Study Protocol of the Korean EGFR Registry: A Multicenter Prospective and Retrospective Cohort Study in Nonsmall Cell Lung Cancer Patients With EGFR Mutation by Chang Dong Yeo, Dong Won Park, Seong Hoon Yoon, Eun Young Kim, Jeong Eun Lee, Shin Yup Lee, Chang‐Min Choi, In‐Jae Oh, Do Jin Kim, Jeong Seon Ryu, Jae Cheol Lee, Young‐Chul Kim, Tae Won Jang, Kye Young Lee, Seung Hun Jang, Seung Joon Kim, for the Korean EGFR Registry Investigators

“…The Korean EGFR Registry will contribute significantly to the understanding of the complex dynamics of EGFR‐mutated NSCLC, aiding in the development of more effective and personalized treatment strategies.…”
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Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study by Béranger Doussot, MD, Alexandre Doussot, MD, PhD, Ahmet Ayav, MD, PhD, Nicolas Santucci, MD, Sophie Deguelte, MD, Amadou Khalilou Sow, MD, Mehdi El Amrani, MD, PhD, Laurence Duvillard, MD, PhD, Guillaume Piessen, MD, PhD, Edouard Girard, MD, PhD, Jean-Yves Mabrut, MD, PhD, Jonathan Garnier, MD, PhD, Pablo Ortega-Deballon, MD, PhD, Isabelle Fournel, MD, PhD, Olivier Facy, MD, PhD

“…Clinically relevant postoperative pancreatic fistula remains a potentially life-threatening complication after pancreatic surgery. Early detection strategies remain key to reduce both the incidence and the burden of pancreatic fistula. …”
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Histone Arginine Methylation-Mediated Epigenetic Regulation of Discoidin Domain Receptor 2 Controls the Senescence of Human Bone Marrow Mesenchymal Stem Cells by Zhenyu Xu, Wenming Wu, Fang Shen, Yue Yu, Yue Wang, Charlie Xiang

“…Understanding the process of in vitro senescence in hBM-MSCs would enable the development of strategies to maintain their vitality after cell culture. …”
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Comparative transcriptome analysis reveals potential regulatory mechanisms in response to changes in physiological functions in Oreochromis aureus under salinity stress by Chang Yuan, Kangqi Zhou, Xianhui Pan, Yong Lin, Junqi Qin, Dapeng Wang, Zhong Chen, Xuesong Du, Yin Huang

“…This study enhances our understanding of O. aureus adaptive strategies under salinity stress, while also providing relevant theoretical insights into the domestication of fish under saline conditions and the mechanisms mediating adaptations to saline aquatic environments.…”
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C-reactive protein testing in primary care and antibiotic use in children with acute respiratory tract infections in Kyrgyzstan: an open-label, individually randomised, controlled... by Elvira Isaeva, Joakim Bloch, Azamat Akylbekov, Robert L. Skov, Anja Poulsen, Jørgen A.L. Kurtzhals, Susanne Reventlow, Nandini Sreenivasan, Maamed Mademilov, Volkert D. Siersma, Talant Sooronbaev, Jesper Kjærgaard, Rune M. Aabenhus

“…Interpretation: Implementing CRP testing in primary care for paediatric ARTI in Kyrgyzstan significantly reduced antibiotic use without negative effects on safety, supporting its role in national antimicrobial stewardship strategies. Funding: International Centre for Antimicrobial Resistance Solutions (ICARS).…”
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Seminal plasma protein profiles based on molecular weight as biomarkers of sperm fertility in horned and polled Bali bulls by Rasyidah Mappanganro, Herry Sonjaya, Sudirman Baco, Hasbi Hasbi, Sri Gustina

“…These findings could inform bull selection and reproductive management strategies. Further research is recommended to validate these biomarkers using advanced proteomic approaches.…”
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The clinical value of Serum hyaluronic acid, procollagen III, N-terminal propeptide levels sST2 and cfDNA in predicting the myocardial damage in children with severe pneumonia by Haoran Jia, Ye Liu, Tingting Zhao, Dexing Wang, Meng Du, Weiwei Wang

“…Conclusions: Serum hyaluronic acid, procollagen III, NTproBNP, sST2, and cfDNA significantly predict severe pneumonia complicated by myocardial damage. Nursing strategies based on these biomarkers can effectively improve treatment outcomes, demonstrating significant clinical application value.…”
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Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment by Jiewen Zhang, Shaobo Wu, Fangze Xing, Ning Kong, Yiwei Zhao, Xudong Duan, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang

“…These findings suggest CSNK1D as a potential therapeutic target for OP, offering insights into new treatment strategies integrating circadian rhythm regulation.…”
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Effectiveness of a bacteriophage YZU_PF006 in controlling dairy spoilage caused by Pseudomonas fluorescens by Lei Yuan, Lili Ma, Yang Liu, Xinhai Yuan, Shuo Wang, Wenyuan Zhou, Zhenbo Xu, Zhenquan Yang

“…Results demonstrated that phage YZU_PF006 can be used alone or in combination with other control strategies to serve as one of the good antimicrobial candidates to control P. fluorescens contamination in dairy processing environments, and to promote the safety and sensory quality of raw milk and milk products.…”
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Comparison of 10-year atherosclerotic cardiovascular disease (ASCVD) risk in metropolitan and rural areas of South of Iran by Mohammad Javad Zibaeenezhad, Mehrab Sayadi, Hossein Pourmontaseri, Davood Khalili, Mojtaba Farjam, Ehsan Bahramail, Nader Parsa, Azizallah Dehghan, Seyyed Saeed Mohammadi, Iman Razeghian-Jahromi, Hamed Bazrafshan drissi, Matin Sepehrinia

