95-95-95 HIV indicators among children younger than 15 years in South Africa: results from the 2017 national HIV prevalence, incidence, behaviour, and communication survey by Rindidzani E. Magobo, Musawenkosi Mabaso, Sean Jooste, Lesiba Molopa, Inbarani Naidoo, Leickness Simbayi, Khangelani Zuma, Nompumelelo Zungu, Olive Shisana, Sizulu Moyo

“…Adjusted odds ratios (AOR) with 95% confidence intervals (CI) are shown, and p < 0.05 indicates statistical significance. Results A total of 12,237 CLHIV < 15 years were included (median 8 years, interquartile range 4–11 years). …”
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Maternal age-related declines in live birth rate following single euploid embryo transfer: a retrospective cohort study by Wei Jiang, Zichen Zheng, Nan Yan, Shuang Yao, Qijun Xie, Danyu Ni, Shanren Cao, Chun Zhao, Xiufeng Ling

“…Results Women aged ≥ 38 years demonstrated a significantly diminished live birth rate (41.7%) ,which was lower than that observed in women aged < 35 years (54.5%) and 35–37 years (54.0%), with statistical significance (P < 0.05). Multivariable regression analysis revealed that compared with women aged ≥ 38 years, younger women had reduced risk of miscarriage (aOR = 0.371, 95% CI: 0.139–0.988 for the < 35 years group; aOR = 0.317, 95% CI: 0.106–0.954 for the 35–37 years group) and increased likelihood of live birth (aOR = 2.188, 95% CI: 1.154–4.147 for the < 35 years group; aOR = 2.239, 95% CI: 1.0103–4.548 for the 35–37 years group) after adjusting for relevant confounders. …”
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Durable responders in advanced NSCLC with elevated TMB and treated with 1L immune checkpoint inhibitor: a real-world outcomes analysis by David P Carbone, David Spigel, Jeffrey S Ross, Karthikeyan Murugesan, Gerald Li, Richard S P Huang, Ryon P Graf, Geoffrey R Oxnard, Alexa Schrock, Liangliang Zhang, Khaled Tolba, Jacob Sands

“…In the low PD-L1 (TS &lt;50%) cohort, TMB &lt;20 muts/Mb showed a more favorable rwPFS (HR: 0.56 (95% CI: 0.40 to 0.79)) and rwOS (HR 0.74 (95% CI: 0.58 to 0.96)) on chemoICPI when compared with ICPI alone while the point estimate in rwPFS favored monoICPI in the TMB ≥20 muts/Mb cohort, the CI is wide and does not reach statistical significance (HR: 1.68 (95% CI: 0.52 to 5.48)).Conclusion This study provides evidence that higher TMB cut-offs, such as 20 muts/Mb, can identify patients with prolonged benefit from ICPI. …”
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Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers by Yuki Ishikawa, Tatsuki Sugio, Kiko Shiga, Keisuke Izumi, Kazumichi Minato, Momoko Kitazawa, Sayaka Hanashiro, Ryo Takemura, Hiroyuki Uchida, Taishiro Kishimoto

“…Results: Participants with PHQ-9 scores ≥5 showed higher median skin conductance and median tonic signal, although these differences lost statistical significance after Bonferroni correction. Logistic regression analysis revealed a negative correlation between age and both PHQ-9 and PSS-10 scores (OR=0.525, 0.646). …”
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Effects of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Feng Sun, Sanbao Chai, Lishi Li, Kai Yu, Zhirong Yang, Shanshan Wu, Yuan Zhang, Linong Ji, Siyan Zhan

“…Reductions of weight treated with liraglutide—1.8 mg once daily (LIR1.8QD) reach statistical significance (−1.43 kg (95% CI: −2.73, −0.15)) versus LIR1.2QD and (−0.98 kg (95% CI: −1.94, −0.02)) versus placebo. …”
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Delayed completion of pneumococcal conjugate vaccination among children 4–48 months in rural Uganda: a socio-demographic inquiry by Herbert Malemo, Andrew Tamale, Paul Kakwangire, Matthew C. Igwe, Dickens R. Mwine, Isa Asiimwe, Solomon A. Mbina, Mary G. Abalinda

