Application of BOPPPS combined with dynamic scenarios simulation in ICU clinical nursing teaching (BOPPPS结合动态情景模拟在ICU护理教学中的应用) by CHEN Xi (陈曦), LI Baoyu (李宝妤), WANG Lingling (王玲玲), ZHANG Chao (张超), XIU Limin (修立敏)

“…After teaching, the planning and implementation, self-management and total score of independent learning ability in the experimental group were significantly higher than those of the control group, with statistical significance (P＜0. 05). There was statistically significant difference in the total score of critical thinking in experimental group before and after teaching (P＜0. 05). …”
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Partner conflict during their index pregnancy and its correlates among a cohort of six weeks postpartum women in Ethiopia by Solomon Abrha Damtew, Niguse Tadele Atnafu, Mahari Yihdego Gidey, Tesfamichael Awoke Sisay, Metages Yohannes

“…Candidate variables were selected using p-value of 0.25. Statistical significance was declared at p-value of 0.05. The overall proportion of IPV during the index pregnancy as measured six weeks postpartum was 12.14% (95%CI: 10.66%, 13.79%). …”
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Predictors of recurrence of ventricular tachycardia and the effectiveness of endocardial ablation at the patients with sudden cardiac death and history of myocardial infarction by O. M. Grytsay, Ya. V. Skybchyk

“…At 12 months after the procedure, the following parameters were associated with relapses of ventricular tachycardia with the greatest statistical significance: left ventricular systolic dysfunction (additive relative risk (ARR) – 43.0 %, relative risk (RR) – 2.57 [1.14–5.82], odds ratio (OR) – 6.50 [7.00–30.70], p < 0.05), arterial hypertension (ARR – 41.0 %, RR – 2.75 [1.08–6.90], OR – 5.96 [1.33–26.70], p < 0.05), diabetes mellitus (ARR – 43.0 %, RR – 2.83 [1.10–7.30], OR – 6.50 [1.25–33.60], p < 0.05), duration of arrhythmic history (ARR – 40.0 %, OR – 5.71 [7.00–28.10], p < 0.05), electrical storm episode at the time of ablation (ARR – 38.0 %, RR – 1.89 [1.27–4.99], OR – 8.57 [7.00–51.50], p < 0.05). …”
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Evaluating academic detailing as an antibiotic stewardship intervention in primary healthcare settings in Croatia by Darija Kuruc Poje, Domagoj Kifer, Maja Kuharić, Katarina Gvozdanović, Željka Draušnik, Ana Posavec Andrić, Vesna Mađarić, Vlatka Janeš Poje, Marina Payerl-Pal, Arjana Tambić Andrašević, Juraj Mark Poje, Vesna Bačić Vrca, Srećko Marušić

“…Inter-county difference in these changes was not statistically significant (ratio = 0.749, 95% CI, 0.460–1.220; p = 0.246). …”
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Effectiveness of the Modified WHO Labour Care Guide to Detect Prolonged and Obstructed Labour Among Women Admitted at Eight Publicly Funded, Midwife-Led Community Health Facilities... by Mugyenyi GR, Tumuhimbise W, Atukunda EC, Tibaijuka L, Ngonzi J, Kayondo M, Kanyesigye M, Musimenta A, Yarine FT, Byamugisha JK

“…Data was collected in REDcap and analyzed using STATA v17; statistical significance was p < 0.05.Results: A total of 991 (49.3%) and 1020 (50.7%) women were monitored using the LCG and partograph, respectively. …”
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Insulin resistance surrogates are associated with all-cause mortality and cardiovascular mortality in population with metabolic syndrome: a retrospective cohort study of NHANES by Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

“…Restricted cubic spline curves showed QUICKI, IGR, and e-IS had a nonlinear relationship with statistical significance. MetS population at the highest quartile of HOMA-β or IGR exhibited lower all-cause and cardiovascular event probabilities compared with those at the lowest quartile, and e-IS had a similar correlation with cardiovascular events. …”
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Preclinical Efficacy and Proteomic Prediction of Molecular Targets for s-cal14.1b and s-cal14.2b Conotoxins with Antitumor Capacity in Xenografts of Malignant Pleural Mesothelioma by Angélica Luna-Nophal, Fernando Díaz-Castillo, Vanessa Izquierdo-Sánchez, Jesús B. Velázquez-Fernández, Mario Orozco-Morales, Luis Lara-Mejía, Johana Bernáldez-Sarabia, Noemí Sánchez-Campos, Oscar Arrieta, José Díaz-Chávez, Jorge-Ismael Castañeda-Sánchez, Alexei-Fedorovish Licea-Navarro, Saé Muñiz-Hernández

“…Finally, we found that both conotoxins reduced the tumor mass in MPM xenografts; s-cal14.1b reached statistical significance. Based on these results, s-cal14.1b and s-cal14.2b conotoxins could be potential therapeutic drugs for MPM neoplasms with no apparent side effects on normal cells.…”
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Group Psychological Therapy Program in Adult Patients with Congenital Heart Disease and Anxious–Depressive Symptoms by Efrén Martínez-Quintana, Karen Codana-Alcántara, Hector M. Montesdeoca-Naranjo, Marta Isabel García-Suárez, María Pino Fleitas-Álvarez, María Alcántara-Castellano, Alejandro Ruiz-Castellano, Ana González-Isasi, Fayna Rodríguez-González, Esperanza Bosch-Casañas

