Engineering cardiology with miniature hearts by Xiaojun Xia, Miner Hu, Wenyan Zhou, Yunpeng Jin, Xudong Yao

“…This review traces the evolution of cardiac organoid technology, from early stem cell differentiation protocols to advanced bioengineering approaches. …”
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Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…Among sphingosine 1-phosphate receptors (S1PRs) family, S1PR1 has been shown to be the most highly expressed subtype in neural stem cells (NSCs) and plays a crucial role in the migratory property of NSCs. …”
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Epoetin-alfa-induced osteogenesis in the bone organoid model by Natalia A. Nadezhdina, Oleg S. Gudyrev, Sergey V. Nadezhdin, Lyudmila M. Danilenko, Aleksandr A. Dolzhikov, Kristina K. Kremleva, Tatyana G. Pokrovskaya

“…Materials and Methods: The study was conducted on human mesenchymal stem cells (hMSC) and trabecular bone organoids (TBO). …”
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Ensemble Deep Learning Object Detection Fusion for Cell Tracking, Mitosis, and Lineage by Imad Eddine Toubal, Noor Al-Shakarji, D. D. W. Cornelison, Kannappan Palaniappan

“…Additionally, we compare our detection and tracking methods to human performance on external data in studying the motility of muscle stem cells with different physiological and molecular stimuli. …”
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When to cryopreserve and when to let it go? A systematic review of priorities in wild animal cryobanking by James Edward Brereton, Sarah Louise Spooner, Susan L. Walker, Andrew Mooney, Philippe Wilson, Gabriela F. Mastromonaco, Elena Hunter, Samuel White

“…In terms of cell type, sperm featured most frequently in cryobanking literature, potentially due to its ease of use in animal breeding programmes. Somatic cells and stem cells featured more commonly in more recently published literature. …”
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Human-based complex in vitro models: their promise and potential for rare disease therapeutics by Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, Fabia Furtmann, Devashree Jahagirdar, Mohua Chakraborty Choudhury, Sujata Mohanty, Harshita Mittal, Saveetha Meganathan, Rakesh Mishra

“…Complex in vitro models (CIVMs), including those using induced pluripotent stem cells (iPSCs), organoids, and organs-on-chips are emerging as powerful human-based pre-clinical systems with the capacity to provide efficacy data enabling drugs to move into clinical trials. …”
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MTFAP: a comprehensive platform for predicting and analyzing master transcription factors by Jianyuan Zhou, Haojie Yu, Chunhui Lou, Min Yang, Yanshang Li, Qian Yang, Shuhan Li, Chunwang Ji, Song Li, Shuang Wang, Haotian Cao, Xuecang Li, Lian Liu

“…Abstract Master transcription factors (MTFs) activate gene expression in pluripotent embryonic stem cells (ESCs) by binding to enhancers and super-enhancers, which precisely control ESC fate. …”
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Regulation of miRNAs in obesity and diabetes by Eva Maher, Ava O'Meara, Cathy Brougham

“…Dysregulated microRNA (miRNA) expression has been linked to the development of obesity and its associated disorders. Adipose derived stem cells (ADSCs) are promising cell models of obesity, obesity-related inflammation and diabetes. …”
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Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis by Ke Bi, Yuxi Chen, Yuhang Hu, Song Li, Weiming Li, Zhange Yu, Lei Yu

“…The results revealed that aging-related and mitochondria-related genes (AR&MRGs) were enriched in the ERK pathway in tissue stem cells (TSCs), and in mitochondrial membrane potential depolarization in monocytes. …”
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Bioceramic Surface Topography Regulating Immune Osteogenesis by Jianxin Hao, Lin Du, Yuening He, Chengtie Wu

“…Further researches show that macrophage of the large spacing micro-groove structure can promote the osteogenic differentiation of bone mesenchymal stem cells, which can benefit osteogenesis and osteointegration. …”
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Functional poly(ether-ketone-ketone) composite scaffold with enhanced cell-material interaction, anti-inflammatory and osteogenesis for facilitating osteointegration and bone regen... by Qianwen Yang, Anbei Chen, Xin Zhang, Zhaoying Wu, Chao Zhang

