A Digital Tool for Clinical Evidence–Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study by Shahzad Mumtaz, Megan McMinn, Christian Cole, Chuang Gao, Christopher Hall, Magalie Guignard-Duff, Huayi Huang, David A McAllister, Daniel R Morales, Emily Jefferson, Bruce Guthrie

“… BackgroundClinical guideline development preferentially relies on evidence from randomized controlled trials (RCTs). RCTs are gold-standard methods to evaluate the efficacy of treatments with the highest internal validity but limited external validity, in the sense that their findings may not always be applicable to or generalizable to clinical populations or population characteristics. …”
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The Application of Three-dimensional Shear Wave Elastography in the Detection of Inguinal Lymph Node Metastasis in Gynecological Malignancies by Yuping Shen, Jiulong Dai, Jiami Li, Man Lu

“…Pathology results from lymph node resections or biopsies served as the reference standard. …”
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Proportion, quality of life and factors associated with perinatal urinary incontinence among pregnant women attending at Muhimbili national hospital by Geofrey P. Chiloleti, Fransia Arda Mushi, Aboud Muhsin, Ally Mwanga

“…The statistical analysis of the data was done in the SPSS version 20, whereby descriptive statistics and categorical data were described by frequency tables, graphs, and percentages, and numerical variables by mean, median, and standard deviation. Bivariate logistic regression was used to obtain variables that were associated with PUI. …”
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The outcomes of residual ametropia correction by LASIK and PRK on pseudophakic eyes depending on IOL model by E.P. Gurmizov, K.B. Pershin, N.F. Pashinova, A.Yu. Tsygankov

“…LASIK (n=70, 91.1%) and PRK (n=7, 8.9%) were performed using standard protocols. Postoperatively, all patients were prescribed with hyaluronic acid-containing eye drops Ocutears®. …”
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Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis. by Tara Cain, Jacinta Brinsley, Hunter Bennett, Max Nelson, Carol Maher, Ben Singh

“…Meta-analyses were conducted using RevMan software (version 5.4), applying random effects models to calculate standardized mean differences (SMD) between pre- and post-CWI exposure outcomes. …”
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Metal-free production of natural blue colorants through anthocyanin–protein interactions by Wenxin Wang, Peiqing Yang, Fuqing Gao, Yongtao Wang, Zhenzhen Xu, Xiaojun Liao

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Role of Gut and Urinary Microbiome in Children with Urinary Tract Infections: A Systematic Review by Anjali Srivastava, Omprakash Shete, Annu Gulia, Sumit Aggarwal, Tarini Shankar Ghosh, Vineet Ahuja, Sachit Anand

“…Further studies with larger cohorts, standardized healthy controls, and longitudinal profiling are essential to validate these observations and translate them into clinical practice.…”
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Clinical experience with cyclosporine eye drops for severe dry eye by O.I. Lebedev, A.V. Surov, E.V. Akentieva

“…In addition, this agent provides favorable outcomes when standard tear replacement and anti-inflammatory treatment is ineffective.…”
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Efficacy of intermittent fasting on improving liver function in individuals with metabolic disorders: a systematic review and meta-analysis by Mousa Khalafi, Sara K Rosenkranz, Faeghe Ghasemi, Shokoufeh Kheradmand, Aref Habibi Maleki, Mallikarjuna Korivi, Jung-Piao Tsao

“…Inclusion criteria were (1) studies of human participants with metabolic diseases, (2) interventions that evaluated the effects of IF, (3) with or without a control group, and (4) measured liver fat, liver steatosis, liver fibrosis, or liver enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as primary outcomes. Standardized mean differences (SMD) and 95% confidence intervals were calculated using random effects models. …”
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The results of using micropulse cyclophotocoagulation for the treatment of patients with primary open-angle glaucoma by V.V. Egorov, A.V. Postupaev, N.V. Postupaeva

“…All patients underwent MP-CPC according to the standard technique with the use of the Cyclo G6 Glaucoma Laser System and the MicroPulse P3 probe (IRIDEX, USA). …”
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ON THE THIN PRACTICAL RATIONALITY AND ITS THICKENINGS by Zenonas Norkus

“…Relatively practically rational is the choice of an agent whose preferences in addition to the standard 6 axioms of the theory of expected utility satisfy two supplementary ones: (7) preferences are realistic and (8) they are shaped in some specific way. …”
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Time-dynamic associations between symptom-related expectations, self-management experiences and somatic symptom severity in everyday life: an ecological momentary assessment study... by Bernd Löwe, Yvonne Nestoriuc, Anne Toussaint, Stefanie Hahn, Franz Pauls, Simon Kirchhof