“…Given the higher risk of cardiovascular events in urban areas and different profiles of risk factors between these two regions, preventive strategies should be precisely and separately designed for each population by the health authorities and policymakers in order to reduce the CVD toll efficiently.…”
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Impaired Hepatitis B and COVID-19 vaccination responses show strong concordance in hemodialysis patients with end stage renal disease by Karsten Lürken, Anna Meinecke, Luis A. Manthey, Anne Cossmann, Metodi V. Stankov, Frank Klawonn, Anna Zychlinsky Scharff, Sandra Steffens, Alexandra Dopfer-Jablonka, Frank Müller, Georg M. N. Behrens, Christine Happle

“…These results may help to adapt vaccination strategies in this highly vulnerable population. Trial registration: German Clinical Trial Registry, DRKS00021152.…”
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A molecular toxicological study to explore potential health risks associated with ultrafine particle exposure in cold and humid indoor environments by Ziyu Shu, Shuo Qing, Xu Yang, Ping Ma, Yang Wu, Baizhan Li, Fangxin Fang, Runming Yao

“…Our findings suggest that the synergistic effects of environmental factors and pollutant exposure significantly impact respiratory health, providing valuable insights for the design of healthier indoor environments and the development of strategies to mitigate these risks.…”
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Inter-laboratory ring test for environmental DNA extraction protocols: implications for marine megafauna detection using three novel qPCR assays by Lauren Kelly Rodriguez, Lorenzo De Bonis, Jack McKee, James A. McKenna, Teddy Urvois, Eleonora Barbaccia, Eileen Dillane, Caterina Lanfredi, Helene Hjellnes, Armelle Jung, Enrico Villa, Arianna Azzellino, Jon-Ivar Westgaard, Erwan Quéméré, Bettina Thalinger

“…Performance differences between protocols can jeopardize effective conservation strategies across regions and focal species. To address potential discrepancies amongst four international partners within a collaborative eDNA initiative, an inter-laboratory comparison (i.e., ring test) was conducted to compare efficiencies of established DNA extraction methodologies based on 39 eDNA samples. …”
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Climate-change impacts on distribution, habitats, sustainability and cultivation planning of two economically and ecologically important forest trees (China fir and Masson pine) in... by Yanghui Zhao, Liang Xu, Ying Zhang, Yafeng Wen, Donglin Zhang

“…Unraveling the influences of ANCC on forest trees is essential for understanding the response of forests to climate change and devising future strategies for forestry construction and production. …”
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The effects of vessel speed and size on the lethality of strikes of large whales in U.S. waters by Lance P. Garrison, Niki E. Lisi, Meghan Gahm, Eric M. Patterson, Hannah Blondin, Hannah Blondin, Caroline P. Good

“…Model-based estimates of mortality rates, which inform management strategies to reduce vessel strike mortality, typically assume a reduced likelihood that a whale-vessel collision will be lethal to the whale at slower vessel speeds. …”
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Duration of exposure to night work and cardiovascular risk factors: results from 52,234 workers of the CONSTANCES study by Eve Bourgkard, Stéphanie Boini, Michel Grzebyk, Mathieu Dziurla, Jean Ferrières, Marcel Goldberg, Céline Ribet, Yolande Esquirol

“…Implementing effective preventive strategies, however, requires further investigation of the effects of exposure duration. …”
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Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy by Yu Chen, Mingyuan Jiang, Liping Li, Shanshan Yang, Zuimeng Liu, Shiwen Lin, Wanxiao Wang, Jinyang Li, Feng Chen, Qiang Hou, Xiaoyin Ma, Ling Hou

“…These findings provide new insights into the complex mechanisms underlying RPE-EMT and PVR pathogenesis, with implications for rational strategies for potential therapeutic applications in PVR by targeting RPE-EMT.…”
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Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

“…This approach provides valuable insights for stakeholder to target interventions and policies adapted to each archetype, for example, payment for ecosystem services, command and control policies, land tenure regulations, land restoration strategies or land use intensification.…”
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Emirates consensus recommendations on cardiovascular risk management in type 2 diabetes by Hani Sabbour, Hani Sabbour, Hani Sabbour, Wael Almahmeed, Wael Almahmeed, Fatheya Alawadi, Fatheya Alawadi, Abdullah Shehab, Abdulamjeed Al Zubaidi, Alaaeldin Bashier, Abdul Rauf Ghulam, Fauzia Rashid, Hosam Zaky, Hussien Heshmat Kassemn, Hussien Heshmat Kassemn, Jamila Bin Adi, Juwairia Tahir, Khadija Hafidh, Mohammed Farghali, Mohamed Hassanien, Mohamed Hassanien, James Januzzi

“…The universal definition and classification of heart failure provides a useful framework for recommending optimal screening, treatment, and referral strategies to diabetic individuals at various stages of the cardiovascular continuum. …”
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Integrated Machine Learning Approaches for Landslide Susceptibility Mapping Along the Pakistan–China Karakoram Highway by Mohib Ullah, Haijun Qiu, Wenchao Huangfu, Dongdong Yang, Yingdong Wei, Bingzhe Tang

“…The proposed modeling approach reduces uncertainties, enhances prediction accuracy, and supports decision-makers in implementing effective landslide mitigation strategies.…”
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