Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…Method In this study, computational models such as flexible docking, induced fit docking, and binding free energy calculation were employed to identify small molecule inhibitors from known bioactive compounds of Spondias mombin in reference to 5-fluorouracil (Colorectal cancer standard drug) targeting apoptosis-signaling kinase 1. …”
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Larvicidal Effectiveness of Azolla pinnata against Aedes aegypti (Diptera: Culicidae) with Its Effects on Larval Morphology and Visualization of Behavioural Response by Nor Shaida Husna Zulkrnin, Nurul Nadiah Rozhan, Nur Amanina Zulkfili, Nik Raihan Nik Yusoff, Mohd Sukhairi Mat Rasat, Nor Hakimin Abdullah, Muhammad Iqbal Ahmad, Rajiv Ravi, Intan H. Ishak, Mohamad Faiz Mohd Amin

“…The larvicidal bioassays were performed using World Health Organization standard larval susceptibility test method for different concentration for powdered and fresh A. pinnata. …”
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Clinical Characteristics and Outcomes of Elderly Patients Undergoing Primary Percutaneous Coronary Intervention: An Observational Cohort Study by Ahmed Hassan, Amr Yosry Emam, Mohammed Thabet, Ahmed Osman, Khaled Ahmed Shams, Mina Samir Labib, Ahmed Elguindy

“…Primary percutaneous coronary intervention (pPCI) is the standard of care for ST-elevation myocardial infarction (STEMI) without an upper age limit. …”
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Application of information-based closed-loop management in optimizing surgical process (基于信息化的闭环管理优化手术流程的设计与实践) by ZHOU Liheng (周立恒), ZHU Xiaodong (朱小东), CHEN Qiannan (陈倩楠), LI Amin (李阿敏)

“…The closed-loop of the whole surgical process based on PDA can optimize and standardize the surgical process, effectively extend the preoperative, intraoperative and postoperative medical services for patients, and has important significance for the fine management of surgery and the overall monitoring and management of hospitals. …”
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A dextrorotatory residues-incorporated bioactive dodecapeptide against enterohemorrhagic Escherichia coli by Ping Zeng, Xuemei Yang, Kwok-Yin Wong, Sheng Chen, Kin-Fai Chan, Sharon Shui Yee Leung, Lanhua Yi

“…Methods: Spatial conformation of synthetic peptide zp39 (GIIAGIIiKIKk-NH2, lowercase letters indicate dextrorotatory amino acids) was predicted by PEPstrMOD and its secondary structure was further determined by circular dichroism (CD) spectroscopy. Then, standard E. coli O157:H7 strain ATCC 43888 was used to evaluate the bioactivity of zp39. …”
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Parasitic infection prevalence in tuberculosis patients and their household contacts in the Littoral Region of Cameroon by Lucy Cho Nchang, Chefor Magha, Patience Agwa Fonong, Narcisse Victor Tchamatchoua Gandjui, Nancielle Mbiatong Tchatat, Desmond Akumtoh Nkimbeng, Frank Noel Nietcho, Juluis Visnel Foyet, Fanny Fri Fombad, Tatiana Djikeussi Katcho, Jerome Fru Cho, Achim Hoerauf, Manuel Ritter, Samuel Wanji

“…Blood, stool, urine and skin snip samples were collected following standard guidelines for investigation of parasitic infections. …”
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Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…In May 2023, the rFib for the volunteer was prepared, meeting the quality standard of T/CSCB0003-2021 Human Mesenchymal Stem Cells. …”
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PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesothelioma by Solange Peters, Urania Dafni, Panagiota Zygoura, Sanjay Popat, Mary O'Brien, Rolf A Stahel, Alessandra Curioni-Fontecedro, Georges Coukos, Amy Roy, Riyaz Shah, Krisztian Homicsko, James Spicer, Stephen P Finn, David Gilligan, Maxim Norkin, Stephanie Tissot, Nicholas Shakarishvili, Anthony Pope, Patricia Fisher, Sylvie Rusakiewicz, Ekaterina Fortis, Nesa Marti, Roswitha Kammler

