Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS).…”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

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Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels by Ruonan Shao, Danchen Meng, Beibei Gao, Lu Zhang, Qingqi Meng, Yanqiu Hou, Zhangbiao Long, Jinsong Yan, Xiaofeng Shi

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Presumed Glenoid SLAP Tear in an Adolescent Football Player Belied the Presence of a Coracoid Growth Plate Fracture: A Diagnostic Conundrum by John G. Skedros, J. Hunter Marshall, John T. Cronin

“…Hoping to expedite his healing with platelet or stem cell injections, the parents sought an opinion from another physician who obtained a right shoulder MRI with intra-articular contrast. …”
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Donor lymphocyte infusions: An experience from a tertiary care center of North India by Divjot Singh Lamba, Parmatma Prasad Tripathi, Rekha Hans, Alka Khadwal, Ratti Ram Sharma

“…Donor lymphocyte infusions (DLIs) are often recommended products after allogeneic hematopoietic stem cell transplant to increase graft – versus – leukemia effect. …”
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Guiding Lights in Genome Editing for Inherited Retinal Disorders: Implications for Gene and Cell Therapy by Carla Sanjurjo-Soriano, Vasiliki Kalatzis

“…Furthermore, we discuss recent advances in the field of genome editing and stem cell technologies, which together enable precise and personalized therapies for patients. …”
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Implications of intratumoral microbiota in tumor metastasis: a special perspective of microorganisms in tumorigenesis and clinical therapeutics by Lei Zhang, Xichu Duan, Yanhua Zhao, Dejiu Zhang, Yuan Zhang

“…Furthermore, intratumoral microbiota have been shown to directly impact tumor metastasis by regulating cell adhesion, stem cell plasticity and stemness, mechanical stresses and the epithelial-mesenchymal transition. …”
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GABAergic Neuronal Precursor Grafting: Implications in Brain Regeneration and Plasticity by Manuel Alvarez Dolado, Vania Broccoli

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Role of Inflammation in Muscle Homeostasis and Myogenesis by Domiziana Costamagna, Paola Costelli, Maurilio Sampaolesi, Fabio Penna

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Real-world safety profile of therapy with ibrutinib or acalabrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma by Ramsay Hafer, Francesco Iadevaia, Thomas Z. Rohan, Teresa Duong, Maria Poluch, Gina Keiffer, Michael Li, Andres Ferber, Luca Laurenti, Alan S. Khoo, Pierluigi Porcu

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Assessment of food toxicology by Alexander Gosslau

“…Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) and efforts to integrate organotypic systems and stem cell-based assays. Despite those achievements, there are numerous challenges in various disciplines of food toxicology.…”
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Using Cell-Based Strategies to Break the Link between Bronchopulmonary Dysplasia and the Development of Chronic Lung Disease in Later Life by Megan O'Reilly, Bernard Thébaud

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Laboratory Diagnosis of Invasive Aspergillosis: From Diagnosis to Prediction of Outcome by Richard C. Barton

“…Invasive aspergillosis (IA), an infection caused by fungi in the genus Aspergillus, is seen in patients with immunological deficits, particularly acute leukaemia and stem cell transplantation, and has been associated with high rates of mortality in previous years. …”
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Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions by Diana Marian, Giuseppe Toro, Giovanbattista D’Amico, Maria Consiglia Trotta, Michele D’Amico, Alexandru Petre, Ioana Lile, Anca Hermenean, Anca Fratila

“…It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gene therapy, and 3D bioprinting. …”
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Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas by Børre Fevang, Unn Merete Fagerli, Hanne Sorte, Harald Aarset, Håkon Hov, Marit Langmyr, Thomas Morten Keil, Ellen Bjørge, Pål Aukrust, Asbjørg Stray-Pedersen, Tobias Gedde-Dahl

“…The patient was given a haploidentical stem cell transplant while in remission for his lymphomas and although the initial course was successful, he succumbed to a serious Pneumocystis jirovecii pneumonia 5 months after the transplant. …”
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Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration by Chun-Sheng Li, Yan Xu, Juan Li, Shu-Hao Qin, Shao-Wen Huang, Xue-Mei Chen, Yi Luo, Cheng-Tao Gao, Jian-Hui Xiao

“…With the rapid increase in the aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based cartilage tissue engineering has emerged as a promising therapeutic option for treating articular cartilage damage. …”
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Dasatinib and FLAG-IDA Is an Effective Therapy for Initial Myeloid Blast Crisis but Involves a High Risk of Opportunistic Infections by Jorge Labrador, Gerardo J. Hermida, Rodolfo Alvarez, Victor Anso, Pilar de Vicente, Mercedes Goñi, Tomas Jose Gonzalez-Lopez

“…Based on this, we present the case of a patient diagnosed with an initial nonlymphoid phenotype BC, who achieved molecular response (MR4.5) with dasatinib and FLAG-IDA, but he suffered a pulmonary aspergillosis, CMV infection, and a CMV reactivation, prior to an allogeneic hematopoietic stem cell transplantation (HSCT). In conclusion, dasatinib and FLAG-IDA is an effective therapy for initial BC. …”
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Mesenchymal Hippo signaling regulates intestinal homeostasis in adult mice by Kyvan Dang, Alka Singh, Xin Chen, Jennifer L. Cotton, Susu Guo, Xiaodi Hu, Zhipeng Tao, Haibo Liu, Lihua J. Zhu, Y. Tony Ip, Xu Wu, Junhao Mao

“…Altogether, our data suggest an important role for mesenchymal Hippo-YAP signaling in the stem cell niche during intestinal homeostasis and pathogenesis.…”
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Bing and Neel Syndrome by S. Jennane, K. Doghmi, E. M. Mahtat, N. Messaoudi, B. Varet, M. Mikdame

“…The treatment was followed by intensification and autologous stem cell transplantation. At D58, the patient died due to a septic shock. …”
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Oncolytic Virotherapy for Hematological Malignancies by Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle

“…For high-risk disease, hematopoietic stem cell transplant (HCT) can be used. However, in the setting of autologous HCT, relapse due to contamination of the autograft with cancer cells remains a major challenge. …”
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