Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Future directions include strategies to reduce MSC heterogeneity, standardized protocols for isolation and expansion of those cells, and the development of well-designed large-scale trials to show significant efficacy during a long follow-up, mainly in individuals with DKD.…”
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Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis by Jian Zhang, Xiaomei Li, Ying Hu, Bin Dong, Yongning Jia, Ziyu Li, Xiaojing Cheng, Jinyao Shi, Jiafu Ji, Zhongwu Li, Hong Du, Ting Guo, Shuqin Jia, Xiaofang Xing, Yunsheng Dou

“…CD8+ cytotoxic T lymphocytes levels were elevated after chemotherapy, which was more significant in the group treated with XELOX regimen and in patients with better response, consistent with the TCR diversity elevation.Conclusions These findings have deepened our understanding of the immune modulating effect of chemotherapy and suggest that the immune profile of specimens after standard chemotherapy should be considered for the personalized immunotherapy to ultimately improve clinical outcome in patients with GC.…”
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Neoadjuvant pyrotinib and trastuzumab in HER2-positive breast cancer with no early response (NeoPaTHer): efficacy, safety and biomarker analysis of a prospective, multicentre, resp... by Fei Wang, Yongjiu Wang, Bin Xiong, Zhenlin Yang, Jingfen Wang, Yumin Yao, Lixiang Yu, Qinye Fu, Liang Li, Qiang Zhang, Chao Zheng, Shuya Huang, Liyuan Liu, Chun Liu, Huaibo Sun, Beibei Mao, Dong-Xu Liu, Zhigang Yu

“…Patients showing poor response, as defined by RECIST 1.1, could opt to receive additional pyrotinib or continue standard therapy. The primary endpoint was the total pathological complete response (tpCR; ypT0/isN0) rate. …”
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Petrological controls on the engineering properties of carbonate aggregates through a machine learning approach by Javid Hussain, Tehseen Zafar, Xiaodong Fu, Nafees Ali, Jian Chen, Fabrizio Frontalini, Jabir Hussain, Xiao Lina, George Kontakiotis, Olga Koumoutsakou

“…A total of 45 carbonate rock samples from different geological formations within the Salt Range (Western Himalayan Ranges, Pakistan) were subjected to comprehensive petrographic analyses and standard aggregate quality control tests. The engineering characteristics encompassed Los Angeles abrasion value, aggregate crushing value, aggregate impact value, specific gravity, water absorption, and unconfined compressive strength, whereas petrographic examination of thin sections quantified the mineralogical composition. …”
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Evaluation of magnetic resonance thermometry performance during MR-guided hyperthermia treatment of soft-tissue sarcomas in the lower extremities and pelvis by Spyridon N. Karkavitsas, Marianne Göger-Neff, Maria Kawula, Kemal Sumser, Benjamin Zilles, Martin Wadepohl, Guillaume Landry, Christopher Kurz, Wolfgang G. Kunz, Olaf Dietrich, Lars H. Lindner, Margarethus M. Paulides

“…Introduction This study evaluated the performance of magnetic resonance thermometry (MRT) during deep-regional hyperthermia (HT) in pelvic and lower-extremity soft-tissue sarcomas.Materials and methods 17 pelvic (45 treatments) and 16 lower-extremity (42 treatments) patients underwent standard regional HT and chemotherapy. Pairs of double-echo gradient-echo scans were acquired during the MR protocol 1.4 s apart. …”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Socazolimab combined with standard EC regimen chemotherapy for first-line treatment of ES-SCLC significantly prolonged overall survival and did not increase the safety risk of treatment.…”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Background: Tumor molecular profiling (TMP) for pancreatic cancer (PC) is recommended by current international guidelines, yet no testing standards exist. Moreover, the magnitude of benefit and the cost-effectiveness of comprehensive next-generation sequencing panels for PC are under debate. …”
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Waist circumference and altered metabolic indices are associated with increased resting pulse rate in middle-aged adults by Laith Ashour, Zaid Taimeh, Moaiad Hussein, Zeid Jarrar, Nicola Hanna Madani, Noor Mnaa, Layan Ayesh, Ahmad Odeh, Sama Samer Abu Monshar, Muath Mohammad Dabas, Rawan Almejaibal

“…The total number of participants was 1839 (weighted n=1,390,763), the mean age was 38.1 [standard deviation (SD)=2.0] and the mean pulse rate was 75.2 (SD=11.6). …”
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Effects of a novel non-pharmacological intervention based on respiratory biofeedback, neurofeedback and median nerve stimulation to treat children with ADHD by Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Eduardo Santamaría-Vázquez, Anayali Estudillo-Guerra, Lna Ali, Diana Martinez, Roberto Hornero, Roberto Hornero, Leon Morales-Quezada

“…Correlations between EEG changes and clinical outcomes were observed, suggesting a potential relationship between neurophysiological markers and ADHD symptoms measured by standardized scales.DiscussionThe study findings suggest that the proposed R-BFB/NFB intervention may be an effective non-pharmacological therapy for ADHD, with the additional application of MNS potentially enhancing its effects.…”
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Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment by James K Min, Paul Knaapen, Nick S Nurmohamed, Erik S G Stroes, Andrew D Choi, Ibrahim Danad, James Earls, Michiel J Bom, Ruben W de Winter, Rachel Bernardo, Ruurt Jukema, Ralf Sprengers

