Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients by Brittni M. Usera, Polly Creveling, Jonathan D. Tward

“…There was no statistically significant difference between the low, average, and high testosterone cohorts for PFS, MFS, or OS. …”
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The Effect of A Number Sense Education Program Supported By Web 2.0 Tools on The Number Sense Development of First Grade Elementary School Students by Zuhal Akbabaoğlu, Özgün Uyanık Aktulun

“…Furthermore, a statistically significant difference emerged between the experimental and control groups' post-test average scores in the NSS subdimensions and overall score (p<.05), underscoring the beneficial impact of Web 2.0 Tools-supported educational processes on enhancing number sense skills.…”
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Taming the transplant troll: Exploring racial and ethnic disparities in cytomegalovirus infection among kidney transplant patients. by M Gabriela Cabanilla, Ashlee Dauenhauer, Briana St John, Deirdre Hill, Joshua Larson

“…Although not statistically significant, all-cause mortality was higher in the minority group (24.5% vs. 11.1%, p = 0.54), with 46.2% of the deaths occurring within 90 days of CMV diagnosis. …”
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Comparison of the accuracy of implant impression by conventional open-tray and digital techniques by Joanna Majid Hayder, Fahd Sudad Ikram

“…Regarding the angular distortion, there was also a statistically significant difference between the digital and conventional implant impression models with the reference model. …”
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Suicide in Patients with Motor Neuron Disease by S. Bak, E. N. Stenager, E. Stenager, J. Boldsen, T. A. Smith

“…The difference between observed and expected suicides was not statistically significant for males and females.…”
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The efficacy and safety of a taxane-based chemotherapy regimen combined with a PD-1 inhibitor in HNSCC: a multicenter real-world study by Min Ouyang, Hanquan Sun, Xiaoyu Liu, Haijun Wu, Feilong Deng, Erdong Shen, Guozheng Peng, Hanbing Wu, Yinshan Zhao, Hui Xiong, Bin Liu, Shasha He, Ying Hu, Ping Liu

“…In the univariate analysis, the distant organ metastasis had a statistically significant impact on both PFS and OS. Subsequent radiotherapy following this protocol also showed a statistically significant effect on PFS and OS. …”
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Effect of Intermittent High Intensity Aerobic Exercise on Exercise Endurance of Patients with Stroke Complicated with Coronary Heart Disease by Rongju YE, Leshan SUN, Zhen ZENG, Guo LI, Qin ZHANG, Zhilan LIU, Kai WANG

“…Compared with before treatment, the PP, ED, peak VO₂, AT, LVEF, METs and Barthel index in the three groups increased significantly after treatment for three months, and the difference was statistically significant (<italic>P</italic>&lt;0.05). Compared with the control group, the PP, ED and peak VO₂in the medium and high intensity groups were significantly higher after treatment for three months, the AT and LVEF in the high intensity group were significantly higher after treatment for three months, and the difference was statistically significant (<italic>P</italic>&lt;0.05), but there was no significant difference in AT and LVEF in the medium intensity group after treatment for three months (<italic>P</italic>&gt;0.05). …”
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Effect of Sling Exercise Therapy combined with Inspiratory Muscle Strength Training for Stroke Patients with Hemiplegia by Wenlin SUN, Dianhuai MENG, Yangyang LIU, Xiaoyong SU, Yang LIU, Fangfang ZHANG, Tiantian ZHAO

