Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

“…Cell proliferation and toxicity test (CCK-8) was used to detect the effect of different concentrations of BBR on cell viability; the flow cytometry was used to detect the mean fluorescence intensity (MFI) of TLR4 on cell membrane ; ELISA method was used to detect the content of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α); the real-time quantitative PCR was used to detect the mRNA level of IL-1β, IL-6, TNF-α; Western blot was used to detect the phosphorylation of p-ERK/ERK, p-p38/p38, p-JNK/JNK, p-p65/p65 and p-IRF3/IRF3 and the expression of TLR4, MyD88 and AP-1; the biochemical assay was used to detect the content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD).Results① CCK-8 assay results: compared with the control group, there was no significant difference in cell activity of the low, medium and high- dose BBR group, the difference was not statistically significant (<italic>P</italic>&gt;0.05). ② Flow cytometry results: compared with the fluorescent antibody group, MFI of the model group was significantly decreased; compared with the model group, MFI of the model group + the high dose BBR group was significantly increased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ③ ELISA results: compared with the control group, the content of IL-1β, IL-6, TNF- α of the model group was significantly increased; compared with the model group, the content of IL-1β, IL-6, TNF- α of the model group + the low, medium and high dose BBR group was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ④ Real-time quantitative PCR results: compared with the control group, the mRNA level of IL-1β, IL-6, TNF-α of the model group was significantly increased; compared with the model group, the mRNA level of IL-1β, IL-6, TNF- α of the model group + the low, medium and high-dose BBR group was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ⑤ Western blot results: compared with the control group, the phosphorylation expression of p65 and IRF-3 protein of the model group after intervention for 45 minutes was significantly increased, and the phosphorylation expression of p65, IRF-3 protein in the model group + the low, medium and high-dose BBR group was significantly decreased. …”
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A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…The corneal staining score improved in both groups, with no statistically significant difference. While 0.3% HA was more effective than 0.1% HA according to the absolute value, this difference was not statistically significant. …”
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Therapeutic Effect of <italic>Self-made Wrist Joint Flexion and Extension Orthoses</italic> Combined with Routine Rehabilitation Training on Wrist Joint Spasm after Brain Infarctio... by Rui JIAO, Shangjie CHEN, Shuqian LI, Xinyan JIA, Heng LIU

“…After three weeks of treatment, the MAS scores of the two groups after treatment were lower than those before treatment (<italic>P</italic>&lt; 0.05), and the decrease of the wrist flexion-extension orthoses group was more obvious than that of the routine rehabilitation group, the differences between the two groups were statistically significant after treatment (<italic>P</italic>&lt; 0.05). …”
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Resilience and Burnout in nurses of a general hospital in Lima, Peru by Alberto A. Alegre, Oscar J. Bedregal, Alejandra Rodrich-Zegarra

“…In addition, statistically significant differences and medium effect sizes in emotional stress and indifference were found according to the type of shift and employment contract. …”
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STUDY ON THE RELATIONSHIP BETWEEN BODY MASS INDEX AND WALKING SPEED IN ADOLESCENTS by Vica Ivașcu, Bogdan Constantin Ungurean

“…There was a statistically significant positive correlation between BMI and the time obtainedin the shuttle run test, p < 0.001, r = 0,578. …”
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ADOPTION LEVEL OF GREEN PRACTICES AND ITS EFFECT ON EMPLOYEE’ PERFORMANCE by Ali Erbaşı, Gökhan Akandere

“…It was concluded that there was a statistically significant and weak positive relationship between the perception of adoption of green practices and task performance and between the perception of adoption of green practices and contextual performance. …”
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Tuberculosis in Humans and Cattle in Jigawa State, Nigeria: Risk Factors Analysis by S. Ibrahim, S. I. B. Cadmus, J. U. Umoh, I. Ajogi, U. M. Farouk, U. B. Abubakar, A. C. Kudi

“…None of these risk factors (food consumption, living with livestock in the same house, and presence of BTB-positive cattle) were found to be statistically significant.…”
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Evaluation of “One Body, One Life”: A Community-Based Family Intervention for the Prevention of Obesity in Children by Marsha Towey, Ruth Harrell, Berni Lee

“…There were small but statistically significant improvements in BMI/BMI percentile for adults and children who started the programme overweight/obese. …”
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Effect of High Frequency Repetitive Transcranial Magnetic Stimulation on Postoperative Cognitive Dysfunction in Elderly Mice Based on BDNF/TrkB Signaling Pathway by LI Min, YANG Xiao, REN Lulu, WU Tingmei, ZHANG Hong

“…Compared with the operation group，the protein expression levels of BDNF，TrkB and NGF in the hippocampus of rTMS group were significantly increased，and the differences were statistically significant （<italic>P</italic>&lt;0. 05）.ConclusionHigh frequency rTMS can improve POCD in aged mice，and its mechanism may be related to rTMS activating BDNF/TrkB signaling pathway and increasing NGF expression.…”
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Effect of Vocational Rehabilitation Training Camp on Patients with Spinal Cord Injury Returning to Society by Lingjuan RAO, Li DAI, Li CHEN, Xiaoling LI, Jichao XIONG, Qingjun YANG, Huazhong YANG, Jinlong CUI

