The feasibility of implementing a digital pregnancy and postpartum support program in the Midwestern United States and the association with maternal and infant health by Colleen J. Klein, Matthew Dalstrom, William F. Bond, Jeremy McGarvey, Melinda Cooling, Katelyn Zumpf, Lisa Pierce, Brad Stoecker, Jonathan A. Handler

“…Our study shows the feasibility of offering digital support to pregnant women who voluntarily enrolled in the PPSP and adds to the evidence evaluating virtual care strategies.…”
Get full text

The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Despite advances in understanding and management, optimal therapeutic strategies remain unclear, with conflicting guidelines. …”
Get full text

Psychosocial wellbeing and risk perception of older adults during COVID-19 pandemic in Nigeria: perspectives on the role of social workers by Farah Naz Rahman, Farah Naz Rahman, Anthony Obinna Iwuagwu, Christopher Ndubuisi Ngwu, Michael Ebe Kalu, Amani Kasherwa, Anika Tasnim, Mohamman Rocky Khan Chowdhury, Mamunur Rashid, Manzur Kader

“…Social workers were not recognized as part of the frontline response team, and their efforts were primarily constrained by governmental and institutional neglect.ConclusionThe findings highlight the need for policy initiatives to enhance social workers involvement in strengthening the psychosocial resilience of older adults and addressing misconceptions during public health emergencies. Comprehensive strategies are essential for safeguarding the psychosocial well-being of older adults in future pandemics or similar crises.…”
Get full text

IFN-γ/TNF-α Synergism Induces Pro-Inflammatory Cytokine and Chemokine Production by In Vitro Canine Keratinocytes by Kyungsook Jung, Ji-Yeong Ku, Je-Seong Kwon, Gayeon Won, Hakyoung Yoon, Sang-Ik Oh, Mi Hye Kim, Chongchan Kim, Ji-Seon Yoon

“…This in vitro culture system could be useful to investigate cytokine-mediated crosstalk between keratinocytes and immune cells and new therapeutic strategies for keratinocyte-mediated inflammatory skin diseases.…”
Get full text

How to Reduce Delayed Gastric Emptying After Pancreatoduodenectomy: A Systematic Literature Review and Meta-Analysis by Artur Rebelo, MD, Randi Kresse, Yoshiaki Sunami, PhD, Ulrich Ronellenfitsch, MD, Jörg Kleeff, MD, Johannes Klose, MD

“…This meta-analysis aims to assess the impact of various interventions, such as the type of surgical reconstruction (specifically pylorus resection or preservation), enhanced recovery after surgery (ERAS), epidural anesthesia (EA), as well as strategies involving nasogastric decompression on DGE. …”
Get full text

Research trends on lymphedema after mastectomy for breast cancer patients from 2000 to 2023: a scientometric analysis by Ling Chen, Yuxian Zheng, Daitian Zheng, Zhiyang Li, Hongwu Chen, Chujun Chen, Chujun Chen, Shuxian Yu

“…Emerging keyword trends from 2021 to 2023 highlighted “prevention” and “validity” as pivotal research frontiers.ConclusionsThis bibliometric study highlights the growing interest in breast cancer-related lymphedema research and identifies key areas for future investigation, including prevention, diagnosis, and treatment strategies. The results underscore the need for further exploration of these emerging research areas to improve patient outcomes.…”
Get full text

Unravelling distinct patterns of metagenomic surveillance and respiratory microbiota between two P1 genotypes of Mycoplasma pneumoniae by Hailong You, Bin Yang, Huifang Liu, Wencai Wu, Fei Yu, Nan Lin, WenJiao Yang, Bingxue Hu, Yong Liu, Hongyan Zou, Sijia Hao, Yunping Xiao, Teng Xu, Yanfang Jiang

“…Our study provides preliminary evidence of clinical severity between M. pneumoniae strains, underscoring the need for ongoing research and development of targeted therapeutic strategies.…”
Get full text

Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration by Sónia Ferreira, Andreia Carvalho Pereira, Bruno Quendera, Aldina Reis, Eduardo Duarte Silva, Miguel Castelo-Branco

“…These findings are relevant for the design of strategies for treating retinal diseases, based on attentional cuing.…”
Get full text

Extreme drought-heatwave exacerbates water quality deterioration in China by Jie Jiang, Zhaoli Wang, Zhenxing Zhang, Xushu Wu, Chengguang Lai, Zhaoyang Zeng, Xiaohong Chen

“…This study revealed that extreme drought-heatwave event critically deteriorate river water quality in China, highlighting the urgent need for adaptive strategies to protect and restore water quality during extreme drought-heatwave events.…”
Get full text

Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Notably, lactate metabolism blockade combined with immune checkpoint blockade (ICB) therapy effectively enhanced the efficacy of ICB therapy, prolonged the survival time of MPE mice, and improved immunosuppression in the microenvironment of MPE.Conclusions The study explains the mechanism that regulates TNFR2 expression on Treg cells and its function in MPE progression, providing novel insights into the epigenetic regulation of tumor development and metabolic strategies for MPE treatment by targeting lactate metabolism in Treg cells.…”
Get full text

A persona-based exploration of rabies post-exposure prophylaxis seeking behavior and its implication for communication strategic planning: Evidence from Thailand by Jitjayang Yamabhai, Patoo Cusripituck, Teerawan Mingbualuang, Nareerat Sangkachai, Wimwiga Sakchainanon, Chanatda Tungwongjulaniam, Onphirul Yurachai, Ratana Theerawat, Anuwat Wiratsudakul

“…This study aimed to identify and characterize different personas of individuals regarding their PEP-seeking behavior and develop tailored communication strategies to encourage PEP adoption among these distinct groups effectively. …”
Get full text

The Rise of SARS-CoV-2 Variants and the Role of Convalescent Plasma Therapy for Management of Infections by Mohamed, Moubarak, Keneth Iceland, Kasozi, Helal F., Hetta, Hazem M., Shaheen, Abdur, Rauf, Hayder M., Al-kuraishy, Safaa, Qusti, Eida M., Alshammari, Emmanuel Tiyo, Ayikobua, Fred, Ssempijja, Adam Moyosore, Afodun, Ritah, Kenganzi, Ibe Michael, Usman, Juma John, Ochieng, Lawrence Obado, Osuwat, Kevin, Matama, Ali I., Al-Gareeb, Emmanuel, Kairania, Monica, Musenero, Susan, Christina Welburn, Gaber, El-Saber Batiha

“…With successive waves of COVID-19 emerging, strategies that mitigate against community transmission need to be implemented, including increased vaccination coverage. …”
Get full text

Extraction and Characterization of Microfibrillated Cellulose from Discarded Cotton Fibers through Catalyst Preloaded Fenton Oxidation by Xianmeng Xu, Ning Lu, Shunmin Wang, Mengqi Huang, Shenglong Qu, Feng Xuan

“…The need for sustainable development strategies has become a global consensus. As the most abundant biological resource on Earth, cellulose is an inexhaustible, natural, and renewable polymer. …”
Get full text

Computational Modeling and Experimental Investigation of CO₂-Hydrocarbon System Within Cross-Scale Porous Media by Feiyu Chen, Linghui Sun, Bowen Li, Xiuxiu Pan, Boyu Jiang, Xu Huo, Zhirong Zhang, Chun Feng

“…The proposed model offers a more precise framework for evaluating phase transitions in unconventional reservoirs, aiding in the optimization of CO₂-based enhanced oil recovery strategies.…”
Get full text

The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review by Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G

“…Further clinical research is needed to fully elucidate the therapeutic potential and safety of TCM-based immunotherapeutic strategies in cancer care.Keywords: traditional Chinese medicine, TCM, cancer, nanocarriers, immune ability, anti-tumor therapy, tumor microenvironment, drug delivery systems…”
Get full text

A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

“…Recent insights into p53 activation have led to two main screening strategies for p53 activators. The target-based approach focuses on p53 and its regulators (MDM2, MDMX, USP7, Sirt proteins), but requires separate systems for each target and may miss multi-target compounds. …”
Get full text

Impact of extended-course oral nirmatrelvir/ritonavir in established Long COVID: a case series by Alison K. Cohen, Toni Wall Jaudon, Eric M. Schurman, Lisa Kava, Julia Moore Vogel, Julia Haas-Godsil, Daniel Lewis, Samantha Crausman, Kate Leslie, Siobhan Christine Bligh, Gillian Lizars, JD Davids, Saniya Sran, Michael Peluso, Lisa McCorkell

Get full text

A systematic review exploring the factors that contribute to increased primary care physician turnover in socio-economically deprived areas. by Jasmine Lee, Evangelos Kontopantelis

“…Therefore, the objective of this systematic review is to synthesise current research to provide a better understanding of the underlying causes of this high turnover, ultimately informing strategies to address the global shortage of primary care physicians.…”
Get full text

Inebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review by Xiaoqian Song, Xiaoqian Song, Jingjiao Chen, Chenyang Jin, Yilong Peng, Yuewen Sun, Xueping Zheng

“…ObjectiveThis study aims to delineate the clinical features underlying the concurrent disease of neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG), and to identify efficacious therapeutic strategies.BackgroundNMOSD and MG are uncommon autoimmune diseases that infrequently co-exist. …”
Get full text

A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum by Alonso Cruz-Cruz, Megan E. Schreeg, John S. Gunn

“…A greater understanding of these mechanisms will allow the formulation of new therapeutic strategies specifically targeted at preventing typhoid fever dissemination from chronic carriers.…”
Get full text