“…Before and after treatment for six weeks, the maximum inspiratory pressure(MIP), peak inspiratory flow(PIF), and forced vital capacity(FVC)were used to assess the lung function and inspiratory muscle function of patients; the Berg balance scale(BBS)was used to assess patients balance ability; the Fugl-Meyer assessment lower extremity(FMA-LE)was used to assess the patient's lower limb motor function; 10-meter maximum walking speed(10 m MWS)was used to assess the patient's walking speed.Results:Before treatment, there were no significant differences in MIP, PIF, FVC, BBS score, FMALE motor function score and 10 m MWS in the three groups(<italic>P</italic>&gt;0.05).Compared with before treatment, the MIP, PIF, FVC, BBS score, FMA-LE motor function score and 10 m MWS in the three groups were significantly improved after treatment for six weeks, and the difference was statistically significant(<italic>P</italic>&lt;0.05).Compared with the control group, the MIP, PIF, FVC, BBS, FMA-LE motor function score and 10 m MWS were significantly improved after treatment for six weeks in the sling group and the combined group, and the difference was statistically significant(<italic>P</italic>&lt;0.05).Compared with the sling group, the MIP, PIF, FVC, BBS score, FMA-LE motor function score and 10 m MWS in the combined group were significantly higher after treatment for six weeks, and the difference was statistically significant(<italic>P</italic>&lt;0.05).Conclusion:Sling exercise therapy combined with inspiratory muscle strength training can effectively improve the balance function and walking function for stroke patients with hemiplegia, which is worthy of clinical promotion.…”
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Effect of Conductive Education Combined with Exercise Therapy on Rehabilitation Function of Children with Cerebral Palsy by Lihong LI, Liya YANG, Feng HAN, Ningning TIAN, Beibei GONG, Suju CHEN

“…The motor function development level and intelligence development index of the two groups after intervention were higher than those before intervention, and the differences were statistically significant (<italic>P</italic>&lt; 0.05). The DQ IQ scores of the study group after intervention were (96.3±7.9), (100.8±9.2), (97.6±10.4), (101.6±8.4) and (98.5±7.8) respectively, which were higher than those of the control group (83.2±6.9), (86.0±8.5), (84.1±9.4), (84.3±7.1) and (83.2±7.0), and the differences were statistically significant (<italic>P</italic>&lt; 0.05). …”
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Investigating the impact of couple counseling based on the CHARMS model on sexual quality of life and marital satisfaction of wives of men suffering from myocardial infarction: a r... by Delniya Ghafuri, Soheila Rabeipoor, Kamal Khademvatani, Samira Barjasteh, Atefeh Yas

“…This difference being statistically significant (Adjusted Mean Difference = 12.95; 95% CI = 1.18 to 21.13; P < 0.001). …”
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Effects of Functional Electrical Stimulation Based on Walking Pattern with Different Treatment Time on Lower Limb Function in Stroke Patients：A Randomized Controlled Study by XUE Jingjing, KONG Huimin, LIAO Meixin, XUE Yunlian, XIAO Lingjun

“…Besides, the 60 min-stimulation group had statistically significant differences in walking speed after treatments for 7 times and 15 times, while the 30 min-stimulation group only had a statistically significant difference after treatments for 15 times (<italic>P</italic>&lt;0.05). …”
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Correlation analysis between preoperative odontoid incidence and clinical outcomes 2 years after anterior cervical discectomy and fusion by Yan Gong, Hao Liu, Yanchi Gan, Jiahui He, Zelin Zhou, Hang Zhuo, Yu Liu, De Liang, Hui Ren, Xiaobing Jiang, Zhaojun Cheng

“…At the 2-year postoperative follow-up, all patients exhibited significant improvements in JOA, NDI, and VAS scores compared with the preoperative values (P < 0.05). No statistically significant difference was observed in the preoperative or baseline data between the larger OI group and the smaller OI group (P > 0.05); however, a statistically significant difference was noted in the postoperative SSA between the two groups (P < 0.05). …”
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The effects of contralateral limb cross-education training on post-surgical rehabilitation outcomes in patients with anterior cruciate ligament reconstruction: a randomized control... by Chao Liu, ShiJia Li, JianPing Li, HongHao Zhang, GuQiang Li, XiangZhan Jiang

“…Results Before the intervention, no statistically significant differences were observed between the two groups across all measured parameters (P > 0.05). …”
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Betulinic Acid Inhibits the Metastasis of Colon Cancer Cells through Regulating TGF-β/Smad Signaling Pathway by Xiaoying LIN, Aling SHEN, Meizhu WU, Ying CHENG, Xiaoping CHEN, Huixin LIU, Liya LIU, Zhiqing SHEN, Xiangyan WU, Nanhui XU, Jianfeng CHU, Youqin CHEN, Jun PENG

