Association of co-existing vitamin B6 and B12 deficiency with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome: a case report by Stephan Hu, Sharon Brown-Kunin, Paul Martin, Yujie Wang

“…He underwent an autologous stem cell transplant and has had improvement in his symptoms. …”
Get full text

Between Charybdis and Scylla—an Odyssey in AL amyloidosis: insights and learnings from a narrative review and case report series by Hani Sabbour, Ahmad Alhuraiji, Amr Hanbali, Faraz Khan, Jawahir Alameri, Sultan Alzaher, Dania Mohty, Giovanni Palladini

“…In addition, patients without significant cardiac involvement may benefit from rapid initial treatment with daratumumab along with cyclophosphamide-bortezomib-dexamethasone, which can render patients eligible for autologous stem cell transplant (ASCT) or in some instances means they can forgo ASCT completely. …”
Get full text

Generation, interrogation, and future applications of microglia-containing brain organoids by Julia Di Stefano, Federica Di Marco, Ilaria Cicalini, Una FitzGerald, Damiana Pieragostino, Marleen Verhoye, Peter Ponsaerts, Elise Van Breedam

“…Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function. …”
Get full text

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. by David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Shuo Lin, Paul D Kingsley, James Palis, Stuart H Orkin, Leonard I Zon

“…Surprisingly, a high level of zygotic tif1gamma mRNA expression delineates ventral mesoderm during hematopoietic stem cell and progenitor formation prior to gata1 expression. …”
Get full text

Bortezomib, thalidomide, and dexamethasone versus bortezomib, lenalidomide, and dexamethasone in transplant-eligible newly diagnosed multiple myeloma: a systemic review and meta-an... by Yin-Che Wang, Cheng-Hsien Lin, Yu-Chen Su, Chieh-Lin Jerry Teng

“…The primary endpoints were response rates after induction therapy and the incidence of a need for autologous hematopoietic stem cell transplantion (auto-HSCT) between the groups. …”
Get full text

The improved prognosis of <i>FLT3</i>-internal tandem duplication but not tyrosine kinase domain mutations in acute myeloid leukemia in the era of targeted therapy: a real-world st... by Matthew Schwede, Gladys Rodriguez, Vanessa E. Kennedy, Solomon Henry, Douglas Wood, Gabriel N. Mannis, Ravindra Majeti, Jonathan H. Chen, Eran Bendavid, Tian Yi Zhang

Get full text

Transcriptome-wide identification and characterization of WUSCHEL-related homeobox (WOX) gene family in Pinus yunnanensis by Junfei Xu, Zhaoliu Hu, Sili Chen, Junrong Tang, Lin Chen, Peizhen Chen, Nianhui Cai, Yulan Xu

“…Abstract WUSCHEL-related homeobox (WOX), a specific gene family in plants, plays a critical role during stem cell regulation, plant regeneration and upgrowth. …”
Get full text

Bortezomib, thalidomide, and dexamethasone versus thalidomide and dexamethasone for response rates in multiple myeloma patients: a retrospective study by Juan M. Cano-Calderón, Juan F. Zazueta-Pozos, Adán G. Gallardo-Rodríguez, Carlos Martínez-Murillo, Irma Olarte-Carrillo, Adolfo Martínez-Tovar, Christian O. Ramos-Peñafiel

“…Materials and methods: Retrospective study based on medical records of patients with multiple myeloma, eligible for stem cell transplantation, who received, first-line, the VTD or TD combination. …”
Get full text

Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis by Tingwei Zheng, Tingwei Zheng, Dandan Wang, Yuxin Miao, Yuxin Miao, Meng Dong, Qin Liu, Qin Liu, Qiuning Zhang, Huiling Bai, Huiling Bai, Hongtao Luo, Meixuan Li

“…Reported toxicity rates included 19% for cataracts, 10% for glaucoma, 5% for lacrimal stenosis, 52% for sicca symptoms, and 11% for limbal stem cell deficiency. The GRADE assessment yielded a low certainty of evidence.ConclusionsProton therapy offers a viable alternative treatment for patients with conjunctival malignancies, with acceptable treatment-related toxicity rates.…”
Get full text

Comparative Effectiveness of Remestemcel-L-rknd versus Ruxolitinib in Pediatric Patients with Steroid-Refractory Acute Graft-Versus-Host Disease using Simulated Treatment Compariso... by Gabriel Tremblay, Dimitrios Tomaras, Eric Strati, Anna Forsythe

