Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…Similarly, the ODI score also decreased from 61.21 ± 11.06 preoperatively to 27.52 ± 10.41 immediately after surgery, 19.12 ± 7.05 at 1 month postoperatively, 12.17 ± 5.21 at 6 months postoperatively, and 8.56 ± 4.32 at 12 months postoperatively. Statistically significant differences were observed in both VAS and ODI scores at each follow-up time point when compared with preoperative parameters (P < 0.01). …”
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The Effect of Coronary Artery Disease on the Prognosis of Hypertrophic Cardiomyopathy: A Multi-Center Cohort Study by Guoqing Hou, Qian Liao, Huihui Ma, Yan Shu, Shengzhi Zeng, Yongmei Zhou, Liangjun Luo, Gang Zhao, Tao He, Mingjiang Liu, Jianhong Tao, Wei Hua, Xiaoping Li

“…Conclusions: In this study, it was observed that there was no statistically significant disparity in mortality rates between patients diagnosed with HCM who concurrently had CAD and those who did not exhibit CAD. …”
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The Chinese version of the immediate mood scaler (IMS): a study evaluating its validity, reliability, and responsiveness in patients with MDD in China by Xiongying Chen, Zizhao Feng, Nanxi Li, Le Xiao, Xu Chen, Xuequan Zhu

“…In patients with MDD who showed changes in mood, the changes in total scores of the IMS from baseline to the retest were statistically significant with a mean difference of 13.3 (SD: 20.1), an ES of 0.66, and an SRM of 0.3, showing good responsiveness. …”
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Reflecting on the impact of the COVID pandemic on patient management and its subsequent influence on long-term outcomes: a case–control study in the field of esophago-gastric cance... by Mohamed Alasmar, Nadia Matias, Norah Ali M. Alhamed, Omneya Alwani, Brogan Rudge, Terngu David Moti, Muhammad Ossama Yassin Abdelwahab, Jennifer Stockton, Charef Raslan, Jess Cairney-Hill, Mohammad Altarawni, Bilal Alkhaffaf, on behalf Greater Manchester Oesophago-Gastric Service

“…A further significant observation was the emergence of more aggressive tumour characteristics, particularly in the P2 group, albeit without a statistically significant difference in two-year overall survival rates among the groups (p-value 0.31). …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…While there was not a statistically significance difference in reproducibility between the OCT models, image quality analysis revealed superior SNR and CNR values for the New OCT in the left eye only, with significant improvements noted (CNR: p = 0.0040 at Visit 2; SNR: p = 0.0383 at Visit 1). …”
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Active Retrograde Extra Backup with a Mother-and-Child Catheter to Facilitate Retrograde Microcatheter Collateral Channel Tracking in Recanalization of Coronary Chronic Total Occlu... by Yong Wang, Xiao-Jiao Zhang, Hong-Wei Zhao, Cheng-Fu Wang, De-Feng Luo, Qing-Kun Meng, Yu Zhu, Jie Tao, Bao-Jun Chen, Yi Li, Ai-Jie Hou, Bo Luan

“…There was no statistically significant difference in major adverse cardiac and cerebrovascular events between the groups during hospitalization p>0.05. …”
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High-throughput untargeted metabolomics reveals metabolites and metabolic pathways that differentiate two divergent pig breeds by S. Bovo, M. Bolner, G. Schiavo, G. Galimberti, F. Bertolini, S. Dall’Olio, A. Ribani, P. Zambonelli, M. Gallo, L. Fontanesi

“…The molecular data were analysed using a bioinformatics pipeline specifically designed for identifying differentially abundant metabolites between the two breeds in a robust and statistically significant manner, including the Boruta algorithm, which is a Random Forest wrapper, and sparse Partial Least Squares Discriminant Analysis (sPLS-DA) for feature selection. …”
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Economic evaluation of a strategy to shorten the time to surgery with neuraxial anaesthesia compared with usual clinical practice in patients on chronic antiplatelet therapy with a... by Claudia Erika Delgado-Espinoza, Rosa Maria Antonijoan, Ignasi Gich, Ignasi Gich, Rafael Anaya, Mireia Rodriguez, Angélica Millan, Jordi Llorca, Gemma Usua, Ana Ruiz, Angela Merchán-Galvis, Angela Merchán-Galvis, Maria Jose Martinez-Zapata, Maria Jose Martinez-Zapata

