and maintaining activity levels comparable to midlife, with potential for personalized interventions based on genetic risk profiles.…”
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An exploratory analysis of differences in serum protein expression by sex in patients with systemic sclerosis associated interstitial lung disease by Giuliana Cerro-Chiang, Matthew Ayres, Alejandro Rivas, Sarah J. Parker, Mitra Mastali, Peter Chen, Jennifer E. Van Eyk, Paul J. Wolters, Francesco Boin, Tanzira Zaman

“…These proteins could influence disease progression and treatment response and underscore the importance of personalized therapeutic strategies and further research into sex-related molecular pathways in SSc-ILD. …”
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