First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study by Laura Moliner, MD, Núria Zellweger, MSc, Sabine Schmid, MD, Martina Bertschinger, MD, Christine Waibel, MD, Ferdinando Cerciello, MD, PhD, Patrizia Froesch, MD, Michael Mark, MD, Adrienne Bettini, MD, Pirmin Häuptle, MD, Veronika Blum, MD, Lisa Holer, MSc, Stefanie Hayoz, PhD, Martin Früh, MD, Samreen Ahmed, FRCP, MD, MBBS, MSc, Shradha Bhagani, MD, Nicola Steele, MD, Hannah-Leigh Gray, BSc, Stephen D. Robinson, MD, Michael Davidson, MD (Res), Samantha Cox, MD, MSc, MBBCh, Taha Khalid, MD, Tom R. Geldart, MD, Luke Nolan, FRCS, PhD, Deborah C. Scott, MBChB (MRCP), Lindsay Hennah, MD, Tom Newsom-Davis, MD, PhD, Emma Rathbone, MD, PhD, Catherine Handforth, MD, Arshi Denton, MD, Shairoz Merchant, PhD, Fiona Blackhall, MD, PhD, Laetitia A. Mauti, MD, Raffaele Califano, MD, Sacha I. Rothschild, MD, PhD

“…One hundred forty-two patients (32.6%) in our cohort would not have been eligible for the pivotal registrational trials owing to an Eastern Cooperative Oncology Group performance status of 2 or higher, autoimmune disease, active brain metastases, or steroid use. Most patients received carboplatin (96.8%) and atezolizumab (97.9%). …”
Get full text

Asthma “Control” by Nick R Anthonisen

“…They found that patients on inhaled steroids were less well-controlled than those who were not on inhaled steroids, and that there was a dose effect, in that the larger the dose of inhaled steroids the worse the control. …”
Get full text

A rare complication in management of traumatic optic neuropathy by Sushad Prasad, Priya Sivakumar

“…Electrolyte workup has a major role in TON management with steroids.…”
Get full text

Bioassay-Guided Fractionation, ESI-MS Scan, Phytochemical Screening, and Antiplasmodial Activity of Afzelia africana by Bright Yaw Vigbedor, Jonathan Osei-Owusu, Ralph Kwakye, David Neglo

“…The column chromatographic fractionation and phytochemical screening of the plant led to the separation of the following four fractions: 1 (flavonoids, phenolics, glycosides, terpenoids, and steroids), 2 (alkaloids, anthraquinones, flavonoids, phenolics, glycosides, terpenoids, and steroids), 3 (anthraquinones, flavonoids, phenolics, glycosides, terpenoids, and steroids), and 4 (alkaloids, flavonoids, phenolics, glycosides, terpenoids, and steroids). …”
Get full text

Osteoporosis Syndrome in Thalassaemia Major: An Overview by Meropi Toumba, Nicos Skordis

“…Growth hormone (GH) and sex steroids play a crucial role in bone remodeling and in the maintenance of skeletal architecture during adult life. …”
Get full text

Clinical and Epidemiological Characterization of Patients with Rheumatoid Arthritis by Zoe Alina González Otero, Jorge Luis Egüez Mesa, Celestino Fusté Jiménez, Eugenio Alejandro Reyes Medina, José Alberto Borges López, Lázaro Hermes González Otero

“…The most common treatment was the combination of non-steroidal anti-inflammatory drugs and steroids.…”
Get full text

Remission of Severe, Relapsed, and Refractory TTP after Multiple Cycles of Bortezomib by Manu R. Pandey, Pankit Vachhani, Evelena P. Ontiveros

“…Plasma exchange (PEX) with or without steroids constitutes standard first-line therapy with rituximab typically reserved for refractory cases. …”
Get full text

Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…The most common therapeutic categories were non-steroidal immunosuppressants (18%), steroids (15%) and antivirals (14%). …”
Get full text

Clinical profile and outcomes of rejection after deep anterior lamellar keratoplasty in keratoconus by Priyanka Sudaboina, Sunita Chaurasia, Somasheila Murthy

“…The rejection episode reversed with topical steroids in all eyes and intravenous methylprednisolone in one eye. …”
Get full text