“…Western blot was used to detect the effect of BA on the protein expression of TGF-β and Smad2/3 in HCT116 cells after treated with BA for 48 h.Results:(1) CCK8 assay showed that the cell viability in each group was significantly reduced after treatment with different concentrations of BA for 24,48 and 72 h, and the differences were statistically significant compared with the 0 μmol/L group respectively (<italic>P</italic>&lt;0.05); The cell count results showed the number of cells in each group was remarkably decreased, and the differences were statistically significant compared with the 0 μmol/L group respectively (<italic>P</italic>&lt;0.05). (2) Transwell assay showed that the number of cells that migrated or invaded into the membrane was profoundly inhibited in each group after treatment with different concentrations of BA for 48 h, and the differences were statistically significant compared with the 0 μmol/L group respectively (<italic>P</italic>&lt;0.05). (3) Western blot assay showed that the protein expression of TGF-β and Smad2/3 was obviously decreased in each group after treated with different concentrations of BA for 48 h compared with the 0 μmol/L group.Conclusion:BA can inhibit the growth and metastasis of colon cancer cells, and its mechanism may be achived by regulating the TGF-β/Smad signaling pathway.…”
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Clinical Efficacy of Muscle Energy Technology Combined with Conventional Rehabilitation Therapy on Patients with Chronic Non-Specific Neck Pain by ZHENG Kun, YANG Haolun, JIA Chengsen, ZHANG Liming

“…The effective rate in the observation group (92.31%) was higher than that of the control group (28.00%), and the difference was statistically significant (<italic>P</italic>&lt;0.05). During the course of treatment, there were no adverse reactions in both groups.ConclusionMET combined with conventional rehabilitation therapy can effectively improve the pain and cervical spine function of patients with CNSNP, which is recommended for clinical promotion and application.…”
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Effects of Duhuo Jisheng Decoction on Calcium Homeostasis and Apoptosis of Chondrocytes under Endoplasmic Reticulum Stress by Qing LIN, Wenyi WANG, Danhong PAN, Yanfeng HUANG, Changlong FU, Jinxia YE

“…Objective:To observe the effect of Duhuo Jisheng decoction on the balance of calcium homeostasis and apoptosis of chondrocytes under endoplasmic reticulum stress(ERS), and to preliminarily explore its mechanism of preventing and treating osteoarthritis.Methods:A steady chondrocyte in vitro culture system was established by using 4-week-old SD rat knee cartilage, and identify the third generation chondrocyte by toluidine blue staining.The 25 μmol/L Thapsigargin(TG)was used to induce chondrocyte in vitro culture to produce endoplasmic reticulum stress(ERS), incubate it in Duhuo Jisheng Decoction(100, 200, 400 μg/mL)for 24 hours after induction.The cells were divided into the blank group, the model group, the low-dose Duhuo Jisheng decoction group, the medium-dose Duhuo Jisheng decoction group, and the high-dose Duhuo Jisheng decoction group.Then morphological changes of chondrocytes were observed respectively by inverted microscope, viability of chondrocyte in each group was examined by CCK-8 method, chondrocyte apoptosis was observed by Hoechst 33342 staining and real-time dynamic changes of intracellular Ca²⁺concentration was examined by double turntable laser confocal microscope.Results:①The morphology of chondrocytes: the cells in the blank group grew in a single-layer paving stone shape, while the cells in the model group increased in a polygonal shape, the pseudopodia increased, the gaps widened, and the number of cells decreased significantly.Compared with the model group, the number of cells in the three dose groups of Duhuo Jisheng decoction(100, 200, 400 μg/mL)increased significantly and the cytoplasm was uniform.The activity of chondrocytes in each group: compared with the blank group, the survival rate of the model group was lower, and the difference was statistically significant(<italic>P</italic>&lt;0.05).The absorbance of each concentration group of Duhuo Jisheng decoction increased with the increase of concentration, and the difference was statistically significant compared with the model group(<italic>P</italic>&lt;0.05).③Apoptosis of chondrocytes: the number of apoptosis in the model group was significantly increased, and the degree of pyknosis of the nucleus was obvious, and some of them were a high density of bright blue or half moon-shaped.The number of apoptotic cells in each dose group of Duhuo Jisheng decoction was significantly reduced, only a few apoptotic cells showed a high density of bright blue or half-moon shape, and the number of apoptosis decreased with the increase of the concentration of Duhuo Jisheng decoction, showing a certain dose-effect relationship.④The changes of intracellular calcium ion concentration: the calcium ion fluorescence intensity of the cells in the blank group was weaker and more uniform, maintaining a stable state.The calcium ion release of the model group was significantly increased, and the fluorescence intensity was enhanced.The fluorescence spectrum showed that calcium sparks were more frequent.Compared with the blank group, the difference was statistically significant(<italic>P</italic>&lt;0.05).Chondrocytes in the medium and high-dose Duhuo Jisheng decoction groups could quickly return to calcium homeostasis, and calcium sparks were significantly reduced.Although there were still some calcium sparks in the low-concentration Duhuo Jisheng decoction group, the fluorescence intensity was significantly weaker than the model group.Conclusion:Duhuo Jisheng decoction has an inhibitory effect on the apoptosis of chondrocyte induced by TG, the mechanism may be that Duhuo Jisheng decoction can alleviate endoplasmic reticulum stress by regulating calcium balance, thus inhibiting the apoptosis of chondrocyte.…”
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Clinical Effects of Smart Phone Speech Training Combined with Scalp Acupuncture in Patients with Non-fluent Aphasia after Stroke by Mingyue XIONG, Yanyan TANG, Lihua CAO, Dian HUANG, Xiaodan LI, Jie TAN

