Exploring the Potential of Malvidin and Echiodinin as Probable Antileishmanial Agents Through In Silico Analysis and In Vitro Efficacy by Luis Daniel Goyzueta-Mamani, Daniela Pagliara Lage, Haruna Luz Barazorda-Ccahuana, Margot Paco-Chipana, Mayron Antonio Candia-Puma, Gonzalo Davila-Del-Carpio, Alexsandro Sobreira Galdino, Ricardo Andrez Machado-de-Avila, Rodolfo Cordeiro Giunchetti, Edward L. D’Antonio, Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli

“…In this study, the in vitro potential of malvidin and echioidinin is examined as antileishmanial agents against <i>L. amazonensis</i>, <i>L. braziliensis</i>, and <i>L. infantum</i>, comparing their effects to amphotericin B (AmpB), a standard drug. Malvidin demonstrated greater potency than echioidinin across all parasite stages and species. …”
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Dietary inflammatory index and disability among older adults in Guangzhou: a cross-sectional analysis by Junbin Liao, Junbin Liao, Wenfeng Cai, Danrong Lin, Yuanyun Xiao, Yanxi Liu, Yahui Wang, Yuquan Zhong, Fan Xiao, Heng Fang, Yilu Yao, Yunfeng Lin, Jiewen Su, Siyu Sun, Bo Zhang, Yan Wang, Wei Zhu, Wei Zhu

“…Disability levels were assessed using the “Assessment Standard for Long-term Care Disability” from the Medical Insurance Bureau, including Activities of Daily Living (ADL), Cognitive Ability, and Sensory Perception and Communication Skills (SPCS). …”
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Clinical characteristics of EGFR-ctDNA shedders in EGFR-mutant NSCLC patients by Martina Ruglioni, Iacopo Petrini, Stefania Crucitta, Andrea Sbrana, Giovanna Irene Luculli, Leila Sadeghi Gol, Carola Forte, Antonio Chella, Christian Rolfo, Romano Danesi, Marzia Del Re

“…EGFR was assessed on tissue by standard procedures, while EGFR status on ctDNA was tested using dPCR at baseline and at the first reassessment. …”
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Genetic and biochemical characterization of staphylococci occurring in Novosibirsk, Russia by Y. N. Kozlova, N. V. Fomenko, V. V. Morozova, I. V. Saranina, A. Yu. Tikunov, D. A. Ganichev, A. G. Samokhin, V. V. Pavlov, O. M. Rozhnova, I. A. Bondar’, E. V. Zenkova, V. V. Nimaev, V. V.  Klimontov, N. V. Tikunova

“…Identification of coagulase positive strains was performed using a standard biochemical method and by real­time PCR of the coa gene. 100 % coincidence between the presence of the gene and coagulase activity for S. aureus strains was recorded, which suggests that detection of the coa gene can be used as a correct method for S. aure us identification. …”
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Phenotypic and Complete Reference Whole Genome Sequence Analyses of Two <i>Paenibacillus</i> spp. Isolates from a Gray Wolf (<i>Canis lupus</i>) Gastrointestinal Tract by Jessika L. Bryant, Jennifer McCabe, C. Cristoph Klews, MiCayla Johnson, Ariel N. Atchley, Thomas W. Cousins, Maya Barnard-Davidson, Kristina M. Smith, Mark R. Ackermann, Michael Netherland, Nur A. Hasan, Peter A. Jordan, Evan S. Forsythe, Patrick N. Ball, Bruce S. Seal

“…The bacteria digested complex carbohydrates and lipids by standard assays. The isolated bacteria also inhibited the growth of <i>Staphylococcus aureus</i> and <i>Micrococcus luteus</i>. …”
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Dissecting Causal Relationships Between Antihypertensive Drug, Gut Microbiota, and Type 2 Diabetes Mellitus and Its Complications: A Mendelian Randomization Study by He Zheng, Shiping Wu, Wenbin Wang, Weida Qiu, Yingqing Feng

“…We performed a two‐step MR to detect the mediating role of GM. A 1‐standard deviation (SD) decrease of KCNJ11 (acting on arteriolar smooth muscle, e.g., Pinacidil) gene expression was associated with lower SBP of 1.12 (95% confidence interval [CI], 0.93–1.31) mmHg, and a decreased risk of diabetic retinopathy (odds ratio [OR], 0.63; 95% CI, 0.52–0.76). …”
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The simulation of ELM control by the advanced divertor configuration in EAST by Y.L. Li, T.Y. Xia, Z.P. Luo, Q.Z. Yu, S.F. Mao, B. Gui, X.X. He, H.M. Qi, P.C. Xie, M.Y. Ye, the EAST team

