Neonatal mortality of live births with congenital diaphragmatic hernia in São Paulo State, Brazil: Failure of care? by Ana Sílvia Scavacini Marinonio, Milton Harumi Miyoshi, Daniela Testoni Costa Nobre, Adriana Sanudo, Kelsy Catherina Nema Areco, Mandira Daripa Kawakami, Rita de Cássia Xavier Balda, Tulio Konstantyner, Carina Nunes Vieira e Oliveira, Paulo Bandiera-Paiva, Rosa Maria Vieira de Freitas, Monica La Porte Teixeira, Bernadette Cunha Waldvogel, Carlos Roberto Veiga Kiffer, Maria Fernanda Branco de Almeida, Ruth Guinsburg

“…These findings suggest the necessity of implementing regionalization strategies for CDH perinatal care in the State.…”
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A Comparative Analysis of Middle-of-Line Contact Architectures for Complementary FETs by Seung Kyu Kim, Johyeon Kim, Gunhee Choi, Kee-Won Kwon, Jongwook Jeon

“…For each scheme, we carried out segmentation analysis of resistance and capacitance, and evaluated the DC performance as well as the power-performance characteristics alongside enhancement strategies. The middle VIA scheme features the lowest capacitance but exhibits inferior AC performance to the conventional structure due to the high resistance of the increased contact region parts and the highly doped silicon. …”
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Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies by Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J. Carter

“…As a result, we, as well as others, have developed engineering strategies designed to facilitate the efficient production of bispecific IgG for clinical development. …”
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Contemporary Management of Patent Foramen Ovale: A Multinational Survey on Cardiologists’ Perspective by Maciej Dębski, Amr Abdelrahman, Halia Alshehri, Marloe Prince, Andrew Wiper, Shajil Chalil, Dariusz Dudek, Christopher J. White, David Hildick-Smith, David H. Roberts

“…The results stress the need for systematic, high-quality data on the diagnostic work-up and follow-up strategies to inform the standardized approach.…”
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Intention to khat chewing among youths in Raya-Azebo district, southern zone of Tigray, Ethiopia: application of the theory of planned behavior by Abadi Hailay Atsbaha, Adugnaw Berhane Mekonnen, Bezawit Ketema, Tigist Haile Gebrehiwot, Hirut Teame Gebru, Embay Amare Alemseged, Yonas Angaw, Haftay Gebremedhin, Fre Gebremeskel, Hagos Degefa Hidru, Zenawi Hagos Gufue

“…The strongest predictors of intention to chew were attitude (β = 0.35, p < 0.001), subjective norm (β = 0.297, p < 0.001), and perceived behavioral control (β = 0.15, p = 0.01).ConclusionBehavioral intention toward khat chewing was a function of attitude, subjective norm, and perceived behavioral control toward khat chewing. Strategies to empower youths to change a positive attitude toward khat chewing, programs targeted at resisting social pressures, and increasing self-efficacy to combat chewing are needed.…”
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Non-classical pulmonary exacerbation in cystic fibrosis revealing ALK-Translocated lung cancer: A case report by Mohamad Hadhud, Johnathan Arnon, Anat Hershko-Moshe, Adi Hollander, Noa Hurvitz-Lehmann, Assaf Potruch, Henny Azmanov, Rottem Kuint, Nurith Hiller, Elie Picard, Naama Sebbag-Sznajder, Shira Leebhoff, Michael Wilschanski, Myriam Grunewald, Liron Birimberg-Schwartz, Malena Cohen-Cymberknoh

“…A better understanding of the relationship between these pathways could provide valuable insights and contribute to the development of more effective and tailored treatment strategies for patients with coexisting conditions. …”
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Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study by Yu-Wei Hsieh, Yu-Hsuan Lin, Jun-Ding Zhu, Ching-Yi Wu, Yun-Ping Lin, Chih-Chi Chen

“…Action observation therapy and mirror therapy, two promising rehabilitation strategies, are aimed at enhancing the motor learning and functional improvement of stroke patients through different patterns of visual feedback and observation. …”
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Otolith annulus validation and population dynamics of dark sleeper Odontobutis potamophila: insights for sustainable fisheries management by Miao Xiang, Miao Xiang, Haoran Liu, Haoran Liu, Haoran Liu, Bo Li, Hongxi Guo, Chuankun Zhu, Man Wang, Man Wang, Jie Wang, Jie Wang, Songguang Xie, Songguang Xie, Lei Zhang, Lei Zhang

“…These results showed that brief generation-time, dominance of juvenile fish and relatively high natural mortality of the O. potamophila provide essential information on the native fish species in Nansi Lake, which may be essential for conservation strategies and artificial propagation. At the same time, these results provide critical data for sustainable fisheries management in Nansi Lake and similar ecosystems.…”
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Risk of acute coronary syndrome and relationship with the use of khat and tobacco products in the Jazan region, Saudi Arabia: A prospective case-control study by Rashad Alsanosy, Mohamed Salih Mahfouz, Abdulelah Mohammed Arishi, Siddig Ibrahim Abdelwahab, Manal Taha, Osama Albasheer, Hasan Mohammed Daghriri, Khalid Ahmed Majrashi, Abdullah Farasani, Ahmed A. A. Altraifi, Isameldin E. Medani, Nasser Hakami

“…Implementing early intervention strategies can help mitigate the impact of khat chewing and smoking on the development of ACS.…”
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Esophageal perforation more than 10 years after anterior cervical spine surgery: a case report and literature review by Hua Luo, Zhangfu Wang, Shuang Mi, Wenjun Pan, Xingbing Feng, Zhenghua Hong

