Pseudo-precocious puberty secondary to Juvenile Granulosa cell tumour in a 30-month-old female toddler: A case report by Taiwo Oni, Adesola Adekoya, Grillo Elizabeth, John Nwadiokwu, Victor Okebalama, Oluwaseun Anifowose

“…She had a 2-year history of steroid-containing cream use. The unrelated parents had normal puberty. …”
Get full text

Estimation of the pattern of ocular manifestations, risk factors, and imaging of rhino-orbital-cerebral mucormycosis in COVID-19 patients by Rajwinder Kaur, Grace Budhiraja, Upasana Bhumbla, Manjot Kaur, Vandana Sharma, Priyanka Gupta, Ritesh Singla, Akashdeep Goel, Ekta Gupta, Priyanka Dahiya

“…The majority (82.9%; n-29) either were diabetics or had high blood glucose levels during the recent COVID-19 infection. 45.7% of patients gave a history of steroid therapy. The most common ocular clinical features were ptosis (80%) and loss of vision 48.7%, respectively. …”
Get full text

Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres by David Young, Sohail Rahmany, Deborah Taylor, Emma Davis, Michael Colwill, Sonia Kalyanji Mehta, Roisin Campbell, Karl Hazel, Karishma Sethi-Arora, Susan Ritchie, Ashley I Heinson, Helen Moyses, Keith Bodger, Emma Johnston, Lucy Hicks, Anjan Dhar, Jimmy Limdi, Rachel Cooney, John Paul Seenan, Kamal Patel, Alissa Walsh, Fraser Cummings

“…There was a reduction in biomarkers and 78% of patients using corticosteroids at baseline were steroid-free. Persistence on filgotinib at 12 months was 66%. …”
Get full text

Tinea manuum: a 5 year retrospective study of demographic data, clinical characteristics, and treatment outcomes by Panittra Suphatsathienkul, Pattriya Jirawattanadon, Lalita Matthapan, Waranyoo Prasong, Chatisa Panyawong, Akkarapong Plengpanich, Sumanas Bunyaratavej, Charussri Leeyaphan

“…Diabetes mellitus was present in 26.2%, and 23.4% had prior topical steroid use. The most common symptom was itching (75.7%), while palm-scale (85.9%) was the most prevalent clinical finding. …”
Get full text

Clinical features, treatment, and prognosis of secukinumab-induced inflammatory bowel disease by Ronghui Li, Haibo Lei, Chunjiang Wang, Xiang Liu

“…After discontinuation of secukinumab, patients reported symptom relief following treatment with systemic steroids (60.0%), targeted therapies (52.5%), and mesalamine (22.5%). …”
Get full text

Active Antialopecia Chemical Identification of Merremia peltata Leaves and Computational Study toward Androgen Receptor Using Molecular Docking and Molecular Dynamic Simulation by Syawal Abdurrahman, Ruslin Ruslin, Aliya N. Hasanah, Resmi Mustarichie, Mus Ifaya

“…Therefore, bufotalinin, a steroid compound, is a potential androgen receptor antagonist and could be useful in the treatment of alopecia.…”
Get full text

The Efficacy of Mizoribine (Inosine Monophosphate Dehydrogenase Inhibitor) for ANCA-Associated Vasculitis with Hepatitis B Virus Carrier by Jun Muratsu, Atsuyuki Morishima, Masayoshi Kukida, Anzu Tanaka, Shigeki Fujita, Katsuhiko Sakaguchi

“…Furthermore, the adverse effects of steroid were seen. We decided the tapering of prednisolone (25 mg/day) and the start of mizoribine (4-carbamoyl-1-β-D-ribofuranosyl imidazolium-5-olate) administration. …”
Get full text

Differential gene expression during recall of behaviorally conditioned immune enhancement in rats: a pilot study [version 3; peer review: 1 approved, 3 approved with reservations] by Marcus Picard-Mareau, Markus Rueckels

“…In the pituitary, we recognized mostly upregulation of steroid synthesis in combination with GABAergic, cholinergic and opioid related neurotransmission, in adrenal glands, altered genes showed a pattern of activated metabolism plus upregulation of adrenoceptors Adrb3 and Adra1a. …”
Get full text

Impact of BRACTS exercises on muscular strength in eumenorrheic women by Wajiha Shahid, Rabiya Noor

“…Abstract The sex steroid hormones significantly impact women’s physiology. …”
Get full text

Porcine granulosa cell transcriptomic analyses reveal the differential regulation of lncRNAs and mRNAs in response to all-trans retinoic acid by Jinzhu Meng, Xiuwen Chen, Huabiao Wang, Yixuan Mi, Runsheng Zhou, Hongliang Zhang

