Role of Traditional Cardiovascular Risk Factors after Initiation of Statin Therapy: A PharmLines Inception Cohort Study by Dennis Steenhuis, Stijn de Vos, Jens Bos, Eelko Hak

“…These factors should be taken into account during the monitoring of statin therapy and may lead to changes in statin treatment or risk-related lifestyle factors.…”
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Effect of Statins on Major Adverse Cardiovascular Events in Patients with Coronary Artery Spasm: A Meta-Analysis of the Asia Region by Tian-Jun Zhao, Duan Luo, Xi Jiang, Feng Tang, Hui Jiang

“…We included data on MACE in a statin therapy patient group and a no-statin therapy control group. …”
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Effect of nanoemulsion carbonated hydroxyapatite-statin administration on Acp 5 and Runx-2 expression during orthodontic relapse in rats by Ananto Ali Alhasyimi, Niswati Fathmah Rosyida, Ika Dewi Ana

“…Materials & methods: Forty-eight rats (n = 48) were assigned to four groups: control, CHA, statin, and CHA-statin, with 12 rats in each group. …”
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Predictors of late complications after coronary artery bypass grafting in patients with stable coronary heart disease by O.J. Zharinov, К.O. Mikhaliev, O.A. Yepanchintseva, B.M. Todurov

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The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization by Qingcong Zheng, Rongjie Lin, Du Wang, Rongsheng Chen, Weihong Xu

“…This study aimed to investigate the genetic associations between lipids, novel non-statin lipid-lowering drug target genes, and OP and BMD. …”
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Statin Use and Mortality among Patients Hospitalized with Sepsis: A Retrospective Cohort Study within Southern California, 2008–2018 by Brannen Liang, Su-jau T. Yang, Kenneth K. Wei, Albert S. Yu, Brendan J. Kim, Michael K. Gould, John J. Sim

“…Despite early goal-directed therapy, sepsis mortality remains high. Statins exhibit pleiotropic effects. Objective. We sought to compare mortality outcomes among statin users versus nonusers who were hospitalized with sepsis. …”
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Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis by Hamdy A. Makhlouf, Amr K. Hassan, Nereen A. Almosilhy, Ahmed S.A. Osman, Shrouk Ramadan, Moaz Elsayed Abouelmagd

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Efek Loading Statin Intensitas Tinggi Sebelum Intervensi Koroner Perkutan pada Pasien Sindrom Koroner Akut: Systematic Review by Cokorda Istri Padmi Suwari, Mutiara Claudia

“…</span><strong>Conclusion</strong>: Loading high-intensity statin before PCI seems to be highly effective in reducing MACE in patients with ACS.…”
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The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations by M. G. W. van den Heuvel, A. Bast, A. W. Ambergen, R. R. W. J. van der Hulst

“…Background. Statins and other cardiovascular medication possess antioxidant capacity. …”
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Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer by Claudia Duranti, Jessica Iorio, Valeria Manganelli, Giacomo Bagni, Rossella Colasurdo, Tiziano Lottini, Michele Martinelli, Chiara Capitani, Giulia Boso, Franco Nicolas D’Alessandro, Maurizio Sorice, Andrea Becchetti, Roberta Misasi, Tina Garofalo, Annarosa Arcangeli

“…From a pharmacological perspective, different statins produce anti-neoplastic effects in synergy with scDb-hERG1-β1. …”
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Influence of Regular Statin Intake on Prostate‐Specific Antigen Values, Prostate Cancer Incidence and Overall Survival in a Prospective Screening Trial (ERSPC Aarau) by Alkiviadis Papagiannakis, Maciej Kwiatkowski, Stephen F. Wyler, Ashkan Mortezavi, Lukas Manka, Marian S. Wettstein, Rainer Grobholz, Angelika Hammerer‐Lercher, Daniel Eberli, Lukas Werner Prause

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Impact of statin use on major adverse cardiovascular events in patients with normal stress myocardial perfusion imaging and elevated coronary artery calcium score by Yi Hui To, Xi Min Tan, Cher-Lyn Low, Htet Htet Min, Min Sen Yew

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Effect of Statins on Serum level of hs-CRP and CRP in Patients with Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Tahmineh Kandelouei, Mitra Abbasifard, Danyal Imani, Saeed Aslani, Bahman Razi, Mahdieh Fasihi, Sajad Shafiekhani, Keyhan Mohammadi, Tannaz Jamialahmadi, Željko Reiner, Amirhossein Sahebkar

“…Several studies have reported that statins have anti-inflammatory effects. Nevertheless, results of clinical trials concerning the effect of statins on the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) have been inconsistent. …”
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Association between the intensity of statin therapy and physical activity 1 year after acute coronary syndrome: a multicentre prospective cohort study in Switzerland by David Nanchen, Stephan Windecker, Isabella Locatelli, Nicolas Rodondi, Lorenz Räber, David Carballo, Francois Mach, Olivier Muller, Baris Gencer, Christian M Matter, Roland Klingenberg, Thomas Lüscher, Alex Boudon

“…Among physically active patients, physical activity level was similar across all statin user categories, with median levels of 2792.5, 2712.0 and 2839.5 MET-min/week in non-statin, moderate/low-statin and high-statin users, respectively (p=0.307).Conclusions One year after ACS, neither low-/moderate-intensity nor high-intensity statin uses were associated with reduced self-reported physical activity compared with non-statin use. …”
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Exploring barriers and facilitators of primary care physicians towards optimising statin therapy in patients with hyperlipidaemia in the very high-risk group: a qualitative study in Singapore by Chun Yen Beh, Rose Wai-Yee Fok, Lay Hoon Goh

“…The major facilitators identified were patient education, providing continuity of care, improving electronic medical record systems’ capabilities, physician education and public education.Conclusion We identified several important barriers and facilitators of statin therapy optimisation in this study. This information offers insights into the development of a multipronged approach to address barriers across different levels with the aim of optimising statin use, reducing cardiovascular events and improving patient outcomes.…”
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Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis by Yuhua Jiang, Yingying Wang, Sijia Ma, Linlin Qian, Yeteng Jing, Xi Chen, Jinsheng Yang

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New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia by Sushmitha Duddu, Yash T. Katakia, Rituparna Chakrabarti, Pooja Sharma, Praphulla Chandra Shukla

“…Statins are the most effective drugs used worldwide to lower the serum LDL-C by inhibiting the rate-limiting step, HMG-CoA reductase, in cholesterol biosynthesis. …”
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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Background: Statins are the cornerstone of low-density lipoprotein cholesterol (LDL-C)-lowering therapy; however, the therapeutic efficacy of statins in countering atherosclerotic cardiovascular disease (ASCVD) is compromised by the concurrent elevation of proprotein convertase subtilisin/kexin type 9 (PCSK9), a pivotal molecule that increases LDL-C levels. …”
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

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Evolocumab safety and efficacy in hypercholesteremia patients with or without diabetes: a retrospective real-world analysis by Sultan Ibrahim Alraddadi, Hind Almodaimegh, Abdullah Kharbosh, Hadeel Alharbi, Ahmed Ibrahim Fathelrahman, Mona Yaser Alsheikh, Lama Alfehaid

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