“…Only boy child [cOR = 1.65, (95%CI: 1.03–2.66); P = 0.039) and caretaker’s age 30–39 [cOR = 2.12 (95%CI: 1.06–4.24); P = 0.033) showed statistical significance at bivariate analysis. The multivariate model found parent’s age 20–29 years [aOR = 2.39 (1.14–5.01); P = 0.021] and 30–39 years [aOR = 2.51 (1.16–5.45); P = 0.020] as positively associated factors whereas being married [aOR = 0.20 (0.04–0.96); P = 0.044] was the only negatively associated factors to delayed completion of PCV vaccination among young children. …”
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The Potential Role of sPD-L1 as a Predictive Biomarker in EGFR-Positive Non-Small-Cell Lung Cancer by Vesna Ćeriman Krstić, Dragana Jovanović, Natalija Samardžić, Milija Gajić, Jelena Kotur Stevuljević, Aleksandra Klisic, Ivan Soldatović, Damir Radončić, Marina Roksandić Milenković, Biljana Šeha, Nikola Čolić, Katarina Lukić, Milan Savić

“…There was no statistically significant difference in PFS between the groups (<i>p</i> = 0.100). …”
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Determining the association of hyperoxia while on extracorporeal life support with mortality in neonates following Norwood operation by Beshish Asaad G., Aljiffry Alaa, Xiang Yijin, Evans Sean, Scheel Amy, Harriott Ashley, Patel Shayli, Amedi Alan, Harding Amanda, Davis Joel, Shashidharan Subhadra, Kwiatkowski David M.

“…Despite being higher in the hyperoxia group, this did not reach statistical significance. Conclusion: Neonates with hyperoxia (PaO2 > 182 Torr) during the first 48-hour of ECLS post-Norwood operation had 5 times higher odds of mortality in the unadjusted analysis, however, this was insignificant when adjusting for confounding variables. …”
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The Thermal Tolerance of Springtails in a Tropical Cave, with the Description of a New <i>Coecobrya</i> Species (Collembola: Entomobryidae) from Thailand by Nongnapat Manee, Louis Deharveng, Cyrille A. D’Haese, Areeruk Nilsai, Satoshi Shimano, Sopark Jantarit

“…An increase in temperature from the control temperature significantly accelerated the developmental rate from egg to juvenile instars to adult with a statistical significance (<i>p</i> < 0.01). This study is the first attempt that provide information on the impact of increasing temperature on the population dynamics, reproductive capacity and life history of a subterranean tropical Collembola.…”
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The Effects of Exercise on Inhibitory Function Interventions for Patients With Major Depressive Disorder (MDD): A Systematic Review and Meta‐Analysis by Zhihui Xu, Cong Liu, Peng Wang, Xing Wang, Yuzhang Li

“…Subgroup analysis showed that exercise had a statistically significant effect on inhibitory control in MDD patients, with an effect size (SMD = 0.563, p < 0.001). …”
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Correlations among fatigue, respiratory function, balance and core muscle morphology in multiple sclerosis: a comprehensive observational study by Marta De La Plaza San Frutos, Ismael Sanz-Esteban, Ismael Sanz-Esteban, Federico Salniccia, Federico Salniccia, Alberto Bermejo-Franco, Alberto Bermejo-Franco, Ameyalli García-Corona, María Cristina Palma-Baquedano, Marina Castel-Sánchez, Marina Castel-Sánchez, Cecilia Estrada-Barranco, Cecilia Estrada-Barranco

“…Correlations were analyzed using Spearman’s correlation, with a statistical significance level of p &lt; 0.05.ResultsSignificant correlations were found between respiratory function and balance scores. …”
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Early Markers of Liver Fibrosis in Children with Beta-thalassaemia Major: A Cross-sectional Study by Himani Aggarwal, Monica Verma, Shuchi Bhalla, Dinkar Yadav, Kapil Bhalla, Abhishek Soni

“…The AUROC for APRI was 0.937 (95% CI: 0.84-1), indicating very strong predictive capability and statistical significance (p<0.001). YKL-40 (pg/mL) emerged as the most effective parameter for negative predictive value, with an AUROC of 0.971 (95% CI: 0.924-1) in predicting fibrosis. …”
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Association between Chronic Pain and Diabetes/Prediabetes: A Population-Based Cross-Sectional Survey in Saudi Arabia by Khaled K. Aldossari, Mamdouh M. Shubair, Jamaan Al-Zahrani, Abdulrahman A. Alduraywish, Khalid AlAhmary, Salwa Bahkali, Sara M. Aloudah, Sami Almustanyir, Laila Al-Rizqi, Sally A. El-Zahaby, Paivi Toivola, Ashraf El-Metwally

“…A P value of less than 0.05 indicated statistical significance. Results. A total of 1003 subjects were included for final analysis. …”
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Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort study by Yidong Xie, Yidong Xie, Ruoti Peng, Li Xiao, Li Xiao, Shangwei Li, Shangwei Li, Xiaohong Li, Xiaohong Li

