3-MA attenuates collagen-induced arthritis in vivo via anti-inflammatory effect and autophagy inhibition by Chong Feng, Zi-rou Wang, Chen-yu Li, Xiang-yu Zhang, Xin-xing Wang

“…Many drugs are used to relieve RA, such as glucocorticoids (GCs), non-steroidal anti-inflammatory drugs (NSAIDs), and disease-modifying anti-rheumatic drugs (DMARDs) in the clinical treatment. …”
Get full text

Application of efgartigimod in Chinese patients with myasthenia gravis: a single-center real-world prospective study by Geke Zhu, Han Zhou, Wanying Wang, Yongbo Ma, Xiangtao Nie, Wenjing Qi, Lei Hao, Xiuming Guo

“…During the treatment, the corticosteroids dosage could be adjusted as appropriate or the non-steroidal immunosuppressive therapies (NSISTs) added. …”
Get full text

Saffron's protective role against atherosclerosis-induced cataract progression in New Zealand white rabbits with phytochemical analysis of saffron's extract. by Yasmin Mohd Zainal Abidin Shukri, Iman Nabilah Abd Rahim, Nurul Alimah Abdul Nasir, Che Puteh Osman, Noor Alicezah Mohd Kasim

“…The phytochemical screening of saffron ethanolic extract was conducted and showed the presence of phytochemical compounds including saponins, flavonoids, tannins, and steroids. The positive effects on lenses in the TG groups could be due to crocin and crocetin, bioactive components of saffron, and its phytochemical compounds. …”
Get full text

Optimization of Soursop (Annona Muricata L.) Leaf Extract in Nanoemulgel And Antiacnes Activity Test Against Propionibacterium Acnes, Staphylococcus Aureus, Staphylococcus Epidermi... by Asyhari, Hanif Fibiana, Cabral, Kibedi B., Wikantyasning, Erindyah R.

“…Soursop leaf extract (Annona muricata L.) has antibacterial activity with active components of alkaloids, flavonoids, steroids, and saponins. This research aims to optimize the use of VCO, Tween 80, and PEG 400 in the nanoemulsion system, which will be added Carbopol 940 as a gelling agent to form a nanoemulgel and to determine antibacterial activity. …”
Get full text

Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
Get full text

Phytochemicals and Antioxidant Activity of Microalgae <I>Dunaliella salina</I> and <I>Botryococcus braunii</I> by Ali Ridlo, Delianis Pringgenies, Ribka Anindita Br Perangin-angin, Dafit Ariyanto

“…Highlight Research • The methanolic extracts of  salinaand B. braunii contained alkaloids, steroids, triterpenoids, flavonoids, and saponins. • Chlorophyll a, chlorophyll b, and carotenoids were most abundant in the ethyl acetate extracts of salinaand B. braunii…”
Get full text

Risk Factors of Post-Tonsillectomy Bleeding and Differences Between Children and Adults: Implications for Risk Assessment by Bülent Öcal, Mehmet Murat Günay, Kemal Keseroğlu, Murad Mutlu, İlker Akyıldız, Cem Saka, Emel Çadallı Tatar, Mehmet Hakan Korkmaz

“…Age, surgical indication, tonsils’ grade, and postoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) were risk factors found to be statistically significant for PTH in univariate analysis (p<0.05). …”
Get full text

Comparative Efficacy and Safety of Cardio-Renoprotective Pharmacological Interventions in Chronic Kidney Disease: An Umbrella Review of Network Meta-Analyses and a Multicriteria De... by Ioannis Bellos, Smaragdi Marinaki, Pagona Lagiou, Vassiliki Benetou

“…Sodium-glucose co-transporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP1a), and non-steroidal mineralocorticoid receptor antagonists (ns-MRA) are promising treatments for chronic kidney disease. …”
Get full text

Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus by Valerie R. Ramiro, Carmegie C. Saliba, John Anthony D. Tindoc, Marinette R. Jambaro, Enrique M. Chua, Donna Ricca M. Hornilla, Maria Teresa B. Abola

“…We report a case of a 47-year-old Filipino female diagnosed with SLE 17 years ago maintained on prolonged oral steroids, azathioprine, and hydroxychloroquine. She also had lupus nephritis, secondary hypertension, and dyslipidemia. …”
Get full text

Pharmacognostic Characterization of Panchatikta, an Ayurvedic Polyherbal Combination—Exploring the Role of Botanical and Phytochemical Techniques in the Standardization and Validat... by C. M. Harinarayanan, M. Deepak, S. P. Geetha, Arun Karnwal, Gaurav Kumar, Anupam Kumar, Tabarak Malik

“…Preliminary phytochemical tests were carried out to verify the presence of alkaloids, flavonoids, saponins, tannins, phenols, glycosides, and steroids. The HPTLC profile comparison of ethanolic, hydroalcoholic, and aqueous extracts of Panchatikta and single drugs showed some type of synergy and antagonistic activities among the chemical principles present. …”
Get full text

Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular flui... by Chong Wang, Ying Feng, Yu Chen, Xianhua Lin, Xiangjuan Li

“…BackgroundMany components in follicular fluid (FF), such as peptide hormones, cytokines, and steroids, undergo dynamic changes during folliculogenesis and have important roles in follicular development. …”
Get full text

