Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress by Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, Amanda Haymond, Lance A. Liotta, Marissa A. Howard

“…Ultimately, our findings may inform new prevention strategies targeting pre-malignant lesions and therapeutic approaches designed to sensitize tumor cells to oxidative stress-inducing therapies.…”
Get full text

The Role of Serum Vitamin D Levels and Vitamin D Receptor (<i>VDR</i>) Gene Variants on Dental Caries by Ece Şengün Berber, Feyza Umay Koç, Ayça Aykut, Burcu Barutçuoğlu, Fahinur Ertuğrul, Merve Tosyalı, Mert Pekerbaş, Arzu Aykut Yetkiner

“…Conclusions: This study provides important insights into the relationship between vitamin D and dental caries and can contribute to the development of effective preventive strategies for oral and dental health.…”
Get full text

RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…Hence, investigating novel pathways implicated in cancer progression and metastasis could lead to the development of targeted therapies and new treatment strategies in breast cancer. Recent studies reported an interplay between the receptor for advanced glycation end products (RAGE) and its ligands, S100 protein group, advanced glycation end products (AGEs) and high-mobility group box 1 protein (HMGB1) and breast cancer growth and metastasis.Materials and methodsWe used articles available in the NCBI website database PubMed to write this scoping review. …”
Get full text

Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease by Manuel Serrano, Jose Angel Martínez-Flores, Maria José Castro, Florencio García, David Lora, Dolores Pérez, Esther Gonzalez, Estela Paz-Artal, Jose M. Morales, Antonio Serrano

“…This finding could have important clinical implications and can suggest new therapeutic strategies in patients with IgA aB2GPI antibodies.…”
Get full text

Improving diagnostics and surveillance of malaria among displaced people in Africa by Toufik Abdul-Rahman, Oyinbolaji Akinwande Ajetunmobi, Gafar Babatunde Bamigbade, Innocent Ayesiga, Muhammad Hamza Shah, Tolulope Sharon Rumide, Abdurahman Babatunde Adesina, Ganiyat Adekemi Adeshina, Oluwabusola Elizabeth Oni, Bet-ini Nsikak Christian, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Hala Ibrahim Thaalibi, Iman Mustafa Abdalla, Sewar Basheer Banimusa, Justice Ndubuisi Jonathan, Isreal Ayobami Onifade, Md Ariful Haque

“…Hence, addressing malaria in displaced populations in Africa requires comprehensive and well-coordinated strategies. Advanced diagnostic and surveillance technologies are essential for promptly identifying and treating malaria, providing chances to monitor and control its spread effectively. …”
Get full text

Temporal Analysis of the Incidence, Mortality and Disability-Adjusted Life Years of Benign Gallbladder and Biliary Diseases in High-Income Nations, 1990–2019 by Dominic W. Proctor, BMBS, MSc, Richard Goodall, BSc, MBChB, MRCS, FHEA, Kim Borsky, MBBS, MMRCS, Justin D. Salciccioli, MBBS, MA, Dominic C. Marshall, MBBS, MRCP, BSc, Kumaran Shanmugarajah, MD, PhD, Joseph Shalhoub, BSc, MBBS, FHEA, PhD, DIC, MEd, FFSTEd, FRCS, FEBVS

“…International variation in lifestyle factors, diagnostic and management strategies likely account for national and sex disparities. …”
Get full text

Alpha/beta values in pediatric medulloblastoma: implications for tailored approaches in radiation oncology by Danny Jazmati, Dennis Sohn, Juliane Hörner-Rieber, Nan Qin, Edwin Bölke, Jan Haussmann, Rudolf Schwarz, Niklas David Niggemeier, Arndt Borkhardt, Florian Babor, Triantafyllia Brozou, Melissa Felek, Balint Tamaskovics, Patrick Melchior, Thomas Beez, Beate Timmermann, Marc Remke, Stefanie Corradini, Rémi Till Schulz, Ronja-Linda Preugschas, Wilfried Budach, Christiane Matuschek

“…This study presents significant potential by enabling the estimation of radiobiological fractionations and dose effects in young, vulnerable patients, highlighting its importance for advancing patient-specific therapeutic strategies.…”
Get full text

Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors by Runi Hou, Lijian Xu, Maolin Yu, Zengmin Tang, Bin Zhou, Qiao Zhang, Na Li, Jianxiong Xu

“…The pursuit of nanogenerators with superior electrical output performance is crucial for advancing high-performance self-powered sensors, yet enhancing their performance through effective strategies remains a formidable challenge. Herein, a kind of piezoelectric-triboelectric hybrid nanogenerator (PTENG) utilizing a tough, stretchable BaTiO3 doped hydrogel was developed. …”
Get full text

Experiences of ‘traditional’ and ‘one-stop’ MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs by Fiona M Walter, Stephanie Archer, Willie Hamilton, Samuel William David Merriel, John McGrath, Alice S Forster, Hashim Uddin Ahmed, David Eldred-Evans

“…GPs remain uncertain how best to identify patients needing referral for urgent prostate cancer testing due to the lack of accurate triage and risk assessment strategies.…”
Get full text

The Aryl Hydrocarbon Receptor (AhR) Is a Novel Gene Involved in Proper Physiological Functions of Pancreatic β-Cells by Shuhd Bin Eshaq, Jalal Taneera, Shabana Anjum, Abdul Khader Mohammed, Mohammad H. Semreen, Karem H. Alzoubi, Mohamed Eladl, Yasser Bustanji, Eman Abu-Gharbieh, Waseem El-Huneidi

