Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism by Rocio Diaz Escarcega, Vijay Kumar M. J., Vasilia E. Kyriakopoulos, Guadalupe J. Ortiz, Aaron M. Gusdon, Huihui Fan, Pedram Peesh, Maria P. Blasco Conesa, Gabriela Delevati Colpo, Hilda W. Ahnstedt, Lucy Couture, Stella H. Kim, Miriam Hinojosa, Christine M. Farrell, Sean P. Marrelli, Akihiko Urayama, Bhanu P. Ganesh, Paul E. Schulz, Louise D. McCullough, Andrey S. Tsvetkov

“…Overall, we identified novel sex-specific metabolites in MCI patients that could serve as biomarkers of MCI in both sexes, help further define AD etiology, and reveal new potential prevention strategies for AD.…”
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Metformin in COVID-19: a magical role beyond the hyperglycemia by Gaurav Kumar Chaubey, Rahul Dilawari, Radheshyam Modanwal, Sharmila Talukdar, Asmita Dhiman, Manoj Raje

“…Researchers confront a worrying situation to rapidly develop effective strategies to combat this novel infection and its long-term aftereffects. …”
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Detection of I491F and V170F rpoB mutations associated with misdiagnosis of rifampicin resistance among patients with drug-susceptible tuberculosis treatment failure, Myanmar, 2022 by Phyu Win Ei, Mi Mi Htwe, Myat Htut Nyunt, Aye Su Mon, Zaw Myint, Wint Wint Nyunt, Su Mon Win, Sandar Aung, Wai Myat Thwe, Wah Wah Aung

“…Conclusion: This study highlighted the presence of rifampicin-resistant TB strains missed by current diagnostic strategies, and are circulating as treatment-failed patients. …”
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The transcriptional analysis of pepper shed light on a proviral role of light-harvesting chlorophyll a/b binding protein 13 during infection of pepper mild mottle virus by Weihong Lin, Shugen Zhang, Hao Zhang, Xiaomei Deng, Tong Jiang, Xifeng Chen, Laihua Dong, Qin Yan, Lianyi Zang, Yongping Xing, Zhenquan Wang, Qin Zhang, Kaitong Du, Huolin Shen, Junmin Zhang, Tao Zhou

“…This study provides valuable insights into the molecular mechanisms underlying resistance and susceptibility in pepper plants and may inform future strategies for disease management.…”
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Spatial-temporal Variation and Local Source Identification of Air Pollutants in a Semi-urban Settlement in Nigeria Using Low-cost Sensors by Oyediran Kayode Owoade, Pelumi Olaitan Abiodun, Opeyemi R. Omokungbe, Olusegun Gabriel Fawole, Felix Samuel Olise, Olalekan O. M. Popoola, Roderic L. Jones, Philip K. Hopke

“…There were strong similarities between pollutants source contribution at two of the monitoring sites that were in residential areas with a frequently used paved road. Mitigation strategies need to be established to avoid further deterioration of ambient air quality that negatively affect public health.…”
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Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations by Ashley E. Tessnow, Rodney N. Nagoshi, Robert L. Meagher, Todd M. Gilligan, Ben M. Sadd, Yves Carrière, Holly N. Davis, Shelby J. Fleischer, Kelly Richers, John C. Palumbo, Patrick Porter, Jose Carlos Verle Rodrigues, Gregory A. Sword

“…These differences should be considered when devising and implementing management strategies.…”
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Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

“…Conclusion In summary, our study developed a classifier for identifying G2MC subtypes, and this finding holds promise for advancing precision treatment strategies for UCEC.…”
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Resistance training beyond momentary failure: the effects of past-failure partials on muscle hypertrophy in the gastrocnemius by Stian Larsen, Paul Alan Swinton, Nordis Østerås Sandberg, Benjamin Sandvik Kristiansen, Andrea Bao Fredriksen, Hallvard Nygaard Falch, Roland van den Tillaar, Milo Wolf

“…Muscle hypertrophy is often a desired goal of resistance training, and strategies that extend training beyond momentary failure may enhance muscular adaptations. …”
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Diagnostic pathways for breast cancer in 10 International Cancer Benchmarking Partnership (ICBP) jurisdictions: an international comparative cohort study based on questionnaire and... by David Weller, Usha Menon, Alina Zalounina Falborg, Henry Jensen, Andriana Barisic, Anne Kari Knudsen, David H Brewster, Victoria Cairnduff, Eva Grunfeld, Elizabeth Harland, Mats Lambe, Rebecca-Jane Law, Yulan Lin, Martin Malmberg, Donna Turner, Richard D Neal, Victoria White, Samantha Harrison, Peter Vedsted, Una MacLeod, Conan Donnelly, Anna Gavin, Jon Emery, Oliver Bucher, Jatinderpal Kalsi, Chantelle Anandan, Evangelia Ourania Fourkala, Therese Kearney, Marie-Louise Essink-Bot, Sigrun Saur Almberg, Breann Hawryluk, Jacqueline Kelly, Jackie Boylan, Jan Willem Coebergh, David Brewster, Stefan Bergström, Victoria Hammersley, Rebecca Bergin, Alina Zalounina Falborg, Andriana Barisi, Kerry Moore, Maria Rejmyr Davis

“…The 10% longest waits ranged between 101 and 209 days (Sweden and Ontario).Conclusions Large international differences in breast cancer diagnostic pathways exist, suggesting some jurisdictions develop more effective strategies to optimise pathways and reduce time intervals. …”
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Foliar image-based characterization of airborne particulate matter in an urban area and its implications for remediation by Ankesh Tiwari, Triratnesh Gajbhiye, Mohineeta Pandey, Kajal Agrawal, Shuvadarshini Naik, Shubhrasmita Meher, Dinesh Patel, Rashmi Dubey, Tanzil Gaffar Malik, Mohammed Zari, Ali Zari, Khalid M Alghamdi, Khalid Rehman Hakeem, Sudhir Kumar Pandey