“…The incremental cost was negative (€1,997.60), a statistically significant difference (P < 0.05). As measured by the reduction in time (days) to surgery, the incremental cost-effectiveness ratio (ICER) for early surgery was negative (777.28€/day). …”
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The impact of pre-transplant ventricular assist device support in pediatric patients with end-stage heart failure on the outcomes of heart transplantation—“a single center experien... by L. Lily Rosenthal, L. Lily Rosenthal, L. Lily Rosenthal, Carola Grinninger, Sarah Marie Ulrich, Robert Dalla Pozza, Nikolaus A. Haas, Paolo Brenner, Michael Schmoeckel, Sebastian Michel, Sebastian Michel, Sebastian Michel, Christian Hagl, Christian Hagl, Jürgen Hörer, Jürgen Hörer, Jürgen Hörer

“…The results demonstrated a statistically significant correlation between prolonged waiting times and length of hospital stay in group 1. …”
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Accuracy of Rhythm Diagnostic Systems’ MultiSense^® in Detection of Arterial Oxygen Saturation and Respiratory Rate During Hypoxia in Humans: Effects of Skin Color and De... by Charles Evrard, Amina El Attaoui, Cristina Pistea, Irina Enache, Mark Marriott, Louis Mayaud, Anne Charloux, Bernard Geny

“…The average root mean square error (ARMS) of SpO₂ for Multisense^® placed on the back and chest was 2.94% and 2.98%, respectively, with permutation testing confirming a significant ARMS below 3.5% for both positions and no statistically significant difference in the ARMS between patch placements. …”
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Alternative psychopharmacologic treatments for pediatric catatonia: a retrospective analysis by Joshua R. Smith, Joshua R. Smith, Isaac Baldwin, Tasia York, Carina Anderson, Trey McGonigle, Simon Vandekar, Lee Wachtel, James Luccarelli, James Luccarelli

“…All patients were stabilized on either clonazepam or diazepam, with 21 (68%) requiring treatment with an additional medication of either an anti-epileptic, N-methyl-D-aspartate (NMDA) receptor antagonist, and aripiprazole or clozapine. Statistically significant reductions in the BFCRS [t = 11.2, df = 30, std = 6.3, p < 0.001, 95% CI = (7.8, 15.1)], KCS [t = 4.6, df = 38, p < 0.001, 95% CI = (12.0, 31.0)], and KCE [t = 7.8, df = 30, std = 1.8, p < 0.001, 95% CI = (1.9, 3.2)] were observed. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…The primary endpoint was a statistically significant demonstration of a clinically relevant mean improvement in the Oswestry Disability Index (ODI) between restorative neurostimulation and OMM arms: ODI (−19.7 ± 1.4 vs. −2.9 ± 1.4; p < 0.001). …”
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Synthesis of novel titania nanoparticles using corn silky hair fibres and their role in developing a smart restorative material in dentistry by Afsheen Mansoor, Emaan Mansoor, Ezza Mansoor, Efrah Mansoor, Atta Ullah Shah, Uzma Asjid, João Filipe Brochado Martins, Sami Ullah Khan, Paulo J. Palma

“…Adding 5 % of these smart titania nanoparticles to GIC resulted in a substantial increase in its shear bond strength to enamel, which rose to 4.93 + 0.74 MPa, with a standard error of 0.23, and this change was statistically significant at p < 0.05. The material's sustainable surface characteristics were confirmed by the presence of increased Fluorine (6.46 %) and Titanium (0.79 %) alongside a decrease in the amounts of Aluminium (23.51 %), Silicon (20.01 %), Phosphorus (0.33 %), and Sulphur (0.09 %), as indicated by spectral mapping. …”
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Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment by Sabrina Pistorio, Gianluca Scotto di Tella, Vittoria Canzanella, Raffaella Merenda, Gianluigi Cuomo, Paola Iacotucci, Vincenzo Carnovale, Leonardo Bencivenga, Maria Vargas, Annalaura Manes, Mauro Cataldi, Giuseppe Rengo, Giuseppe Rengo, Michela Zanetti, Grazia Daniela Femminella, Grazia Daniela Femminella