“…Meanwhile, the Rosenberg Self-Esteem Scale score was close to reaching statistical significance (27.4 ± 6.0 vs. 25.1 ± 5.4, <i>p</i> = 0.051), while the State–Trait Anxiety Inventory did not. …”
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Changes in infant respiratory pathogens pre-, during, and post-COVID-19 non-pharmacological interventions in Beijing by Tongying Han, Yajuan Wang, Di Zhang, Ying Li, Li Zhang, Jin Yan, Chi Li, Shengnan Yang, Litao Guo, Huijuan Yan

“…There were statistically significant differences in the detection rates of Flu A, PIV, SARS-CoV-2, HRV, HMPV, ADV, and C.pn before, during, and after implementation of the NPIs during the COVID-19 epidemic (P < 0.05). …”
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The fibrosis-4 index and its association with carotid atherosclerosis in type 2 diabetes: a cross-sectional study in China by Ying Miao, Yu Wang, Qin Wan, Nanwei Tong

“…Following adjustments for various factors, the prevalence of CA exhibited a progressive increase in the Fib-4 < 1.3, 1.3 ≤ Fib-4 < 2.67, and Fib-4 ≥ 2.67 groups, with statistically significant differences (P < 0.05). Moreover, the prevalence of increased CIMT and carotid plaques in the Fib-4 ≥ 2.67 group remained significantly higher than that in the Fib-4 < 1.3 group after considering various factors (P < 0.05). …”
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Prenatal vitamin utilization and its determinants among pregnant women in south Gondar zone: multicenter cross-sectional study by Begizew Yimenu Mekuriaw, Dagne Addisu, Wassie Yazie Ferede, Fillorenes Ayalew Sisay, Assefa kebie Mitiku, Tegegne Wale Belachew, Tigist Seid Yimer, Habtie Bantider Wubet, Selamawit Girma Tadesse, Negesse Zurbachew Gobezie, Alemie Fentie Mebratie, Moges Kefale Alachew, Temesgen Dessie Mengistu, Yonas Zenebe Yiregu, Rahel Birhanu Arage, Anteneh Mengist Dessie, Fikadu Geremew Gebeyehu, Geremew Bishaw Mekonen, Habtam Desse Alemayehu, Abeba Belay Ayalew, Yitayal Ayalew Goshu, Besfat Berihun Erega

“…Educational level of women, pregnancy plan, decision on health care, knowledge and attitude on prenatal vitamins had statistically significant with utilization of prenatal vitamins. …”
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Utilization of patient-reported outcomes to assess adherence to relugolix when combined with stereotactic body radiation therapy for intermediate to high-risk prostate cancer by Kelly Gaudian, Min Jung Koh, Min Ji Koh, Ryan R. Collins, Shaine Eden, Zoya Zwart, Malika Danner, Alan Zwart, Mark Fallick, Deepak Kumar, Paul Leger, Nancy A. Dawson, Simeng Suy, Sean P. Collins

“…A p-value &lt; 0.05 determined statistical significance.ResultsBetween August 2021 and December 2023, 78 men were treated at Georgetown with relugolix and prostate SBRT per an institutional protocol. …”
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Vibration therapy as an intervention for trochanteric hip fractures – A randomized double-blinded, placebo-controlled trial by Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Chun Sing Chui, Wing Hong Liu, Ning Tang, James Griffith, Ning Zhang, Wing Hoi Cheung

“…For fracture healing, CT scan at 6 weeks showed improved osseous union for the LMHFV group at 71.5 ± 19.4 % compared to placebo group at 58.8 ± 30.5 %, but no statistical significance detected. X-rays showed fractures healed at 12 months. …”
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Research Reports on Assessment of Handwriting Ability in Children Aged 6-12 Years by Using Smart Handwriting Analysis Recognition Platform by HAN Ping, YANG Wenyi, XIE Yiyang, XIE Qiurong, WANG Jiawei, YANG Caihong, ZHAN Shiqi, YAN Zhaoshan, ZHANG Yu