“…Functional annotation analysis revealed that the DEGs were remarkably enriched in ovary function and reproduction which contained FoxO, Hippo, Oocyte meiosis, mammalian target of rapamycin signaling pathway, as well as several pathways associated with hormone regulation like oxytocin signaling pathway and steroid hormone biosynthesis. Moreover, an interaction network of lncRNAs and their cis-target DEGs was constructed, and 7 differentially expressed lncRNAs and 6 cis-target DEGs were enriched in ovarian steroidogenesis and reproduction. …”
Get full text

Usage of Surfactant and Evaluation of Lung Problems in Late Preterm Infants by Ozlem Yilman, Senem Alkan Ozdemir, Sebnem Calkavur, Tulin Gokmen Yildirim

“…CONCLUSION: It must not be forgotten that infants who are born late preterm infants are preterm infants and the evaluation of antenatal steroid administration must not be ignored. …”
Get full text

Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy by Thaíza Passaglia Bernardes, Thalita Alvarenga Ferradosa Paula, Gabriel Teixeira Montezuma Sales, Patrícia Varela Calais, Renato Demarchi Foresto, Luiz Antonio Moura, Marcelino de Souza Durão Junior, João Bosco Pesquero, Gianna Mastroianni Kirsztajn

“…Treatment can be challenging in such a context, as no antiviral drug is efficient and immunosuppression has no discernable benefit, although steroid use was efficient in treating renal manifestations in this case.…”
Get full text

Primary liver lymphoma: review of the literature and clinical case presentation by A. K. Smolyaninova, A. V. Gubkin, Ye. Ye. Zvonkov, Yu. A. Kucheryavy

“…Empirical therapy by prednisolon resulted in no responce and was complicated by development of steroid diabetes. The diagnosis of diffuse B-macrocellular lymphoma was established only via open liver biopsy. …”
Get full text

Prevalence of Erosive-ulcerative Lesions of the Stomach and Helicobacter Pylori Infection in Patients with Ulcerative Colitis by N. A. Ponkratova, P. V. Pavlov, O. S. Shifrin

“…No effect of previous steroid therapy, as well as the high activity of ulcerative colitis on the frequency of the stomach erosive lesions (respectively, p = 0.433; p = 0.158) was detected. …”
Get full text

Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial by Marian Majchrzycki, Piotr Kocur, Tomasz Kotwicki

“…To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID). Design. Prospective controlled randomized single blinded trial. …”
Get full text

Integrated transcriptome and metabolome analysis of liver reveals unsynchronized growth mechanisms in blunt-snout bream (Megalobrama amblycephala) by Qi Liu, Xue Zou, Ming Zhao, Qianqian Guan, Zhaoyang Xuan, Lusha Liu, Zexia Gao

“…KEGG and GO enrichment analysis indicated that the DEGs with higher expression level were significantly correlated with insulin signaling pathway, steroid hormone and lipid metabolism related pathway (PPAR signaling pathway and fatty acid degradation). …”
Get full text

Results of formation of primary and secondary smallintestinal reservoirs at ulcerative colitis by V. N. Kashnikov, S. I. Achkasov, K. V. Bolikhov, O. I. Sushkov, I. V. Nazarov, A. V. Gusev

“…Comparable results of treatment in analyzed groups have been received due to refusal of primary reservoir formation in patients with more severe course of disease and more intensive and long-term steroid therapy.…”
Get full text

Loxoscelism: Cutaneous and Hematologic Manifestations by Ngan Nguyen, Manjari Pandey

“…We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism. Methods. …”
Get full text

Clinical presentation and management challenges of sphingosine-1-phosphate lyase insufficiency syndrome associated with an SGPL1 variant: a case report by Vahid Saeedi, Nahid Rahimzadeh, Fahimeh Ehsanipour, Neda Shalbaf, Amirhosein Farahi, Khalil Rashidi, Leila Kamalzadeh

“…Case presentation A 2-year-old Iranian female presented with steroid-resistant nephrotic syndrome (NS), primary adrenal insufficiency (AI), growth delay, seizures, and hyperpigmentation. …”
Get full text

Needle Tip Position and Bevel Direction Have No Effect in the Fluoroscopic Epidural Spreading Pattern in Caudal Epidural Injections: A Randomized Trial by Won Kyoung Kwon, Ah Na Kim, Pil Moo Lee, Cheol Hwan Park, Jae Hun Kim

“…Background. Caudal epidural steroid injections (CESIs) are an effective treatment for pain. …”
Get full text