Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface by Dafina M. Angelova, Aleksandra Tsolova, Malwina Prater, Noura Ballasy, Wendi Bacon, Russell S. Hamilton, Danielle Blackwell, Ziyi Yu, Xin Li, Xin Liu, Myriam Hemberger, D. Stephen Charnock-Jones

“…Here, using single-cell RNA sequencing of mouse trophoblast stem cells during the earliest phases of differentiation, we identify gatekeepers of the stem cell state, notably Nicol1, and uncover unsuspected trajectories of cell lineage diversification as well as regulators of lineage entry points. …”
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Novel insights into immunopathogenesis and crucial biomarkers between primary open‐angle glaucoma and systemic lupus erythematosus by Yixian Liu, Mengling You, Zhou Zeng, Jing Wang, Rong Rong, Xiaobo Xia

“…Finally, reverse transcription quantitative real‐time polymerase chain reaction (RT‐qPCR) was performed in human trabecular meshwork stem cells to validate the five identified biomarkers. …”
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Advances in cardiac organoid research: implications for cardiovascular disease treatment by Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

“…Cardiac organoids, which are three-dimensional structures derived from the induced differentiation of stem cells, are particularly promising. These organoids not only replicate the autonomous beating and essential electrophysiological properties of the heart but are also widely employed in studies related to cardiac diseases, drug efficacy testing, and regenerative medicine. …”
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Comprehensive analysis of inhibin-β A as a potential biomarker for gastrointestinal tract cancers through bioinformatics approaches by Rohit Kumar Verma, Prashant Kumar Srivastava, Ashutosh Singh

“…The KEGG pathway analysis revealed that INHBA and its interacting proteins are involved in several pathways, including TGF-beta signaling, Signalling pathways regulating pluripotency of stem cells, colorectal cancer, pancreatic cancer, AGE-RAGE signaling, and so on as major pathways. …”
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Fibroblasts in rheumatoid arthritis: novel roles in joint inflammation and beyond by Elpida Neofotistou-Themeli, Elpida Neofotistou-Themeli, Panagiota Goutakoli, Panagiota Goutakoli, Theodoros Chanis, Theodoros Chanis, Maria Semitekolou, Maria Semitekolou, Eirini Sevdali, Eirini Sevdali, Prodromos Sidiropoulos, Prodromos Sidiropoulos

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Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent exp... by Gennady Meerovich, Evgeniya Kogan, Igor Romanishkin, Nikolay Zharkov, Sofiya Avraamova, Elena Shchelokova, Ekaterina Akhlyustina, Marina Strakhovskaya, Irina Meerovich, Sofya Demura, Irina Tiganova, Yulia Romanova, Zhi-Long Chen, Igor Reshetov

“…The analysis shows that the photodynamic effect of long-wavelength polycationic photosensitizers suppresses the tumor process (including the destruction of cancer stem cells), SARS-CoV-2 coronavirus infection, Gram-positive and Gram-negative bacteria, including those that can cause pneumonia. …”
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Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders by Yuesheng Tu, Weixin Zheng, Zichu Ding, Jie Xiang, Qinfeng Yang, Yuchen Liu, Jue Cao, Yuling Shen, Zinan Tang, Shen Lin, Lei Fan, Yaowen Xu, Bin Chen

“…This study explored a novel tannic acid-thioctic acid (TATA) hydrogel, enriched with exosomes derived from bone marrow mesenchymal stem cells, as a therapeutic strategy for enhancing skin wound healing in a hemophilia model. …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic mutations with normal proteins. …”
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Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling by Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark J. Millan, Emilio Merlo Pich, PierFranco Spano

“…Since D3R agonists are highly expressed on DA neurons in humans, we studied the effect of ropinirole and pramipexole on structural plasticity using a translational model of human-inducible pluripotent stem cells (hiPSCs). Two hiPSC clones from healthy donors were differentiated into midbrain DA neurons. …”
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Bioprinted hydrogels in bone regeneration: a bibliometric analysis by Huijie Zhang, Xiaoyu Li, Zhenyu Jia, Kun Jiao, Kun Jiao, Chen Liu, Chen Liu, Zixiang Deng, Yushu Bai, Xianzhao Wei, Xiaoyi Zhou