Treat-to-target strategy with secukinumab as a first-line biological disease modifying anti-rheumatic drug compared to standard-of-care treatment in patients with active axial spon... by Xenofon Baraliakos, Denis Poddubnyy, Ludwig Hammel, Marvin Heyne, Justyna Veit, Claudia Jentzsch

“…Introduction In patients with axial spondyloarthritis (axSpA), biological disease-modifying anti-rheumatic drugs (bDMARDs) are recommended to those with inadequate response or contraindications to non-steroidal anti-inflammatory drugs (NSAIDs). In case of failure of the first bDMARD, a switch within the class or to other bDMARD is recommended. …”
Get full text

Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

“…This study presents “SBR-Pel,” a new therapeutic blend of Shinbaro tab (SBR), a traditional herbal formula, and pelubiprofen (Pel), a non-steroidal anti-inflammatory drug, and investigated their combined anti-inflammatory effects to create a treatment that both improves efficacy and reduces side effects. …”
Get full text

Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach by Pei Liu, Lin Xu, Jing-han Guo, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Guang-xin Miao, Cui-zhe Liu, Jian-yu Zhou

“…Diosgenin, a steroidal sapogenin, has attracted attention worldwide owing to its pharmacological properties, including antitumor, cardiovascular protective, hypolipidemic, and anti-inflammatory effects. …”
Get full text

The Potential of Ethanol Extract of Aleurites Moluccanus Leaves as TNF-α Inhibitor in Oral Incision Wound Care Model by Elfi Zahara, . Darmawi, Ummu Balqis, Cut Soraya

“…Phytochemical screening results revealed that the ethanol extract of candlenut leaves contains abundant secondary metabolites, including alkaloids, flavonoids, steroids/terpenoids, tannins, phenols, and saponins. …”
Get full text

Gym exercising patterns, lifestyle and high-risk sexual behaviour in men who have sex with men and in heterosexual men by N Davidovitch, Z Mor, K Parfionov, I Grotto

“…The research was based on the assumption that men who become muscular and physically attractive increase their number of sex partners and consequently their risk of HIV or other sexually transmitted infections (STIs).Setting Five gyms in central Tel Aviv, Israel.Participants In 2012, a sample of 182 (48%) MSM and 197 (52%) heterosexual men who train in gyms completed anonymous questionnaires regarding their training, health and sexual behaviours.Outcomes Participants in this cross-sectional study who exercised more than the median number of anaerobic training hours were defined as performing intensive anaerobic training (IAT), and those who had performed more than one act of unprotected anal/vaginal intercourse in the preceding 6 months with a partner whose HIV status was unknown were defined as high risk.Results MSM showed a stronger desire to become muscular than heterosexual men, were more likely to perform IAT, and used protein powders or anabolic steroids. They reported that improving their body shape and increasing their self-confidence were their main reasons for training, whereas heterosexual men indicated weight loss and health improvement as the main reasons for training. …”
Get full text

Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Measurements: Number of patients prescribed antiplatelets, PPIs, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids; indications for aforementioned medications. …”
Get full text

Currently prescribed drugs in the UK that could upregulate or downregulate ACE2 in COVID-19 disease: a systematic review by Paul Little, Simon J Griffin, Hajira Dambha-Miller, Nazrul Islam, Ali Albasri, Christopher R Wilcox, Sam Hodgson, Shareen Khan

“…More studies reported upregulation than downregulation with ACE-I (n=22), ARBs (n=55), insulin (n=8), thiazolidinedione (n=7) aldosterone agonists (n=3), statins (n=5), oestrogens (n=5) calcium channel blockers (n=3) glucagon-like peptide 1 (GLP-1) agonists (n=2) and Non-steroidal anti-inflammatory drugs (NSAIDs) (n=2).Conclusions There is an abundance of the academic literature and media reports on the potential of drugs that could attenuate or exacerbate COVID-19 disease. …”
Get full text

Weight-Based Standardized Sugammadex Dosing in Pediatrics: A Quality Improvement Initiative to Improve Compliance with Dosing Guidelines and Reduce Waste and Cost by Sydney E. S. Brown, Michael Meyer, Andrea Meyer, Ruth Cassidy, Xinyi Zhao, Deborah Wagner, Laura Wetzel, Douglas A. Colquhoun

“…Results. 7,889 patients 2–17 years (4,771 with documented TOF), ASA 1–4 receiving general anesthesia with a steroidal NMB medication and sugammadex reversal. Pre- and postintervention mean doses were 2.5 mg/kg (SD: 1.2) and 2.4 mg/kg (SD: 0.96), respectively. …”
Get full text

Separate Evaluation of the Effects of Hydroalcoholic Extracts of Eryngium Caucasicum L. and Zataria Multiflora L. on Gastric Ulcers in an Animal Model by mahdi Jalahi, Mohammad Azadbakht, Jafar Akbari, Fereshteh Talebpuor, Fatemeh Akbari

“…Background and purpose: The aging population and its associated complications, such as chronic pain, have led to an increased use of non-steroidal anti-inflammatory drugs (NSAIDs) like indomethacin. …”
Get full text