Classification of distinct tendinopathy subtypes for precision therapeutics by Chenqi Tang, Zetao Wang, Yuanhao Xie, Yang Fei, Junchao Luo, Canlong Wang, Yue Ying, Peiwen He, Ruojing Yan, Yangwu Chen, Jiayun Huang, Yiwen Xu, Zicheng Wang, Boon Chin Heng, Hengzhi Liu, Jianyou Li, Zi Yin, Haobo Wu, Weishan Chen, Hongwei Ouyang, Xiao Chen, Weiliang Shen

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Tracheobronchial Manifestations of Aspergillus Infections by Rafal Krenke, Elzbieta M. Grabczak

“…Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.…”
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Long-Term Use of Ruxolitinib in an AML Patient with Posttransplant Steroid Refractory GVHD by Philip T. Sobash, Achuta K. Guddati, Vamsi Kota

“…We present a case of a 32-year-old male on ruxolitinib with GVHD status postmatched unrelated donor stem cell transplant (MUD SCT) for acute myeloid leukemia (AML) with FLT3 mutation currently on ruxolitinib for 5 years who is not able to tolerate reduction in dosage due to flare-ups. …”
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Prolonged Pediatric Extracorporeal Membrane Oxygenation Support with Cardiopulmonary Failure in Juvenile Myelomonocytic Leukemia by Maris Bartkevics, Bert Hennig, Tayfun Gungor, Roland Ammann, Alexander Kadner

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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration by Nan Jiang, Cheng Wu, Xunrong Zhou, Guanghua Zhai, Jian Wu

“…In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. …”
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Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin’s Lymphomas by Marco Gunnellini, Lorenzo Falchi

“…Alternative chemoimmunotherapy regimens are often used as salvage strategy and stem cell transplant remains an option for selected patients. …”
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Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population by L. Akhmaltdinova, V. Sirota, V. Zhumaliyeva, D. Babenko, I. Kadyrova, Z. Tauesheva, D. Taizhanova, A. Ibraeva, M. Maratkyzy, A. Turmukhambetova

“…The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β (TGF), tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), and programmed death ligand 1 (PD-L1). …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

“…Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobody enzyme chimeras represent an approach to specifically manipulate PTMs, with applications in both the laboratory and the clinic.…”
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Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions by Tiantian Wang, Dong Zhou, Zhen Hong

“…This review discusses the muscle microenvironment's changes contributing to these conditions, recent therapeutic approaches like lifestyle modifications, small molecules, and nutritional interventions, and emerging strategies such as gene editing, stem cell therapy, and gut microbiome modulation. We also address the challenges and opportunities of multimodal interventions, aiming to provide insights into the pathogenesis and molecular mechanisms of sarcopenia and cachexia, ultimately aiding in innovative strategy development and improved treatments.…”
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Molecular Monitoring in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with the Variant e13a3 BCR-ABL1 Fusion by Mireille Crampe, Laura Kearney, David O’Brien, C. Larry Bacon, Derville O’Shea, Stephen E. Langabeer

“…Molecular monitoring reflected the disease response from diagnosis through allogeneic stem cell transplantation which resulted in undetectable e13a3 BCR-ABL1 transcripts. …”
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HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature by Michael J. Grant, Mitchell E. Horwitz

“…Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…This study analysed the secretomes of bone-marrow (BM.MSCs), umbilical-cord (UC.MSCs), adipose-tissue (AT.MSCs) and clinical/commercial-grade induced pluripotent stem cell-derived MSCs (iMSCs), under resting and inflammatory licenced conditions. iMSCs recapitulated the inflammatory licensing process, validating their comparability to tissue-derived MSCs. …”
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Nanodrug‐Engineered Exosomes Achieve a Jointly Dual‐Pathway Inhibition on Cuproptosis by Hanxiao Sun, Yang Zou, Zhengtai Chen, Yan He, Kai Ye, Huan Liu, Lihong Qiu, Yufan Zhang, Yuexue Mai, Xinghong Chen, Zhengwei Mao, Wei Wang, Chenggang Yi

“…A Cu‐chelator (Clioquinol, CQ) polydopamine (PDA)‐modified stem cell exosome loaded with siRNA‐FDX1, named EXOsiFDX1‐PDA@CQ, is designed to efficiently inhibit the two cuproptosis pathways. …”
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Treatment of Acute Graft-versus-Host Disease in Liver Transplant Recipients by Edward Kim, Alina Adeel, Adel Bozorgzadeh, Shinya Amano, Curtis T. Barry, Jennifer S. Daly, Deepika Devuni, Zendee Elaba, Laura Houk, Paulo N. Martins, Babak Movahedi, Muthalagu Ramanathan, Nicole M. Theodoropoulos

“…We report on two patients who developed aGvHD after liver transplantation who were treated with ruxolitinib, a novel Janus kinase 1/2 (JAK) inhibitor that has been shown to improve outcomes in steroid refractory cases of aGvHD after allogenic hematopoietic stem cell transplantation. We reviewed the literature to discuss various therapeutic options currently available for aGvHD after liver transplantation.…”
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Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches by Yang-Jin Shen, Yin-Cheng Huang, Yi-Chuan Cheng

“…This review provides a comprehensive and critical evaluation of recent advancements in antioxidant-based therapeutic strategies for SCI, including natural compounds, RNA-based therapies, stem cell interventions, and biomaterial applications. …”
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Persistent Mixed Donor Chimerism following Double Umbilical Cord Transplantation in a Patient with T-Cell Prolymphocytic Leukemia by Ronak H. Mistry, Elizabeth O. Hexner, James K. Mangan

“…Current standard of care for T-PLL is with alemtuzumab, followed by allogeneic or autologous stem cell transplant. Little is found in the literature about alternative donor transplantation in T-PLL. …”
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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS).…”
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Host factor PLAC8 is required for pancreas infection by SARS-CoV-2 by Lesly Ibargüen-González, Sandra Heller, Darío López-García, Hanna Dietenberger, Thomas FE Barth, Patricia Gallego, Israel Fernández-Cadenas, Sayoa Alzate-Piñol, Catalina Crespí, Julieth A. Mena-Guerrero, Eugenia Cisneros-Barroso, Alejandro P. Ugalde, Gabriel Bretones, Charlotte Steenblock, Alexander Kleger, Marta L. DeDiego, Carles Barceló

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Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels by Ruonan Shao, Danchen Meng, Beibei Gao, Lu Zhang, Qingqi Meng, Yanqiu Hou, Zhangbiao Long, Jinsong Yan, Xiaofeng Shi

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Presumed Glenoid SLAP Tear in an Adolescent Football Player Belied the Presence of a Coracoid Growth Plate Fracture: A Diagnostic Conundrum by John G. Skedros, J. Hunter Marshall, John T. Cronin

“…Hoping to expedite his healing with platelet or stem cell injections, the parents sought an opinion from another physician who obtained a right shoulder MRI with intra-articular contrast. …”
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