Associations between Children’s Exposure to PM2.5 and their Serum Inflammatory Responses in Taiwan by Wei-Jung Tseng, Jian-He Lu, How-Ran Chao, Ming-Hsien Tsai, Yu-Ting Chang, Liang-Jen Wang, Chih-Cheng Chen, Wan-Nurdiyana-Wan Mansor, Juliana Jalaludin, Chih-Lung Wang, Ying-I Tsai

“…Children’s serum TNF-α was significantly linked to PM2.5 exposure scenarios (p = 0.031) by the test of the multivariate analysis (adjusted R2 = 0.033, p = 0.039), but the other variables of age (p = 0.147) and gender (p = 0.291) were not statistically significant. In conclusion, serum TNF-α might be positively and significantly correlated with the longitudinal exposure of schoolchildren to PM2.5, especially among children living in TRAP-PM2.5 region.…”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…The levels of both biomarkers were higher in 28-day non-survivors than in survivors, in patients with sepsis (EphA2:898.09 vs. 475.88 pg/mL, p < 0.001; Del-1:46.09 vs. 32.68 pg/mL, p = 0.193); however, only EphA2 was statistically significant. The area under the curve for the EphA2 was 0.74 in the receiver operating characteristic curve analysis for predicting 28-day mortality, whereas APACHE II, SOFA, and Del-1 showed values of 0.762, 0.614, and 0.595, respectively. …”
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Nonthermal atmospheric pressure plasma (NTAPP) effectively eliminates skin tumors in a mouse model of UV-induced carcinogenesis with a short-term treatment regimen by Szabolcs Bozsányi, Ruby Acquah, Rhea Carmel Glen Rodrigues, Erin C. Tracy, Sean P. Murphy, Gregory Fridman, Wendy J. Huss, Peter C. Friedman, Gyorgy Paragh

“…External control tumors showed an increase in size, which was not statistically significant. Discussion: The results demonstrated that a one-week NTAPP protocol could effectively eliminate 74 % of mouse tumors induced by UV radiation. …”
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Russian Non-Interventional Study of the Efficacy and Tolerability of Rifaximin-α Therapy in Patients with Uncomplicated Diverticular Disease under the Conditions of Outpatient Prac... by O. S. Shifrin, E. A. Poluektova, A. V. Korolev, T. I. Semenova, M. V. Shein, G. N. Leksikova, O. A. Tokareva, O. E. Davydova, P. S. Andreev, S. E. Katorkin, A. A. Chernov, A. V. Zhuravlev, O. S. Sek, A. A. Kopina, N. Yu. Samokhina, Yu. V. Gorozhankina, M. F. Samigullin, V. S. Groshilin, E. N. Borisova, T. A. Petrova, I. Yu. Pirogova, S. V. Mednikov, N. V. Smagin, A. S. Sarsenbaeva, N. V. Smirnova, L. G. Kirsanova, N. M. Malyutina, M. A. Smirnova, E. N. Shleikova, V. T. Ivashkin

“…The total score of symptom intensity decreased from 5.6 at the inclusion visit, to 2.2 points at the second visit and to 0.9 points at the end of the observation. A statistically significant (p <0.05) positive dynamics was observed in relation to all evaluated symptoms (abdominal pain, constipation, diarrhea, flatulence, tenesmus). …”
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Systematic bias between blinded independent central review and local assessment: literature review and analyses of 76 phase III randomised controlled trials in 45 688 patients with... by Jianrong Zhang, Yu Huang, Hengrui Liang, Wenhua Liang, Jianxing He, Yiyin Zhang, Jiaxi He, Jieyu Wu, Long Jiang, Shiyan Tang, Qihua He, Lindsey Tristine Hamblin, Zhiheng Xu, Yaoqi Chen, Difei Chen, Xinyu Wang, Kexin Deng, Shuhan Jiang, Jiaqing Zhou, Jiaxuan Xu, Xuanzuo Chen

“…Additionally, the articles should report objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS) or time to progression (TTP); the treatment effect of these endpoints, OR or HR, should be based on central and local assessments.Results Of 76 included trials involving 45 688 patients, 17 (22%) trials reported their endpoints with statistically inconsistent inferences (p value lower/higher than the probability of type I error) between central and local assessments; among them, 9 (53%) trials had statistically significant inference based on central assessment. …”
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Derivation and validation of a clinical predictive model for longer duration diarrhea among pediatric patients in Kenya using machine learning algorithms by Billy Ogwel, Vincent H. Mzazi, Alex O. Awuor, Caleb Okonji, Raphael O. Anyango, Caren Oreso, John B. Ochieng, Stephen Munga, Dilruba Nasrin, Kirkby D. Tickell, Patricia B. Pavlinac, Karen L. Kotloff, Richard Omore

