Protocol for a prospective observational cohort study of cutaneous leishmaniasis in Ethiopia [version 2; peer review: 2 approved, 1 approved with reservations] by Fewzia Shikur Mohammed, Amel Beshir Mohammed, Shimelis Doni Nigusse, Feleke Tilahun Zewdu, Abebaw Yeshambel Alemu, Teklu Cherkose, Kidist Bobosha, Eshetu Molla, Iris Mosweu, Vanessa Yardley, Saba Maria Lambert, Mirgissa Kaba, Endalamaw Gadisa, Yohannes Hailemichael, Catherine Pitt, Elizabeth Allen, Stephen L. Walker, Michael Marks

“…Conclusions These data will inform the design of randomized controlled trials to evaluate new treatment strategies, with appropriate economic evaluations. This will help improve evidence-based guidelines and support evidence-led policy decisions, not only in Ethiopia but also globally.…”
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Influence of tension cracks on moisture infiltration in loess slopes under high-intensity rainfall conditions by Xuancheng Ren, Weifeng Sun, Hengxing Lan, Han Bao, Langping Li, Shijie Liu, Changgen Yan, Xiaochan Wang, Zhouchen Li, Chaoyang Tian

“…These findings deepen our understanding of moisture migration dynamics in loess slopes with crest-tension cracks, providing insights for developing effective slope hazard mitigation strategies.…”
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…This study investigates the causal links between variations in mitochondrial protein genes and neurodegenerative diseases, aiming to elucidate their potential contributions to disease progression and identify novel therapeutic strategies. Methods Herein, we utilized data from genome‐wide association studies (GWAS) on mitochondrial proteins and neurodegenerative diseases. …”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…The single-cell transcriptome and bioinformatics analyses provided insights into the mechanisms driving MVI, potentially aiding the development of targeted diagnostic and therapeutic strategies. Future research should further validate the role of MARCKSL1 in MVI progression and explore its potential clinical applications.…”
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A pan-immune panorama of bacterial pneumonia revealed by a large-scale single-cell transcriptome atlas by Kun Xiao, Yan Cao, Zhihai Han, Yuxiang Zhang, Laurence Don Wai Luu, Liang Chen, Peng Yan, Wei Chen, Jiaxing Wang, Ying Liang, Xin Shi, Xiuli Wang, Fan Wang, Ye Hu, Zhengjun Wen, Yong Chen, Yuwei Yang, Haotian Yu, Lixin Xie, Yi Wang

“…Current therapeutic strategies beyond antibiotics and adjuvant therapies are limited, highlighting the need for a deeper understanding of the disease pathogenesis. …”
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ROS-regulated SUR1-TRPM4 drives persistent activation of NLRP3 inflammasome in microglia after whole-brain radiation by Yuan Chang, Yihua He, Di Wang, Kunxue Zhang, Yuzhen Zhang, Zhentong Li, Shuxin Zeng, Sheng Xiao, Suyue Pan, Kaibin Huang

“…In summary, this study deciphers that SUR1-TRPM4 crucially mediates the persistent activation of microglial NLRP3 inflammasome under the action of ROS after whole-brain radiation, offering novel therapeutic strategies for delayed RIBI as well as other NLRP3-related neurological disorders involving excessive ROS production.…”
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Advancement of Pt and Pd-based catalysis for green, sustainable energy and bio-medical applications by Nithyadharseni Palaniyandy, Sekhosana Kutloano, Lakshmi Devaraj, Xolile Fuku, Sathish Sundar Dhilip Kumar

“…In response to the growing demand for these products, the development of strategies to produce various materials is being intensified. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…This review summarizes the application strategies and delivery methods of CRISPR/Cas, discusses recent progress in CRISPR/Cas-based disease models and therapies, and provides an overview of the landscape of clinical trials. …”
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The intestinal microbial community and function of Riptortus pedestris at different developmental stages and its effects on development by Yanbin Wang, Rong Li, Chunjing Wang, Ting Sun, Hongjuan Zhang, Fang Zhao, Jiehui Liu, Yuqiong Hao, Xiansheng Xie

“…This study provides the basis for stinkbug management strategies that focus on the pivotal gut microbiota.…”
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Genomic variation responding to artificial selection on different lines of Pekin duck by Xinye Zhang, Fangxi Yang, Jinxin Zhang, Tao Zhu, Xiurong Zhao, Yuchen Liu, Junhui Wen, Hongchang Gu, Gang Wang, Xufang Ren, Anqi Chen, Lujiang Qu

“…These findings contribute to a deeper understanding of the distinct evolutionary processes in Pekin ducks under artificial selection and provide valuable insights for future breeding strategies.…”
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Mapping the intellectual structure and emerging trends on nanomaterials in colorectal cancer: a bibliometric analysis from 2003 to 2024 by Man Lu, Yi Liu, Jin Zhu, Jiarong Shang, Lu Bai, Zhichao Jin, Wenting Li, Yue Hu, Xia Zheng, Jun Qian

