The perfect molecule for hormonal contraception: Estetrol benefits. A review by Elena A. Gorbunova, Inna A. Apolikhina

“…During E4 therapy, the risk of venous thromboembolism is minimized, and there is less impact on hepatic enzymes, which improves the quality of sexual life and opens up the opportunities of prescribing COCs with E4 to women who are continuously receiving other drugs – statins, antiretroviral agents, or anticonvulsants. …”
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Overview of Community-Acquired Pneumonia and the Role of Inflammatory Mechanisms in the Immunopathogenesis of Severe Pneumococcal Disease by Helen C. Steel, Riana Cockeran, Ronald Anderson, Charles Feldman

“…This is focused on macrolides, corticosteroids, and statins with respect to their modes of anti-inflammatory action, current status, and limitations.…”
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Effectiveness of PCSK9 inhibitors: A Target Trial Emulation framework based on Real-World Electronic Health Records. by Giulia Barbati, Caterina Gregorio, Arjuna Scagnetto, Carla Indennidate, Chiara Cappelletto, Andrea Di Lenarda

“…Treated individuals were slightly younger, predominantly male, had more severe CV conditions, and were more often treated with statin compared to the untreated subjects. The latter exhibited a higher prevalence of non-CV comorbidities. …”
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The value of revascularization and adherence to therapy in the development of cardiovascular complications in long-term monitoring of patients with myocardial infarction of the rig... by V.Y. Tseluyko, T.A. Lozova, V.P. Zheleznyy, O.S. Sasyuk

“…Reducing risk of CV events in the 1st group was associated with higher adherence to ACE inhibitors / ARA (86.7–79.4 %), statins (97.1–64.7 %) and clopidogrel (98.5–79.4 %) at 6 months and at the end of the observation period, compared to patients with conservative strategy (p < 0.05). …”
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Ultra-small phospholipid nanoparticles in the treatment of combined hyperlipidemia: a randomized placebo-controlled clinical trial by Alexander Archakov, Valery Kukharchuk, Andrey Lisitsa, Elena Ponomarenko, Yulia Romashova, Tatiana Pleshakova, Elena Yarovaya, Vladimir Kutsenko, Maria Guseva, Valery Beregovykh, Olga Ipatova, Marina Zubareva, Elena Tikhonova, Sergei Ivanov, Farid Bedretdinov, Sergey Markin

“…It can be used as an add-on therapy to statins.…”
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Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function by Luis Miguel Román-Pintos, Geannyne Villegas-Rivera, Adolfo Daniel Rodríguez-Carrizalez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz

“…Treatment should be directed to improve etiologic factors besides reducing symptoms; several approaches have been evaluated to reduce neuropathic impairments and improve nerve conduction, such as oral antidiabetics, statins, and antioxidants (alpha-lipoic acid, ubiquinone, and flavonoids).…”
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The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women by Irma B. Ancheta, Cynthia A. Battie, Dan Richard, Christine V. Ancheta, Nancy Borja-Hart, Annabelle S. Volgman, Yvette Conley

“…However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level (P<0.01). …”
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Medical treatment of patients before surgical myocardial revascularization by I.V. Shklianka, O.J. Zharinov, O.A. Yepanchintseva, B.M. Todurov

“…The data on the effectiveness of high-dose statins in the postoperative period in reducing the incidence of postoperative atrial fibrillation are presented. …”
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Impact of Clazosentan on Vasospasm Reduction and Functional Recovery after Aneurysmal Subarachnoid Hemorrhage by Sosho KAJIWARA, Takayuki KAWANO, Yu HASEGAWA, Yukihiko NAKAMURA, Kiyohiko SAKATA, Jin KIKUCHI, Masaru HIROHATA, Motohiro MORIOKA

“…In every hospital in Japan, until 2022, the primary treatment for preventing delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) involved a combination of ozagrel sodium (Oz), fasudil hydrochloride (Fs), cilostazol, and statins. However, with the approval of clazosentan in January 2022, it has been used as a first-choice drug more frequently. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…., 24-nor-ursodeoxycholic acid), farnesoid X receptor agonists (obeticholic acid, tropifexor), statins, acetylsalicylic acid. Combinations are superior to individual-drug schemes.Conclusion. …”
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Sex, Prescribing Practices and Guideline Recommended, Blood Pressure, and LDL Cholesterol Targets at Baseline in the BARI 2D Trial by Michelle F. Magee, Jacqueline E. Tamis-Holland, Jiang Lu, Vera A. Bittner, Maria Mori Brooks, Neuza Lopes, Alice K. Jacobs, BARI 2D Study Group

