Comparative growth kinetics and drug susceptibility of Mycobacterium tuberculosis lineages prevalent in Ethiopia: implications for tuberculosis treatment and management by Tesfaye Gebreyohannis Hailemariam, Tesfaye Gebreyohannis Hailemariam, Melaku Tilahun, Abay Atnafu, Tesfaye Gelanew, Tewodros Tariku Gebresilase, Mekdes Alemu Tola, Abaysew Ayele, Shewki Moga Siraj, Workineh Shibeshi, Kidist Bobosha, Liya Wassie, Yonas Hirutu, Ephrem Engidawork

“…These findings highlight the importance of considering lineage-specific differences in Mtb strains for optimizing treatment regimens and improving TB control strategies, particularly in regions with diverse Mtb populations like Ethiopia.…”
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Decades of leopard coexistence in the Himalayas driven by ecological dynamics, not climate change by Paras Bikram Singh, Pradip Saud, Prakash Chandra Aryal, Pawan Rai, Jeff R. Muntifering, Huijian Hu, Ajay Karki, Yiming Hu, Kumar P. Mainali

“…The interaction between two predators in overlapping habitats with distinct habitat requirements poses critical challenges for conservation and management strategies. This study explores the ecological dynamics and coexistence of common leopards (Panthera pardus) and snow leopards (Panthera uncia) in the Himalayan regions, explicitly focusing on their spatial and temporal distribution as well as factors influencing their habitat overlap. …”
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Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen by Alexandra Miere, Hassiba Oubraham, Francesca Amoroso, Pauline Butori, Polina Astroz, Oudy Semoun, Elsa Bruyere, Alexandre Pedinielli, Manar Addou-Regnard, Camille Jung, Salomon Y. Cohen, Eric H. Souied

“…This should be taken into account when using OCTA for CNV follow-up or planning therapeutic strategies.…”
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Unmet Medical Needs in the Management of Ulcerative Colitis: Results of an Italian Delphi Consensus by Marco Daperno, Alessandro Armuzzi, Silvio Danese, Walter Fries, Giuseppina Liguori, Ambrogio Orlando, Claudio Papi, Mariabeatrice Principi, Fernando Rizzello, Angelo Viscido, Paolo Gionchetti

“…The consensus group met with a major focus of delineating the unmet needs of current treatment strategies and overall management of ulcerative colitis, while also focusing on quality of life and patient care. …”
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Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages by Cong Chen, Zhengfeng Liang, Yuqi He, Yan Gao, Shuhui Ouyang, Lili Wang, Jianghua Liu, Jingsong Cao

“…The findings provide a new theoretical and experimental bases for optimizing the strategies for prevention and treatment of T2D VC.…”
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Malignant phyllodes tumors with sarcomatous components: A histopathologic and molecular study by Ting Lei, Yunjie Song, Zhiyi Shen, Yongqiang Shi, Cunyan Xia, Xu Deng, Wenyue Da, Yan Peng, Qing Li

“…A more comprehensive characterization of their clinicopathological features and molecular profiles may offer significant potential innovative therapeutic strategies. Methods: A total of ten cases were collected with eight cases undergoing DNA next-generation sequencing (NGS). …”
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Enhancing diagnostic outcomes in kidney genetic disorders: the KidGen national kidney genomics study protocol by Amali Mallawaarachchi, Hugh McCarthy, Thomas A. Forbes, Kushani Jayasinghe, Chirag Patel, Stephen I. Alexander, Tiffany Boughtwood, Jeffrey Braithwaite, Aron Chakera, Sam Crafter, Ira W. Deveson, Randall Faull, Trudie Harris, Lilian Johnstone, Matthew Jose, Anna Leaver, Melissa H. Little, Daniel MacArthur, Tessa Mattiske, Christine Mincham, Kathy Nicholls, Catherine Quinlan, Michael C. J. Quinn, Gopala Rangan, Jessica Ryan, Cas Simons, Ian Smyth, Madhivanan Sundaram, Peter Trnka, Laura Wedd, Erik Biros, Zornitza Stark, Andrew Mallett

“…These include re-analysing existing data and/or undergoing advanced genomic testing methods, including short and long-read whole-genome sequencing, RNA sequencing, and functional genomics strategies using mouse modelling or kidney organoids. …”
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Quality of life among healthcare workers in the hospitals and primary healthcare centers in Gaza Strip: a cross-sectional study by Joma Younis, Lina Wang, Amal Abed, Hong Jiang, Yahui Fan, Zhaofang Li, Mei Ma, Le Ma, Zhaozhao Hui, Linlin Hua, Wei Zhang

“…Age, smoking status, workplace, and work shifts were associated with overall QoL. Strategies to improve HCWs’ QoL, such as lifestyle interventions, additional support through training or educational programs, and reducing work schedules, could be considered under high-pressure situations.…”
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GM-CSF and IL-21-armed oncolytic vaccinia virus significantly enhances anti-tumor activity and synergizes with anti-PD1 immunotherapy in pancreatic cancer by Yujing Xuan, Wenyi Yan, Ruimin Wang, Xibin Wang, Yu Guo, Huilin Dun, Ziyan Huan, Lihua Xu, Ruxia Han, Xianlei Sun, Lingling Si, Nicholas R. Lemoine, Nicholas R. Lemoine, Yaohe Wang, Yaohe Wang, Pengju Wang