“…Current therapeutic strategies for CRC have limitations, while nanomaterials show significant potential for diagnosing and treating CRC. …”
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Relationship between TyG-related index and hearing loss in people over 45 s in China by Chao Wang, Mengdi Shi, Liangzhen Xie, Chenhao Jiang, Yunxin Li, Jingxiao Li, Shulin Li, Yan Li

“…Further research is needed to elucidate the mechanisms underlying these associations and to develop age-inclusive strategies for addressing hearing impairment in the aging population.…”
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Pre-Season Precipitation and Temperature Have a Larger Influence on Vegetation Productivity than That of the Growing Season in the Agro-Pastoral Ecotone in Northern China by Yuanyuan Zhang, Qingtao Wang, Xueyuan Zhang, Zecheng Guo, Xiaonan Guo, Changhui Ma, Baocheng Wei, Lei He

“…These findings not only emphasize the critical role of both historical and contemporary climate conditions in shaping vegetation growth but also provide valuable insights into how to adjust agricultural and animal husbandry management strategies to improve regional climate adaptation based on climate information from previous seasons in fragile regions.…”
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The Global Burden of Emerging and Re-Emerging Orbiviruses in Livestock: An Emphasis on Bluetongue Virus and Epizootic Hemorrhagic Disease Virus by Shanta Barua, Eaftekhar Ahmed Rana, M. Asaduzzaman Prodhan, Syeda Hasina Akter, Jully Gogoi-Tiwari, Subir Sarker, Henry Annandale, Debbie Eagles, Sam Abraham, Jasim M. Uddin

“…Effective prevention and control strategies are paramount and rely on vaccination, vector control using insecticides, and the destruction of breeding sites, husbandry practices including the isolation and quarantine of infected hosts, restriction of animal movement, prompt diagnosis and identification of circulating strains, and effective surveillance and monitoring plans such as the pre-export and post-import screening of semen used for artificial insemination. …”
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Prognostics optical coherence tomography biomarker in macular oedema secondary to retinal vein occlusion by Andrea R. Silitonga, Hanna T.H. Silitonga, Rova Virgana, Iwan Sovani, Arief Kartasasmita, Erwin Iskandar, Grimaldi Ihsan, Made Indra

“…Background: Identifying biomarkers predictive of future best-corrected visual acuity (BCVA) in macular oedema secondary to retinal vein occlusion (RVO-MO) is crucial for improving risk assessment, management strategies and patient consultations. Aim: This study aimed to identify baseline optical coherence tomography (OCT) predictors of visual prognosis in RVO-MO following intravitreal bevacizumab (IVB) injection. …”
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Neutralizing antibody responses to three XBB protein vaccines in older adults by Guo-Jian Yang, Mei Lu, Rui-Rui Chen, Shuang-Qing Wang, Sheng Wan, Xue-Dong Song, Guo-Ping Cao, Lei Lv, Xue-Juan He, Bing-Dong Zhan, Mai-Juan Ma

“…These findings indicate that booster vaccination with XBB-containing vaccines can effectively elicit strong neutralizing responses against a number of SARS-CoV-2 variants in older adults over 65 years, which will help guide vaccine strategies in this elderly population.…”
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Batterer typologies: substance use, impulsivity and results of an IPVAW offender treatment program in Spain by Pedro V. Mateo-Fernández, Pedro V. Mateo-Fernández, Pedro V. Mateo-Fernández, Iria Osa-Subtil, Iria Osa-Subtil, Iria Osa-Subtil, Román Ronzón-Tirado, María Elena de la Peña Fernández

“…Meanwhile, the tools used included AUDIT and EuropASI to assess alcohol consumption, CTS2 to measure the frequency and intensity of violent behaviors over the last year, and SCID-II for personality disorders.ResultsOur findings reflected marked improvements in conflict resolution strategies, especially in terms of reduced psychological violence and sexual coercion, but not physical violence. …”
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Thermal Development, Mortality, and Fertility of an Apulian Strain of <i>Drosophila suzukii</i> at Different Temperatures by Nuray Baser, Luca Rossini, Gianfranco Anfora, Kürşat Mustafa Temel, Stefania Gualano, Emanuele Garone, Franco Santoro

“…Given its high invasive potential and the increasing need for low-impact control strategies, an in-depth exploration of the biology of this species and of the stage thermal response is fundamental. …”
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Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study by Zhang-Yang Xu, Hong Zheng, Zi-Jun Pan, Shou-Yi Hu, Yun-Xia Wang, Wen-Jun Su

“…These insights provide valuable guidance for developing more effective strategies for the prevention and treatment of depressive disorders. …”
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Post-craniotomy infections: A point-by-point approach by Giovanni Carone, Marta Bonada, Evelyn Gisell Belotti, Eugenia D'Angeli, Annica Piccardi, Fabio Martino Doniselli, Guido Gubertini, Cecilia Casali, Francesco DiMeco, Massimiliano Del Bene

“…Advancements in diagnostic and therapeutic strategies may bring future improvements in clinical outcomes, despite antibiotic resistance phenomena and the complexity of surgical decisions required. …”
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