“…Overall, this research serves as a crucial step in developing strategies to combat air pollution and fosters the creation of healthier and more sustainable urban environments.…”
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The burden of irritable bowel syndrome and functional dyspepsia in Poland: a cross-sectional study from West Pomeranian Voivodship by Patrycja Krynicka, Mariusz Kaczmarczyk, Karolina Skonieczna-Żydecka, Danuta Cembrowska-Lech, Konrad Podsiadło, Krzysztof Dąbkowski, Katarzyna Gaweł, Natalia Botke, Iwona Zawada, Małgorzata Ławniczak, Andrzej Białek, Wojciech Marlicz

“…Our findings highlight the need for regional studies to understand local DGBI prevalence, aiding targeted healthcare strategies. Graphical Abstract…”
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Nurse management of minor problems in primary care emergencies: a non-randomized controlled trial by Jordi Estarlich-Corominas, Neus Soler-Abril, Anna Casanellas-Chuecos, Sara Becerra-Corzo, Andrea Sofia Bianco, Pere Torán-Monserrat, Rosa García-Sierra

“…Abstract Background Health systems must implement strategies to adapt to the high demand in primary care caused by social changes. …”
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Assembly mechanisms, not species pool, shape β-diversity of soil methanotrophic communities in steppes of China by Yongping Kou, Zhe Feng, Huan Li, Yanjiao Liu, Yanjiao Liu, Lin Xu, Lin Xu, Xiangzhen Li

“…Notably, the differential environmental conditions (such as soil pH, yearly average temperature, and precipitation) across scales and steppe habitats primarily modulate the intensity of these assembly processes, thereby influencing β-diversity.ConclusionIn summary, our study emphasizes the crucial role of local community assembly in changing soil methanotrophic β-diversity’s geographical patterns, highlighting the significance of a nuanced understanding of these processes for effective conservation and management strategies.…”
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Cloning, expression, and purification of fusion antigens MPT83 and ESAT6 from the local strain of Mycobacterium tuberculosis in Escherichia coli as a seed vaccine candidate against... by Rusdina Bte Ladju, Ahyar Ahmad, Abdul Karim, Rugaiyah Arfah, Rosana Agus, Najdah Hidayah, Muhammad Nasrum Massi, Astutiati Nurhasanah, Harningsih Karim, Irda Handayani

“…The development of more potent TB vaccines is critical to complement overall TB control strategies and overcome the growing challenge of drug resistance. …”
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Study of subterranean biodiversity of the upper Neretva River catchment in Bosnia and Herzegovina by Maja Zagmajster, Ester Premate, Špela Borko, Behare Rexhepi, Vojo Milanović, Anton Brancelj, Michaela Brojer, Christophe Douady, Josef Grego, Milica Jovanović, Florian Malard, Nataša Mori, Vladimir Pešić

“…Further studies are needed to properly highlight the great diversity of the subterranean habitats of the Neretva River catchment and its wider region, and to include this knowledge in conservation strategies. …”
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Impact of the COVID-19 pandemic on epidemiological and clinical characteristics of inpatients with burns in a Northwest China burn centre: a retrospective study by Jiaqi Liu, Jian Feng, Yuheng Zhang, Yiwei Cui, Shuao Xiao, Yige Han, Yongqian Bian, Xueyong Li

“…These findings might highlight the significance of implementing specific public health strategies and safety measures to improve family safety both during and after the pandemic.…”
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Chemokine family significance and prognostic value in colorectal cancer by Yi Ding, Yi Ding, Yi Ding, Yinnan Chen, Yinnan Chen, Yinnan Chen, Siyun Xie, Quanpeng Qiu, Quanpeng Qiu, Xiaolong Guo, Yun Feng, Yun Feng, Hongxia Li, Hongxia Li, Fang Zhu, Yaping Liu, Yaping Liu, Yaping Liu

“…Validation against clinical metadata, executed through immunohistochemistry analysis, affirmed the relevance and accuracy of our model in predicting patient survival.ConclusionOur findings illuminate the critical role of chemokines in shaping the immune microenvironment of CRC, thereby highlighting potential therapeutic targets for future treatment strategies. Our new prognostic model could provide important information for the development of targeted therapies for CRC, enhancing personalized treatment approaches andultimately improving survival for CRC patients.…”
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Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model by C. Probst, M. J. Mirzayan, P. Mommsen, C. Zeckey, T. Tegeder, L. Geerken, M. Maegele, A. Samii, M. van Griensven

“…Experimental investigation in an animal model may provide relevant insight for therapeutic strategies. We describe the effects of a combined injury with respect to lymphocyte population and cytokine activation. …”
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CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions by Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

“…Collectively, our findings demonstrate the functional significance of the CK2α-DUB3 axis in YAP1 stabilization and YAP1-driven tumor progression, highlighting that strategies to target this axis might be of benefit in the clinical management of ovarian cancer and several other lethal cancers with aberrantly upregulated YAP1.…”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…BackgroundAlthough finger joint capsulitis has been described among the most frequent injuries in climbers, no clinical studies on treatment strategies and outcomes are available.Study designProspective case series study.MethodsBetween 2015 and 2018 we prospectively treated 50 patients (38 male, 12 female) with a total number of 69 independent finger joint capsulitis according to a clinic specific treatment regimen and evaluated the outcome retrospectively. …”
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