The transcriptional regulator Lrp activates the expression of genes involved in the biosynthesis of tilimycin and tilivalline enterotoxins in Klebsiella oxytoca by Miguel A. De la Cruz, Hilda A. Valdez-Salazar, Diana Rodríguez-Valverde, Santa Mejia-Ventura, Nayely Robles-Leyva, Tania Siqueiros-Cendón, Quintín Rascón-Cruz, Nancy León-Montes, Jorge Soria-Bustos, Fernando Chimal-Cázares, Roberto Rosales-Reyes, María L. Cedillo, Jorge A. Yañez-Santos, J. Antonio Ibarra, Javier Torres, Jorge A. Girón, James G. Fox, Miguel A. Ares

“…Our results underscore a molecular mechanism by which TM and TV production by toxigenic K. oxytoca strains is regulated and shed further light on developing strategies to prevent the intestinal illness caused by this enteric pathogen.…”
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Genomic scans for selection and runs of homozygosity in southern Italian turkey populations by Medhat S. Saleh, Vincenzo Landi, Martijn F.L. Derks, Gerardo Centoducati, Martien A.M. Groenen, Pasquale De Palo, Elena Ciani, Nicola Pugliese, Elena Circella, Antonio Camarda

“…Understanding the genomic patterns of BAS-APU turkeys is critical for effective breeding and preservation strategies. In this study, we characterized runs of homozygosity (ROH), and selection signatures using the integrated haplotype score (iHS) and ROH approaches. …”
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Efficacy of the Foodbot Factory digital curriculum-based nutrition education intervention in improving children’s nutrition knowledge, attitudes and behaviours in elementary school... by Wendy Lou, Michael Farkouh, JoAnne Arcand, Jacqueline Marie Brown, Saman Tahir, Beatriz Franco-Arellano, Ann LeSage, Janette Hughes, Bill Kapralos, Ellen Vogel, Claire Tugault-Lafleur

“…Introduction Schools are an important setting for supporting children’s development of food literacy, but minimal research has assessed which strategies are most suitable for school nutrition education. …”
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Toxicity effect of Ricinus communis methanolic extracts against Bactrocera cucurbitae (Diptera: Tephritidae) by Sadia Manzoor, Rasheed Akbar, Afaq Hussain, Amjad Ali, Brekhna Faheem, Maid Zaman, Abid Farid, Ijaz Hussain, Imtiaz Ali Khan, Kahkashan Perveen (ORCID:

“…Conventional control methods, often reliant on chemical pesticides, pose environmental and ecological concerns, necessitating the exploration of alternative strategies for sustainable pest management. Invasive plants often exert deleterious effects on ecosystems, and the castor bean plant, Ricinus communis, is no exception. …”
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Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology by Xuan Lin, Kun Lin, Yue Lai, Qingping Peng, Miao Xu, Yiting Xu, Jialin Yang, Huan Liu, Jianlin Shen

“…Collectively, our findings provide a theoretical scaffold for comprehending the intricate molecular mechanisms mediating ATBC’s effects on bone metabolism, and paves the way for the development of preventive and therapeutic strategies against orthopedic disorders that may arise from exposure to plastic products containing ATBC or excessive ATBC environments.…”
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Trends in incidence, mortality, and DALYs of cystic echinococcosis in Central Asia from 1992 to 2021: an age-period-cohort analysis by Wulan Talafuhan, Kaibinuer Tuoheti, Ye Lixia, Qi Shuang, Mieyier Yeerjiang, Guzalinuer Aizezi, Wei Jingjing, Peierdun Mijiti, Peierdun Mijiti

“…Future research should continue to monitor these trends and explore targeted prevention strategies within diverse socioeconomic contexts, such as integrating regional socioeconomic factors and public health resources.…”
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Low energy density, high nutrient adequacy and high nutrient density are each associated with higher diet costs in Chinese adults from Henan Province by Junya Zhai, Baihui Ma, Lijun Guo, Hongbo Wu, Quanjun Lyu, Pipasha Khatun, Rui Liang, Fangfang Yao, Minghua Cong, Yongxia Kong