“…Accuracy of AI-QCT was compared with a level 3 and two level 2 clinical readers against an invasive quantitative coronary angiography (QCA) reference standard (≥50% stenosis) in an area under the curve (AUC) analysis, evaluated per-patient and per-vessel and stratified by plaque volume.Results Among 208 patients with a mean age of 58±9 years and 37% women, AI-QCT demonstrated superior concordance with QCA compared with clinical CCTA assessments. …”
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Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…Functional magnetic resonance imaging and positron emission tomography are the modern standard for diagnosing vegetative states; however, these methods are still difficult to access in Ukraine. …”
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Durvalumab as consolidation therapy in patients who received chemoradiotherapy for unresectable stage III NSCLC: Real-world data from an expanded access program in Brazil (LACOG 01... by Mauro Zukin, Victor Gondim, Andrea Kazumi Shimada, Ellias Magalhães e Abreu Lima, Clarissa Mathias, Williams Fernandes Barra, William Nassib William Junior, Mônica Padoan, Yuri Bittencourt, Rosely Yamamura, Carlos Eduardo Baston Silva, Letícia de Jesus Rossato, Caio de Almeida Monteiro, Rafaela Gomes de Jesus, Gustavo Gössling, Ana Caroline Zimmer Gelatti

“…ABSTRACT Objective: The PACIFIC trial established standard therapy for patients with unresectable stage III NSCLC who did not progress after platinum-based concurrent chemoradiation therapy. …”
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Associations between fear of COVID-19 and mental health in Ghana: A sequential mediation model by Jiajia Ye, Po-Ching Huang, Emma Sethina Adjaottor, Frimpong-Manso Addo, Mark D. Griffiths, Daniel Kwasi Ahorsu, Chung-Ying Lin

“…Results: Results from structural equation modeling found that (i) fear of COVID-19 was associated with stress and perceived stigma (standardized coefficients [βs] = 0.518 and 0.148, p-values < 0.001), (ii) stress and perceived stigma were associated with frequency of preventive behaviors (β = 0.173, p < 0.001 for stress; −0.100, p < 0.05 for perceived stigma), and (iii) preventive behaviors were associated with mental health status (β = 0.118, p < 0.01). …”
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Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…Methods: A retrospective analysis was conducted on patients with ES-SCLC who experienced disease progression after receiving programmed cell death ligand 1 (PD-L1) inhibitors combined with standard chemotherapy as first-line treatment at three sites in China. …”
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A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…In the present study, we investigated semantic fluency as a cognitive strength in English-speaking children with dyslexia aged 8–13.MethodsNinety-seven children with dyslexia completed tests of letter and semantic verbal fluency, standardized measures of reading and cognitive functions, and task-free resting-state functional magnetic resonance imaging (rs-fMRI). …”
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Temporal Trends in Mortality and Hospitalization Risk in Patients With Heart Failure According to the Hospital Frailty Risk Score by Noor K. Abassi, Nina Nouhravesh, Mariam Elmegaard, Marte Austreim, Deewa Zahir, Caroline Hartwell Garred, Jawad H. Butt, Camilla Fuchs Andersen, Jarl E. Strange, Caroline Sindet‐Pedersen, Daniel M. Christensen, Emil Fosbøl, Charlotte Andersson, Lars Køber, Morten Schou

“…These findings indicate the need for further evidence on the optimization of care for frail patients with HF, and future research should address the development of comprehensive management strategies, integrating frailty assessment into standard clinical care and focused care for older patients with HF.…”
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Application of quality control circle activities to improve the implementation rate of prevention on deep venous thrombosis in patients undergoing urological surgery (提高泌尿外科手术患者深静脉... by QIU Deyuan (仇德媛), DUAN Junfang (段俊芳), LI Ping (栗平), QIN Xiaocui (秦晓翠), WANG Huihui (王惠惠), ZHANG Yingying (张莹莹), CHEN Menghan (陈孟涵)

“…Conclusion Application of QCC management tool can improve the management standard of DVT prevention in patients undergoing urological surgery and effectively reduce the incidence of DVT. …”
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Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial by Lu Zhang, Shu Li, Jing Huang, Yan Wu, Liang Han, Tian Gao, Qingxia Fan, Suxia Luo, Binlei Liu, Lixin Zhou, Xinyu Wang, Ling Jia, Jianhua Shi, Zhichao Tan, Zhengfu Fan, Sijuan Ding, Chujie Bai, Ruifeng Xue, Jiayong Liu

“…Here, we examined the safety and efficacy of OH2 as a single agent or in combination with HX008, an NMPA-approved PD-1 inhibitor, in locally advanced or metastatic sarcoma patients.Methods This multicenter, phase 1/2 trial enrolled patients with injectable sarcoma lesions, who had failed at least 1 or more lines of standard treatment. Patients were treated with OH2 at three dose levels (106, 107 and 108 CCID50/mL) as single agent or in combination with a fixed dose of HX008. …”
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Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography by Simone Calcagno, Fabio Infusino, Olga Dettori, Temistocle Taccheri, Pasqualina Bruno, Viviana Maestrini, Gennaro Sardella, Massimo Mancone, Francesco Fedele

“…Twenty-eight consecutive patients with residual angina after PCI were randomized to ivabradine 5 mg twice/day (IG) or standard therapy (CG). All patients performed a stress echocardiography at the enrollment and after 30 days. …”
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Diagnostic performance of digital breast tomosynthesis (DBT) versus digital mammography (DM) in a population clinically referred for breast imaging – a retrospective cohort study by Naomi Noguchi, Farzaneh Boroumand, Katy Bell, Margaret Pooley, Aileen Zeng, Lauren Arnold, Armando Teixeira-Pinto, Nehmat Houssami

“…Methods: Diagnostic performance of DBT (in 2016, after transition to DBT) was compared with DM (in 2011, before the transition) in consecutively referred patients (N = 10,742 exams). Reference standard was outcomes from all tests including histopathology and clinical review within the same year. …”
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