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The landscape of cell regulatory and communication networks in the human dental follicle
Published 2025-02-01“…However, the specific cellular components and the intricate regulatory mechanisms governing the postnatal development and biological function of the dental follicle have not been completely understood.MethodsWe analyzed dental follicles with single-cell RNA sequencing (scRNA-seq) to reveal their cellular constitution molecular signatures by cell cycle analysis, scenic analysis, gene enrichment analysis, and cell communication analysis.ResultsTen cell clusters were identified with differential characteristics, among which immune and vessel-related cells, as well as a stem cell population, were revealed as the main cell types. …”
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2762
Deep imaging of LepR+ stromal cells in optically cleared murine bone hemisections
Published 2025-01-01“…Deciphering the spatial interaction of leptin receptor-expressing (LepR+) stromal cells with other compartments in the bone marrow is crucial for a deeper understanding of the stem cell niche and the skeletal tissue. In this study, we introduce an optimized protocol for the 3D analysis of skeletal tissues, enabling the visualization of hematopoietic and stromal cells, especially LepR+ stromal cells, within optically cleared bone hemisections. …”
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2763
Xenopus laevis neural stem progenitor cells exhibit a transient metabolic shift toward glycolysis during spinal cord regeneration
Published 2025-01-01“…It has been described that mitochondria and cellular metabolism play essential roles in stem cell proliferation, self-renewal, and differentiation. …”
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2764
DyCeModel: a tool for 1D simulation for distribution of plant hormones controlling tissue patterning
Published 2023-12-01“…We demonstrate the tool’s efficiency by simulation of the effect of auxin and cytokinin distributions on tissue patterning in two types of Arabidopsis thaliana stem cell niches: the root and shoot apical meristems. …”
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2765
Transcriptome-wide identification and characterization of WUSCHEL-related homeobox (WOX) gene family in Pinus yunnanensis
Published 2025-02-01“…Abstract WUSCHEL-related homeobox (WOX), a specific gene family in plants, plays a critical role during stem cell regulation, plant regeneration and upgrowth. …”
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2766
Seahorse nanos3 plays essential roles in germ cell development in the absence of nanos2
Published 2025-01-01“…We showed that the nanos family members in the seahorse are the nanos1a, nanos1b, and nanos3 genes, while nanos2, a key germline stem cell (GSC) maintenance factor, is intriguingly absent. …”
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2767
Mendelian Susceptibility to Mycobacterial Diseases (MSMD) in a 13-Year-Old Ethiopian Girl with Autosomal Dominant Interferon Gamma Receptor 1(IFN-γ R1) Defect: A Clinical Diagnosti...
Published 2022-01-01“…Treatments constitute antimycobacterial, interferon-gamma, surgery, and hematopoietic stem cell transplantation (HSCT), which is the only known curative treatment. …”
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2768
The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem D...
Published 2016-01-01“…CAOMECS were cultured on a temperature-responsive surface and grafted onto rabbit corneas with Limbal Stem Cell Deficiency (LSCD). E-cadherin levels were significantly higher in CAOMECS compared to normal and LSCD epithelium. …”
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2769
Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience
Published 2011-01-01“…TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation. …”
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2770
RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models
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2771
Comparative Effectiveness of Remestemcel-L-rknd versus Ruxolitinib in Pediatric Patients with Steroid-Refractory Acute Graft-Versus-Host Disease using Simulated Treatment Compariso...
Published 2021-02-01“…**Background:** Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a lifesaving treatment for hematologic malignancies, but acute graft-versus-host-disease (aGVHD) is a potentially deadly adverse effect experienced by up to half of allo-HSCT recipients. …”
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2772
Two Unrelated Iranian Patients with Adenosine Deaminase 2 Deficiency: A Case Report and Review of Treatment
Published 2024-01-01“…In cases where there is no appropriate response to these treatments, hematopoietic stem cell transplantation can be beneficial.…”
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2773
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2774
CD22 modulation alleviates amyloid β-induced neuroinflammation
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2775
Bacterial extracellular vesicles in the initiation, progression and treatment of atherosclerosis
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2776
The Feasibility of Percutaneous Dilatational Tracheostomy in Immunosuppressed ICU Patients with or without Thrombocytopenia
Published 2022-01-01“…Distribution of gender ratio, age, SAPS II, time of ventilation before tracheostomy, and preexisting hematooncological diseases was comparable between the two groups. After allogeneic stem cell transplantation (alloSCT), patients were more likely to undergo PDT than OST (p=0.033). …”
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2777
Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis
Published 2025-01-01“…Planarians, as ideal model animals for studying regeneration, stem cell proliferation, and apoptosis, have the strong regenerative abilities. …”
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2778
Menopausal Hormone Therapy: Its Role in the Prevention of Cardiovascular Diseases and the Risk of Breast Cancer in Women
Published 2025-01-01“…Moreover, MHT is associated with cell proliferation and mutation signaling pathways in breast cancer, as well as the process of growing the breast cancer stem cell. …”
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2779
Macrofocal multiple myeloma in the era of novel agents in China
Published 2025-01-01“…MFMM patients demonstrated better overall responses compared to the control cohort ( p = 0.027) in those not receiving upfront autologous stem cell transplantation (ASCT). During a median follow-up of 42.8 months for the entire cohort, the MFMM cohort exhibited significantly superior progression-free survival (PFS) and overall survival (OS) compared to the control cohort. …”
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2780
The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review
Published 2025-01-01“…Specifically, DEHP activated AhR, leading to elevated expression of EMT markers, increased cancer stem cell populations, and enhanced drug metabolism and resistance. …”
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