“…In the observation group, spontaneous speech(<italic>Z</italic>=-3.934, <italic>P</italic>=0.001), comprehension(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001), retelling(<italic>Z</italic>=-3.642, <italic>P</italic>=0.001), naming(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001), AQ(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001)and CADL-T scores(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001)were significantly improved before and after treatment, and the differences were statistically significant. In the control group, there were significant improvements in retelling(<italic>Z</italic>=-3.921, <italic>P</italic>=0.001), naming(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001)and AQ(<italic>Z</italic>=-3.922, <italic>P</italic>=0.001)before and after treatment, but there were no significant improvements in spontaneous speech(<italic>Z</italic>=-2.255, <italic>P</italic>=0.061), comprehension(<italic>Z</italic>=-1.756, <italic>P</italic>=0.079)and CADL-T(<italic>Z</italic>=-1.403, <italic>P</italic>=0.161), and the differences were not statistically significant. …”
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Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study by Habtamu Tadesse Gudeta, Shalama Lekasa Nagari, Dessalegn Emana Jabana, Mustefa Aflegn Legese, Demekisa wondimu Biyena, Fantahun Cheklie Kassie

“…This study revealed that variables such as antenatal care, hemoglobin, mid-upper arm circumference, malaria status, and hypertension were statistically significant predictors of adverse birth outcomes. …”
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Pengaruh Pelvic Floor Muscle Training terhadap Pengembalian Fungsi Miksi dan Defekasi pada Ibu Postpartum Spontan by Mustika Dewi, Ermawati ., Nuzulia Irawati

“…The percentage of normal defecation was higher in mothers who did PFMT than mothers who did not PFMT (87.5%: 16.7%), the difference was statistically significant (p &lt; 0.05). The results showed that of PFMT did affect micturition, although there is a tendency to spontaneous micturition in the intervention group than the control group, but not statistically significant. …”
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Effect of Repetitive Transcranial Magnetic Stimulation Combined with Exercise Therapy on the Motor Function in Stroke Patients with Hemiplegia by Wani ZHOU, Lei ZHANG, Rundong LI, Kaiquan XU, Chengji WU

“…After three months'treatment, FMA scores of upper limbs and lower limbs in the excitation group were significantly higher than those in the exercise group, with statistically significant differences (<italic>P</italic>&lt;0.001). …”
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