Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…Despite the initial effectiveness of treatment, acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPis) represents a major challenge for the clinical management of HGSOC, highlighting the necessity for the development of novel therapeutic strategies. This study investigated the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a pivotal regulator of glycolysis, in PARPi resistance and explored its potential as a therapeutic target to overcome PARPi resistance. …”
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Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases by Syeed Mehbub Ul Kadir, Mukti Rani Mitra, Riffat Rashid, Murtuza Nuruddin, Md. Kamrul Hassan Khan, Golam Haider, Mst. Sayedatun Nessa

“…To assess the relative frequency of eyelid malignancies in the Bangladesh population, state their clinical features and outcome of management strategies and build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. …”
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Biological control of ticks in domestic environments: Modeling the potential impact of entomopathogenic fungi on the transmission of East Coast fever in cattle by Joseph Wang'ang'a Oundo, Nienke Hartemink, Mart C.M. de Jong, Constantianus J.M. Koenraadt, Shewit Kalayou, Daniel Masiga, Quirine ten Bosch

“…The epidemiological impact of EPF was evaluated across a range of product profiles and implementation strategies. Model results indicate that, for the explored product profiles, EPF derives most of its epidemiological impact through the delayed mortality effect. …”
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自发性脑出血术后早期使用阿司匹林的可能性：来自中国学者的首个脑出血围手术期管理高级别循证依据 Possibility of Early Use of Aspirin after Spontaneous Intracerebral Hemorrhage Surgery: The First High-Level Evidence-Based Evidenc... by 周航，陈高(ZHOU Hang, CHEN Gao)

“…Although surgical treatment has become increasingly mature, the corresponding postoperative management strategies remain poorly defined. In this context, patients who survive after intracerebral hemorrhage surgery have a significantly increased risk of major cardiovascular, cerebrovascular, and peripheral vascular events. …”
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How the nursing work environment moderates the relationship between clinical judgment and person-centered care among intensive care unit nurses. by Mi Hwa Seo, Eun A Kim, Hae Ran Kim

“…<h4>Conclusions</h4>The ICU nurses' clinical judgment ability positively affected person-centered care, and the nursing work environment moderated the relationship between clinical judgment ability and person-centered care. Therefore, strategies for enhancing person-centered care among ICU nurses should focus on developing educational programs to improve clinical judgment ability and implementing comprehensive efforts to effectively improve and manage the nursing work environment.…”
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Genotypic and Phenotypic Characterizations of Methicillin-Resistant Staphylococcus aureus (MRSA) on Frequently Touched Sites from Public Hospitals in South Africa by Siyethaba Mkhize, Daniel G. Amoako, Christiana O. Shobo, Oliver T. Zishiri, Linda A. Bester

“…This highlights the need for improved infection prevention and control (IPC) strategies in public hospitals in the country to curb their potential transmission risks.…”
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Folklore et écriture vernaculaire dans The Autobiography of Miss Jane Pittman by Laurence Cossu-Beaumont

“…Certes, le rythme, la grammaire de l’anglais oral noir américain jalonnent ce récit qui se place lui-même dans son prologue sous le signe stylistique des conversations informelles sur les marches d’un perron de Louisiane, ces « porch talk » dont Gaines répète s’être inspiré.Cependant, l’analyse confinerait à la couleur locale si la « folk autobiography » n’était pas lue comme autobiographie fictive d’un peuple et d’une stratégie de survie : Miss Jane incarne aussi la dimension fonctionnelle du parler vernaculaire dont la théorie de signifyin(g) a montré les enjeux vitaux. …”
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Sustainability of Mahogany Production in Plantations: Does Resource Availability Influence Susceptibility of Young Mahogany Plantation Stands to Hypsipyla robusta Infestation? by C. B. Darko, E. Opuni-Frimpong, S. A. Owusu, B. Kyere, A. J. Storer

“…These findings will assist plantation developers, forest managers, and investors in mahogany plantations to devise integrated pest management strategies to reduce the impact of Hypsipyla attacks on their plantations.…”
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卒中：回眸2024 Highlights in Stroke in 2024 by 熊云云1，2，3，4，李光硕1，马宇洁1，李祉馨1，沈柯佳1，马瑛1，孙大鹏1，孙溢阳1，王拥军1，2，3，5，6，7（XIONG Yunyun1,2,3,4, LI Guangshuo1, MA Yujie1, LI Zhixin1, SHEN Kejia1, MA Ying1, SUN Dapeng1, SUN Yiyang1, WANG Yongjun1,2,3,5,6,7 ）

“…Stroke researchers worldwide have actively contributed their expertise, and further refined the diagnosis, treatment, and management strategies for cerebrovascular diseases. Exciting breakthroughs have been made in the field of hemorrhagic stroke, including the treatment of subdural hematoma and primary intracerebral hemorrhage. …”
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Spatiotemporal Evolution and Driving Mechanisms of kNDVI in Different Sections of the Yangtze River Basin Using Multiple Statistical Methods and the PLSPM Model by Zhenjiang Wu, Fengmei Yao, Adeel Ahmad, Fan Deng, Jun Fang

“…Spatiotemporal vegetation changes serve as a key indicator of regional ecological environmental quality and provide crucial guidance for developing strategies for regional ecological protection and sustainable development. …”
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Most diverse, most neglected: weevils (Coleoptera: Curculionoidea) are ubiquitous specialized brood-site pollinators of tropical flora by Haran, Julien, Kergoat, Gael J., de Medeiros, Bruno A. S.

