How Antiretroviral Drug Concentrations Could Be Affected by Oxidative Stress, Physical Capacities and Genetics: A Focus on Dolutegravir Treated Male PLWH by Jessica Cusato, Anna Mulasso, Micol Ferrara, Alessandra Manca, Guido Accardo, Alice Palermiti, Miriam Antonucci, Gianluca Bianco, Francesco Chiara, Jacopo Mula, Maria Cristina Tettoni, Simone Cuomo, Giulia Trevisan, Stefano Bonora, Giovanni Di Perri, Corrado Lupo, Alberto Rainoldi, Antonio D’Avolio

“…No statistical differences were suggested for drug concentrations, with the exception of intracellular DTG (<i>p</i> = 0.047). Statistically significant correlations between DTG plasma concentrations and white blood cells (<i>p</i> = 0.011; S = 0.480) and cytoplasmic N-acetyl-cysteine (<i>p</i> = 0.033; S = −0.419) were observed. …”
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Enhancing accuracy and efficiency in upper extremity disability assessments: development and testing of a desktop application by Emre Ozmen, Gamze Gül Güleç, Hazal İzol Özmen, Melih Civan, Esra Circi, Serdar Yuksel, Alican Baris

“…The average rating di"erence between the 2 methods was minor (0.40 points, 0.92% di"erence) and not statistically significant (P=.931). The app-assisted method showed e#ciency in disability assessment with comparable accuracy to the manual methods. …”
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Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples by Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Vladimir Lyadov, Vladimir Lyadov, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin

“…We detected no statistically significant difference in the number of chimeric transcripts in FFPE and FF RNAseq profiles. …”
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Microperimetric Biofeedback Training Improved Visual Acuity after Successful Macular Hole Surgery by Tomoko Ueda-Consolvo, Mitsuya Otsuka, Yumiko Hayashi, Masaaki Ishida, Atsushi Hayashi

“…Reading speed improved in all patients (p=0.29), fixation stability improved in 5 patients (p=0.70), and 63% BCEA improved in 7 patients (p=0.21), although these improvements were not statistically significant. Conclusion. MAIA biofeedback training improved visual acuity in patients with insufficient recovery of BCVA after successful MH surgery.…”
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Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study by DengZhuo Chen, YongLi Ma, JingHui Li, Liang Wen, GuoSheng Zhang, ChengZhi Huang, XueQing Yao

“…Random-effects IVW analysis showed an association between insulin use and increased risk of colorectal cancer (OR = 1.1037, 95%CI = 1.0183–1.1962, P = 0.016). No statistically significant association was found between insulin use and the development of other digestive system tumours. …”
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The role of intrapartum ultrasound combined with free position delivery in the management of abnormal fetal positions during labor by Shanshan Sun, Wenwen Liang, Fen Sun, Meili Yu, Liting Wu, Ting Xu, Cui Zhang, Wenfang Zhuang, Jia Li

“…Additionally, the experimental group experienced lower rates of postpartum hemorrhage and shorter hospital stays, with statistically significant differences observed. Conclusion Combining intrapartum ultrasound with free maternal positions shows promise in improving delivery outcomes for women with abnormal fetal positions during labor. …”
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Are socio-economic inequalities related to cardiovascular disease risk? A systematic review and meta-analysis of prospective studies by Ololade J. Baruwa, Federica Alberti, Sunday Onagbiye, Annalisa Guddemi, Anna Odone, Hannah Ricci, Maddalena Gaeta, Schmid Daniela, Cristian Ricci

“…Conclusion Although not statistically significant, women of low SES were at higher CVD risk than men. …”
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Factors Associated with the Clinical Course of Vitreomacular Traction by Petros Petrou, Evangelia Chalkiadaki, Marie-Helene Errera, Sidath Liyanage, Louisa Wickham, Evangelia Papakonstantinou, Aristotelis Karamaounas, Menelaos Kanakis, Ilias Georgalas, Stylianos Kandarakis, David Charteris

“…Of the other variables that were studied, no statistical significant predictors were identified. Conclusions. …”
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Correlation of Gleason Scores with Diffusion-Weighted Imaging Findings of Prostate Cancer by Rajakumar Nagarajan, Daniel Margolis, Steven Raman, Ke Sheng, Christopher King, Robert Reiter, M. Albert Thomas

“…The ADC values were statistically significant (𝑃<0.05) between the three different scores with a trend of decreasing ADC values with increasing Gleason scores by one-way ANOVA method. …”
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Biofunctional Characterization of Collagen from Orange-Spotted Grouper, <i>Epinephelus coioides</i>: Maintenance of Cartilage in Aged Zebrafish by Shao-Yang Hu, Chen-Han Tsou, Chung-Chih Tseng, Tai-Wei Han, Chun-Hung Liu

“…Although the differences in swimming performance among the groups were not statistically significant, zebrafish that received PHC or the combined supplements demonstrated enhanced endurance compared to the control group. …”
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Transpalpebral Electrical Stimulation as a Novel Therapeutic Approach to Decrease Intraocular Pressure for Open-Angle Glaucoma: A Pilot Study by Félix Gil-Carrasco, Daniel Ochoa-Contreras, Marco A. Torres, Jorge Santiago-Amaya, Fidel W. Pérez-Tovar, Roberto Gonzalez-Salinas, Luis Nino-de-Rivera