“…Women were less frequent on metformin or sulfonylurea and more likely to take insulin and to be on higher doses of hydroxymethylglutaryl-CoA reductase inhibitors (statins) than men. After adjusting for baseline differences and treatment prescribed, women were less likely to achieve goals for HbA1c (OR = 0.71, 95% CI 0.57, 0.88) and LDL-C (OR = 0.64, 95% CI 0.53, 0.78). …”
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The Impacts of Breakthrough Drug Classes on Total Healthcare Expenditures by Zeynal Karaca, Steven N. Wiggins

“…We examined six different groups of breakthrough drugs, selective serotonin reuptake inhibitors, statins, angiotensin-converting-enzyme (ACE) inhibitors, histamine type 2 antagonists, proton pump inhibitors, calcium channel blockers and fluoroquinolones. …”
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Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients by Shayesteh Khalili, Tahereh Sabaghian, Meghdad Sedaghat, Zahra Soroureddin, Elham Askari, Neda Khalili

“…Multivariate analysis showed that invasive mechanical ventilation, proteinuria, HBA1c level, history of cardiovascular disease, and use of statins were independent risk factors for AKI development in patients with diabetes. …”
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Biomarkers of residual risk and all-cause mortality after acute coronary syndrome. by Anna Toso, Mario Leoncini, Mauro Maioli, Simona Villani, Francesco Bellandi

“…Conclusions: In this population on high-intensity statin therapy only hsCRP and eGFR were independently associated with medium-term mortality. …”
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The Ankle-brachial Index as a Predictor of Multivess el Coronary Disease in Patients with Acute Coronary Syndrome and Peripheral Arterial Disease by Tessa Negrín Valdés, Ailed Elena Rodríguez Jiménez, Raikel Fardales Rodríguez, Luis Alberto Castellanos Gallo, José Carlos Meneses Jiménez, Magda Alina López Callejas

“…They received treatment with clopidogrel (86.1 %), acetylsalicylic acid (86.3 %), ACEI or ARB (85.8 %), statins (73.2 %), beta-blockers (87.5 %) and nitrates (86, 3 %). …”
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Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker? by Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Anca Ouatu, Ciprian Rezus, Manuela Ciocoiu, Claudia Florida Costea, Mariana Floria

“…As such, conventional cardiovascular drugs (statins, calcium channels blockers, and ACEIs/ARBs) have shown additional anti-inflammatory effects that could be linked to their blood pressure lowering properties. …”
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Atorvastatin Improves Inflammatory Response in Atherosclerosis by Upregulating the Expression of GARP by Xiaoqi Zhao, Yuzhou Liu, Yucheng Zhong, Bo Liu, Kunwu Yu, Huairui Shi, Ruirui Zhu, Kai Meng, Wei Zhang, Bangwei Wu, Qiutang Zeng

“…The antiatherosclerosis effects of statins partly depend on their multiple immune modulatory potencies. …”
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Burden of coronary artery calcification in ANCA-associated vasculitis by Claire Cook, Brittany Weber, Catherine Ahola, Zachary S. Wallace, Michael Hendrickson, Anushri Parakh, Sandeep Hedgire, Michael Lu

“…Although CAC is associated with CVD risk and an indication for statins, the use was inconsistent. The role of CT imaging to screen for CVD and guide primary prevention in AAV requires further study.…”
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Practical Aspects of Clinical Manifestations, Pathogenesis and Therapy of Alcoholic Liver Disease and Non-alcoholic Fatty Liver Disease: Expert Opinion by V. V. Tsukanov, M. F. Osipenko, E. V. Beloborodova, M. A. Livzan, I. B. Khlynov, S. A. Alekseenko, Yu. P. Sivolap, J. L. Tonkikh, A. V. Vasyutin

“…In the treatment of NAFLD, diet and lifestyle modification, weight loss, the use of insulin sensitizers, vitamin E, statins (in the presence of hyperlipidemia) and drugs with metabolic activity are effective.Currently, a point of view is being actively expressed about the synergism of the action of alcohol and the metabolic syndrome on the development of fibrosis, cirrhosis, and hepatocellular carcinoma. …”
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Natriuretic Peptide System Activation in Acute Heart Failure Patients with Diabetes by Filipe M. Cunha, Joana Pereira, Pedro Marques, Helena Moreira, Pedro Rodrigues, Maria João Pinto, Patrícia Lourenço, Paulo Bettencourt

“…Diabetics were more often discharged on ACE inhibitors/ARB, antiplatelet therapy, and statins. Neither admission nor discharge BNP values differed between diabetics and pair-matched nondiabetics. …”
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