“…Additionally, the IVF/ICSI group exhibited higher levels of negative psychological factors as measured by the CES-D and PSS during T1 and T2, showing statistical significance in T1 (P = 0.008, P &lt; 0.001) and T2 (P = 0.038, P &lt; 0.001), except at T3 (P = 0.107, P = 0.253). …”
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Comparative Analysis of the Occurrence and Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Hemophilic Arthropathy and Osteoarthritis by Piotr Wojdasiewicz, Łukasz A. Poniatowski, Andrzej Kotela, Marta Skoda, Michał Pyzlak, Aleksandra Stangret, Ireneusz Kotela, Dariusz Szukiewicz

“…In our study, we have documented increased average concentration of CX3CL1 in the blood serum of the study group (7.16±0.53 ng/ml) compared to the control group (5.85±0.70 ng/ml) without statistically significant difference in synovial fluid concentration at the same time. …”
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Frequency and accuracy of intraoperative bone margin sampling for T4a cancers of the head and neck at the QEII Health Sciences Centre: a retrospective chart review by Anna-Claire Lamport, Colin A. MacKay, Martin J. Bullock, S. Mark Taylor, Jonathan R. Trites, Martin Corsten, Matthew H. Rigby

“…Median survival of patients with positive final bone margins was 0.58 years lower than those with negative final bone margins, although this difference did not reach statistical significance. This will provide baseline data for comparison of the standardized intraoperative bone margin sampling protocol implemented at the QEII Health Sciences Centre. …”
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Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…The data were analysed for statistical significance using Statistical Package for the Social Sciences (SPSS) software, version 23.0. …”
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Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in people living with HIV by Teresa Aldámiz-Echevarria, Chiara Fanciulli, Mónica Lopez, Leire Perez, Francisco Tejerina, David Sanchez, Blanca Lodeiros, Juan Carlos López, Juan Berenguer, Jose Maria Bellon, Maria Ferris, Mario Blazquez, Almudena Calvo, Mario Domene, Oswaldo Vegas, Carmen Rodriguez, Patricia Muñoz, Paloma Gijon, Pedro Montilla, Elena Bermudez, Maricela Valerio, Roberto Alonso, Belen Padilla, Critina Ventimilla, Cristina Diez

“…In multivariate analysis, that included all PLHIV seen for the first time in the ID Unit between 2019 and 2022, lack of healthcare coverage was the only independent predictor of lost to FU that reached statistical significance (HR 5.19, CI 2.76–9.47). Furthermore, time from HIV diagnosis to ART initiating was shortened from 14 to 6 days without affecting linkage to care. …”
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Factors associated with HIV testing among young women in Tanzania: Insights from the 2022 Tanzanian Demographic and Health Survey using Anderson’s Behavioral Model by Mesfin Abebe, Yordanos Sisay Asgedom, Amanuel Yosef Gebrekidan, Yohannes Addisu Wondimagegne, Habtamu Endashaw Hareru, Tsion Mulat Tebeje

“…In the multivariable analysis, we calculated adjusted odds ratios (AORs) along with their 95% confidence intervals (CIs) to assess the strength of associations between various predictors and HIV testing. Statistical significance was determined at a p-value of less than 0.05.ResultIn our study, the prevalence of HIV testing among young women was 60.18% (95% CI: 58.91 to 61.43%). …”
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Post-craniotomy intracranial pressure monitoring: a novel approach combining optic nerve sheath diameter ultrasonography and cervical-cerebral arterial ultrasound by Zunfeng Fu, Lin Peng, Laicai Guo, Naixia Hu, Yamin Zhu, Shouxin Tang, Hongliang Lou, Jiajun Zhang, Chongqiang Wang

“…The correlation coefficients for the relationships between ONSD, PI ratio, FVdMCA, and PI with ICPi were 0.62, 0.33, 0.32 and 0.21, respectively, each demonstrating statistical significance (p &lt; 0.05). Analysis of the ROC curves demonstrated that the area under the curve (AUC) for predicting elevated ICPi at thresholds of 15 mmHg, 20 mmHg, and 22 mmHg via combined ultrasonographic measurements of the PI ratio and ONSD was the largest, specifically 0.74 (95% CI: 0.65–0.82), 0.77 (95% CI: 0.69–0.85), and 0.79 (95% CI: 0.70–0.86), respectively.ConclusionUltrasonographic measurements of ONSD, PI-ratio, MCAPI and MCAFVd demonstrate a moderate to low weak correlation with ICPi measurements. …”
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