“…A multiple linear regression was performed to identify factors associated with higher NPI score and a logistic regression model was built to identify drug classes associated with ACB ≥ 3.ResultA total of 173 patients (mean age 74 ± 7, 74 men) were included in the study; 132 patients with ACB &lt; 3 (low risk) versus 41 patients with ACB ≥3 (high risk) were compared. No statistically significant differences were found between the two groups in terms of demographics (age, sex) and anamnestic variables (education, marital status, family history of dementia, hypertension, diabetes, smoking, dyslipidemia, atrial fibrillation, coronary heart disease and use of alcohol). …”
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The Performance of Equations That Estimate Glomerular Filtration Rate against Measured Urinary Creatinine Clearance in Critically Ill Patients by Hasan M. Al-Dorzi, Abdulmajeed A. Alsadhan, Ayman S. Almozaini, Ali M Alamri, Hani Tamim, Musharraf Sadat, Lolowa Al-Swaidan, Elwaleed Elhassan, Yaseen M. Arabi

“…The correlations between the different equations and CrCl24h-urine were modest (r: 0.62 to 0.79; p<0.0001). Bias was statistically significant for CGactual-wt (21 ml/min), CGadjusted-wt (12 ml/min), and MDRD-6 (-10 ml/min) equations. …”
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Comparison of the Insertion Conditions and Haemodynamic Changes during I-Gel Insertion using Propofol, Ketamine-Propofol (Ketofol) and Thiopentone Intravenous Induction Agents: An... by Pooja Arpapan Shah, Aashi Nilesh Surti, Anupapama Kumari, Dinesh K Chauhan, Sara Mary Thomas

“…A p-value of ≤0.05 was considered statistically significant. Results: The mean age of Group-1, Group-2 and Group-3 was 34.67±5.97 years, 33.25±8.70 years and 36±8.48 years, respectively. …”
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Chinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial by Nicola Robinson, Mei Han, Ling Yan, Vincent Chi Ho Chung, Jian-Ping Liu, Hui-Juan Cao, Shi-Bing Liang, Hong-Jie Cheng, Qiao-Yan Zhang, Yu-Fei Li, Ze-Yu Yu, Ling-Yao Kong, Yan-Mei Cai, Li-Bao An, Bao-Tuan Zhao, Shan-Shan Xu, Nai-Wei Zhang, Bo-Yi Jia, Wei-Fang Liu, Fang Niu, Ba-Teer Wu, Jin-Ming Song, Shu-Xin Jia, Meng-Meng Shi, Xiao-Na Zhang

“…There were no statistically significant differences between the two groups on secondary outcomes, although both groups showed substantial improvements. …”
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Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner by Nils F. Trautwein, Eduardo Calderón, Pia M. Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S. Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P. Schmidt, Lena S. Kiefer

“…Conclusion Reducing the administered activity of injected [18F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. …”
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Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults: A systematic review and meta-analysi... by Ben Singh, Cristina Cadenas-Sanchez, Bruno G.G. da Costa, José Castro-Piñero, Jean-Philippe Chaput, Magdalena Cuenca-García, Carol Maher, Nuria Marín-Jiménez, Ryan McGrath, Pablo Molina-García, Jonathan Myers, Bethany Gower, Francisco B. Ortega, Justin J. Lang, Grant R. Tomkinson

“…For both all-cause and CVD mortality, there were no statistically significant differences in RR per higher MET between objectively measured (RR range: 0.86–0.90) and maximal exercise-estimated (RR range: 0.85–0.86), submaximal exercise-estimated (RR range: 0.91–0.94), and non-exercise-estimated CRF (RR range: 0.81–0.85). …”
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Effectiveness of different solvent-modulated Traditional Chinese Medicine applied to Shenque(RN8) in the treatment of constipation (不同溶剂调制药物贴敷神阙穴治疗便秘的效果观察)... by ZHANG Li (张莉), SHEN Juan (沈娟), PAN Lei (潘磊), ZHANG Yuanyuan (张园园), LI Yuye (李玉叶), DI Yanhui (邸延辉), ZHOU Xiaoyan (周晓艳)

“…Results The total effective rate of treatment group and control group was 96. 67% and 73. 33% respectively and there was statistically significant difference between the two groups (P＜0. 05). …”
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