“…Due to the release of bioactive ions, SPBC can significantly promote the polarization of RAW264.7 cells towards M2 and the secretion of anti-inflammatory cytokines, while also enhancing the proliferation and differentiation of rat mesenchymal stem cells (rMSCs) in vitro. Furthermore, the in vivo results confirmed the enhanced anti-inflammatory properties and the integration of SPBC with the host tissue. …”
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Effect of pore geometry on properties of high-temperature oxidized additively manufactured magnesium scaffolds by Chaoxin Wang, Shuyuan Min, Jinge Liu, Bingchuan Liu, Bo Peng, Caimei Wang, Xiaolin Ma, Peng Wen, Yufeng Zheng, Yun Tian

“…Additionally, the magnesium alloy porous structures influenced the magnesium scaffold material degradation rate and the surrounding environment, impacting the osteogenic differentiation of bone mesenchymal stem cells and bone tissue regeneration. This work offers conceptual support for optimizing pore geometry to alter the mechanical and degradable characteristics of additively manufactured porous magnesium to meet therapeutic demands.…”
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Population Pharmacokinetic–Pharmacodynamic Modeling of Granulocyte Colony‐Stimulating Factor to Optimize Dosing and Timing for CD34+ Cell Harvesting by Xu Jiang, Jun Seok Cha, Byung Hak Jin, Choon Ok Kim, Dongwoo Chae

“…CD34+ cell mobilization was best captured by a modified Friberg model, assuming continual entry of proliferating BM stem cells into PB via a single transit compartment. …”
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Melatonin and its physiological and therapeutic effects: A review by Stefanović Bojana V., Spasojević Nataša M., Ferizović Harisa N., Janković Milica D., Virijević Kristina M., Dronjak Slađana S.

“…In the near future, melatonin will be a promising agent to control the fate of mesenchymal stem cells by regulating the generation of reactive oxygen species and the release of immune factors in regenerative medicine. …”
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Interruption of mitochondrial symbiosis is associated with the development of osteoporosis by Haoling Zhang, Haoling Zhang, Haoling Zhang, Rui Zhao, Xuemei Wang, Yaqian Qi, Doblin Sandai, Wei Wang, Zhijing Song, Zhijing Song, Qiudong Liang

“…In this paper, we reviewed the mechanism of mitochondrial intersymbiosis interruption in OP, discussed the relationship between mitochondrial intersymbiosis interruption and bone marrow mesenchymal stem cells, osteoblasts and osteoclasts, as well as the inheritance and adaptation in the evolutionary process, and prospected the future research direction to provide new ideas for clinical treatment.…”
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How to Deal with Pulpitis: An Overview of New Approaches by Jakub Fiegler-Rudol, Wojciech Niemczyk, Katarzyna Janik, Anna Zawilska, Małgorzata Kępa, Marta Tanasiewicz

“…These methods utilize stem cells, growth factors, and biomaterials to regenerate vascularized, functional pulp tissue. …”
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High-intensity focused ultrasound: an innovative approach for micro-manipulation of demineralized dentine by Sheetal Maria Rajan, Barsha Shrestha, Amr Fawzy

“…Furthermore, HIFU promoted the proliferation of dental pulp stem cells (n = 3/group) while maintaining the associated temperature-rise within the physiological tolerance. …”
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In situ-formed cryomicroneedles for intradermal cell delivery by Mengjia Zheng, Tianli Hu, Yating Yang, Xuan Qie, Huaxin Yang, Yuyue Zhang, Qizheng Zhang, Ken-Tye Yong, Wei Liu, Chenjie Xu

“…As a proof-of-concept, we examined the loading and intradermal delivery of three cell types in clinically relevant in vitro and in vivo models, including mesenchymal stem cells for wound healing, melanocytes for vitiligo treatment, and antigen-pulsed dendritic cells for cancer vaccination.…”
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Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis by Célia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Mario Fernandez Comaduran, Morgane Verbrugghe, Jia Ming Stella Xu, Sandra Minotti, James Lynch, Jeetayu Biswas, Tad Wu, Heather D. Durham, Gene W. Yeo, Maria Vera

“…Stress-mediated HSPA8 mRNA localization to the dendrites is impaired by depleting fused in sarcoma—an amyotrophic lateral sclerosis-related protein—in cultured spinal cord mouse motor neurons or by expressing a pathogenic variant of heterogenous nuclear ribonucleoprotein A2/B1 in neurons derived from human induced pluripotent stem cells. These results reveal a neuronal stress response in which RNA-binding proteins increase the dendritic localization of HSPA8 mRNA to maintain proteostasis and prevent neurodegeneration.…”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. by Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

“…Here, we generated RTS patient-derived induced pluripotent stem cells (iPSCs) to dissect the pathological signaling leading to RTS patient-associated osteosarcoma. …”
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