“…While the random forest model showed slight deviations from perfect calibration, these deviations were not statistically significant (Brier score = 0.17, Spiegelhalter p-value = 0.219). …”
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Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy by Lavinia Gabara, Jonathan Hinton, Mohamed Kira, James Shambrook, Ausami Abbas, Sam Wilding, Jonathon A. Leipsic, Pamela S. Douglas, Nick Curzen

“…In multivariable Cox analysis the presence of significant coronary artery disease (hazard ratio [HR], 2.91; 95% CI, 1.30–6.51) and having a positive fractional flow reserve derived from computed tomography (HR, 4.11; 95% CI, 1.15–14.69) were independent predictors of major adverse cardiovascular events at 9 months, whereas sex was not statistically significant (p=0.13). Conclusions There are significant sex differences in the anatomico‐functional assessment of coronary artery disease leading to differences in clinical management, costs, and adverse events.…”
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The Influence of Cell Source and Donor Age on the Tenogenic Potential and Chemokine Secretion of Human Mesenchymal Stromal Cells by Weronika Zarychta-Wiśniewska, Anna Burdzińska, Katarzyna Zielniok, Marta Koblowska, Kamila Gala, Piotr Pędzisz, Roksana Iwanicka- Nowicka, Anna Fogtman, Aleksandra Aksamit, Agnieszka Kulesza, Aleksandra Zołocińska, Leszek Pączek

“…In regard to CXCL6, MOHAWK, and RUNX2 gene expression, no statistically significant differences between groups were observed. …”
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Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes by Hailing Zhao, Haojun Zhang, Yan Wang, Tingting Zhao, Meihua Yan, Xi Dong, Qian Wang, Jialin Li, Liang Ma, Ping Li

“…The combined effect of PNPLA2 rs28633403 AA+rs1138714 AG or GG genotype showed an association with DKD, adjusted by confounders (aOR, 2.194; 95% CI 1.378-3.492; P=0.001), which was considered statistically significant with a markedly increased risk of DKD after a Holm-Bonferroni correction for multiple tests (P<0.00125). …”
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Spatio-temporal dynamics of speleothem growth and glaciation in the British Isles by S. Panitz, S. Panitz, M. Rogerson, J. Longman, N. Scroxton, T. J. Lawson, T. C. Atkinson, V. Ersek, J. Baldini, L. Baldini, S. Umbo, M. A. Lone, G. M. Henderson, S. F. M. Breitenbach

“…The frequency distribution of 1020 U series dates based on three different dating methods between 300 and 5 ka shows statistically significant periods of speleothem growth during the last interglacial and several interstadials during the last glacial. …”
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Use High-Flow Nasal Cannula for Acute Respiratory Failure Patients in the Emergency Department: A Meta-Analysis Study by Cheng-Chieh Huang, Hao-Min Lan, Chao-Jui Li, Tsung-Han Lee, Wen-Liang Chen, Wei-Yuan Lei, Pei-You Hsieh, Mei-Chueh Yang, Chu-Chung Chou, Han-Ping Wu, Yuan-Jhen Syue

“…There was a decreasing trend regarding the application of HFNC therapy and the intubation rate, but the difference was not statistically significant (RR, 0.53; 95% CI, 0.26–1.09; p=0.08; I2 = 0%). …”
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Long-term Impact of Carotid Endarterectomy on Choroidal and Choriocapillaris Perfusion: The INFLATE Study by Alessandro Berni, MD, Yi Zhang, PhD, Sandy Zhou Wenting, MD, Natalie Noam, MD, David Rabinovitch, BSc, Basheer Sheick Yousif, MD, Gissel Herrera, MD, Mengxi Shen, MD, PhD, Robert O’Brien, PhD, Giovanni Gregori, PhD, Ruikang K. Wang, PhD, Philip J. Rosenfeld, MD, PhD, Omer Trivizki, MD

“…While CVV demonstrated a short-term rise immediately post-CEA (P < 0.001), the difference was not statistically significant at the long-term evaluation (P = 0.06). …”
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Effectiveness and Safety of Preoperative Halo Gravity Traction-Assisted Posterior Spinal Fusion Surgery for Severe and Rigid Scoliosis: A Comparative Matched-Cohort Study by Yangpu Zhang, Bo Han, Jianqiang Wang, Yuzeng Liu, Yiqi Zhang, Yong Hai, Lijin Zhou

“…There were no statistically significant differences in preoperative parameters of sagittal vertical axis (SVA) (P=0.13) or thoracic kyphosis (TK) (P=0.07) between the two groups. …”
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Quality of Life and Related Factors in Discharged Patients with COVID-19 by Jinzhuo HU, Wenhuan WU, Jinwen SUN, Wei ZHANG, Shu CHENG, Zicheng GAO, Jinghua QIAN