“…This might be important for public health policies to develop strategies to promote healthy diets by regulating food supply and its costs.…”
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Rationale and design for Healthy Hearts in Manufacturing (HHM): A pragmatic single-arm hybrid effectiveness-implementation study for hypertension management and tobacco cessation by Hanzi Jiang, Yao Tian, Jennifer Bannon, Amy E. Krefman, Lawrence C. An, Dustin D. French, Claude R. Maechling, Jane Holl, Richard Chagnon, Theresa L. Walunas, Christopher Burch, Anthony Musci, Darce Latsis, Dawn Carey, Megan McHugh

“…The HHM intervention involves monthly coaching to assist WHCs with implementing evidence-based strategies for hypertension management and tobacco cessation advocated by the Million Hearts initiative and the U.S. …”
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Groundwater Potential Assessment Using Integrated Geospatial and Analytic Hierarchy Process Techniques (AHP) in Chemoga Watershed, Upper Blue Nile Basin, Ethiopia by Samuel Berihun Kassa, Fasikaw Atanaw Zimale, Arega Mulu, Tadege Aragaw Worku, Mindesilew Lakew Wossene, Taye Minichil Meshesha, Yoseph Buta Hailu, Tadele F. Aman, Mekash S. Kifelew, Habtamu Asrat Mekonnen

“…The findings of this study provide crucial insights for decision-makers, enabling the formulation of more effective groundwater management strategies. By identifying cost-effective and suitable well sites, this research contributes to ensuring a sustainable water supply for Debre Markos Town.…”
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Development and Validation of a Machine Learning Model for the Prediction of Bloodstream Infections in Patients with Hematological Malignancies and Febrile Neutropenia by Antonio Gallardo-Pizarro, Christian Teijón-Lumbreras, Patricia Monzo-Gallo, Tommaso Francesco Aiello, Mariana Chumbita, Olivier Peyrony, Emmanuelle Gras, Cristina Pitart, Josep Mensa, Jordi Esteve, Alex Soriano, Carolina Garcia-Vidal

“…<b>Background/Objectives:</b> The rise of multidrug-resistant (MDR) infections demands personalized antibiotic strategies for febrile neutropenia (FN) in hematological malignancies. …”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…Overall, this study provides insights into L. stagnalis's adaptive responses to thermal stressors, emphasizing different molecular strategies for coping with heat versus cold challenges in aquatic environments. …”
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The short-, medium-, and long-term prevalence of physical health comorbidities in first-episode psychosis: a systematic review and meta-analysis protocol [version 2; peer review: 3... by Michael Norton, Brian O'Donoghue, Mary Clarke, Karen O'Connor, Jennifer Murphy, Anna Zierotin

“…Conclusions This systematic review will clarify the progression of physical health comorbidities in FEP, informing early intervention strategies and policies. Subsequent findings will be submitted to a leading journal, supplemented by a recovery education module and a lay summary for wider dissemination. …”
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Development and validation of an interprofessional collaborative educational module on the self-management of foot for individuals with type II diabetes mellitus in India [version... by Gagana Karkada, Sushma Prabhath, Ciraj Ali Mohammed, Arun G. Maiya, Harihara Prakash Ramanathan, M Ganesh Kamath, Ganesh Handady

“…The present study aims to develop and validate an interprofessional collaborative (IPC) educational program involving HCPs to efficiently oversee and instruct the public on appropriate strategies for self-managing diabetic foot health in the Indian population. …”
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Mechanism of Threshold Voltage Instability in Double Gate &#x03B1;-IGZO Nanosheet TFT Under Bias and Temperature Stress by Muhammad Aslam, Shu-Wei Chang, Yi-Ho Chen, Yao-Jen Lee, Yiming Li, Wen-Hsi Lee

