Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response by Carlos P. Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A. Hollingsworth, Mark A. Carlson

“…Innovations in modeling pancreatic epithelial transformation provide valuable insights into the pathogenesis and potential therapeutic strategies for PDAC. We employed a porcine (Oncopig) model, utilizing the Ad-K8-Cre adenoviral vector, to investigate the effects of variable doses (107 to 1010 pfu) on pancreatic epithelial cells. …”
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Facilitators and barriers in the implementation of patient-centred care interventions among general practitioners: a systematic review protocol by Wenhui Li, Min Su, Zhengrong Li, Xiaojing Fan

“…This review will identify gaps and challenges in existing studies and propose strategies for the effective implementation of behavior change interventions among GPs. …”
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ENSURING HUMAN RIGHTS IN THE CONTEXT OF IMPLEMENTATION OF ELECTRONIC VOTING IN UKRAINE: PERSPECTIVES AND RISKS by Liudmyla Gudz

“…Therefore, the purpose of the study is to identify public policy strategies for the successful implementation of e-voting in Ukraine, taking into account international experience and ensuring human rights and freedoms in the electoral process. …”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…The results were compared with standard optimization methods such as traditional Bayesian optimization, genetic algorithms, evolutionary strategies, and other machine learning models. The optimized model achieved an accuracy of 89.3 %, outperforming other models across all metrics, including a sensitivity of 85.4 % and a precision of 91.6 %. …”
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First-line treatment for advanced or metastatic EGFR mutation-positive non-squamous non-small cell lung cancer: a network meta-analysis by Mengyao Zhang, Lan Sun

“…However, there is a lack of comprehensive evaluation encompassing multiple treatment strategies. Our objective is to conduct a network meta-analysis that includes various treatment modalities, enabling both direct and indirect comparisons for a more thorough assessment.MethodsWe conducted a search of PubMed, Embase, Cochrane Library, and Web of Science databases from inception until May 8, 2024, to identify eligible randomized controlled trials (RCTs). …”
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Amyopathic dermatomyositis with a rapidly progressing interstitial pneumonia by Darija Logvinova, Dace Žentiņa, Kristīne Ivanova, Inita Buliņa, Zaiga Kravale

“…While there is no standardized treatment regimen, current therapeutic strategies are generally focused on combination immunosuppressive therapies. …”
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Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response by Jing Wu, Qi Lu, Jing Hou, Yueqin Qiu, Min Tian, Li Wang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…Therefore, it is urgent to identify new strategies for preventing and controlling PRRSV infections. …”
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Combination therapy of intravitreal ranibizumab and sub-tenon triamcinolone for treatment of resistant diabetic macular edema: a clinical study in Egypt by Hossam Eldin M. A. Khalil, Hazem E. Haroun, Alaa A. I. Shalan, Waleed M. Mahran

“…DME that is resistant to therapy is now being treated with a number of different management strategies. This research was to examine the efficacy of sub-tenon steroid and anti- vascular endothelial growth factor (VEGF) injections as a combination therapy for the treatment of resistant DME, owing to the synergistic effect of this combination. …”
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Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia by Qi Zhou, Yongyu Guan, Pingping Zhao, Huiyuan Chu, Yaming Xi

“…Dysregulation of histone modification affects the genesis and progression of AML. Strategies targeting key histone regulators have not been applied to the treatment of AML. …”
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Susceptibility of different mice species to chemical induction of colorectal cancer by 1,2-dimethylhydrazine by Nourhan M. Abdelmaksoud, Ahmed I. Abulsoud, Tamer M. Abdelghany, Shereen Saeid Elshaer, Ahmed Samaha, Nadine W. Maurice, Sherine Maher Rizk, Mahmoud A. Senousy

“…Animal models play a crucial role in understanding the disease pathology and development of effective treatment strategies. Chemically induced CRC represents a cornerstone in animal model development; however, due to the presence of different animal species with different genetic backgrounds, it becomes mandatory to study the susceptibility of different mice species to CRC induction by different chemical entities such as 1,2-dimethylhydrazine (DMH). …”
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Participatory research towards the control of snakebite envenoming and other illnesses in a riverine community of the Western Brazilian Amazon. by Alícia Patrine Cacau Santos, Evellyn Antonieta Rondon Tomé Silva, Hiran Sátiro Souza da Gama, Jady Shayenne Mota Cordeiro, Ana Paula Silva Oliveira, Jéssica Albuquerque Araújo, Rafaela Nunes Dávila, Hélio Afonso Amazonas Júnior, Altair Seabra Farias, Jacqueline Almeida Gonçalves Sachett, Vinícius Azevedo Machado, Wuelton Marcelo Monteiro, Felipe Leão Gomes Murta