“…**Background:** Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a lifesaving treatment for hematologic malignancies, but acute graft-versus-host-disease (aGVHD) is a potentially deadly adverse effect experienced by up to half of allo-HSCT recipients. …”
Get full text

CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

Get full text

Prevalence of mental disorders and work ability among unemployed individuals in Germany: a register-based analysis of socio-medical assessments by the Federal Employment Agency bet... by Patrik Roser, Kirsi Manz, Norbert Scherbaum, Gabriele Lotz-Metz, Andreas G. Franke

Get full text

Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling by Ghada H. Elsayed, Asmaa M. Fahim

Get full text

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…To mimic the disease in a reconstituted system, soluble amyloidogenic LCs purified from urine of AL-CA patients were added to a mixture of induced pluripotent stem cell-issued human cardiomyocytes (hiPSC-CM) and human primary cardiac fibroblasts, which resulted in formation of spheroids within 7 days. …”
Get full text

Long-term real-world evidence of CPX-351 of high-risk patients with AML identified high rate of negative MRD and prolonged OS by Thomas Cluzeau, Fabio Guolo, Edmond Chiche, Paola Minetto, Ramy Rahme, Sarah Bertoli, Luana Fianchi, Jean-Baptiste Micol, Michele Gottardi, Pierre Peterlin, Sara Galimberti, Xavier Thomas, Giuliana Rizzuto, Olivier Legrand, Michela Rondoni, Emmanuel Raffoux, Giambattista Bertani, Alexis Caulier, Michelina D’Argenio, Caroline Bonmati, Atto Billio, Caroline Lejeune, Barbara Scappini, Arnaud Pigneux, Patrizia Zappasodi, Christan Recher, Francesco Grimaldi, Lionel Ades, Roberto M. Lemoli

“…We also observed a trend toward a better median OS in patients who underwent hematopoietic stem cell transplantation with MRD <10–3 (not reached vs 26.0 months; P = .06). …”
Get full text

DIFFERENCES OF BONE REGENERATION USING BOVINE HYDROXYAPATITE AND BOVINE HYDROXYAPATITE WITH FREEZE-DRIED PLATELET RICH PLASMA ALLOGRAFT IN BONE DEFECT OF FEMORAL WHITE RABBIT by Mouli Edward, Henry Dominica, Ferdiansyah Mahyudin, Fedik Abdul Rantam

Get full text

Cost-Minimization Analysis for Subcutaneous Daratumumab in the Treatment of Newly Diagnosed Multiple Myeloma in Three Gulf Countries by Anas Hamad, Shereen Elazzazy, Ruba Y. Taha, Hani Osman, Sana Alblooshi, Islam Elkonaissi, Mustaqeem A. Siddiqui, Khalil Al-Farsi, Mohammed Al Lamki, Sali Emara, Gihan H. Elsisi

“…The model differentiated precisely between autologous stem cell transplantation (ASCT)–eligible and ASCT-ineligible NDMM patients in terms of their number in each group and the associated therapeutic regimens. …”
Get full text

Tissue-friendly dentin treatments as a potential element in revascularization protocol (ex-vivo study) by Hala Fayek Khalil, Nadia Ezz El Din Metwalli, Sara Magdy, Mohamed Shamel

“…Dual rinse HEDP efficiently increases stem cell adherence to dentin discs and their osteogenic differentiation. …”
Get full text

Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

“…Patients with DLBCL (vs HGBCL), complete response before infusion, prior autologous or allogeneic haematopoietic stem cell transplant and lactate dehydrogenase (LDH) within normal limits experienced more favourable efficacy outcomes, and those with Eastern Cooperative Oncology Group performance status of ≥2, ≥3 prior lines of therapy, elevated LDH and fludarabine-based lymphodepleting chemotherapy experienced less favourable safety outcomes.Conclusions This real-world study of tisagenlecleucel for patients with R/R DLBCL/HGBCL shows consistent efficacy and better safety outcomes than the pivotal trial. …”
Get full text

Occupational adjustments and work ability of young adult cancer survivors: results from the AYA-Leipzig study by Hannah Brock, Katharina Schröter, Michael Friedrich, Annekathrin Sender, Diana Richter, Anja Mehnert-Theuerkauf, Kristina Geue, Katja Leuteritz

“…Younger age (< 30) and stem cell transplant were associated with a lower benefit of support from colleagues (R2 = 0.077). …”
Get full text