“…Here we mainly discuss the standard single-null (SN), snowflake plus (SF+), and snowflake minus (SF-) divertors. …”
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Identifying the healthy places to live in Australia with a new environmental quality health index by Shuang Zhou, Zhihu Xu, Wenzhong Huang, Yao Wu, Rongbin Xu, Zhengyu Yang, Pei Yu, Wenhua Yu, Tingting Ye, Bo Wen, Shanshan Li, Yuming Guo

“…Our methodology can be adapted globally to standardize risk evaluation.…”
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A preliminary investigation into self-compassion and compassion-based intervention for mental health in the performing arts by Courtney C. Walton, James N. Kirby, Sabrina McKenzie, Sabrina McKenzie, Caroline X. Gao, Caroline X. Gao, Rosemary Purcell, Rosemary Purcell, Simon M. Rice, Simon M. Rice, Margaret S. Osborne, Margaret S. Osborne

“…Qualitative data demonstrated that participants experienced self-compassion to be helpful, however fears of lowering standards existed. Participants feedback from this study can now directly inform future compassion-based interventions among performers.ConclusionWhile acknowledging the small sample size, these findings suggest that self-compassion may help performing artists manage various forms of internal, interpersonal, and environmental distress. …”
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Causal associations of ambient particulate matter 10 and Alzheimer’s disease: result from a two-sample multivariable Mendelian randomization study by Zehan Huang, Guodong He, Shuo Sun, Yingqing Feng, Yuqing Huang

“…In the univariate MR, pooled meta-analysis of genetically predicted PM10 was associated with a 99% increased risk of AD (95% CI: 1.25, 3.15, p = 0.004) per 1 standard deviation (SD) increment of PM10 by IVW, and in the multivariable MR with pooled meta-analysis, we found that each SD increase in PM10 was associated with a 127% increase in the risk of AD (95% CI: 1.33, 3.86, p = 0.002) after accounting for education levels. …”
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ANTIOXIDANT POTENTIAL OF TEMULAWAK (CURCUMA XANTHORRHIZA) EXTRACT GEL AS A CANDIDATE FOR WOUND HEALING by Reghita Claudia Malau, Sri Wahyuni Nasution, Ali Napiah Nasution, Wahyu Widowati, Faradhina Salfa Nindya, Hanna Sari Widya Kusuma

“…The antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazil (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)-reducing activity assay in a gel formula that was close the standards. The measurement results were then used in the calculation of antioxidant activity to determine the IC50 value. …”
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Simultaneous Multiband Photometry of the Early Optical Afterglow of GRB 240825A with Mephisto by Yehao Cheng, Yu Pan, Yuan-Pei Yang, Jinghua Zhang, Guowang Du, Yuan Fang, Brajesh Kumar, Helong Guo, Xinzhong Er, Xinlei Chen, Chenxu Liu, Tao Wang, Zhenfei Qin, Yicheng Jin, Xingzhu Zou, Xuhui Han, Pinpin Zhang, Liping Xin, Chao Wu, Jianhui Lian, Xiangkun Liu, Xiaowei Liu

“…To reconcile the measured much softer spectral energy distribution (SED) with that predicted by the standard afterglow model, an extra host-galaxy extinction of E _B _− _V  ∼ (0.37–0.57) mag is required. …”
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Person-based design and evaluation of MIA, a digital medical interview assistant for radiology by Kerstin Denecke, Daniel Reichenpfader, Dominic Willi, Karin Kennel, Harald Bonel, Harald Bonel, Knud Nairz, Nikola Cihoric, Damien Papaux, Hendrik von Tengg-Kobligk

“…The application of a standardized evaluation framework helped in saving time and ensures comparability of results.…”
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Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center by Simona Fecarotta, Lorenzo Vaccaro, Alessandra Verde, Marianna Alagia, Alessandro Rossi, Chiara Colantuono, Maria Teresa Cacciapuoti, Patrizia Annunziata, Sara Riccardo, Antonio Grimaldi, Tonya Fusco, Rosa De Santis, Fernando Barretta, Lucia Albano, Daniela Crisci, Fabiana Vallone, Antonietta Tarallo, Marcella Cesana, Nicola Brunetti-Pierri, Giulia Frisso, Margherita Ruoppolo, Davide Cacchiarelli, Giancarlo Parenti