“…As the grades increased, the writing speed gradually accelerated between adjacent grades of grades 1 to 4 (<italic>P</italic>&lt;0.05), and between grades 5 and 6 (<italic>P</italic>&lt;0.05), but the increase in writing speed between grades 4 and 5 showed no significant difference (<italic>P</italic>&gt;0.05). 2) In terms of writing control ability, the overall trend of grades 1 to 6 showed a gradual development, with the performance of writing control ability in grade 3 being better than that in grade 2 (<italic>P</italic>&lt;0.05), and the performance of writing control ability in grade 5 being better than that in grade 4 (<italic>P</italic>&lt;0.05), and there was no statistical significance between the other adjacent grades (<italic>P</italic>&gt;0.05). 3) In terms of the writing integration ability and time-on-paper ratio, as the grades increased, the higher grades developed better than the lower grades between adjacent grades 1 to 4 (<italic>P</italic>&lt;0.05), and the difference between grades 4 to 5 and 5 to 6 was not statistically significant (<italic>P</italic>&gt;0.05). 4) in terms of the accuracy of writing outcomes, grade 2 was better than grade 1 (<italic>P</italic>&lt;0.05), and grade 4 was better than grade 3 (<italic>P</italic>&lt;0.05), and there was no statistically significant difference between the other adjacent grades (<italic>P</italic>&gt;0.05); 5) In terms of overall writing performance, grade 2 performed better than grade 1 (<italic>P</italic>&lt;0.05), and the differences between other adjacent grades were not statistically significant (<italic>P</italic>&gt;0.05). …”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Although STK11 mutations and heightened PD-L1 expression indicated a trend toward poorer outcomes, these correlations lacked statistical significance. Conclusion This research affirms KRAS-G12C inhibitors as promising treatments, especially for certain patient subgroups, and underscores KEAP1 mutations as key biomarkers for resistance. …”
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Association of tea consumption with all-cause/cardiovascular disease mortality in the chronic kidney disease population: an assessment of participation in the national cohort by Jin Li, Xing-Ling Chen, Xiao-Lu Ou-Yang, Xiao-Jiao Zhang, Yue Li, Shu-Ning Sun, Ling-Jun Wang, Zhong-Qi Yang, Shi-Hao Ni, Lu Lu

“…Consuming up to 4 cups of tea per day was significantly associated with lower all-cause mortality compared with that never drinking tea, among CKD patients at 1–2 stages [Hazard Ratio (HR) = 0.89; 95% Confidence Interval (CI) = 0.79, 0.99; p = 0.04], while the association between tea consumption and CVD mortality didn’t reach statistical significance. Dose-response effect was observed, showing that consuming up to three to five cups of tea per day was associated with mitigated risks of all-cause mortality, particularly in early CKD stages (non-linear p > 0.05). …”
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Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study by Seda Kahraman, Mutlu Hizal, Burcin Cakan Demirel, Deniz Can Guven, Ozge Gumusay, Basak Oyan Uluc, Ertugrul Bayram, Burcu Gulbagci, Alper Yasar, Sena Ece Davarci, Eda Eylemer Mocan, Omer Acar, Deniz Isik, Esra Aydin, Yusuf Karakas, Melike Ozcelik, Murat Keser, Sadi Kerem Okutur, Onder Eren, Serkan Menekse, Dincer Aydin, Funda Yilmaz, Ozlem Dogan, Gulhan Ozkanli, Hakan Yucel, Veli Sunar, Musa Baris Aykan, Ozlem Ozdemir, Berna Bozkurt Duman, Merve Keskinkilic, Teoman Sakalar, Ali Inal, Muge Karaoglanoglu, Asude Aksoy, Muhammed Muhiddin Er, Nazim Serdar Turhal, Nurhan Onal Kalkan, Mehmet Ali Nahit Sendur

“…There was a meaningfull numerical difference that did not reach statistical significance in patients who received CDK4/6i treatment as the first line for MBC. …”
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Promotion and practice of an online service offering Traditional Chinese Medicine constitution conditioning under the normalization of epidemic prevention and control (疫情防控常态化背景下中医... by MA Qian (马茜), YU Hong (俞红), XU Junhua (徐俊华), XU Lidan (许丽丹), FANG You (方友), ZHEN Yanping (郑艳平), LI Yanlan (李燕兰), LIANG Xiao (梁肖), LU Mingya (陆明雅), ZHANG Yijun (张轶俊)

“…Results Compared with before intervention, the conversion score of Qi-deficiency, the frequency of respiratory infection in 6 months, the negative emotion score and total score of the five dimensions of depression, nervous decline, fear, compulsion-anxiety and hypochondria of the subjects decreased, with statistical significance(P<0. 01). Conclusion The online service of TCM constitution conditioning can regulate TCM constitution, prevent respiratory tract infection and regulate negative emotions of Qi-deficiency people susceptible to the virus, and can be popularized under the normalization of epidemic prevention and control. …”
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Logistic Regression Model in a Machine Learning Application to Predict Elderly Kidney Transplant Recipients with Worse Renal Function One Year after Kidney Transplant: Elderly KTbo... by Ubiracé Fernando Elihimas Júnior, Jamila Pinho Couto, Wallace Pereira, Michel Pompeu Barros de Oliveira Sá, Eduardo Eriko Tenório de França, Filipe Carrilho Aguiar, Diogo Buarque Cordeiro Cabral, Saulo Barbosa Vasconcelos Alencar, Saulo José da Costa Feitosa, Thais Oliveira Claizoni dos Santos, Helen Conceição dos Santos Elihimas, Emilly Pereira Alves, Marcio José de Carvalho Lima, Frederico Castelo Branco Cavalcanti, Paulo Adriano Schwingel

“…Multivariable analysis among covariables predisposing chronic kidney disease epidemiology collaboration (CKD-EPI) equation <60 mL/min/1.73 m2 presented a statistical significance for age ≥60 years (P = 0.01) and reduction in serum haemoglobin (P = 0.03). …”
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