“…Oncolytic viruses armed with immunoregulatory molecules are promising strategies to overcome limited efficacy and target inaccessible and metastatic tumors. …”
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Historical perspectives supporting the ambitious anesthetist aiming for zero nausea/vomiting: should one trust every consensus statement every time? by Brian A. Williams, Brian A. Williams, Christopher A. Schumacher, Ridhi Choragudi, Kelly E. Garbelotti, John M. Ludden, Daniel E. Hall, Daniel E. Hall, Daniel E. Hall

“…This meaningful prevention thematically differs from the scholarly prevention benchmark that may be over-reliant on patient-specific preoperative risk factors, described in the 1990s and before, dictating prophylaxis strategies. Meaningful prevention with 5-medication PONV prophylaxis (which we recommend before entry into the operating theater) (i) may serve as a surprisingly effective antecedent to further avoid postoperative opioids, (ii) may be augmented throughout hospitalization and convalescence with daily “booster dosing”, and (iii) may (in combination with booster dosing) mitigate possible “rebound nausea” that has been reported by esteemed PONV thought leaders in the context of post-discharge nausea and/or vomiting. …”
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Congenital Zika Syndrome: Insights from Integrated Proteomic and Metabolomic Analysis by Leticia Gomes-de-Pontes, Lucila Akune Barreiros, Lillian Nunes Gomes, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleão, Paulo V. Soeiro-Pereira, Saulo Duarte Passos, Antonio Condino-Neto

“…The identification of specific alterations in the PI3K-AKT-mTOR pathway highlights a possible therapeutic target, providing new opportunities for the development of more effective treatment strategies for CZS. Our findings significantly advance the understanding of CZS and underscore the need for further investigations using advanced techniques to validate and explore these potential molecular targets.…”
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Exploration of metastasis-related signatures in osteosarcoma based on tumor microenvironment by integrated bioinformatic analysis by Shiyao Liao, Xing Gao, Kai Zhou, Yao Kang, Lichen Ji, Xugang Zhong, Jun Lv

“…Exploration of metastasis-related signatures in TME may be valuable for enhancing treatment strategies for OS.…”
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Drought stress tolerance based on selection indices of resistant crops variety by R. Daneshvar rad, H. Heidari Sharifabad, M. Torabi, R. Azizinejad, H.R. Salemi, M. Heidari Soltanabadi

“…Several coping mechanisms (recovery, avoidance, tolerance and drought escape) have been developed to mitigate the impact of drought stress, and  most strategies involve survival during stress condition. …”
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Reducing catheter-associated urinary tract infections in a large health system: a quality improvement approach using a fractal management system by Elie A. Saade, Esther J. Thatcher, Tina Lewis, Susan Carr, Marcia Cornell, Rachel Arnold, Lisa Bushong, Zainab Albar, Peter Pronovost

“…Methods: A broad set of quality improvement (QI) strategies was developed by an interdisciplinary team and guided by the Fractal Management System framework to ensure accountability, communication, and alignment across teams and facilities. …”
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Comparative evaluation of management practices among large-scale broiler farms of Punjab, Pakistan by Muhammad Tahir Amin, Muhammad Usman, Hafiz Muhammad Ishaq, Asad Ali, Muzamal Tariq, Mian Mubashar Saleem, Syed Ghulam Mohayud Din Hashmi, Kinza Saleem, Sohail Ahmad

“…Future studies are needed to explore this area further and develop strategies to address challenges faced by poultry farmers.…”
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Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

“…Further research is needed to validate these findings and optimize treatment strategies for patients with severe asthma.…”
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The responses of vegetation water use efficiency to biomass density and CO2 balance in dryland of Central Asia during 21st century by Alphonse Kayiranga, Xi Chen, Xuexi Ma, Dative Ingabire, Tie Liu, Yaoming Li, Emeka Edwin Igboeli, Eldiiar Duulatov, Hubert Hirwa, Clement Nzabanita, Ping Hu

“…These findings have implications on regional strategies for CO2 controls and climate change mitigations and adaptation along the different global desert ecosystems.…”
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Abnormal dynamic features of cortical microstates for detecting early-stage Parkinson's disease by resting-state electroencephalography: Systematic analysis of the influence of eye... by G. Gimenez-Aparisi, E. Guijarro-Estelles, A. Chornet-Lurbe, D. Cerveró-Albert, Dongmei Hao, Guangfei Li, Y. Ye-Lin

“…Our results suggest that the source-space microstate analysis of resting-state EEG could provide robust biomarkers to detect early-stage PD, which would allow the development of patient-oriented strategies to prevent the disease and improve the patients’ quality of life.…”
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Adaptations to the welsh national exercise referral scheme during the COVID-19 pandemic: a qualitative study exploring the experiences of service users and providers and supplement... by Katie Newby, Neil Howlett, Adam P. Wagner, Nigel Lloyd, Imogen Freethy, Charis Bontoft, Olujoke Fakoya, Shelley Jackson, Carla Jackson, Wendy Wills, Mary-Ann McKibben, Annie Petherick, Katherine E. Brown

“…Conclusions This study indicates that offering a virtual version of NERS could make the scheme more accessible to those who are typically underserved, provided strategies to address digital inclusion are addressed. …”
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Prevalence of disability in Iranian older adults in Tehran, Iran: A population-based study by Vahid Rashedi, Mohsen Asadi-Lari, Mahshid Foroughan, Ahmad Delbari, Reza Fadayevatan

“…Conclusion: For older adults, disability directly affects daily functioning by restricting physical and social activities, the ability to maintain self-sufficiency, and ultimately the freedom to live a chosen lifestyle. Prevention strategies should focus on reducing the incidence of chronic disease and improving socioeconomic status of older adults.…”
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