“…These findings suggest that AhR could be a potential target for future therapeutic strategies in treating type 2 diabetes (T2D).…”
Get full text

Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Thus, we detail recommendations for best practice and strategies for identifying cryptic taxa and hybridisation. …”
Get full text

Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…This discovery could provide novel insights into therapeutic strategies for T2D provoked by environmental toxicants.…”
Get full text

Duvelisib is a novel NFAT inhibitor that mitigates adalimumab-induced immunogenicity by Aboli Bhingarkar, Yuyin Wang, Keito Hoshitsuki, Katherine Marie Eichinger, Katherine Marie Eichinger, Sanjay Rathod, Yin Zhu, He Lyu, Andrew T. McNutt, Larry W. Moreland, Lee McDermott, David R. Koes, Christian A. Fernandez

“…Although methotrexate (MTX) can mitigate TNFi immunogenicity, its adverse effects necessitate alternative strategies. Targeting nuclear factor of activated T cells (NFAT) transcription factors may protect against biologic immunogenicity. …”
Get full text

Suicidal Behaviors Among United States Adolescents: Increasing Clinical and Public Health Challenges by Jhon Ostanin, Helena Miranda, Simon Shugar, Dina Abdo, Maria Carmenza Mejia, Charles H. Hennekens, Panagiota Kitsantas

“…They suggest the need for gender-sensitive approaches in mental health support and prevention strategies. Overall, given the significant increase in suicidal behaviors, healthcare providers as well as public health professionals should prioritize mental health initiatives, promote awareness, and ensure access to mental health resources for adolescents.…”
Get full text

Using machine learning to predict outcomes following transcarotid artery revascularization by Ben Li, Naomi Eisenberg, Derek Beaton, Douglas S. Lee, Leen Al-Omran, Duminda N. Wijeysundera, Mohamad A. Hussain, Ori D. Rotstein, Charles de Mestral, Muhammad Mamdani, Graham Roche-Nagle, Mohammed Al-Omran

“…Our ML algorithm has potential for important utility in guiding peri-operative risk-mitigation strategies to prevent adverse outcomes following TCAR.…”
Get full text

Diel changes in the expression of a marker gene and candidate genes for intracellular amorphous CaCO3 biomineralization in Microcystis by Bruley, Apolline, Gaëtan, Juliette, Gugger, Muriel, Pancrace, Claire, Millet, Maxime, Gaschignard, Geoffroy, Dezi, Manuela, Humbert, Jean-François, Leloup, Julie, Skouri-Panet, Fériel, Callebaut, Isabelle, Benzerara, Karim, Duprat, Elodie

“…While we ignore the biological function of iACC and the molecular mechanisms driving their formation, this process may impact local geochemical cycles and/or be used for bioremediation strategies. Recently, a marker gene of this biomineralization pathway, named ccyA, was discovered. …”
Get full text

Graphene oxide scaffolds promote functional improvements mediated by scaffold-invading axons in thoracic transected rats by Marta Zaforas, Esther Benayas, Raquel Madroñero-Mariscal, Ana Domínguez-Bajo, Elena Fernández-López, Yasmina Hernández-Martín, Ankor González-Mayorga, Elena Alonso-Calviño, Eduardo R. Hernández, Elisa López-Dolado, Juliana M. Rosa, Juan Aguilar, María C. Serrano

“…One of the most promising therapeutic strategies to date for these patients involves the use of epidural electrical stimulation. …”
Get full text

Triple burden of malnutrition among Vietnamese 0·5–11-year-old children in 2020–2021: results of SEANUTS II Vietnam by Nga Thuy Tran, Van Khanh Tran, Duong Thanh Tran, Tu Tran Ngoc Nguyen, Son Duy Nguyen, Ha Thu Nguyen, Tu Song Nguyen, Tung Van Thanh Le, Phuong Thi Lan Nguyen, Hanh Thi Dang, Hoa Anh Le, Gerard Wong, Ilse Khouw

“…The high prevalence of low serum Zn, vitamin D insufficiency and the inadequate intakes of Ca and vitamin D are of concern. Nutrition strategies for Vietnamese children should consider three sides of malnutrition and focus on approaches for the prevention of malnutrition. …”
Get full text

Pyroxsulam Resistance in <i>Apera spica-venti</i>: An Emerging Challenge in Crop Protection by Soham Bhattacharya, Madhab Kumar Sen, Katerina Hamouzová, Pavlína Košnarová, Rohit Bharati, Julio Menendez, Josef Soukup

“…This evolution underscores the adaptive capacity of weed populations under herbicide pressure, emphasizing the need for alternative control strategies.…”
Get full text

Biomass allocation between reproductive and vegetative organs of Artemisia along a large environmental gradient by Tumenjargal Tsogtsaikhan, Xuejun Yang, Ruiru Gao, Jiangrui Liu, Wenqiang Tang, Guofang Liu, Xuehua Ye, Zhenying Huang

“…Abstract Background Biomass allocation reflects functional tradeoffs among plant organs and thus represents life history strategies. However, little is known about the patterns and drivers of biomass allocation between reproductive and vegetative organs along large environmental gradients. …”
Get full text