Single-cell transcriptomics reveals novel chondrocyte and osteoblast subtypes and their role in knee osteoarthritis pathogenesis by Yuan Liu, Wacili Da, Ming-Jie Xu, Chao-Xin Xiao, Tao Deng, Sheng-Liang Zhou, Xiao-Ting Chen, Yao-Jia Zhou, Li Tang, Yong Nie, Yi Zeng, Hui-Qi Xie, Bin Shen

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Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity by Maïlis Darmuzey, Franck Touret, Emily Slowikowski, Ivan Gladwyn-Ng, Karan Ahuja, Lorena Sanchez-Felipe, Xavier de Lamballerie, Catherine Verfaillie, Pedro E. Marques, Johan Neyts, Suzanne J. F. Kaptein

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KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

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A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia by Masayuki Nagasawa, Yuki Aoki

“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies. …”
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Engineering of ovarian tissue for ovarian dysfunctions: A review by Aliya Zhylkybekova, Gulbakit K. Koshmaganbetova, Myltykbay S. Rysmakhanov, Nurgul Abdullayevna Abenova, Nadiar Maratovich Mussin, Asset Askerovich Kaliyev, Mahdi Mahdipour, Amin Tamadon

“…The review focuses on two main approaches in tissue engineering: scaffold-based (3D printing, electrospinning, decellularization) and scaffold-free (stem cell transplantation, organoid cultivation). Both approaches show promise in preclinical studies for creating functional ovarian tissue. …”
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Mucopolysaccharidosis: A rare case from ophthalmology perspective by Santosh Singh Patel, Rajesh Kumar Sahu, Reshu Malhotra, Anju Bhaskar, A. K. Chandrakar

“…Newer treatment modalities such as hematopoietic stem cell transplantation and enzyme-replacement therapy have increased the life span of many MPS patients and created the need to improve the management of ocular symptoms.…”
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Current Uses of Poly(lactic-co-glycolic acid) in the Dental Field: A Comprehensive Review by Maria Justina Roxana Virlan, Daniela Miricescu, Alexandra Totan, Maria Greabu, Cristiana Tanase, Cristina M. Sabliov, Constantin Caruntu, Bogdan Calenic

“…PLGA scaffolds have been used to regenerate damaged tissues together with stem cell-based therapy. There is solid evidence that the development of PLGA microparticles and nanoparticles may be beneficial to a wide range of dental fields such as endodontic therapy, dental caries, dental surgery, dental implants, or periodontology. …”
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Role of Cold atmospheric plasma in cancer management by Shrikant B. Mali

“…Cold atmospheric plasma (CAP) has shown potential in treating skin diseases and chronic wounds, reducing tumor-cell viability and stimulating stem-cell proliferation. CAP triggers responses in tumor cells, causing epigenetic changes in DNA methylation levels and histone modification, and altering the expression and activity of non-coding RNAs, affecting cell regulatory functions. …”
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TLRs, Alcohol, HCV, and Tumorigenesis by Keigo Machida

“…Recent studies of HCC have centered on cancer-initiating stem cell (CSC), including detection of CSC in cancer, identification of CSC markers, and isolation of CSC from human HCC cell lines. …”
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Using the Neurofibromatosis Tumor Predisposition Syndromes to Understand Normal Nervous System Development by Cynthia Garcia, David H. Gutmann

“…Development is a tightly regulated process that involves stem cell self-renewal, differentiation, cell-to-cell communication, apoptosis, and blood vessel formation. …”
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Allografting for Bosutinib, Imatinib, Nilotinib, Dasatinib, and Interferon Resistant Chronic Myeloid Leukemia without ABL Kinase Mutation by B. Uz, O. Bektas, E. Eliacik, H. Goker, Y. Erbilgin, M. Sayitoglu, N. Sayinalp, S. Aksu, Y. Buyukasik, O. Ozcebe, I. C. Haznedaroglu

“…The aim of this paper is to report a patient with complicated CML resistant to treatment and progressed despite the administration of bosutinib, imatinib mesylate, nilotinib, dasatinib, interferon alpha 2a, cytotoxic chemotherapy, and allogeneic hematopoietic stem cell transplantation. The striking point of this case story is that no Abl kinase domain mutation against TKIs has been detected during this very complicated disease course of CML. …”
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Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart by Leonard M. Eisenberg, Carol A. Eisenberg

“…Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. …”
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Heritable human genome editing in South Africa – time for a reality check by M Ramsay, M Pepper, J de Vries, S Mahomed, E Flack-Davison

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Xanthoma Disseminatum with Tumor-Like Lesion on Face by Habib Ansarin, Hoda Berenji Ardestani, Seyed Mehdi Tabaie, Nasrin Shayanfar

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The History of Cystinosis: Lessons for Clinical Management by Paul Goodyer

“…Major conceptual break-throughs include (a) its discovery in 1903, (b) recognition of the renal Fanconi syndrome, (c) realization that tissue accumulation of cystine reflects a defective channel in the lysosomal membrane, (d) translation of this discovery to trials of cysteamine, (e) discovery of the CTNS gene, and (f) report of successful stem cell therapy in the cystinotic mouse. This paper focuses on the importance management lessons from these milestones and the potential new therapeutic strategies which may be looming in the near future.…”
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Bioluminescence in cancer research - Applications and challenges by Shrikant B. Mali

“…BLI is also widely employed in cancer imaging, especially in light of recent advances in genetic engineering, stem cell, and gene therapy therapies. Because of their distinct benefits over standard fluorescent reporters, bioluminescent reporters are increasingly being employed in research. …”
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Right of reply - Response to: In defence of South Africa’s National Health Research Ethics Council guidelines on heritable human genome editing by M Ramsay, M S Pepper, J de Vries, S Mahomed, E Flack-Davison

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François Gros: from antibiotics to messenger RNA by Yaniv, Moshe

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Epigenetic and gene regulatory functions of small RNAs by Cecere, Germano

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Innovations in Lung Transplant Research and Practice: The Future is Now by Robin Vos, Robin Vos, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Sandra Lindstedt, Deborah J. Levine, Norihisa Shigemura

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