Soil warming increases the active antibiotic resistome in the gut of invasive giant African snails by Yiyue Zhang, Hong-Zhe Li, Martin Breed, Zhonghui Tang, Li Cui, Yong-Guan Zhu, Xin Sun

“…These findings emphasize the urgent need for integrated environmental and health strategies to manage the rising threat of antibiotic resistance in the context of global climate change. …”
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Salivary alpha-amylase activity and its association with early childhood caries and rampant caries experience: a cross-sectional study by Vivek Padmanabhan, Md Sofiqul Islam, Muhammed Mustahsen Rahman, Manjunatha B. K. Goud, Latifa Majed Sulaiman Allay Alshehhi, Hebah Mushref Ahmad Hamed, Sheela Haridas, Dileep Sharma

“…These findings suggest that salivary alpha-amylase could serve as a valuable biomarker for assessing caries risk and guiding preventive strategies.…”
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Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction by Hongjian Zhou, Zhipeng Xu, Chun Jiang, Qiuyue Wu, Chuanyue Zhang, Zhenyu Liu, Xiaoxue Zhang, Weiwei Li, Yujia Pang, Jing Zhang, Wenju Pan, Min Chen, Xinyi Xia

“…This study not only provides new insights for further research into IR-induced damage and spermatogenic disorders caused by other factors, but also offers potential therapeutic strategies for developing radioprotective agents in cancer radiotherapy.…”
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“Sleepless nights are a daily reality for us” how women experiencing homelessness in Addis Ababa, Ethiopia describe street life: a photovoice study by Kalkidan Yohannes, Kalkidan Yohannes, Kalkidan Yohannes, Mats Målqvist, Hannah Bradby, Yemane Berhane, Dagmawit Tewahido, Dagmawit Tewahido, Sibylle Herzig van Wees, Sibylle Herzig van Wees

“…However, the mitigation strategies and long-term effects of women’s homelessness require further research.…”
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Biofilmed-PGPR: Next-Generation Bioinoculant for Plant Growth Promotion in Rice under Changing Climate by Jeberlin Prabina Bright, Hemant S. Maheshwari, Sugitha Thangappan, Kahkashan Perveen, Najat A. Bukhari, Debasis Mitra, Riyaz Sayyed, Andrea Mastinu

“…We concluded that CBB could be used as a novel biofilm-based bio-inoculant to increase rice productivity and crop fitness as a component in integrated nutrient management and sustainable organic farming strategies with reduced chemical fertilizers.…”
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Prognostic value of immunosuppression scores in patients with esophageal squamous cell carcinoma: a multicenter study by Shao-jun Xu, Shao-jun Xu, Shao-jun Xu, Yun-fan Luo, Yun-fan Luo, Yun-fan Luo, Jin Huang, Jin Huang, Jin Huang, Jia-hua Tu, Chao Chen, Chao Chen, Chao Chen, Yan-ming Shen, Yan-ming Shen, Yan-ming Shen, Zhao-min Sun, Zhao-min Sun, Zhao-min Sun, Shu-chen Chen, Shu-chen Chen, Shu-chen Chen

“…After IPTW adjustment, the low ISS group showed improved five-year RFS (80.1% vs. 35.4%, p < 0.001) and five-year CSS (82.3% vs. 42.5%, p < 0.001) compared to the high ISS group.ConclusionsESCC with different ISS statuses represents two distinct biological subtypes, underscoring the need for personalized treatment strategies tailored to varying tumor behaviors.…”
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A Shared Path: Co-occurrence and Clinical Implications of Celiac Disease and Type 1 Diabetes Mellitus by Wojciech Florczak, Joanna Śnieżna, Jakub Dziewic, Karol Dzwonnik, Wiktoria Domino, Urszula Zelik, Gabriela Trestka, Maria Przygoda, Jagienka Włodyka, Kamila Stępień, Sabina Adamczyk

“…Early screening and diagnosis are very important regarding the management strategies for these conditions. Gluten free diet (GFD) is the main treatment for CeD, but its adherence may be challenging, especially in T1DM patients who already face many restrictions on a daily basis. …”
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Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…Evidence from real-world data represents a valuable opportunity to improve personalised treatment and patient-centred guidelines for vulnerable populations and inform strategies to reduce opioid-related mortality. Our objective is to determine the comparative effectiveness of methadone versus buprenorphine/naloxone, both overall and within key populations, in a setting where both medications are simultaneously available in office-based practices and specialised clinics.Methods and analysis We propose a retrospective cohort study of all adults living in British Columbia receiving opioid agonist treatment (OAT) with methadone or buprenorphine/naloxone between 1 January 2008 and 30 September 2018. …”
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Microvascular dysfunction in a murine model of Alzheimer’s disease using intravital microscopy by Danielle Sidsworth, Noah Tregobov, Noah Tregobov, Colin Jamieson, Jennifer Reutens-Hernandez, Joshua Yoon, Geoffrey W. Payne, Geoffrey W. Payne, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers, Stephanie L. Sellers