“…This case report presents the clinical course, diagnostic challenges and management strategies of a patient who had a late-diagnosis esophageal perforation after anterior cervical spine surgery (ACSS). …”
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3-Hydroxybutyrate alleviates septic liver injury by promoting macrophage polarization from M1 to M2 by Hu Jingjuan, Deng Fan, Sun Qishun, Min Yue, Feng Siyuan, Wu Ling, Chen Xiaofeng, Liu Kexuan

“…This effect is dependent on the participation of macrophages, providing new insights and potential intervention strategies for the clinical treatment of septic liver injury.…”
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Reshaping lipid metabolism with long-term alternate day feeding in type 2 diabetes mice by Eleni Beli, Yuanqing Yan, Leni Moldovan, Todd A. Lydic, Preethi Krishman, Sarah A. Tersey, Yaqian Duan, Tatiana E. Salazar, James M. Dominguez, Dung V. Nguyen, Abigail Cox, Sergio Li Calzi, Craig Beam, Raghavendra G. Mirmira, Carmella Evans-Molina, Julia V. Busik, Maria B. Grant

“…Abstract Strategies to improve metabolic health include calorie restriction, time restricted eating and fasting several days per week or month. …”
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Definitions matter: Multicenter investigation of incidence and outcome of poor graft function after hematopoietic cell transplantation by Konradin F. Müskens, Winny N. R. Collot‐d'Escury, Rana Dandis, Saskia Haitjema, Jürgen Kuball, Moniek A. deWitte, Marc Bierings, Caroline A. Lindemans, Stefan Nierkens, Mirjam E. Belderbos

“…Future studies, using standardized, quantitative thresholds for PGF, are required to determine optimal treatment strategies for both mild and severe forms of PGF.…”
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How integrated knowledge translation worked to reduce federal policy barriers to the implementation of medication abortion in Canada: a realist evaluation by Sarah Munro, Kate Wahl, Sheila Dunn, Courtney Devane, Linda C. Li, Wendy V. Norman

“…Methods We conducted a realist evaluation of what iKT strategies worked, for whom, and in what context to impact federal mifepristone regulations. …”
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Advancing precision medicine in esophageal squamous cell carcinoma using patient-derived organoids by Suya Shen, Bing Liu, Wenyan Guan, Ziyao Liu, Yuqing Han, Yingzhe Hu, Yiqiang Chen, Siyuan Liu, Jian He, Zhiwen Li, Weifeng Tang, Pengju Zhang, Wei Ren, Yudong Qiu, Hongping Zheng, Jingjing Li

“…The paclitaxel plus cisplatin (TP)-sensitive group demonstrated significantly longer progression-free survival (PFS) compared to the resistant groups, Hazard ratio (HR), 5.12; 95% confidence intervals (CI 0.58–44.71; p < 0.05), thus illustrating the potential of this approach for guiding personalized treatment strategies. Conclusion Organoid biobanks were established across multiple institutes to facilitate PDOs-based functional precision medicine. …”
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Multimodal treatments and the risk of breast cancer-related lymphedema: insights from a nationally representative cohort in South Korea by Sung Hoon Jeong, Seong Min Chun, Miji Kim, Ye Seol Lee, Jisun Kim, Ja-Ho Leigh, Yoon-Hee Choi

“…Our findings suggest that multidisciplinary strategies are required to minimize the risk of BCRL development in patients with breast cancer.…”
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Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes by Cherilyn Uhm, Jianlei Gu, Weina Ju, Stephanie Pizzella, Hande Oktay, Joyce Yao-Chun Peng, Sararose Guariglia, Yong Liu, Hongyu Zhao, Yong Wang, Ramkumar Menon, Nanbert Zhong

“…The specific effects of placental trophoblasts on the pathological development of sPTB subtypes—preterm premature rupture of fetal membranes (pPROM) and spontaneous preterm labor (sPTL)—are not fully understood, making it crucial to uncover these impacts for the development of effective therapeutic strategies. Using single-nucleus RNA sequencing, we investigated transcriptomic and cellular differences at the maternal–fetal interface in pPROM and sPTL placentas. …”
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Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics by Xinying Zhang, Jiajie Xie, Zixin Yang, Carisa Kwok Wai Yu, Yaohua Hu, Jing Qin

“…Tumour cell subpopulations from the five cancers listed above were classified into three major groups corresponding to different treatment strategies. The findings of this study not only focus on the differences but also on the similarities among tumour cell subpopulations across different cancers, providing new insights for individualised therapy.…”
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p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension by Chaowei Hu, Kun Zuo, Kuibao Li, Yuanfeng Gao, Mulei Chen, Roumu Hu, Ye Liu, Hongjie Chi, Hongjiang Wang, Yanwen Qin, Xiaoyan Liu, Jiuchang Zhong, Jun Cai, Xinchun Yang, Jing Li

“…These novel findings yield new insights into the genetic and biological basis of hypertension and are fundamental for further studies to explore the intervention strategies targeting L3MBTL4 and p38/JNK to counteract the progression of hypertension.…”
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Wild Boar Attacks on Hunting Dogs in Czechia: The Length of the Hunting Season Matters by Jana Adámková, Karolína Lazárková, Jan Cukor, Hana Brinkeová, Jitka Bartošová, Luděk Bartoš, Kateřina Benediktová

“…Further investigation into wild boar and hunting dog interactions is necessary for constructing strategies to improve hunting practices and reduce dog injury risks.…”
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