Rare Manifestation of a Rare Disease, Acute Liver Failure in Adult Onset Still’s Disease: Dramatic Response to Methylprednisolone Pulse Therapy—A Case Report and Review by Nalini Valluru, Venkata S. Tammana, Michael Windham, Eyasu Mekonen, Rehana Begum, Andrew Sanderson

“…Three months later, while she was on tapering dose of steroid, she presented with fever, abdominal pain, jaundice, and markedly elevated transaminases. …”
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Rash with DERMABOND PRINEO Skin Closure System Use in Bilateral Reduction Mammoplasty: A Case Series by R. W. Knackstedt, J. A. Dixon, P. J. O’Neill, F. A. Herrera

“…All three patients required systemic steroid treatment to resolve the rash. One patient was identified as having a prior adhesive reaction. …”
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The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World by Peter C. Church, Jeffrey Hyams, Frank Ruemmele, Lissy de Ridder, Dan Turner, Anne M. Griffiths

“…North Americans more often used anti-TNF (median 50% vs. 30%, p<0.001) and before immunomodulator (80% vs. 35% CD, p<0.001; 76% vs. 43% steroid-dependent UC, p<0.001). Anti-TNF monotherapy was more common in North America. …”
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Serum microRNAs as Diagnostic Markers in Polycystic Ovary Syndrome: A Narrative Review by K Lavanya, N Palaniappan, VM Vinodhini, Santhi Silambanan

“…By targeting hormone receptors and their release, microRNAs influence the production of steroid hormones and play a significant role in the formation and regulation of follicular growth in the ovaries. …”
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Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions by Girvan Burnside, Munir Pirmohamed, Rostam Osanlou, Dyfrig A Hughes, Lauren Walker

“…Drugs most commonly implicated were diuretics, steroid inhalers, anticoagulants and antiplatelets, proton pump inhibitors, chemotherapeutic agents and antihypertensives. 40.4% of ADRs were classified avoidable or possibly avoidable. …”
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A Case of Adenomatous Goiter Involving Diffuse, Acute, and Painful Thyroid Enlargement after Fine-Needle Aspiration Cytology by Toshiro Shimo, Katsuhiro Tanaka, Ryohei Ogata, Wataru Saito, Yusuke Ohta, Yoshikazu Koike, Tetsumasa Yamashita, Yutaka Yamamoto, Junichi Kurebayashi

“…Thus, we continued the steroid (prednisone) treatment, but the dose was gradually reduced from 10 mg/day to 5 mg/day at 1 week after the patient’s symptoms disappeared. …”
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RETRACTED: Associations of vitamin D receptor polymorphisms with risk of Alzheimer’s disease, Parkinson’s disease, and mild cognitive impairment: a systematic review and meta-analy... by Yanjun Du, Peizhen Geng, Qunqun Chen, Laixi Han, Lu Liu, Maoquan Yang, Mingzhu Tan, Jun Meng, Xiaojuan Sun, Lidan Feng

“…Vitamin D is a lipid soluble steroid hormone, which plays a critical role in the calcium homeostasis, neuronal development, cellular differentiation, and growth by binding to vitamin D receptor (VDR). …”
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Genome Analysis of Rhodococcus Sp. DSSKP-R-001: A Highly Effective β-Estradiol-Degrading Bacterium by Hongyan Zhao, Kejian Tian, Qing Qiu, Yu Wang, Hongyan Zhang, Shuang Ma, Shenbao Jin, Hongliang Huo

“…The results showed that there were ten steroid-degrading enzymes distributed in the whole genome of the strain. …”
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Systemic Lupus Erythematosus Presenting as Anorexia Nervosa in a Middle‐Aged Woman: A Rare Case Report and Literature Review by Maen Nizam Baroudi, Anwar I. Joudeh, Mohammed Kays Alattiya, Abdo Qaid Ahmed Lutf, Hassan Abuzaid, Salah Mahdi

“…The patient was treated successfully with intravenous pulse steroid therapy, rituximab, and antithyroid medications with no residual symptoms or laboratory abnormalities. …”
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Inebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review by Xiaoqian Song, Xiaoqian Song, Jingjiao Chen, Chenyang Jin, Yilong Peng, Yuewen Sun, Xueping Zheng

