Densely vascularized thick 3D tissue shows enhanced protein secretion constructed with intermittent positive pressure by Misako Katsuura, Jun Homma, Yuhei Higashi, Hidekazu Sekine, Tatsuya Shimizu

“…The present study investigated the effects of air-compressing intermittent positive pressure (IPP) on co-cultured mesenchymal stem cells and vascular endothelial cells and evaluated the potential of IPP-cultured cell sheets for transplantation therapy. …”
Get full text

Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration by Yang Liu, Chenguang Wang, Guanfang Su

“…Stimulating intrinsic neuronal regeneration is a potential approach to therapy in retinal degenerative diseases. In contrast to stem cells, as embryonic/pluripotent stem cell-derived retinal progenitor cell or mesenchymal stem cells, Müller glia provided an endogenous cellular source for regenerative therapy in the retina. …”
Get full text

Cellular therapy for the peripheral arterial disease treatment: Protocol for a systematic review and meta-analysis. by Mónica Rodríguez-Valiente, Cristina Fuente-Mora, Javier Sánchez-Gálvez, Micaela Ortín-Pérez, Manuel Pardo-Ríos, José Manuel Sánchez-Sáez, Isac Davidson Santiago Fernandes Pimenta, Grasiela Piuvezam, Laura Ramos-Petersen

“…Many studies have proposed the use of stem cells, such as mesenchymal stem cells, or even mononuclear cells isolated from peripheral blood or bone marrow, to treat PAD. …”
Get full text

Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design by Rita CCS. Santos, Larissa FCDMS. Lima, Pâmela V. Andrade, Joilson M. Santos, Leonardo Galleni, Antonio FR. Junior, Lucas S. Souza, Beny Schmidt, Acary SB. Oliveira, José LG. Amaral, Mariz Vainzof, Helga CA. Silva

Get full text

Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer by Rabia Hursitoglu, Abdulkadir Yasir Bahar, Sezen Koçarslan, Gökmen Aktaş, Neslihan Kurtul, Emine Kılınç

“…Cancer stem cells (CSCs) are cancer cells responsible for cancer initiation, growth, metastasis, recurrence and resistance to treatment. …”
Get full text

Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells by Jelena Krstic, Juan F. Santibanez

Get full text

Bioprinting approaches in cardiac tissue engineering to reproduce blood-pumping heart function by Minji Kim, Dong Gyu Hwang, Jinah Jang

Get full text

Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…., genomics for personalized medicine, nanomedicine to overcome low free-drug bioavailability and targeting, systematic search of “melanoma stem cells” to enhance the prognosis and develop more valuable theranostics). …”
Get full text

Non-medical treatment for late age-related macular degeneration by A.K. Drakon, A.G. Kurguzova, V.M. Sheludchenko, N.B. Korchazhkina

“…It was demonstrated that retinal pigment epithelium (RPE) cells derived from human embryonic stem cells or induced pluripotent stem cells express typi cal RPE markers that can phagocytize photoreceptor segments. …”
Get full text

Highly efficient construction of monkey blastoid capsules from aged somatic cells by Junmo Wu, Tianao Shao, Zengli Tang, Gaojing Liu, Zhuoyao Li, Yuxi Shi, Yu Kang, Jiawei Zuo, Bo Zhao, Guangyu Hu, Jiaqi Liu, Weizhi Ji, Lei Zhang, Yuyu Niu

“…Prior research has predominantly utilized embryonic stem cells. In this work, we demonstrate the efficient generation of blastoids from induced pluripotent stem cells and somatic cell nuclear transfer embryonic stem cells derived from aged monkeys, achieving an 80% formation efficiency. …”
Get full text

Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

Get full text

Implant-Prosthetic Rehabilitation in Bilateral Agenesis of Maxillary Lateral Incisors with a Mini Split Crest by M. M. Figliuzzi, A. Giudice, S. Pileggi, D. Pacifico, M. Marrelli, M. Tatullo, L. Fortunato

Get full text

Characterization of Ex Vivo Expanded Oral Mucosal Epithelium Cells on Acellular Porcine Corneal Stroma for Ocular Surface Reconstruction by Jia-Song Wang, Hua-Tao Xie, Ming-Chang Zhang

“…Characterization showed that these sheets retain the morphologic and phenotypic characteristics of OMECs within differentiated cells and stem cells. The optimal transplantable sheets can prove to be particularly beneficial to both bilateral limbal stem cell deficiency and deep corneal lesions.…”
Get full text

Organoids and spheroids: advanced in vitro models for liver cancer research by Mirella Pastore, Alessia Giachi, Elena Spínola-Lasso, Fabio Marra, Chiara Raggi

“…Organoids derived from stem cells or patient tissues that accurately emulate the complexity and functionality of liver tissue. …”
Get full text

Oxidative Stress, Epigenetics, Environment, and Epidemiology of Diabetic Retinopathy by Goran Petrovski, Kai Kaarniranta, Daniel Petrovič

Get full text

Extracorporeal photopheresis in stiff person syndrome by Yandy Marx Castillo-Aleman, Pierre Christophe Krystkowiak

Get full text

Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…We then investigated the MARK4L and MARK4S expression profile in 21 glioma cell lines and 36 tissues of different malignancy grades, glioblastoma-derived cancer stem cells (GBM CSCs) and mouse neural stem cells (NSCs) by real-time PCR, immunoblotting and immunohistochemistry. …”
Get full text

Cell-marking techniques for cell lineage tracing by A. M. Yunusova, N. R. Battulin

“…In most cases, however, studying cellular lineages and identification of stem cells’ subpopulations are a true challenge for investigators. …”
Get full text

A CASE SERIES: MICRO AND NANO FAT GRAFTING FOR THE TREATMENT OF TESSIER 3 AND 4 CRANIOFACIAL CLEFTS VOLUME DEFECT by Carolus Aldo Windura, Tomie Hermawan Soekamto, Fonny Josh

“…Growth factors and stem cells in nano fat complemented the micro fat properties, thus increasing the survivability rate. …”
Get full text

The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…EZH2 forms a repressive chromatin structure which eventually participates in regulating the development as well as lineage propagation of stem cells and glioma progression. Posttranslational modifications are distinct approaches for the adjusted modification of EZH2 in the development of cancer. …”
Get full text