Pravastatin-Induced Eczematous Eruption Mimicking Psoriasis by Michael P. Salna, Hannah M. Singer, Ali N. Dana

“…Background. Statins, an example of the most commonly prescribed medications to the elderly, are not without side effects. …”
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Assessing the impact of clinically relevant medicinal chemistry teaching: Learning gains from case study approach by Fernanda Domingues Lustoza, João Paulo S. Fernandes

“…A lecture containing pharmacological information on statins was delivered to the students from the control group. …”
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Rhabdomyolysis Induced by Coadministration of Fusidic Acid and Atorvastatin: A Case Report and Comprehensive Review of the Literature by Dimitrios Patoulias, Theodoros Michailidis, Thomas Papatolios, Rafael Papadopoulos, Petros Keryttopoulos

“…Statins are among the most widely prescribed medications worldwide. …”
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Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery by Gulnur Sevin, Yasemin Delen Akcay, Gonen Ozsarlak-Sozer, Mukadder Yasa

“…3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly known as statins, are the medical treatment of choice for hypercholesterolemia. …”
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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…Because it is an inhibitor of the hepatic transporters OATP1B1 and OATP1B3, two uptake transporters regulating the intrahepatic availability of statins, it increases the systemic exposure of co-administered statins. …”
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Simvastatin Does Not Affect Vitamin D Status, but Low Vitamin D Levels Are Associated with Dyslipidemia: Results from a Randomised, Controlled Trial by Lars Rejnmark, Peter Vestergaard, Lene Heickendorff, Leif Mosekilde

“…Objectives. Statin drugs act as inhibitors of the 3-hydroxy-3methylglutaryl coenzyme A (HMG-CoA) reductase enzyme early in the mevalonate pathway, thereby reducing the endogenous cholesterol synthesis. …”
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Analysis of the drug treatment in patients with stable coronary artery disease before and after surgical myocardial revascularization by О.J. Zharinov, О.А. Yepanchintseva, К.O. Mikhaliev, I.V. Shklianka

“…At the same time, we paid attention to the insufficient usage of statins. I.e., high-intensity treatment with statins during one week before surgery was prescribed only in 19 (12.2 %) patients. …”
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Towards the Application of Atorvastatin to Intensify Proapoptotic Potential of Conventional Antileukemic Agents In Vitro by Jolanta D. Żołnierczyk, Arleta Kaźmierczuk, Paweł Hikisz, Barbara Cebula-Obrzut, Ewa Wawrzyniak, Jerzy Z. Błoński, Małgorzata Misiewicz, Paweł Robak, Piotr Smolewski, Zofia M. Kiliańska

“…It has been previously revealed that statins used at high concentrations display antileukemic potential towards chronic lymphocytic leukemia (CLL) cells. …”
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Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway by Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Tuba Esatbeyoglu, Sherif M. Afifi, Alyaa F. Hessin, Sahar S. Abdelrahman, Hany M. Fayed

“…By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. Statins have several benefits, including antioxidant and anti-inflammatory characteristics. …”
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Primary and Secondary Hypogonadism in Male Persons with Diabetes Mellitus by João Martin Martins, Mafalda de Pina Jorge, Catarina Martins Maia, João Roque, Carlos Lemos, Daniel Nunes, Dinis Reis, Catarina Mota

“…Low TT levels were related to older age, poor metabolic control, metformin and statins use, and microvascular disease.…”
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Do doctors in dispensing practices with a financial conflict of interest prescribe more expensive drugs? A cross-sectional analysis of English primary care prescribing data by Ben Goldacre, Carl Reynolds, Anna Powell-Smith, Alex J Walker, Tom A Yates, Richard Croker, Liam Smeeth

“…Data were obtained prescribing of statins, proton pump inhibitors (PPIs), angiotensin receptor blockers (ARBs) and ACE inhibitors (ACEis). …”
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Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model by Kaya Hacer Kayhan, Demirtas Berjan, Yokus Beran, Kesim Dilek Aygün, Tasdemir Ezel, Sermet Abdurrahman

“…Statin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. …”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Certain drugs like aspirin, statins, GLP-1 RAs, and metformin may reduce HCC occurrence, but further research is needed to confirm these effects.…”
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Xanthoma of Bone: A Case Report by Hasnae Guerrouj, Ayat Mouaden, Nouzha BenRais

“…The patient was put under fenofibrate and statins. The evolution was marked by gradual regression of lesions in bone scans of control.…”
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Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending by Gregory R Pond, Ian F Tannock, Daniel A Goldstein, Leonard B Saltz

“…In the field of general medicine, class effects, or therapeutic interchangeability, have been declared for several families of drugs including statins, calcium channel blockers and ACE inhibitors. …”
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Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study by Yuko Fukuda, Risa Ito, Misaki Kakihana, Tsutomu Takahashi, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

“…Furthermore, discrepancies in medication discontinuation or reduction recommended by a stroke specialist, which may increase the risk of stroke recurrence, were identified in five patients (seven drugs: four antiplatelet drugs and three statins). Of 13 discrepancies, community pharmacists inquired about 3 cases with physicians, none were approved. …”
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Comprehensive review of myocardial injury after noncardiac surgery: prevention, intervention, and long-term management strategies by Moiud Mohyeldin, Sarah J. Norman, Ayzia Carney, Courtney Odza

“…We discuss the role of aspirin, statins, anticoagulation, and Dual Antiplatelet Therapy (DAPT) within the context of MINS, drawing on evidence from notable clinical trials as well as observational studies. …”
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Vasospasm in Cerebral Inflammation by Michael Eisenhut

“…Therapeutic trials in vasospasm related to inflammation in subarachnoid haemorrhage in humans showed a reduction of vasospasm through calcium antagonists, endothelin receptor antagonists, statins, and plasminogen activators. Combination of therapeutic modalities addressing calcium dependent and independent vasospasm, the underlying inflammation, and depletion of nitric oxide simultaneously merit further study in all conditions with cerebral inflammation in double blind randomised placebo controlled trials. …”
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The Chylomicron: Relationship to Atherosclerosis by Gerald H. Tomkin, Daphne Owens

“…The ratio of dietary to synthesised cholesterol is variable but tightly regulated: hence intervention with diet at best reduces serum cholesterol by <20% andusually <10%. Statins are the mainstay of cholesterol reduction therapy, but they increase cholesterol absorption, an example of the relationship between synthesis and absorption. …”
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GC-MS analysis of cholesterol lowering dietary supplements by Velislava Todorova, Diana Karcheva-Bahchevanska, Stanislava Ivanova

“…However, it must be taken into account the potential interaction of statins to induce myopathy and rhabdomyolizis. In order to prevent adverse effects, it is necessary to thoroughly evaluate and be careful when using DSs containing monacolin K.…”
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