“…For NMOSD treatment, although most patients received steroid hormones and immunosuppressive agents, quite a few patients had persistent severe disability. …”
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Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…IL-37b may be involved in Th2 cytokine regulation in AR and its expression was related to the efficacy of intranasal steroid therapy.…”
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Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study by Takashi Shimazui, Takehiko Oami, Tadanaga Shimada, Keisuke Tomita, Taka-aki Nakada

“…This association remained significant after adjusting for sex, body mass index, steroid use prior to sepsis onset, and number of chronic organ dysfunctions (HR 1.66, 95% CI 1.20–2.32, P = 0.002). …”
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Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…To date, there have been more than 100 variations identified in the gene responsible for 5ARD2 development (steroid 5-alpha-reductase 2, SRD5A2). However, few studies have examined the molecular characterisation of Indonesian 5ARD2 cases. …”
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The Influence of Ouabain on Human Dendritic Cells Maturation by C. R. Nascimento, R. C. Valente, J. Echevarria-Lima, C. F. L. Fontes, L. de Araujo-Martins, E. G. Araujo, V. M. Rumjanek

“…Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation, synergizing with glucocorticoids in spontaneous thymocyte apoptosis, and also lessening CD14 expression and blocking CD16 upregulation on human monocytes. …”
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Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells by Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Bianca Serio, Mariarosaria Sessa, Valentina Giudice, Idalucia Ferrara, Libuse Tauchmanovà, Annamaria Colao, Carmine Selleri

“…Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT.…”
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Pericardial mesothelioma mimicking mediastinal lymphoma and systemic rheumatic disease: a case report by Grzegorz Hirnle, Michał Kapałka, Michał Krawiec, Tomasz Hrapkowicz

“…The patient was diagnosed with systemic lupus erythematosus (SLE) and initiated on chronic steroid therapy. As heart failure progressed, the patient was admitted to the cardiology department. …”
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The effect of an additional pre-extubational loading dose of caffeine citrate on mechanically ventilated preterm infants (NEOKOFF trial): Study protocol for a multicenter randomize... by Kinga Kovács, Rita Nagy, Lilla Andréka, Brigitta Teutsch, Miklós Szabó, Péter Varga, Péter Hegyi, Péter Hársfalvi, Nándor Ács, Ágnes Harmath, Csaba Nádor, Ákos Gasparics

“…The randomization will be stratified by gestational age and antenatal steroid prophylaxis. Preterm infants in the experimental group will receive an additional intravenous (IV) loading dose (20 mg/kg) of caffeine citrate one hour before the first planned extubation, in addition to the standard dosing regimen (20 mg/kg caffeine citrate IV on the first day of life and 5 to 10 mg/kg IV or orally caffeine citrate each consecutive day). …”
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Development of Fulminant Type 1 Diabetes Mellitus in a Patient with DRESS Syndrome by Pedro Perez, Wilson Sze, Daniel Lozeau, Dipa Avichal, Joshua Miller

“…She had numerous complications including significant facial edema, seizures, bacterial pneumonia, sepsis, hypovolemic shock, acute respiratory distress syndrome, diabetic ketoacidosis, nonalcoholic steatohepatitis, liver failure, and recurring DRESS rashes despite treatment with high-dose intravenous steroids and immunosuppressants. During this time, the patient developed a rare form of uncontrolled type 1 diabetes mellitus not explained by autoantibody production or continued high-dose steroid use. …”
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Characteristic external genitalia in male neonates with 5α-reductase deficiency by Takeshi Munenaga, Yosuke Ichihashi, Satsuki Nakano, Hironori Shibata, Takeshi Sato, Hiroshi Asanuma, Keiko Homma, Tomonobu Hasegawa, Tomohiro Ishii

“…This study enrolled 31 Japanese cases of 46,XY DSD whose external genitalia was examined during the neonatal period; four were diagnosed as 5αRD and 15 were defined as non-5αRD by genetic analysis of SRD5A2 or urinary steroid metabolites. We compared the following characteristics between 5αRD and non-5αRD groups, adjusting the severity of undermasculinization of the external genitalia: stretched penile length (SPL), glans width, location of the external urethral opening, and proportion of undescended testis. …”
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells by Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa

“…However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). …”
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