What Is New in Glaucoma: From Treatment to Biological Perspectives by Raffaele Nuzzi, Paola Marolo, Alessia Nuzzi

“…On the other hand, the most recent approaches to treat glaucoma outcomes in its advanced stages include electrical stimulation, stem cells, exosomes, extracellular vesicles, and growth factors. …”
Get full text

Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology by Azusa Maeda, Iris Kulbatski, Ralph S. DaCosta

“…Studies have demonstrated that various components of tumors and their microenvironments, including vasculature, immune and stem cells, and stromal cells, can influence the response of solid tumors to radiation. …”
Get full text

Epigenetics of cancer drug resistance by Sayandeep Mukherjee, Ronit Dey, Subhabrata Guha, Nabendu Murmu, Gaurav Das

“…The major factors contributing to metastasis of cancer cells are epithelial–mesenchymal transition and cancer stem cells. There are multiple evidences which suggest that malfunction of epigenetic regulation in functioning of a gene is directly related to the development of cancer. …”
Get full text

Transfection Agent Induced Nanoparticle Cell Loading by Karin Montet-Abou, Xavier Montet, Ralph Weissleder, Lee Josephson

“…Loading cells with magnetic nanoparticles, and tracking their fate in vivo by high resolution MRI, is an attractive approach for enhancing the efficacy of cell-based therapies including those utilizing hematopoietic stem cells, neuroprogenitor cells, and T cells. The transfection agent (internalization agent) assisted loading with the Feridex IV ® nanoparticle is an attractive method of loading because of the low cost of materials, and possible low regulatory barriers for eventual clinical use. …”
Get full text

Which Are the Cells of Origin in Merkel Cell Carcinoma? by Thomas Tilling, Ingrid Moll

“…However, for several reasons, for example, heterogeneous differentiation of MCCs and postmitotic character of MCs, it is not very likely that MCC develops from differentiated MCs. Skin stem cells, probably from the epidermal lineage, are more likely to be cells of origin in MCC. …”
Get full text

Pathogenesis and regenerative therapy in vitiligo and alopecia areata: focus on hair follicle by Yuan Zhou, Yu-Xuan Zhang, Yu-Yun Xiong, Yu-Mei Li

“…Hair follicles, dynamic mini-organs, house diverse stem cell populations that form hair structures. Melanocyte stem cell (McSCs) and hair follicle stem cells (HFSC) located in the hair follicle bulge contribute to follicular structures during each anagen phase of the hair cycle, synchronizing periodic activities to impact color to the hair. …”
Get full text

T model of growth and its application in systems of tumor-immunedynamics by Mohammad A. Tabatabai, Wayne M. Eby, Karan P. Singh, Sejong Bae

“…The T model is useful in modeling cellularproliferation or regression of cancer cells, stem cells, bacterial growth anddrug dose-response relationships. …”
Get full text

Platelet-Rich Plasma Supplemented Revascularization of an Immature Tooth Associated with a Periapical Lesion in a 40-Year-Old Man by Ganesh Ranganath Jadhav, Naseem Shah, Ajay Logani

“…The misconception that stem cells number as well as viability in older age group patients will not allow revascularization to be successful is also contradicted by this case. …”
Get full text

Cancer Is to Embryology as Mutation Is to Genetics: Hypothesis of the Cancer as Embryological Phenomenon by Jaime Cofre, Eliana Abdelhay

“…On the other hand, “cancer disease” is the representation of an abnormal state of the cell that might happen in the stem cells of an adult person, in which the mechanism for joint gene regulating of differentiation, proliferation, cell invasion, and migration could be reactivated in an entirely inappropriate context.…”
Get full text

Age-Adjusted Schedules of Venetoclax and Hypomethylating Agents to Treat Extremely Elderly Patients with Acute Myeloid Leukemia by Aaron M. Lee, Aaron M. Goodman, James K. Mangan