“…The qualitative analysis identified three main themes: Snakebites in the Community, which focused on personal experiences with snakes; Common Health Problems, which addressed other health issues faced by community members; and Community Defining Solutions, which discussed strategies and solutions proposed by the community to address these challenges.…”
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Self-reported secondhand smoke exposure following the adoption of a national smoke-free policy in Poland: analysis of serial, cross-sectional, representative surveys, 2009–2019 by Mateusz Jankowski, Vaughan Rees, Wojciech Stefan Zgliczyński, Dorota Kaleta, Mariusz Gujski, Jarosław Pinkas

“…Nevertheless, smoke-free laws must continue to be refined in terms of their legal boundaries as well as implementation strategies to eliminate disparities in SHS exposure in certain types of venues.…”
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Sleep patterns and smartphone use among left-behind children: a latent class analysis and its association with depressive symptoms by Xue Han, Cheng-Han Li, Heng Miao, Su Xu, Wen-Jing Yan, Juan Chen, Juan Chen

“…The identified behavioral profiles provide insights into population heterogeneity and inform targeted intervention strategies. Findings emphasize the importance of addressing both sleep and technology use in mental health initiatives for this vulnerable population.…”
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Knowledge, attitude, and practice of beef providers and consumers regarding microbial safety measures along the supply chain in Mizan-Aman, southwest Ethiopia by Girma Mamo Zegene, Seblework Mekonen Shegen, Seid Tiku Mereta

“…In this study both beef providers and consumers microbial safety status was assessed and will contribute evidences in public health protection strategies. Methods: A cross-sectional study was carried out among randomly selected beef retailers' owners, managers (n = 44) and systematically selected beef consumers (n = 422). …”
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Economic Burden of HIV in a Commercially Insured Population in the United States by Cindy Y. Chen, Prina Donga, Alicia K. Campbell, Babafemi Taiwo

“…The chronic nature of HIV warrants further exploration of factors contributing to disease burden and opportunities to improve prevention strategies.…”
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Spatiotemporal clusters of acute respiratory infections associated with socioeconomic, meteorological, and air pollution factors in South Punjab, Pakistan by Munazza Fatima, Ibtisam Butt, Shahab MohammadEbrahimi, Behzad Kiani, Oliver Gruebner

“…In addition, this study provides the first baseline of ARI cases in Pakistan to plan for intervention and adaptation strategies and may be replicated in other regions of comparable settings worldwide.…”
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Prevalence and spectrum of haemoglobinopathies in females of reproductive age group- A first tertiary care center experience in Punjab, North India by Vikram Narang, Anshul Jain, Sumit Grover, Ankita Soni, Monika Narang, Ashima Taneja

“…Conclusion: Preventive strategies are cost-effective and include population screening, premarital screening, screening of spouses, genetic counseling, and prenatal diagnosis. …”
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Effects of falls prevention interventions on falls outcomes for hospitalised adults: protocol for a systematic review with meta-analysis by Anne-Marie Hill, Meg E Morris, David L Carey, Susan C Slade

“…A better understanding of hospital falls and the most effective strategies to prevent them is vital to keeping people safe.Objectives To evaluate the effectiveness of falls prevention interventions on reducing falls in hospitalised adults (acute and subacute wards, rehabilitation, mental health, operating theatre and emergency departments). …”
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Tailored exercise and manual therapy versus standardised exercise for patients with shoulder subacromial pain: a feasibility randomised controlled trial (the Otago MASTER trial) by J Haxby Abbott, Daniel C Ribeiro, Zohreh Jafarian Tangrood, Gisela Sole, Ross Wilson

“…Adverse events (n=2, only in the tailored group) were minor in nature and included skin injury or pain following taping.Conclusions Our feasibility trial showed that additional strategies are required for improving recruitment, enrolment and minimising drop-out of participants into the trial and making it feasible to conduct a full trial.Trial registration number ANZCTR: 12617001405303.…”
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Healthcare professionals face ethical challenges in managing care for neurodevelopmental disorders: a qualitative study in Lebanon by Mustafa Saleh, Hani Chanbour, Lara Saoudi, Ingrid Nader, Maryse Hayek

“…Secondary outcomes included insights into the strategies employed by HCPs to balance patient autonomy with surrogate decision-making and the communication challenges they face with patients’ families.Results Thematic analysis revealed several key ethical challenges, including (1) balancing patient autonomy with the need for surrogate decision-making, (2) tailoring healthcare to individual cognitive abilities and (3) navigating the complexities of communication with patients and their families. …”
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