“…Objective The present study investigated the associations between symptom-related expectations, self-management experiences and expectation framing on somatic symptom severity in university students in two conditions (positive or standard expectation framing). We hypothesised that symptom-related expectations are significantly associated with concurrent and subsequent levels of somatic symptom depending on expectation framing.Design A smartphone-based micro-longitudinal ecological momentary assessment study with randomisation to one of two expectation framing groups (positive vs negative) was carried out. …”
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Effects of a nutrition education intervention on nutrition knowledge and attitude among overweight and obese primary schoolchildren: a cluster randomized controlled trial by Rusidah Selamat, Nur Azlina Abdul Aziz, Junidah Raib, Norlida Zulkafly, WNurul Ashikin W. Mohamad, Ainan Nasrina Ismail, Muhammad Yazid Jalaludin, Fuziah Md. Zain, Zahari Ishak, Abqariyah Yahya, Abdul Halim Mokhtar

“…Out of 1,196 eligible government primary schools in central Peninsular Malaysia, 23 were randomly assigned into seven intervention schools (647 children) and 16 control schools (750 children). A standard nutrition education module was delivered for 24 weeks to the intervention group, whereas children in the control group followed only the currently existing school nutrition education program. …”
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Real-World Experience with CDK4/6 Inhibitors in the First-Line Palliative Setting for HR+/HER2− Advanced Breast Cancer by Ram Patel, John Mathews, Caroline Hamm, Swati Kulkarni, Rasna Gupta, Tarquin Opperman, John Dean Chiong, Abdullah Nasser

“…Introduction: CDK4/6 inhibitors in combination with aromatase inhibitors (AIs) are the standard first-line treatment for hormone receptor-positive (HR+), HER2-negative (HER2−) metastatic breast cancer. …”
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The gene Sr38 for bread wheat breeding in Western Siberia by E. S. Skolotneva, V. N. Kelbin, V. P. Shamanin, N. I. Boyko, V. A. Aparina, E. A. Salina

“…In 2019–2020, 139 single pustule isolates of P. graminis f. sp. tritici were obtained on seedlings of the standard susceptible cultivar Khakasskaya in an environmentally controlled laboratory (Institute of Cytology and Genetics SB RAS) from samples of urediniospores collected on commercial and experimental bread wheat fields in the Novosibirsk, Omsk, Altai, and Krasnoyarsk regions. …”
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Desempeño de pavimentos estabilizado con asfalto espumado en una prueba de pavimentos a escala real y carga acelerada Performance of foamed bitumen pavements in accelerated testing... by Alvaro Gonzalez, Misko Cubrinovski, Bryan Pidwerbesky, David Alabaster

“…After the application of 5,710,000 Equivalent Standard Axles (ESAs), the sections stabilised with cement only, bitumen only, and the control section all showed large amounts of rutting. …”
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Optical Coherence Tomography Guided Intravascular Lithotripsy in the Peripheral Vasculature: Technique and Case Series Analysis by Rohit Mehra, Vikram Patra, Rishi Dhillan, Rahul Merkhed, C V N M Dattatraya

“…The study was approved by an institutional ethical committee, and standard statistical tools were used to do the descriptive analysis. …”
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Utilization and quality of primary and specialized palliative homecare in nursing home residents vs. community dwellers: a claims data analysis by Juliane Poeck, Franziska Meissner, Bianka Ditscheid, Markus Krause, Ulrich Wedding, Cordula Gebel, Ursula Marschall, Gabriele Meyer, Werner Schneider, Antje Freytag

“…Analyses were conducted using simple and multiple logistic regression. Data were standardized by age and gender. Results From 117,436 decedents in 2019, 71,803‬ could be included in the first, 55,367‬ in the second analysis. …”
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Meta-analysis of efficacy and safety of pembrolizumab for the treatment of advanced or recurrent cervical cancer by Xue Zhang, Wen-Jie Yin, Ai-Li Zhang, Xiao-Xiao Zhang, Li-Juan Ding, Jiao Zhang, Shu-Ting He, Jie-Ping Yan

“…Designed to maximise patient benefit and efficiently control adverse effects while maintaining a high standard of living.…”
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The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation by Mark Bitsch Vestergaard, Aftab Bakhtiari, Merete Osler, Erik Lykke Mortensen, Ulrich Lindberg, Ian Law, Martin Lauritzen, Krisztina Benedek, Henrik Bo Wiberg Larsson

“…Results ΔCBFVis.Act. correlated negatively ( $$\beta$$ β = -32.1 [95% confidence interval (CI): -60.2; -4.1], r = -0.30, p = 0.025) with PiB standardized uptake value ratio (SUVr) in the brain regions activated by visual stimulation. …”
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