“…The statuses of returning to work of patients were followed up by telephone six months after discharge.Results:There were no statistically significant differences between the two groups in GSES scores and CIQ scores before treatment (<italic>P</italic>&gt; 0.05). …”
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Mechanism of Bushen Huoxue Recipe on Improving Arterial Calcification in Rats with Osteoporosis Based on OPG/RANKL Signaling Pathway by LIN Xiaorong, YANG Na, ZHENG Bei, ZHAO Hu, XU Junxia

“…Compared with the osteoporosis group, the BMD of the Bushen Huoxue group increased significantly, and IOD value of thoracic aorta calcification deposition decreased significantly, the difference was statistically significant (<italic>P</italic>&lt;0.05). 2) The level of PⅠNP, BGP and CTX-Ⅰ in the serum: compared with the control group, the level of PⅠNP and BGP of the osteoporosis group decreased significantly, the level of CTX-Ⅰ, a bone resorption marker increased significantly, the difference was statistically significant (<italic>P</italic>&lt;0.05). …”
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Triple pillars of sustainable finance: The role of green finance, CSR, and digitalization on bank performance in Bangladesh by Shaikh Masrick Hasan, K. M. Anwarul Islam, Tawfiq Taleb Tawfiq, Priya Saha

“…In addition, control variables, including default rate and bank size, exhibit a statistically significant negative relationship with performance measures. …”
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Evaluation of impact strength of heat cure and chemical cure acrylic resin denture base material by Ahmed Saleh Hamadameen

“…Result: Although the difference was not statistically significant, during evaluation on average thermosetting resins were more resistant to fracture than self-curable resins. …”
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The mediating effect of emotional schemas in the relationship between online gaming addiction and life satisfaction by Samet Makas, Mustafa Koç

“…Conversely, there were negative, low and statistically significant correlations with the emotional schemas of rumination, difference and duration. …”
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How to Enhance Product Quality, Ad Credibility, and Location on Purchase Decisions by Muhammad Idrus Khisamuddin, Rita Ambarwati, Dewi Komala Sari

“…The variable of product quality demonstrates a statistically significant and favorable impact on consumer purchasing decisions within the context of Starbucks. …”
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To Evaluate and Compare the Microleakage of Chitosan Nano Hydrogel-Incorporated MTA and Glass Ionomer Cements When used as a Retrograde Filling Material by Vinaykumar G. Suryavanshi, Ravi K. Tale, Vivekanand D. Kolvekar, Rashmi Chordiya, P S Amal, B Abijeet

“…Results: The results showed that the MTA + chitosan group had less microleakage values compared to the MTA group but was not statistically significant and GIC + chitosan had less microleakage values compared to the GIC group and was statistically significant. …”
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Effect Analysis of Practical Teaching Reform for Service Process of Low-temperature Orthosis by Xue ZHANG, Kaiyi QIU, Kuicheng LI, Xiaowei ZHANG, Jingming OUYANG, Minyi YE, Yuxing MO, Bei WANG

“…At the end of the course, comparison of the students' theoretical and practical operation assessment scores between the two groups, and feedback on teaching effects through questionnaire.Results:The observation group students' theory and operation assessment scores were significantly better than the control group, with statistically significant differences (<italic>P</italic>&lt;0.05).The questionnaire survey results showed that the average scores of the individual questionnaires and survey questionnaires of the observation group were higher than those of the control group, with statistically significant differences (<italic>P</italic>&lt;0.05).Conclusion:In practice teaching of rehabilitation treatment technology, to standardize the application of the low-temperature orthosis service processmodular teaching gives better training outcome.…”
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Facteurs alimentaires et environnementaux de risque du cancer du rhino-pharynx au Maroc et leur répartition géographique by Soumia Ammor, Abdellatif Baali, Mohamed Cherkaoui, Annie Hubert

“…A logistic regression analysis has shown that preservation of food in brine, along with living in an agricultural environment and having contact with toxic compounds seem to be statistically significant factors related to NPC. However, we did not find a statistically significant relationship with other food factors such as khlii and quaddid, probably due to a decrease or irregularity in their consumption. …”
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Teeth and Covariates: Association with Risk of Falls by Shivani Kohli, Aaron Lam Wui Vun, Christopher Daryl Philip, Cassamally Muhammad Aadil, Mahenthiran Ramalingam

“…Subjects with depression (p=0.03) and presence of illness related to fall showed statistically significant difference (p=0.001) in comparison with those who did not suffer from the same. …”
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Implant Stability Changes for Nonsubmerged and Submerged Protocols for a Single Implant Mandibular Overdenture Using Ball Attachment by Ahmed Salah, Karim Foda, Mohamed Farouk Abdalla, Marwa Abdel Aal, Amr Naguib, Nouran Abdel Nabi

“…Two-sided p values less than 0.05 was considered statistically significant. Results. There was no statistically significant difference in the mean change in PTV reading between the NS and S group at the different follow-up intervals. …”
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