Transcriptome analysis reveals potential regulatory mechanism of genes and pathways following Aeromonas veronii infection and hypoxic stress in Chinese mitten crab, Eriocheir sinen... by Gang Jiang, Fengyuan Yan, Yuanfeng Xu, Jianlin Li, Wenrong Feng, Guo an Hua, Wen jing Li, Jun Zhou, Yongkai Tang

“…These findings contribute to understanding the mechanisms of stress responses in aquatic animals, potentially aiding in the development of strategies to enhance health and productivity in aquaculture.…”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

“…BackgroundThe pathological progression from liver injury to fibrosis is a hallmark of liver disease, with no effective strategies to halt this transition. Ginsenoside Rg1 has demonstrated a range of hepatoprotective properties; however, systematic preclinical evidence supporting its therapeutic potential for liver injury and fibrosis remains limited. …”
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Stigma and fear during the COVID-19 pandemic: a qualitative study on the perceptions of healthcare workers in Canada and Singapore by Christine Fahim, Christine Fahim, Chou Chuen Yu, Jeanette Cooper, Suvabna Theivendrampillai, Taehoon (Tom) Lee, Michelle Wai-Ki Lau, Christine Marquez, Bernard Tang, Mathews Mathew, Malika Sharma, Malika Sharma, Eric Wong, Eric Wong, Tracey O'Sullivan, James Alvin Low, James Alvin Low, Sharon E. Straus, Sharon E. Straus

“…Most themes were consistent across Canada and Singapore. Strategies to mitigate COVID-19 related stigma toward HCPs and at-risk patient populations are warranted.…”
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Interrelationship between altered metabolites and the gut microbiota in people living with HIV with different immune responses to antiretroviral therapy by Xuebin Tian, Zhongyao Gao, Yiwen Xie, Xiangyun Lu, Yulong Zhao, Peng Yao, Mingqing Dong, Lifeng Yu, Nanping Wu

“…Conclusion: The multi-omics approach highlighted potential biomarkers for immune recovery in HIV, suggesting avenues for further research into treatment strategies.…”
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Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study by Qiuping Liao, Qiuping Liao, Qiuping Liao, Tiantian Yu, Tiantian Yu, Tiantian Yu, Jiajia Chen, Jiajia Chen, Jiajia Chen, Xiuqiong Zheng, Xiuqiong Zheng, Xiuqiong Zheng, Lianghui Zheng, Lianghui Zheng, Lianghui Zheng, Jianying Yan, Jianying Yan, Jianying Yan

“…The data suggest that different management strategies should be implemented for pregnant women with a pre-pregnancy BMI below 27.78 kg/m2 and above 27.78 kg/m2, particularly in cases of GDM. …”
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Experiences of infertility among couples in Morocco by Amal Benbella, Amal Benbella, Gitau Mburu, Asmaa Zaidouni, Sanae Elomrani, Abdelhakim Yahyane, Karima Gholbzouri, James Kiarie, Rachid Bezad, Rachid Bezad

“…A health system strengthening approach is essential to address those challenges, and multiple strategies are needed to improve the experiences of couples with infertility in Morocco. …”
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Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 by Yifan Chen, Long Sun, Meiqi Wang, Yunxi Zhong, Xiaoying Su, Qixiu Li, Ziming Shao

“…At the national level, the most pronounced increase in the incidence was in Greenland.Conclusions The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.…”
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Evaluation of S100A8/A9 and neutrophils as prognostic markers in metastatic melanoma patients under immune-checkpoint inhibition by Yasmin F Melzer, Nadine L Fergen, Christian Mess, Julia-Christina Stadler, Glenn Geidel, Ysabel A Schwietzer, Julian Kött, Klaus Pantel, Stefan W Schneider, Jochen Utikal, Ewa Wladykowski, Sabine Vidal-y-Sy, Alexander T Bauer, Christoffer Gebhardt

“…By enhancing monitoring and prognosis assessment, these biomarkers contribute to refining treatment strategies, ultimately improving patient care and outcomes. …”
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Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway by Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao

“…Our present work revealed a novel regulatory model of myocardial necrosis composed of miR-193b-3p, Syt1, Parkin, and CypD, which may provide potential therapeutic targets and strategies for heart protection.…”
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Assessing the detection and interaction of Lawsonia intracellularis and porcine circovirus 2 in low and high-performance wean-to-finish pig groups in different porcine reproductive... by Guilherme Cezar, Fernando L. Leite, Eduardo Fano, Reid Phillips, John Waddell, Kate Dion, Edison Magalhães, Giovani Trevisan, Gustavo Silva, Daniel C. Linhares

“…IntroductionEffective disease management strategies are essential for achieving optimal pig performance, ensuring high-quality animal health and welfare, and maintaining the economic viability of swine systems. …”
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Iterative delivery of an implementation support package to increase and sustain the routine provision of antenatal care addressing alcohol consumption during pregnancy: study proto... by John Attia, Luke Wolfenden, Nicole Nathan, Melanie Kingsland, Olivia Wynne, Penny Reeves, Alix Hall, John Wiggers, Elizabeth J Elliott, Tameka McFadyen, Tracey W Tsang, Emma Doherty, Belinda Tully, Adrian John Dunlop, Ian Symonds