“…The hypotensive response obtained using transpalpebral electrical stimulation on POAG patients, both on treatment-naïve patients and on patients receiving maximum tolerable treatment, was statistically significant when comparing basal IOP measurements to those obtained at the four-month follow-up visit.…”
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Tumor volume changes after stereotactic, hypofractionated and conventional radiotherapy in paragangliomas of head and neck by Paweł J. Polanowski, Agnieszka R. Kotecka‐Blicharz, Andrzej Tukiendorf, Natalia J. Amrogowicz, Aleksandra M. Nasiek, Agnieszka Pietruszka, Katarzyna M. Polanowska, Krzysztof A. Składowski

“…The analysis demonstrates a statistically significant (p < 0.05) treatment advantage in patients after the lowest fractional and highest total doses. …”
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Prognostic impact of chronic obstructive pulmonary disease on short-term and long-term outcomes following coronary artery bypass grafting by Mohammad Sadeq Najafi, Arash Jalali, Zahra Karimi, Mohadese Dashtkoohi, Kimia Moradi, Mojgan Ghavami, Saeed Davoodi, Seyed Hossein Ahmadi Tafti, Rasoul Aliannejad

“…After multiple imputations, the mortality and MACCE hazard ratio in IPW analysis remained statistically significant. COPD significantly increases long-term mortality and MACCE following CABG, independent of smoking status.…”
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Prognostic Factors Predicting Remission Following Rituximab Therapy for Pemphigus Vulgaris by Tal Raviv, Keren Pevzner, Aviv Barzilai, Felix Pavlotsky, Sharon Baum

“…Notably, sex, age at symptom onset and rituximab therapy, ethnicity, comorbidities, skin involvement, weight, rituximab dosing protocol, and other variables were not statistically significant between the complete remission and partial remission groups. …”
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The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout by Caiyu Zheng, Caiyu Zheng, Qingwen Tong, Qingwen Tong, Zhijun Zhang, Chunmei Lin, Zhiyi Wang, Dongshu Kang, Yanmei Lin, Jianqing Tian

“…Similarly, there were no statistically significant differences in blood lipid levels, CRP, CA724, eGFR, and ALT among the three groups post-treatment. …”
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A comparative analysis of toxicity and treatment outcomes of adaptive radiotherapy and intensity-modulated radiotherapy in cervical cancer by Xiaohan Liu, Wei Tian, Anli Dai, Hui Li, Mei Zhu, Mengsi Zeng, Ronghua Feng, Zhenyu Zhang, Xiaosong Jiang, Yu Wen, Tao Wu, Zemin Xiao

“…However, the difference between the two groups was not statistically significant. In summary, ART may be advantageous in reducing the incidence of chronic constipation among patients with locally advanced cervical cancer, and both clinical prognosis and near-term survival are satisfactory.…”
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Prevalence and determinants of ideal cardiovascular health by sex and region—a population-based study in Peru by Víctor Juan Vera-Ponce, Víctor Juan Vera-Ponce, Fiorella E. Zuzunaga-Montoya, Fiorella E. Zuzunaga-Montoya, Luisa Erika Milagros Vásquez-Romero, Joan A. Loayza-Castro, Eder Jesús Orihuela Manrique, Mario J. Valladares-Garrido, Mario J. Valladares-Garrido, Mario J. Valladares-Garrido, Carmen Inés Gutierrez De Carrillo, Carmen Inés Gutierrez De Carrillo

“…The prevalence is trending lower in correlation with rising age and educational attainment levels and for those inhabitants residing at higher elevations. Likewise, statistically significant variations were observable concerning the prevalence of ICVH contingent on the region of residence and marital status, in particular amongst the feminine inhabitants.ConclusionsThese results demonstrate that the frequency of ICVH in the grown-up inhabitants of Peru is comparatively tiny. …”
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Biosynthesis of reduced graphene oxide using Turbinaria ornata and its cytotoxic effect on MCF‐7 cells by K. M. Smita, L. Stanley Abraham, V. Ganesh Kumar, Raguraman Vasantharaja, R. Thirugnanasambandam, Ajit Antony, K. Govindaraju, T. Senthil Velan

“…In addition, there was a statistically significant difference in cell viability between MCF‐10A and MCF‐7 cells in the treatment of TrGO. …”
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The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population by Guoda Ma, Haiyang Wang, Guixi Mo, Lili Cui, You Li, Yiming Shao, Xin Liu, Yuliu Xie, Jia Li, Jiawu Fu, Hua Tao, Bin Zhao, Liangqing Zhang, Keshen Li

“…However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (P=0.014 for allele and P=0.012, for genotype). …”
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Combination of Triple Therapy and Chronic PPI Use May Decrease Risk of Colonic Adenomatous Polyps in Helicobacter pylori Infection by Rina Zuniga, Josef Bautista, Katherine Sapra, Keith Westerfield, Susan Williams, Alexander M. Sy

“…Analysis revealed a statistically significant reduction in patients who received both triple therapy and chronic PPI, lowering the odds by 60% (adjusted OR 0.43, 95% CI 0.27–0.67). …”
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