“…Our bibliometric-based visualization analysis revealed that the mechanical properties and osteogenic differentiation capacity of biomaterials have been a focal research topic over the past decade, while emerging research has also concentrated on the in vitro fabrication of stem cells for bone regeneration and osteogenic differentiation, particularly the precise application of in situ stem cell-loaded bioprinted organoids.ConclusionThis study provides an in-depth analysis of the research trajectory in the application of bioprinted hydrogels for bone regeneration. …”
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Tofacitinib and budesonide treatment affect stemness and chemokine release in IBD patient-derived colonoids by Arun Sridhar, Ingunn Bakke, Shreya Gopalakrishnan, Nimo Mukhtar Mohamud Osoble, Emilie Prytz Hammarqvist, Henrik P. Sahlin Pettersen, Arne Kristian Sandvik, Ann Elisabet Østvik, Marianne Doré Hansen, Torunn Bruland

“…During homeostasis, epithelial renewal is maintained by crypt stem cells and progenitors that cease to divide as they differentiate into mature colonocytes. …”
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Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

“…More pronounced changes in the blood cells composition, which was accompanied by activation of hematopoietic stem cells of myeloid and erythroid set, were determined in hamsters. …”
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<i>Weizmannia coagulans</i> BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation by Ying Wu, Cheng Li, Yinyin Gao, Jie Zhang, Yao Dong, Lina Zhao, Yuwan Li, Shaobin Gu

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The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways by Ju Ang Kim, Soomin Im, Jiwon Lim, Jung Min Hong, Hye Jung Ihn, Jong-Sup Bae, Jung-Eun Kim, Yong Chul Bae, Eui Kyun Park

“…Osteoblast differentiation and bone regeneration were analyzed using bone marrow mesenchymal stem cells (BMSCs) and various animal models. C21 significantly enhanced osteoblast differentiation and mineral deposition in mouse MC3T3-E1 cells and in human and mouse BMSCs. …”
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Surface functionalization of microscaffolds produced by high-resolution 3D printing: A new layer of freedom by Oliver Kopinski-Grünwald, Stephan Schandl, Jegor Gusev, Ourania Evangelia Chamalaki, Aleksandr Ovsianikov

“…Previously, we demonstrated the successful differentiation of such building blocks, produced from immortalized human adipose-derived stem cells, towards different phenotypes, and the possibility of creating macro-sized tissue-like constructs in vitro. …”
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Editorial: The Artificial Intelligence in Translational Medicine and Biomedical Research, How Future Can be Shaped?!! by Karzan Abdulmuhsin Mohammad

“…Attempts toward drug discovery, wound recoveries and self-proliferating stem cells were made. Most recently, scientists at Tufts University and Harvard University’s Wyss Institute have designed and created living small robots from cells of human trachea. …”
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Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…Busulfan, an alkylating chemotherapeutic agent widely used to treat chronic myelogenous leukemia, is known to induce NOA through its toxic effects on spermatogonial stem cells (SSCs). This study aimed to identify key molecular targets and pathways disrupted by busulfan in the testicular environment. …”
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Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development by Yue-Wei Chen, Qiu-Rong Du, Yu-Juan He, Wen-Shu Chen, Wen-Yang Jiang, Qi Gui, Cheng-Cheng Xu, Wei Wang, Hong-Yun Cheng

“…We also found that cancer stem cell properties were restrained by silencing circ_0044516 in A549 and SPC-A1 cells. …”
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Revisiting Fat Graft Harvesting and Processing Technique to Optimize Its Regenerative Potential by Karina Karina, MD, PhD, Johannes A. Biben, MD, Krista Ekaputri, MD, Grady Krisandi, BMed, Imam Rosadi, MSc, Siti Sobariah, BSc, Irsyah Afini, MBiomed, Tias Widyastuti, BSc, Alfida Zakiyah, BSc, Difky Ernanda, BSc

“…The use of fat grafting has expanded to include cell and tissue regeneration, necessitating investigations to ensure the viability of stromal and adipose-derived mesenchymal stem cells (ASCs) within the transferred fat parcels. …”
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Fluoroscopy Assisted Minimally Invasive Transplantation of Allogenic Mesenchymal Stromal Cells Embedded in HyStem Reduces the Progression of Nucleus Pulposus Degeneration in the Da... by Rifa Aquidah Subhan, Karunanithi Puvanan, Malliga Raman Murali, Hanumantha Rao Balaji Raghavendran, Samuel Shani, Basri Johan Jeet Abdullah, Azlina Amir Abbas, Jamal Azmi Mohamed, Tunku Kamarul

“…This study was conducted to develop a technique for minimally invasive and accurate delivery of stem cells to augment nucleus pulposus (NP) in damaged intervertebral discs (IVD). …”
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