“…Another characteristic feature is that flowers often perform thermogenesis and exhibit a range of strategies to separate sexual phases, either spatially or temporally. …”
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PERAN DIVIDEND POLICY SEBAGAI MODERASI PADA HUBUNGAN FAKTOR KEUANGAN DENGAN RETURN SAHAM by Nur Alimah, Mohamad Agus Salim Monoarfa, Meriyana Franssisca Dungga

“…Selain itu, Dividend policy terbukti memperkuat hubungan antara ketiga variabel independen dengan Return Saham, menunjukkan peran strategis kebijakan dividen dalam memaksimalkan pengembalian saham. …”
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Sex-Specific Analysis of the Relationship Between Ventricular Premature Contractions Frequency Distribution and Heart Rate: A Cross-Sectional Study in Chinese Adults by Li Z, Fang Y, Wu J, Ma W

“…These findings may inform future research and have implications for the development of sex-specific diagnostic and therapeutic strategies for PVCs.Keywords: premature ventricular contractions, autonomic nervous system, Holter monitoring, heart rate variability…”
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Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

“…These findings align with and advance previous insights into the use of microfluidics and desolvation methods, paving the way for improved therapeutic strategies in breast cancer treatment.…”
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Pain management in trauma: the need for trauma-informed opioid prescribing guidelines by Ben L Zarzaur, Suresh Agarwal, Colleen Trevino, Amelia Baltes, David M Horton, Julia Malicki, Randall T Brown

“…Focus group transcripts were independently coded and analyzed using a modified grounded theory approach to identify themes related to the facilitators and barriers of opioid prescribing guidelines in trauma and acute care.Results Three major themes were identified as impactful to opioid-related prescribing and care provided in the setting of traumatic injury; these include (1) acute treatment strategies; (2) patient interactions surrounding pain management; and (3) the multifactorial nature of trauma on pain management approaches.Conclusion Providers and staff at four Wisconsin trauma centers called for trauma-specific opioid prescribing guidelines in the setting of trauma and acute care. …”
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Navigating DR-TB Treatment care: a qualitative exploration of barriers and facilitators to retention in care among people with history of early disengagement from drug-resistant tu... by Ndiviwe Mphothulo, Sindisiwe Hlangu, Jennifer Furin, Mosa Moshabela, Marian Loveday

“…Methods We interviewed people with DR-TB who had disengaged from care and their family members to identify barriers and facilitators to retention in care as well as possible strategies to address these barriers. We recruited 16 people with DR-TB and 8 family members from five health facilities in Johannesburg, Gauteng Province, South Africa. …”
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Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis by Yifei Zhang, Zeyu Zhang, Zijing Cao, Xuehui Bai, Shujiao Zhang, Shuaixing Zhang, Jingyi Tang, Junyu Xi, Yiran Xie, Yuqi Wu, Zhongjie Liu, Weijing Liu

“…Future research should address these limitations and investigate the mechanisms linking these risk factors to sarcopenia to develop targeted prevention and treatment strategies.…”
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Optimizing in vitro spherulation cues in the fungal pathogen Coccidioides by Christina M. Homer, Elena Ochoa, Mark Voorhies, Anita Sil

“…Together, our data reveal multiple strategies to optimize in vitro spherulation growth, enabling characterization of this virulence-relevant morphology.IMPORTANCECoccidioides spp. are thermally dimorphic fungal pathogens found in the Southwest United States, Mexico, Central America, and South America. …”
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Can Thinning Foster Forest Genetic Adaptation to Drought? A Demo‐Genetic Modelling Approach With Disturbance Regimes by Victor Fririon, Hendrik Davi, Sylvie Oddou‐Muratorio, Gauthier Ligot, François Lefèvre

“…This study emphasises the potential of evolution‐oriented forestry strategies to combine drought stress mitigation with genetic adaptation. …”
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Silent struggles: a qualitative study exploring mental health challenges of undergraduate healthcare students by Shahd Al-Najdi, Abdulla Mansoor, Ola Al Hayk, Najah Al-Hashimi, Kamran Ali, Alaa Daud

“…Social isolation further exacerbated mental health challenges, while many students highlighted a lack of well-established coping strategies. Stigma related to seeking mental health support was a significant barrier, preventing students from accessing available services. …”
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