“…We aimed to identify novel markers in malignant pleural mesothelioma to select patients better.Methods We performed a multiplex-immune histochemistry analysis of tumor samples from the phase III PROMISE-meso study, which randomized 144 pretreated patients to receive either pembrolizumab or standard second-line chemotherapy. Our panel focused on CD8+T cell, CD68+macrophages, and the expression of PD-1 and PD-L1 on these and cancer cells. …”
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Carotid Artery Stenting Outcomes by Neurointerventional Surgeons (CASONI) by Mohamad Ezzeldin, Ameer E. Hassan, Ali Kerro, Maria Martucci, Muhammad Shazam Hussain, Osman Mir, Faheem G. Sheriff, Peter Kan, Chizoba Ezepue, Nazli A. Janjua, Kaiz S. Asif, Ramesh Grandhi, Ali Alaraj, Muhammad Niazi, Ossama Yassin Mansour, Michael Chen, Saif Bushnaq, Omar Tanweer, Adnan H. Siddiqui, Adam Delora, Rime Ezzeldin, Bains Navpreet, Varun Chaubal, Mohammad Ammar Abdulrazzak, Hamzah Saei, Gustavo J. Rodriguez, Mohammad AlMajali, Gautam Edhayan, Amer Al Shekhlee, Christopher Hadjialiakbari, Musaab Froukh, Walid K. Salah, Elsa Nico, Adrusht Madapoosi, Yazan Radiaideh, Darko Quispe‐Orozco, Oz Haim, Noel Garza, Alberto Maud, Morgan Rolon‐Newton, Benan Barakat, Tejas Gowda, Muhammad Monk, Zuhair Ali, Tunmi Anwoju, Osama O. Zaidat, Farhan Siddiq

“…Physician training, higher frequency, and standardized stroke care in a comprehensive stroke center may contribute to this low complication rate.…”
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Exploring cement Production's role in GDP using explainable AI and sustainability analysis in Nepal by Ramhari Poudyal, Biplov Paneru, Bishwash Paneru, Tilak Giri, Bibek Paneru, Tim Reynolds, Khem Narayan Poudyal, Mohan B. Dangi

“…In cross-validation, the Extra Trees model with a mean cross-validation R2 score of 0.93 and a low standard deviation of 0.04 proved to be the best-performing model, as evidenced by lower differences in R2 score across folds compared to other models, demonstrating its high predictive performance. …”
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Seasonal Variations in Chemical Composition and Antibacterial and Antioxidant Activities of <i>Rosmarinus officinalis</i> L. Essential Oil from Southwestern Romania by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Andrei Biţă, Felicia Tuţulescu, Antonia Radu, Maria Viorica Ciocîlteu, George Dan Mogoşanu

“…The analysis aimed to identify and quantify the various components by comparing their mass spectra with reference spectra from the National Institute of Standards and Technology (NIST) Library 2020. The minimum inhibitory concentration (MIC) values of <i>Staphylococcus aureus</i> minimum were determined using the microdilution method (96-well plates). …”
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Evolution of Spanish population well-being during the COVID-19 pandemic: Results from the COSMO-Spain study by Catarina Santos-Ribeiro, Carmen Rodríguez-Blázquez, Alba Ayala, María Romay-Barja, María Falcón, Maria João Forjaz

“…Results: The WHO-5 total score showed a significant increase from rounds 6 (May–June 2021) to 8 (September–October 2021). Women (standardized b coefficient (b) = -0.10), youth or people with lower socioeconomic status (worsened financial situation (b = −0.10) or unemployed/furloughs (b = −0.04)) reported lower well-being levels, whereas having a university-level education showed the opposite (b = 0.11). …”
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A new distal radius fracture classification depending on the specific fragments through machine learning clustering method by Yuling Gao, Yanrui Zhao, Yang Liu, Shan Lei, Hanzhou Wang, Yuerong Lizhu, Tianchao Lu, Zhexian Cheng, Dong Wang, Binzhi Zhao, Ziyi Li, Junlin Zhou