“…Overall, the reported results offer a comprehensive understanding of scaled-channel DG-NS-IGZO-TFTs, which help shape performance-enhancement strategies, control degradation mechanisms, and define appropriate application scenarios.…”
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Trends in tuberculosis mortality among older adults in China, 2004–2021: a Joinpoint regression and age–period–cohort analysis by Mengdi Zhang, Xin Wang, Yiran Xiao, Qiqi Wang, Fei Huang, Xiang Ren, Xiaomin Guo, Wenshan Sun, Jinqi Deng, Qi Jiang, Jianjun Liu, Wenjing Zheng, Hongyan Yao

“…Variations in age, period, and cohort effects highlight differences by gender, urban and rural areas, and regions, providing insights for targeted intervention strategies.…”
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Doctor, what is my risk of bleeding after cardiac surgery while on combined anticoagulant with antiplatelet therapy? A validated nomogram for risk assessment by Haolong Han, Haolong Han, Hang Xu, Hang Xu, Jifan Zhang, Weihui Zhang, Yi Yang, Xia Wang, Li Wang, Dongjin Wang, Weihong Ge

“…The model holds significant potential for clinical applications in bleeding risk assessment, decision-making and personalized treatment strategies.…”
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Multiplexed SSR marker analysis of Diplocarpon coronariae reveals clonality within samples from Middle Europe and genetic distance from Asian and North American isolates by Thomas Oberhänsli, Anna Dalbosco, Virginie Leschenne, Anne Bohr, Sascha Buchleither, Lucius Tamm, Lukas Wille, Srđan G. Aćimović, Fatemeh Khodadadi, Young-Hyun Ryu, Bruno Studer, Hans-Jakob Schärer, Andrea Patocchi

“…Application of the SSR markers to large-scale and diverse Dc samples will help to better understand the epidemiology of AB, which has become a global apple disease, and will help guide effective mitigation strategies based on disease management and resistance breeding.…”
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Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular ta... by Jingyang Xie, Alicia S. Bicu, Melanie Grehn, Mustafa Kuru, Adrian Zaman, Xinyu Lu, Christian Janorschke, Luuk H.G. van der Pol, Martin F. Fast, Jens Fleckenstein, Marcus Both, Stephan Hohmann, Egor Borzov, Peter Winkler, Roland R. Tilz, Dirk Rades, Frank A. Giordano, Daniel Buergy, Boris Rudic, David Duncker, Roland Merten, Tomer Charas, Mahmoud Suleiman, Thomas Brunner, Daniel Scherr, Evgeny Lian, Achim Schweikard, Oliver Blanck, Judit Boda-Heggemann, Lena Kaestner

“…Background and purpose: Motion management strategies such as gating under breath-hold can reduce breathing-induced motion during stereotactic arrhythmia radioablation (STAR) for refractory ventricular tachycardia. …”
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Autoantibodies in type 1 diabetes: Prevalence and clinical profiles by Raja Hazime, Saad Lamjadli, Morad Guennouni, Mounir Belkrachni, Fatima-Ezzohra Eddehbi, Ider Oujamaa, Lahcen Elmoumou, Aicha Bourrahouate, Imane Ait Sab, Hicham Baizri, Nawal El Ansari, Brahim Admou

“…Identifying autoantibodies can help predict the onset of T1D and associated autoimmune disorders, enhancing patient management strategies.We aimed to determine the prevalence of T1D autoantibodies and their clinical significance in the pediatric and adult populations. …”
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Cohort profile: maternal and child health and parenting practices during the COVID-19 pandemic in Ceará, Brazil: birth cohort study (Iracema-COVID) by Marcia C Castro, Márcia Maria Tavares Machado, Simone Farías-Antúnez, David Augusto Batista Sá Araújo, Ana Luiza Penna, Francisco Ariclene Oliveira, Camila Machado de Aquino, Antônio Silva Lima Neto, Geziel dos Santos de Sousa

“…Additional topics will be included in future waves (eg, food insecurity and parenting practices). Communication strategies for bonding, such as picture cards, pictures of mothers with their children and phone calls to the participants, will be used to minimise attrition. …”
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