Connections and Unmet Needs: Severe Asthma Biologics and Osteoporosis by Fabiana Furci, Marco Umberto Scaramozzino, Giuseppe Rocco Talesa, Corrado Pelaia

“…Asthma is a chronic inflammatory disease with the main anti-inflammatory drugs for better disease control being steroids or corticosteroids. The use of steroids in asthma patients, in particular in uncontrolled asthma patients, is associated with an increased risk of osteoporosis and fragility fractures. …”
Get full text

H. capsulatum: A Not-So-Benign Cause of Pericarditis by Paolo K. Soriano, Muhammad Iqbal, Shakthishri Kandaswamy, Sami Akram, Abhishek Kulkarni, Tamer Hudali

“…In patients with pericarditis who fail standard therapy with NSAIDs and steroids, it is suggested that they undergo thorough evaluation and that histoplasmosis be considered as an etiology, especially in endemic regions.…”
Get full text

The Role of Thoracic Medial Branch Blocks in Managing Chronic Mid and Upper Back Pain: A Randomized, Double-Blind, Active-Control Trial with a 2-Year Followup by Laxmaiah Manchikanti, Vijay Singh, Frank J. E. Falco, Kimberly A. Cash, Vidyasagar Pampati, Bert Fellows

“…To determine the clinical effectiveness of therapeutic thoracic facet joint nerve blocks with or without steroids in managing chronic mid back and upper back pain. …”
Get full text

Overreliance on Bronchodilators as a Risk Factor for Life-Threatening Asthma by Pierre Ernst, Brenda Hemmelgarn, Donald W Cockcroft, Samy Suissa

“…OBJECTIVE: To assess the potential impact on the risk of life-threatening asthma of current recommendations in pharmacotherapy, which emphasize the early use of steroids and the avoidance of beta-agonist overuse.…”
Get full text

Pseudotumor of Ciliary Body by Mary Varghese, Raghavendra Ramappa, Sripathi Kamath

“…He was treated with systemic steroids, which was tapered over a period of 8 weeks. …”
Get full text

COVID-19 and Mucormycosis Coinfection: How Challenging It Is by Niranjan Nayak, Erum Khan, Debadatta Panigrahi

“…Diabetes mellitus though happens to be an independent risk factor both for severe COVID-19 and mucormycosis, administration of steroids is attributed as a precipitating factor for acquiring the comorbid condition. …”
Get full text

Isolated Neurosarcoidosis Presenting as Chronic Progressive Pachymeningitis by Joshua Abata, Danielle Bazer, Nicholas Koroneos, Olga Syritsyna

“…The patient also notably failed a 3-month course of steroids after his biopsy due to a lack of symptomatic improvement. …”
Get full text

Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis by Syedda Ayesha, Masood Muhammad Karim, Maria Ali, Abdul Hadi Shahid, Salman Naseem Adil

“…The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.…”
Get full text

Aseptic Meningitis as an Immune-Related Adverse Event after Pembrolizumab by Gian Lima, Adriana Kahn, Shashank Sama, Jacqueline Savage

“…The patient was started on high doses of IV steroids and progressed with significant improvement of his symptoms. …”
Get full text

An Analysis of an Inflammatory Bowel Disease Practise in an Urban Community Hospital by David Adam, Jonathan Adam, Howard Price

“…The aspects studied were distribution of disease, need for hospital admission, immunosuppressants, systemic steroids, and surgery and its indications. The incidence of cancer was also reviewed.…”
Get full text

The Canadian Optimal Therapy of COPD Trial: Design, Organization and Patient Recruitment by Shawn D Aaron, Katherine Vandemheen, Dean Fergusson, Mark FitzGerald, Francois Maltais, Jean Bourbeau, Roger Goldstein, Andrew McIvor, Meyer Balter, Denis O'Donnell

“…BACKGROUND: There are no published studies that have assessed whether adding long-acting beta 2-agonist bronchodilators and/or inhaled steroids to chronic therapy with tiotropium would provide additional clinical benefit to patients with moderate to severe chronic obstructive pulmonary disease (COPD).…”
Get full text