“…The volar plate fixation was performed as the standard treatment, while the combined plate fixation was used for comminuted dorsal bone defects of the metaphysis and impaction. …”
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Impact of Motivational Enhanced Adherence Counseling and Point-of-Care Viral Load Monitoring on Viral Load Outcome in Women on Life-Long ART: A Randomized Pilot Study by Mercy T. Mutambanengwe-Jacob, Charles C. Maponga, K. Rivet Amico, Bernard Ngara, Nonhlanhla Yende-Zuma, Tariro D. Chawana, Teacler Nematadzira, Justice F. Gumbo, Tendayi Goverayi, Petronella Matibe, Bernadette V. Malunda, Jim Aizire, Taha E. Taha, Mary G. Fowler, Lynda Stranix-Chibanda

“…In an unblinded randomized study, consenting women with last viral load ≥200 copies/ml and/or pill count outside 90–110% range were randomized 1 : 1 to receive the intervention or continue routine care, comprising laboratory-based VL monitoring and standard EAC, from trained nurses and counsellors. …”
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In vitro modeling of feline gut fermentation: a comprehensive analysis of fecal microbiota and metabolic activity by Qianle Ren, Qianle Ren, Yuling Li, Mingmei Duan, Jinjun Li, Fangshu Shi, Yun Zhou, Wanjing Hu, Junfu Mao, Xiaoqiong Li

“…Despite advancements in standardized protocols for culturing human GM, research concerning animals—particularly companion animals—remains limited. …”
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Risk Factors of Anaemia among Children under Five Years in the Hohoe Municipality, Ghana: A Case Control Study by Phyllis Atta Parbey, Elvis Tarkang, Emmanuel Manu, Hubert Amu, Martin Amogre Ayanore, Fortress Yayra Aku, Sorengmen Amos Ziema, Samuel Adolf Bosoka, Martin Adjuik, Margaret Kweku

“…Continuous variables were presented as means and standard deviations and categorical variables as frequencies and proportions. …”
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Testing of Retail Cheese, Butter, Ice Cream, and Other Dairy Products for Highly Pathogenic Avian Influenza in the US by David L. Suarez, Iryna V. Goraichuk, Lindsay Killmaster, Erica Spackman, Nicole J. Clausen, Tristan J. Colonius, Cynthia L. Leonard, Monica L. Metz

“…This preprocessing step was suitable in allowing efficient RNA extraction with standard methods. Trial studies were conducted with different cheese types with spiked-in avian influenza virus to show that inoculation of the liquified cheese into embryonating chicken eggs was not toxic to the embryos and allowed virus replication. …”
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Improper lung volume-dose parameters are risk factors for acute fatal radiation pneumonitis among esophageal cancer patients receiving chemoradiotherapy: a case-control study by Ruinuo Jia, Liuyan Li, Xiaoyi Liu, Junqian Zhang, Shuoguo Li, Ziqi Wang, Jingxia Li, Bingyi Xu, Manxi Sheng, Lei Ni, Danni Yang, Shegan Gao, Shegan Gao, Shegan Gao

“…BackgroundDefinitive concurrent chemoradiotherapy (DCRT) is the standard treatment for locally advanced unresectable esophageal cancer (EC). …”
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Self-perception of risk for HIV acquisition among people in prisons in Iran: A nationwide survey in 2017 by Zahra Abdolahinia, Seyed Aria Nejadghaderi, Soheil Mehmandoost, AliAkbar Haghdoost, Abedin Iranpour, Mohammad Karamouzian, Hamid Sharifi

“…Data were collected via gender-matched face-to-face interviews using a standard HIV risk assessment questionnaire. Multivariable logistic regression models were built to identify correlates of high self-perceived HIV risk. …”
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Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
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