COLLABORAZIONE INTERPROFESSIONALE E ORGANIZZAZIONE SANITARIA: uno studio esplorativo sulle sfide e opportunità per i professionisti della riabilitazione. by Simone Sottana, Andrea Vianello, Matteo Tognin, Deborah Mazzarotto, Marco Ceccato, Daria Visintin, Riccardo Martignon, Francesca Magaton Rizzi, Noemi Pasquon, Lucia Savietto

“…L'analisi ha sottolineato la complessità della collaborazione interprofessionale come realtà in continua evoluzione, che necessita dello sviluppo di strategie educative e organizzative che superino le barriere esistenti e valorizzino la diversità professionale.   …”
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MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy by Jiabin Liang, Jingxiu Zhao, Lin Yang, Qian Wang, Jing Liao, Jianhao Li, Weizhao Zhuang, Fanghong Li, Jinxian He, Yukuan Tang, Hanwei Chen, Chen Huang

“…This study aims to investigate a novel strategy to enhance the therapeutic efficacy against PF by DSS preconditioning MSCs-derived exosomes (DSS-Exo). …”
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Perbandingan Metode Penyelesaian Permasalahan Optimasi Lintas Domain dengan Pendekatan Hyper-Heuristic Menggunakan Algoritma Reinforcement-Late Acceptance by Anang Firdaus, Ahmad Muklason, Vicha Azthanty Supoyo

“…Dalam meningkatkan kinerja, penelitian ini menguji pengaruh dari adaptasi algoritma Reinforcement Learning (RL) sebagai strategi seleksi LLH dikombinasikan dengan algoritma Late Acceptance sebagai move acceptance, selanjutnya disebut algoritma Reinforcement Learning-Late acceptance (RL-LA). …”
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Impacts of irrigation expansion on moist-heat stress based on IRRMIP results by Yi Yao, Agnès Ducharne, Benjamin I. Cook, Steven J. De Hertog, Kjetil Schanke Aas, Pedro F. Arboleda-Obando, Jonathan Buzan, Jeanne Colin, Maya Costantini, Bertrand Decharme, David M. Lawrence, Peter Lawrence, L. Ruby Leung, Min-Hui Lo, Narayanappa Devaraju, William R. Wieder, Ren-Jie Wu, Tian Zhou, Jonas Jägermeyr, Sonali McDermid, Yadu Pokhrel, Maxwell Elling, Naota Hanasaki, Paul Muñoz, Larissa S. Nazarenko, Kedar Otta, Yusuke Satoh, Tokuta Yokohata, Lei Jin, Xuhui Wang, Vimal Mishra, Subimal Ghosh, Wim Thiery

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Long-Term Therapeutic Effects of ²²⁵Ac-DOTA-E[c(RGDfK)]₂ Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma by Mitsuyoshi Yoshimoto, Kohshin Washiyama, Kazunobu Ohnuki, Ayano Doi, Miki Inokuchi, Motohiro Kojima, Brian W. Miller, Yukie Yoshii, Anri Inaki, Hirofumi Fujii

“…<b>Background</b>: Alpha radionuclide therapy has emerged as a promising novel strategy for cancer treatment; however, the therapeutic potential of ²²⁵Ac-labeled peptides in pancreatic cancer remains uninvestigated. …”
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Perancangan Perangkat Audit Internal untuk Sistem Keamanan Informasi pada Organisasi XYZ by Arif Rahman Hakim, Rizky Aditya Pratama Wijaya

“…Organisasi xyz sebagai penyelenggara sistem elektronik strategis harus mempunyai mekanisme audit internal terhadap keamanan sistem elektronik yang dimilikinya. …”
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Assessing Mental Illness Referral Request Acceptance: A Nationwide E-Referral Data From Saudi Arabia by Alharbi AA, Aljerian NA, Alghamdi HA, Binhotan MS, Alsultan AK, Arafat MS, Aldhabib A, Aloqayli AI, Alwahbi EB, Horner RD

“…Saudi Arabia has implemented an innovative nationwide electronic referral system (SMARC) as part of its digital health transformation strategy to enhance mental healthcare accessibility. …”
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CD32B1, a versatile non-signaling antibody-binding scaffold for enhanced T cell adhesion to tumor stromal cognate antigens by Sara W. Feigelson, Tali Dadosh, Nehora Levi, Anita Sapoznikov, Hadas Weinstein-Marom, Hadas Weinstein-Marom, Dayana Blokon-Kogan, Dayana Blokon-Kogan, Yahel Avraham, Tamar Unger, Gideon Gross, Gideon Gross, Rony Dahan, Ronen Alon

“…Targeting cytotoxic T lymphocytes (CTLs), as chimeric antigen T cells (CAR-T), T cell receptor-engineered (TCR)-T cells or adoptive cell transfer of tumor infiltrating T cells (TILs) to solid tumors is a major therapeutic challenge. We describe a new strategy to confer these lymphocytes with de novo adhesiveness to surface proteins enriched in the tumor microenvironment. …”
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Evaluation of parent and youth experiences in advisory groups as part of a mental healthcare clinical trial: protocol for a mixed-method study by Maria-Jose Santana, Gina Dimitropoulos, Suneeta Monga, Isabelle J Gagnon, Bruce Wright, Jananee Rasiah, Katrina Hurley, Antonia Stang, Amanda Newton, Stephen Freedman, Jennifer Thull-Freedman, Kassi Prisnie, Yazid N Al Hamarneh, Ellen Louise Lipman, Yaron Finkelstein, Robert Porter, Mohamed Eltorki, Lee Macdonald, Gareth Hopkin, Matthew Prebeg, Margaret Steele, Ahmed Mater, Laurence Katz, Brian Greenfield, Laurie Plotnick

