Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Our results revealed that increasing innate immunity by G-CSF pretreatment and decreasing inflammatory responses using LBPK95A improved the survival rates in a rat sepsis model and could be a novel strategy to treat sepsis.…”
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Optimized Method to Generate Well-Characterized Macrophages from Induced Pluripotent Stem Cells by Qimin Hai, Peter Bazeley, Juying Han, Gregory Brubaker, Jennifer Powers, Claudia M. Diaz-Montero, Jonathan D. Smith

“…<b>Methods</b>: We refined the traditional embryoid body-based differentiation strategy to create a novel three-phase method that optimizes yield, consistent quality, and reproducibility. …”
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Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response by Jing Wang, Jin Wang, Yi-Na Wang, Yuan-Yuan Wang, Wen-Juan Bai, Nai-Jun Miao

“…Our data reveal a previously unrecognized antitumor mechanism of VBL and suggest a drug repurposing strategy combining VBL with immune checkpoint inhibitors to improve malignant tumor immunotherapy.…”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The hydrogel group exhibited a significant promotion in collagen content and reduction in HIF-1α, which effectively hastened tract maturation.Conclusion: Therefore, our study provides new and critical insights into a strategy to design bioactive hydrogels with multiple functions, which can open up a new avenue for accelerated wound healing after gastrostomy. …”
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Sputum Smear Positive Pulmonary Tuberculosis Diagnostic Dropout Rate in Public Health Facilities, Addis Ababa, Ethiopia by Daniel Melese Desalegn, Kumera Terfa Kitila, Boja Dufera Taddese, Tinsae Kidanemariam Hailu, Tariku Takle Dinku, Kassahun Demisse Asferie, Hanna Mekonnen Balcha, Chalachew Sisay Gebeyehu, Girmay Medhin

“…In this study smear positive pulmonary tuberculosis diagnostic dropout rate was high compared to WHO reported for the new strategy shift implying the importance of shifting to same-day approach. …”
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Bi-level data-driven enterprise-wide optimization with mixed-integer nonlinear scheduling problems by Hasan Nikkhah, Zahir Aghayev, Amir Shahbazi, Vassilis M. Charitopoulos, Styliani Avraamidou, Burcu Beykal

“…Building on this foundation, we extend this strategy to solve a high-dimensional and highly constrained nonlinear crude oil refinery operation problem that has not been previously tackled in this context. …”
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A comparison of drug‐eluting stent and coronary artery bypass grafting in mildly to moderately ischemic heart failure by Kun Wang, Le Wang, Hongliang Cong, Jingxia Zhang, Yuecheng Hu, Yingyi Zhang, Rui Zhang, Wenyu Li, Wei Qi

“…Abstract Aims The best revascularization strategy for patients with ischaemic heart failure (IHF) remains unclear. …”
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Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling s... by Matthew D Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I Aoko, Erick M Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B Shade, Gabriel Chamie, Laura B Balzer, Maya L Petersen, Diane V Havlir, Moses R Kamya, Andrew N Phillips

“…For our primary analysis, we used a cost-effectiveness threshold of US $500 per disability-adjusted life-year (DALY) averted, a 3% annual discount rate, and a 50-year time horizon. A strategy was considered cost-effective if it led to the lowest net DALYs, which is a measure of DALY burden that takes account of the DALY implications of the cost for a given cost-effectiveness threshold. …”
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Factors associated with cervical cancer screening among women of reproductive age in Moshi municipality, Kilimanjaro, Tanzania: a cross-sectional study by Sia E Msuya, Jeremiah John Hhera, Regina Dahaye, Witness Erasto Zakayo, Yohana Z Kazula, Seif Abdul, Redempta Mamseri

“…Objective Screening for cervical cancer has been a globally advocated preventive strategy to reduce cervical cancer morbidity and mortality. …”
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Geochemical signatures and nanomechanical properties of echinoid tests from nearshore habitats of Florida: environmental and physiological controls on echinoid biomineralization by Przemysław Gorzelak, Luis Torres Jr., Dorota Kołbuk, Tobias B. Grun, Michał Kowalewski