“…Such insights may inform the development of vascular-targeted therapeutic strategies.…”
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Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction by Irene López-Ferreruela, Sara Malo, Blanca Obón-Azuara, María José Rabanaque, Adriana Gamba, Sara Castel-Feced, Isabel Aguilar-Palacio

“…It is crucial to analyse them from an intersectional perspective, considering the influence of multiple axes of inequality on health, in order to develop gender-sensitive strategies with a multidisciplinary approach.…”
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Physical symptoms distress and demoralization among haemodialysis patients; the mediating effect of spirituality and self-compassion. A cross-sectional questionnaire survey by Chia-Hui Lin, Yi-Chien Chiang, Wen-Yi Li, Tsung-Lan Chu, Ya-Chu Hsiao

“…Our findings imply that developing strategies to increase spirituality and self-compassion could help patients manage chronic symptom distress associated with haemodialysis, reduce demoralization, and ultimately improve their quality of life.…”
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Efforts to strengthen anatomic pathology diagnostic services for cancer in sub-Saharan Africa: a scoping review protocol by Katherine Van Loon, Elia John Mmbaga, Marcia Edelweiss, Dianna L. Ng, Asteria Herman Kimambo, Edda Vuhahula, Beatrice Paul Mushi, Omolade Adegoke, Johanna Goldberg, Pendo M. Ibrahim, Zainab Illonga, Julia Jackman, Luisa Jamisse

“…This scoping review will be conducted to summarise the current state of practices and evidence for interventions and implementation strategies to improve anatomic pathology services for cancer in the region. …”
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Tools to improve discharge equity: Protocol for the pilot TIDE trial by Kirsten Austad, Cecilia Thai, Alegna Zavatti, Nhi Nguyen, Diana Bautista-Hurtado, Patrick Kenney, Noelia Lugo, Joo H. Lee, Howard Lanney, Ziming Xuan, Erika G. Cordova-Ramos, Mari-Lynn Drainoni, Brian Jack

“…A mixed methods evaluation will identify determinants of intervention uptake to guide selection of multi-level implementation strategies to test in a future hybrid type III trial. …”
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Analysis of the spatial pattern and causes of ecological environmental quality in Myanmar based on the RSEI model and the Geodetector-GCCM method by Shuangfu Shi, Shuangfu Shi, Shuangyun Peng, Shuangyun Peng, Zhiqiang Lin, Zhiqiang Lin, Bangmei Huang, Dongling Ma, Dongling Ma, Ziyi Zhu, Ziyi Zhu, Yilin Zhu, Yilin Zhu, Rui Zhang, Ting Li

“…Facing the challenges brought about by global climate change and biodiversity loss, accurately assessing ecological environmental quality (EEQ), and its driving factors are crucial for formulating effective strategies for ecological protection and restoration. …”
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Thyroid nodule rupture after thermal ablation for benign thyroid nodules: incidence, risk factors, and clinical management by Yu-tong Liu, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-an Yu

“…Background Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).Objective To summarize the incidence of TNR after TA and analyze the causes and prevention strategies.Materials and methods This retrospective study enrolled 3971 patients who underwent TA for BTN from January 2014 to March 2024. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…Conclusions The identification of primary and secondary vectors, their seasonal dynamics, and biting behaviour contribute to enhances our understanding of malaria transmission risks in these areas, guiding future strategies toward effective and context-specific control measures, while stressing the need for individual protection during daytime.…”
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Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin, Biren B. Kamdar

“…<b>Methods:</b> Spanning an 8-month quality improvement project period, our single-ICU interdisciplinary effort involved delivery of CAM-ICU pocket cards to bedside nurses, and lectures by experienced champions that included a live delirium detection demonstration using the CAM-ICU, and a comprehensive discussion of evidence-based delirium prevention strategies (e.g., benzodiazepine avoidance). Subsequent engagement by health system leadership motivated the development of an electronic health record dataset to evaluate unit-level outcomes, including CAM-ICU documentation and benzodiazepine administration. …”
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Uric acid to albumin ratio is a novel predictive marker for all-cause and cardiovascular death in diabetic patients: a prospective cohort study by Shengnan Chen, Shengnan Chen, Ming Zhang, Shouye Hu, Xiaolong Shao, Lin Liu, Zhi Yang, Kai Nan

“…The clinical utility of UAR and nomogram based on age and UAR can help physicians identify individuals at higher risk and therefore promote prevention strategies.…”
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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…Background Although most patients with newly diagnosed high-risk neuroblastoma (NB) achieve remission after initial therapy, more than 50% experience late relapses caused by minimal residual disease (MRD) and succumb to their cancer. Therapeutic strategies to target MRD may benefit these children. …”
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Nomogram-derived immune-inflammation-nutrition score could act as a novel prognostic indicator for patients with head and neck squamous cell carcinoma by Wen-Yan Wang, Yue Chen, Qian Chen, Hong-Wei Sun, Nuo-Xuan Niu, Hong-Hui Li, Yu-Dan Cao, Yan-Xia Bai, Xiang Li, Xiang Li

“…It offers enhanced predictive accuracy compared to existing markers and has the potential to guide personalized treatment strategies and clinical decision-making.…”
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