“…The package will consist of evidence-based strategies to support increases in care provision (remind clinicians; facilitation; conduct educational meetings) and sustainment (develop a formal implementation blueprint; purposely re-examine the implementation; conduct ongoing training). …”
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How drinking motives mediate associations between sexual orientation and indicators of alcohol use – a study among young Swiss men by Matthias Wicki, Matthias Wicki, Simon Marmet, Joseph Studer, Joseph Studer, Kim Bloomfield, Kim Bloomfield, Kim Bloomfield, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel, Gerhard Gmel

“…Understanding the varied motives for alcohol use across the spectrum of sexual orientations facilitates tailored prevention strategies.…”
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Workload-capacity imbalances and their impact on self-management complexity in patients with multimorbidity: a multicenter cross-sectional study by Binyu Zhao, Yujia Fu, Jingjie Wu, Erxu Xue, Chuyang Lai, Dandan Chen, Qiwei Wu, Jianing Yu, Qiaoyu Wu, Zhihong Ye, Jing Shao

“…Introduction Multimorbidity is increasing globally, emphasizing the need for effective self-management strategies. The Cumulative Complexity Model (CuCoM) offers a unique perspective on understanding self-management based on workload and capacity. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…Traditional treatment strategies often follow a one-size-fits-all approach obtaining suboptimal outcomes for many patients who fail to experience response or recovery. …”
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Direct Oral Anticoagulants Versus Vitamin K Antagonists After Mitral Valve Transcatheter Edge‐to‐Edge Repair in Patients With Atrial Fibrillation: A Single‐Center Observational Stu... by Jan‐Hendrik Schipper, Anne‐Sophie Sommer, Richard Julius Nies, Clemens Metze, Max Maria Meertens, Jonas Wörmann, Sebastian Dittrich, Jan‐Hendrik van den Bruck, Arian Sultan, Jakob Lüker, Daniel Steven, Christopher Hohmann, Roman Pfister, Stephan Baldus, Ingo Eitel, Christian Frerker, Tobias Schmidt

“…Further randomized trials are needed to confirm these results and establish optimal anticoagulation strategies in this patient population.…”
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Diabetes Fact Sheets in Korea 2024 by Se Eun Park, Seung-Hyun Ko, Ji Yoon Kim, Kyuho Kim, Joon Ho Moon, Nam Hoon Kim, Kyung Do Han, Sung Hee Choi, Bong Soo Cha

“…Therefore, early intervention programs, education, and strategies tailored to younger populations are urgently required.…”
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Men care too: a qualitative study examining women’s perceptions of fathers’ engagement in early childhood development (ECD) during an ECD program for HIV-positive mothers in Malawi... by Linda Richter, Thomas J Coates, Tijana Temelkovska, Pericles Kalande, Evelyn Udedi, Laurie Bruns, Siyenunu Mulungu, Julie Hubbard, Sundeep Gupta, Kathryn Dovel

“…Data were coded using inductive and deductive strategies and analysed using constant comparison methods in Atlas.ti V.1.6.Setting Four health facilities in Malawi where PMTCT services were provided.Participants Study participants were mothers infected with HIV who were enrolled in the PMTCT–ECD programme for >6 months.Interventions The PMTCT–ECD intervention provided ECD education and counselling sessions during routine PMTCT visits for mothers infected with HIV and their infants (infant age 1.5–24 months). …”
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Achieving equiaxed and lamellar TiAl alloys via cold-cathode electron beam additive manufacturing with dual-wire synergistic control by Yilei Shi, Shuili Gong, Haiying Xu, Wei Chen, Zhuang Wang, Guang Yang, Xin Liu, Bojin Qi

“…These findings offer important insights into enhancing the performance of TiAl alloys through cost-effective alloying strategies.…”
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The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms by Fenella Beynon, Hélène Langet, Leah F. Bohle, Shally Awasthi, Ousmane Ndiaye, James Machoki M’Imunya, Honorati Masanja, Susan Horton, Maymouna Ba, Silvia Cicconi, Mira Emmanuel-Fabula, Papa Moctar Faye, Tracy R. Glass, Kristina Keitel, Divas Kumar, Gaurav Kumar, Gillian A. Levine, Lena Matata, Grace Mhalu, Andolo Miheso, Deusdedit Mjungu, Francis Njiri, Elisabeth Reus, Michael Ruffo, Fabian Schär, Kovid Sharma, Helen L. Storey, Irene Masanja, Kaspar Wyss, Valérie D’Acremont, TIMCI Collaborator Group

“…Effective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. …”
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Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…An AF freedom of 65% in the RFM+AAD and of 60% in the CA is expected; therefore, 202 patients will be enrolled to achieve the non-inferiority with 80% power, 5% one-sided alpha and a non-inferiority margin of 12%.Ethics and dissemination The PRAGUE-25 trial will determine if modern non-invasive AF treatment strategies are non-inferior to CA. The study was approved by the Ethics Committee of the University Hospital Kralovske Vinohrady. …”
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