“…The correlation between the quality of life of patients and anxiety, depression and dyspnea and the related factors were analyzed.Results:A total of 57 questionnaires were distributed, and three duplicate and invalid questionnaires were eliminated, 54 valid questionnaires were obtained, with an effective questionnaire of 94.74%.①Quality of life of discharged patients with COVID-19: the physical component summary (PCS) scores and mental component summary (MCS) scores were (37.02±12.32) and (38.46±14.42) respectively; there were 3 cases (5.56%), 45 cases (83.33%), 5 cases (9.26%), and 1 case (1.85%) with dyspnea grade 0 to 3 respectively; 19 cases (35.19%) had an anxiety state (SAS≥50), and 19 cases (35.19%) had an anxiety state (SDS≥53). ②Comparison of quality of life of COVID-19 patients with different characteristics: patients with different disease types showed statistically significant differences in the SF-12V2 PCS(<italic>P</italic>&lt; 0.05). ③Correlation analysis between quality of life, anxiety, depression and dyspnea: Pearson's correlation indicated that, anxiety (<italic>r</italic>=-0.34, <italic>P</italic>=0.011) and dyspnea (<italic>r</italic>=-0.39, <italic>P</italic>=0.003) were negatively correlated with the PCS scores, anxiety (<italic>r</italic>=-0.46, <italic>P</italic>=0.001) and depression (<italic>r</italic>=-0.40, <italic>P</italic>=0.002) were negatively correlated with the MCS scores.④Analysis of influencing factors on the quality of life of COVID-19 patients: multiple linear regression indicated that, sex (β=8.27), depression (β=-0.34) and severity of illness (β=-11.68) were significant predictors of the SF-12V2 PCS scores (<italic>P</italic>&lt; 0.05). …”
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Differential impact of TyG and TyG-BMI indices on short- and long-term mortality in critically ill ischemic stroke patients by Yufan Pu, Na Xing, Ying Wang, Huihuang Wang, Jiang Xu, Xuejing Li

“…The RCS analysis results demonstrated that the TyG index did not exhibit a statistically significant nonlinear relationship with mortality across all time points. …”
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Protective effects and possible mechanisms of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles against kidney fibrosis in animal models: a systematic... by Yuanchen Lv, Zibo Hua, Xiaomei Lu

“…P &lt; 0.05 is deemed to indicate a statistically significant difference. Alpha-smooth muscle actin (α-SMA) is a specific protein that is normally expressed in myofibroblasts. …”
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Application of refined nursing model based on Watson’s theory of human caring for patients undergoing electronic bronchoscopy (基于Watson人性照护理论的精细化护理模式在电子支气管镜检查中的应用)... by LI Lin (李琳), LIU Yinshuang (刘银双), FENG Wenying (冯文英), ZHAO Jing (赵静)

“…Results After implementing the refined nursing model based on Watson’s theory of human caring, the humanistic care ability of nurses was improved, and the difference was statistically significant (P<0. 01). The scores of SAS and SDS and the time of microscopic examination in the observation group were significantly lower than those in the control group (P<0. 01), and the satisfaction of patients in the observation group was significantly higher than that in the control group (P<0. 01). …”
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Clinical significance of determining individual intraocular pressure in patients with primary open-angle glaucoma in ophthalmological practice by S.V. Balalin, V.P. Fokin, O.V. Yuferov, S.Z. Boskhomdzhieva

“…<br> <b>Results</b>: the mean value of true IOP against the background of the initial drug therapy was 19.5±0.3 mm Hg, and the mean value of the tolerant pressure was 16.3±0.05 mm Hg, the difference between them was statistically significant (t=10.7; p=0.001). The mean value of the intolerance index was 3.1±0.27 mm Hg. …”
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Time-series analysis on relationship between short-term exposure to atmospheric ozone and the risk of non-accidental deaths in Hefei during 2017−2020 by Linling YU, Yu ZHU, Changchun XIAO

“…After adjusting the degrees of freedom of time trend and other atmospheric pollutants, there was no statistically significant change in the risk of NAD death among residents associated with O3-8h concentration.ConclusionThe increase O3 concentration in Hefei is correlated with an increased NAD risk among residents, with males and people over 65 years old having a higher risk of death due to O3 exposure. …”
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Immunohistochemical Expression of p53 Gene and Clinicopathological Assessment of Low-grade Serous Ovarian Cancer and High-grade Serous Ovarian Cancer: A Cohort Study by Geeta Bazard, Minakshi Vashist, Sunita Singh, Gulshan Rohilla, Nidhi Paliwal

“…Among all serous carcinoma cases, 17 cases (45.95%) showed null p53 expression, 16 cases (43.24%) showed diffuse p53 expression, and four cases (10.81%) had focal positive expression (wild type). Statistically significant differences (p-value=0.02) between the grade of serous ovarian cancer and the expression of p53 were observed. …”
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