“…Such heterogeneity in Mg distribution within single specimens cannot be ascribed solely to environmental changes, indicating that these echinoids actively regulate their intraskeletal Mg content: the higher magnesium concentration at the tubercles relative to that of the underlying stereom may be interpreted as a strategy for enhancing their mechanical strength to withstand surface friction and wear. …”
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Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…More universities and colleges are pursuing a quality improvement strategy focused on three main components – learning outcomes, student personality and continuous improvement. …”
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Implementasi Kebijakan Pengembangan Pariwisata Pada Objek Wisata Alam Goa Akbar Di Kabupaten Tuban by Irdina Iffata Qottrunnada, Ananta Prathama

“…Objek wisata Goa Akbar yang dikelola oleh Pemerintah Kabupaten Tuban, memiliki potensi besar sebagai salah satu tumpuan pendapatan asli daerah sektor pariwisata berkat lokasinya yang strategis di tengah kota Tuban. Meskipun demikian, dalam implementasi kebijakan pengembangannya masih menunjukkan adanya kekurangan. …”
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Spatiotemporal evolution of landscape ecological risk and its driving factors of the Beijing–Tianjin–Hebei major mineral belt, 1985–2022 by Yilin Wang, Xiaohong Wang, Wei Zhang, Weidong Man, Mingyue Liu, Linlin Jiao

“…Effective monitoring and assessment of the regional landscape ecological risk can provide a scientific basis for an ecological protection strategy for the environmental protection of the Beijing-Tianjin-Hebei major mineral belt. …”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Therefore, targeting NETosis through modulation of HMGB1 presents a promising multipotent therapeutic strategy for mitigating ischemic brain damage.…”
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Relationship Between Obstructive Sleep Apnea and Enuresis in Children: Current Perspectives and Beyond by Wang Z, Zhang P, Shi R, Yang S, Liu K, Zhou Z, Li Q

“…This review summarizes the relationship between NE and OSA and how to treat them, aiming to provide a reference for the clinical treatment of OSA and NE in children.Methods: All pertinent original publications to this point from PubMed database have been collected, including investigations on the connection between OSA and NE as well as studies on the mechanism and therapeutic strategy of NE in children with OSA.Results: There is a bidirectional relationship between OSA and NE in children. …”
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Taohong Siwu Decoction Exerts a Beneficial Effect on Cardiac Function by Possibly Improving the Microenvironment and Decreasing Mitochondrial Fission after Myocardial Infarction by Zhi-rong Luo, Han Li, Zhong-xin Xiao, Shui-jin Shao, Tian-tian Zhao, Yue Zhao, Fang-fang Mou, Bo Yu, Hai-dong Guo

“…Hence, this may present a promising auxiliary strategy in the treatment of ischemic cardiomyopathy such as MI.…”
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Growth response of <i>Emiliania huxleyi</i> to ocean alkalinity enhancement by G. Faucher, M. Haunost, A. J. Paul, A. U. C. Tietz, U. Riebesell

“…While theoretical studies hold promise for OAE as a climate mitigation strategy, careful consideration of its ecological implications is essential. …”
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Safety and efficacy of intravenous thrombolysis: a systematic review and meta-analysis of 93,057 minor stroke patients by Mostafa Hossam El Din Moawad, Talal Salem, Anas Alaaeldin, Youssef Elaraby, Peter D. Awad, Amr Ahmed Khalifa, Ahmed El Naggar, Khaled Ashraf Mohamed, Mohamed Elhalal, Mostafa Badr, Ramy Abdelnaby

“…Methods Using the search strategy assigned which was based on three keywords: “mild” or “minor”, “stroke”, and “intravenous thrombolysis”, we searched for eligible articles on PubMed, Web of Science, Embase, and Scopus from inception till 10th January 2024. …”
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Developing a business model focused on the planning sustainability of forest sector enterprises by Ihor Soloviy, Orest Kiyko, Vasyl Lavnyy, Igor Bukhanevych, Oksana Pelyukh, Mykhailo Ilkiv, Taras Chelepis, Dmytro Savka, Andriy Lutsenco

“…In general, it is concluded that in order to change the economic model from linear to circular, it is necessary to develop a strategy for the transition to circular economy principles, since its elements are only reflected in certain regulatory documents and publications, but have not become a platform for making business decisions based on sustainable development.…”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…No life-threatening AEs were reported.ConclusionThe HAIC-L-P regimen correlated with enhanced tumor responses and prolonged survival, alongside manageable adverse effects, indicating its potential as a viable therapeutic strategy for individuals afflicted with uHCC.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024594109.…”
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