IMMUNE THROMBOTIC THROMBOCYTOPENIC PURPURA: PATHOPHYSIOLOGY, DIAGNOSIS AND OPEN ISSUES. by Silvia Maria Trisolini, Alessandro Laganà, Saveria Capria

“…Some patients do not achieve an ADAMTS13 remission following the acute phase despite steroids and rituximab treatment, requiring an individualized immunosuppressive approach to prevent clinical relapse. …”
Get full text

Association of CYP2C9∗3 and CYP2C8∗3 Non-Functional Alleles with Ibuprofen-Induced Upper Gastrointestinal Toxicity in a Saudi Patient by Amina M. Bagher

“…Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used to alleviate pain and inflammation. …”
Get full text

Identifying Conservative Interventions for Individuals with Subacromial Pain Syndrome Prior to Undergoing a Subacromial Decompression: A Scoping Review by Joseph A Signorino, Aubrey G. Thompson, Benjamin R Hando, Jodi L Young

“…Subacromial injections (SI) (55.3%, n=26) and non-steroidal anti-inflammatories (NSAIDs) (31.9%, n=15) were the next most frequently delivered interventions. …”
Get full text

Previous Intestinal Resection Is Associated with Postoperative Complications in Crohn’s Disease: A Cohort Study by Yantao Duan, Yifan Liu, Yousheng Li

“…After multivariate analysis, previous intestinal resection (P=0.019), preoperative use of steroids (P=0.026), and ASA score of more than II (P<0.001) were determined to be the independent prognostic risk factors for postoperative complications. …”
Get full text

Diabetic ketoacidosis and hyperglycaemic hyperosmolar syndrome in patients with cancer: A multicentre study by Rabia K. Shahid, Qasem Haider, Sunil Yadav, Duc Le, Shahid Ahmed

“…Overall, 52 % patients received a systemic cancer therapy prior to the admission, and 41 % received steroids. Ten (42 %) of 24 patients with an advanced cancer died, compared to none of the nine patients with an early-stage cancer (p = 0.032). …”
Get full text

Glucose-6-phosphate dehydrogenase deficiency with coinherited Gaucher disease: A rare association by Nupur Parakh, Kusha Sharma, Sunita Sharma, Priti Chatterjee, Varinder Singh

“…He was transfused intermittently and given steroids to manage his anemia. He was on regular follow up during which his blood counts revealed persistent anemia and thrombocytopenia. …”
Get full text

Comparative Analysis of Utility and Efficacy of Ozone Therapy versus Laser Therapy in Periarthritis Shoulder by Sunil Kumar, Harish Kumar, Prashant Pratap Singh, Dinesh Kumar, Vyutpanna Mishra, Ishan Ahmad

“…Most of adhesive capsulitis patients are successfully treated with nonsurgical treatment such as non-steroidal anti-inflammatory drugs (NSAIDS), oral/intra-articular corticosteroids, and hydrodialtation, among nonsurgical modalities, ozone and laser are newer, safe, and show promising results in adhesive capsulitis management. …”
Get full text

Exploring Medicinal Plants for Antimicrobial Activity and Synergistic Effects With Doxycycline Against Bacterial Species by Joel Frank Kenmeni, Ibrahim Sifi, Borel Ndezo Bisso, Prudence Ngalula Kayoka-Kabongo, Ulrich Joël Tsopmene, Jean Paul Dzoyem

“…All extracts contained phenols, flavonoids, steroids, triterpenes, and anthraquinones. The methanolic extract of Psidium guajava exhibited the highest total phenolic and flavonoid contents (90.48 ± 0.55 mg GAE/g), while the ethanolic extract of Olax subscorpioidea showed the highest flavonoid content (6.48 ± 0.33 mg QE/g). …”
Get full text

Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19. by Sarah E Holton, Mallorie Mitchem, Hamid Chalian, Sudhakar Pipavath, Eric D Morrell, Pavan K Bhatraju, Jessica A Hamerman, Cate Speake, Uma Malhotra, Mark M Wurfel, Steven E Ziegler, Carmen Mikacenic

“…We tested for associations between protein concentrations and respiratory outcomes using logistic regression adjusting for age, sex, treatment with steroids, and APACHE III score. In a subset of patients who had CT scans during hospitalization (n = 75), we tested for associations between protein concentrations and radiographic features of fibroproliferation. …”
Get full text

Assessing the quality of CKD care using process quality indicators: A scoping review. by Na Zhou, Chengchuan Chen, Yubei Liu, Zhaolan Yu, Aminu K Bello, Yanhua Chen, Ping Liu

“…Among the frequently reported quality indicators (in five or more studies), the following have a median proportion of study participants achieving that quality indicator exceeding 50%: monitoring of kidney markers (Scr/eGFR), use of medications (ACEIs/ARBs, avoiding non-steroidal anti-inflammatory drugs (NSAIDs)), management of blood pressure (with a target of ≤140/90, or without specific targets), and monitoring for glycated hemoglobin A1c (HbA1c)). …”
Get full text

Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult‐Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Repo... by Kanchan Bishwakarma, Kajal Bishwakarma, Sunil Bogati, Saket Jha

“…MAS was suspected of abnormally high ferritin levels, and a bone marrow aspiration biopsy was done. She was given IV steroids with some improvement. The biopsy showed hypercellular marrow with erythroid hyperplasia, dyserythropoietic changes, and increased macrophages with phagocytic activity suggestive of MAS. …”
Get full text

The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…To reduce inflammation, high-dose steroids are ineffective and toxic in Caucasian patients, although lower-dose regimens may be effective in Chinese patients. …”
Get full text

Nebulised 3% hypertonic saline versus 0.9% saline for treating patients hospitalised with acute bronchiolitis: protocol for a randomised, double-blind, multicentre trial by Sara Szupieńko, Aleksandra Buczek, Henryk Szymański

“…However, non-evidence-based diagnostic and therapeutic approaches, including the use of inhaled bronchodilators, nebulised epinephrine, and nebulised and systemic steroids, are common. The inhalation of 3% hypertonic saline is not recommended in bronchiolitis management. …”
Get full text

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution? by Zirintunda, Gerald, Biryomumaisho, Savino, Keneth Iceland, Kasozi, Batiha, Gaber El-Saber, Kateregga, John, Vudriko, Patrick, Nalule, Sarah, Olila, Deogracious, Mariam Kajoba, Mariam, Matama, Kevin, Kwizera, Mercy Rukundo, Ghoneim, Mohammed M., Abdelhamid, Mahmoud, Alshehri, Sultan, Abdelgawad, Mohamed A., Acai-Okwee, James, Zaghlool, Sameh S.

“…Benzo (c) phenanthridine and isoquinoline alkaloids are neurotoxic to helminths. Steroidal saponins (polyphyllin D and dioscin) interact with helminthic mitochondrial activity, alter cell membrane permeability, vacuolation and membrane damage. …”
Get full text

Nitrogen-rich covalent organic polymers for efficient solid phase extraction of nonsteroidal anti-inflammatory drugs from water samples by Yuqi Cheng, Jia Li, Xiaochen Xiu, Xinghua Teng, Wen Zhang, Lei Ji, Leilei Wang

“…Non-steroidal anti-inflammatory drugs (NSAIDs) have received increasing attention owing to their ubiquitous occurrence in environmental water systems and adverse effects. …”
Get full text

Early Refractive and Clinical Outcomes of High-Myopic Photorefractive Keratectomy as an Alternative to LASIK Surgery in Eyes with High Preoperative Percentage of Tissue Altered by Nir Sorkin, Amir Rosenblatt, David Smadja, Eyal Cohen, Marcony R. Santhiago, David Varssano, Yossi Yatziv

“…The rate of stromal haze, managed successfully with topical steroids only, was 4.8%. Conclusion. High-myopic PRK with application of mitomycin-C in the eyes at risk of developing ectasia because of high preoperative PTA was demonstrated to be a safe and effective alternative to the LASIK procedure.…”
Get full text

Bronchoscopic lung lavage and exogenous surfactant successfully reverse respiratory failure after severe chlorine exposure: A pediatric case report by Paola Papoff, Benedetto D'Agostino, Roberto Cicchetti, Antonella Bitti, Valentina Pennetta, Elena Caresta

“…Upon arrival in the pediatric emergency department, the patient received oxygen administration, nebulized salbutamol, and intravenous steroids because of dyspnea and cyanosis. Despite this treatment, the patient's respiratory condition deteriorated. …”
Get full text

Soybean and avocado unsaponifiables: a review of their potential use in the treatment of osteoarthritis by Ana Sabucedo-Suárez, Ana Sabucedo-Suárez, Mónica López-Peña, Mónica López-Peña, María Permuy, María Permuy, Fernando Muñóz, Fernando Muñóz

“…These qualities can potentially lessen the need for non-steroidal anti-inflammatory medicines (NSAIDs) and their secondary effects. …”
Get full text

Effectiveness of purple leaves (Graptophyllum pictum L. Griff) and hydroxyapatite as socket preservation biomaterials by Ratri Maya Sitalaksmi, Rizkipriyanto Azharpratomo, Shafira Ninditya Irsan, Primanda Nur Rahmania, Sisca Meida Wati, Syafira Salsabila Adam, Kavanila Bilbalqish, Khairul Anuar bin Shariff, Harry Laksono, Agus Dahlan, Devi Rianti

“…Purple leaves contains flavonoids, steroids, tannins, saponins,and non-toxic alkaloids. …”
Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…These include (but are not limited to): non-steroidal anti-inflammatory drugs (NSAIDs), colchicine, prednisone, methotrexate, canakinumab, pexelizumab, anakinra, succinobucol, losmapimod, inclacumab, atreleuton, LP-PLA2 (darapladib) and sPLA2 (varespladib). …”
Get full text