“…BCL-2 has been identified as an antiapoptotic protein and promotes survival of leukemia stem cells. Recently, the United States FDA has approved venetoclax, a selective oral BCL-2 inhibitor, for use in conjunction with hypomethylating agents (azacitidine or decitabine) or low-dose cytarabine as a first-line treatment option for those AML patients ineligible for standard induction chemotherapy. …”
Get full text

RNA-binding proteins as versatile metabolic regulators by Ellie Koletsou, Ina Huppertz

“…Abstract Metabolic shifts are a hallmark of numerous biological processes, including the differentiation of stem cells along a specific lineage and the activation of diverse cell types, such as immune cells. …”
Get full text

Longitudinal omics data and preclinical treatment suggest the proteasome inhibitor carfilzomib as therapy for ibrutinib-resistant CLL by Lavinia Arseni, Gianluca Sigismondo, Haniyeh Yazdanparast, Johanne U. Hermansen, Norman Mack, Sibylle Ohl, Verena Kalter, Murat Iskar, Mathias Kalxdorf, Dennis Friedel, Mandy Rettel, Yashna Paul, Ingo Ringshausen, Eric Eldering, Julie Dubois, Arnon P. Kater, Marc Zapatka, Philipp M. Roessner, Eugen Tausch, Stephan Stilgenbauer, Sascha Dietrich, Mikhail M. Savitski, Sigrid S. Skånland, Jeroen Krijgsveld, Peter Lichter, Martina Seiffert

Get full text

A feedback loop between Paxillin and Yorkie sustains Drosophila intestinal homeostasis and regeneration by Dan Jiang, Pengyue Li, Yi Lu, Jiaxin Tao, Xue Hao, Xiaodong Wang, Wei Wu, Jinjin Xu, Haoen Zhang, Xiaoyu Li, Yixing Chen, Yunyun Jin, Lei Zhang

“…Abstract Balanced self-renewal and differentiation of stem cells are crucial for maintaining tissue homeostasis, but the underlying mechanisms of this process remain poorly understood. …”
Get full text

Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury by Baoguo Liu, Sumei Liu, Dejun Sun

“…In our study, we systematically investigated the differentiation of neural stem cells (NSCs) in vitro and functional recovery in injured rats in vivo following Taxol treatment. …”
Get full text

Effects of melatonin on planaria head regeneration are dependent on both timing and duration of exposure by Simon C. Beeching, Hanna E. Ruland, Katelyn M. Sparks

“…Head regeneration in planaria is a remarkable phenomenon in which stem cells (neoblasts) migrate to the wound site, proliferate, then differentiate into all functional tissue types within days of injury. …”
Get full text

The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
Get full text

Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy by Ekaterina Pashkina, Maria Bykova, Maria Berishvili, Yaroslav Lazarev, Vladimir Kozlov

“…Receptors for HA overexpressed in subpopulations of cancer cells, and one of them, CD44, is recognized as a molecular marker for cancer stem cells. This review examines the role of HA and its receptors in health and tumors and analyzes existing HA-based delivery systems and their use in various types of cancer. …”
Get full text

Biologic Augmentation of the Ulnar Collateral Ligament in the Elbow of a Professional Baseball Pitcher by James K. Hoffman, Nicole M. Protzman, Amit D. Malhotra

“…A construct comprising a dermal allograft, platelet rich plasma (PRP), and mesenchymal stem cells (MSCs) has been shown to successfully improve healing in the rotator cuff. …”
Get full text

Resolving the Two “Bony” Faces of PPAR-γ by Beata Lecka-Czernik, Larry J. Suva

“…Osteoblasts and adipocytes are derived from marrow mesenchymal stroma/stem cells (MSC). The milieu of intracellular and extracellular signals that controls MSC lineage allocation is diverse. …”
Get full text

Iron Chelation Therapy in Myelodysplastic Syndromes by Emanuela Messa, Daniela Cilloni, Giuseppe Saglio

“…Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. …”
Get full text