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Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma by Laura Scalambra, Francesca Ruzzi, Olga Maria Pittino, Maria Sofia Semprini, Chiara Cappello, Stefania Angelicola, Arianna Palladini, Patrizia Nanni, Louise Goksøyr, Cyrielle Fougeroux, Manuel L. Penichet, Adam Frederik Sander, Pier-Luigi Lollini

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a novel therapeutic strategy for the management of dyslipidemia by enhancing the clearance of low-density lipoprotein cholesterol receptors, however recent evidence also shows links between PCSK9 and cancer cells. …”
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THE PUBLIC DEBT OF UKRAINE: A NEW DIMENSION OF DYNAMICS AND ARCHITECTURE OF THE MODEL FRAMEWORK OF THE MANAGEMENT SYSTEM by Serhii Petrukha, Nina Petrukha, Roman Miakota

“…The conclusions emphasise the necessity to approximate the optimal practices of fiscal consolidation and to implement measures, including those envisaged by the National Revenue Strategy until 2030, in order to increase the revenues of the state budget of Ukraine. …”
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Progress of research on aviation kerosene preparation using bioethanol by Pan LI, Yu ZHAO, Xingguo WU, Lulu ZHANG, Junhao HU, Wei CHEN, Jing BAI, Chun CHANG, Shuqi FANG

“…With the rapid development of China’s bioethanol industry and abundant production, the energy supply-diversification strategy represented by ethanol and other alternative energy sources has become a guide for energy policies in various countries. …”
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A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery by Jin-Can Huang, Shao-Cheng Lyu, Bing Pan, Han-Xuan Wang, You-Wei Ma, Tao Jiang, Qiang He, Ren Lang

“…There still has been a debate about which predictive strategy is better in patients with borderline resectable pancreatic cancer (BRPC). …”
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Optimization of Dual-energy Spectral Lower-extremity Computed Tomography Venography Scanning Protocol: Phantom Study by Shigeng WANG, Renwang PU, Yijun LIU, Xin FANG, Wei WEI, Beibei LI

“…Conclusions: Setting the NI to 11 and reconstructing monoenergetic images at 50 keV combined with 60% ASIR-V is the optimal imaging strategy for dual-energy spectral lower-extremity CTV, which balances between image quality and radiation dose in the current phantom study.…”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…Targeting tau protein has emerged as a promising therapeutic strategy. By investigating the effects of monoclonal antibodies on cognitive function, disease progression, and overall quality of life in patients with AD, which can provide valuable insights into their potential as a therapeutic option for this devastating neurodegenerative disorder.MethodsThe randomized controlled trials (RCTs) investigating the efficacy of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in Alzheimer’s disease (AD) were systematically searched across PubMed, Embase, Web of Science and Cochrane Library, up to May 2024. …”
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Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…ELA also activated ERK1/2 phosphorylation, while inhibition of ERK1/2·with U0126 abrogated F-actin polymerization and migration, increasing miR-299a-5p levels and reducing Exo70.ConclusionELA enhances BMSCs migration and homing to injured cardiomyocytes by activating the APJ receptor, promoting ERK1/2 phosphorylation, downregulating miR-299a-5p, and upregulating Exo70, providing a potential therapeutic strategy for improving stem cell-based cardiac repair.…”
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USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer by Fang Yuan, Juan Xu, Lingmei Xuan, Chan Deng, Wei Wang, Rong Yang

“…Conclusions: These data revealed the potential role of DGS/X-ray co-therapy in controlling ESCA resistance to radiotherapy by inhibiting the USP14/YAP1 axis, providing a candidate strategy for ESCA treatment.…”
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Three different methods for ZnO-RGO nanocomposite synthesis and its adsorption capacity for methylene blue dye removal in a comparative study by Safaa A. Hussein, Gharib M. Taha, F. A. Adam, Marwa A. Moghazy

“…Zinc oxide- reduced graphene oxide (ZnO-RGO) nanocomposite is used in this study as an adsorbent for the adsorption of methylene blue (MB) dye from an aqueous solution. An easy strategy was used for the synthesis of reduced graphene oxide nanoparticles (RGO), Zinc oxide nanoparticles (ZnO) and ZnO-RGO nanocomposite. …”
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Effect of Physical Activity on Physical and Mental Health in Young Cancer Patients and Survivors: A Systematic Review of RCTs and CCTs by Ann Christin Schneider, Sofia Anzeneder, Lars Rehbein, Eva Katharina Brack, Mirko Schmidt, Valentin Benzing

“…Physical activity (PA) is increasingly recognized as a strategy to address physical, mental, cognitive, and social challenges faced by YCP and survivors (Braam et al., 2016). …”
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