“…Methods based on liquid chromatography/mass spectrometry (LC–MS/MS) analysis are viewed worldwide as the gold standard procedure for the expanded NBS programs for these disorders. …”
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Quality assessment of spent laying hens and analysis of influencing factors by Runzhe Wang, Jiahui Lai, Guiyun Xu, Chuanwei Zheng, Zhiqiong Mao, Jiangxia Zheng

“…The USDA quality assessment standards for post-slaughter evaluation, it was found that the incidence of dislocation was 11.1 %, which emerged as a primary factor affecting carcass quality, directly resulting in a decline in quality. …”
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Is Dry Needling Effective When Combined with Other Therapies for Myofascial Trigger Points Associated with Neck Pain Symptoms? A Systematic Review and Meta-Analysis by César Fernández-De-Las-Peñas, Gustavo Plaza-Manzano, Jorge Sanchez-Infante, Guido F Gómez-Chiguano, Joshua A Cleland, José L. Arias-Buría, Ibai López-de-Uralde-Villanueva, Marcos J. Navarro-Santana

“…Between-groups mean differences (MD) and standardized mean difference (SMD) were calculated. Results. …”
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Biomechanical Modeling and Evaluation of Buttocks Automatic Assisted Repositioning in Bedridden Patients by Liqing Yang, Ganjun Song, Di Luo, Haotian Xu, Jiamei Han, Mingzhao Xiao, Dingqun Bai, Shan Tian, Wensheng Hou, Jisi Tang, Xin Zhang, Lin Chen

“…Model validation demonstrated a deformation error of <inline-formula> <tex-math notation="LaTeX">$6.93~\pm ~7.41$ </tex-math></inline-formula> mm (mean &#x00B1; standard deviation) and interface pressure differences within 22.4%, demonstrating the efficacy and bio-fidelity of the system. …”
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PretoxTM: a text mining system for extracting treatment-related findings from preclinical toxicology reports by Javier Corvi, Nicolás Díaz-Roussel, José M. Fernández, Francesco Ronzano, Emilio Centeno, Pablo Accuosto, Celine Ibrahim, Shoji Asakura, Frank Bringezu, Mirjam Fröhlicher, Annika Kreuchwig, Yoko Nogami, Jeong Rih, Raul Rodriguez-Esteban, Nicolas Sajot, Joerg Wichard, Heng-Yi Michael Wu, Philip Drew, Thomas Steger-Hartmann, Alfonso Valencia, Laura I. Furlong, Salvador Capella-Gutierrez

“…The PretoxTM Corpus is a gold standard corpus of preclinical treatment-related findings annotated by toxicology experts. …”
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Learning from wildfires: A scalable framework to evaluate treatment effects on burn severity by Caden P. Chamberlain, Garrett W. Meigs, Derek J. Churchill, Jonathan T. Kane, Astrid Sanna, James S. Begley, Susan J. Prichard, Maureen C. Kennedy, Craig Bienz, Ryan D. Haugo, Annie C. Smith, Van R. Kane, C. Alina Cansler

“…Our framework used (1) machine learning to identify key bioclimatic, topographic, and fire weather drivers of burn severity in each fire, (2) standardized workflows to statistically sample untreated control units, and (3) spatial regression modeling to evaluate the effects of treatment type and time since treatment on burn severity. …”
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Development of a vegetation canopy reflectance sensor and its diurnal applicability under clear sky conditions by Naisen Liu, Naisen Liu, Naisen Liu, Jingyu Guo, Fuxia Liu, Fuxia Liu, Fuxia Liu, Xuedong Zha, Jing Cao, Yuezhen Chen, Haixia Yan, Chenggong Du, Chenggong Du, Chenggong Du, Xuqi Wang, Jiping Li, Jiping Li, Jiping Li, Yongzhen Zhao

“…The sensor’s accuracy was validated using a standard reflectance gray scale board. The results indicate that the root mean square error (RMSE) and mean absolute error (MAE) at 710 nm were 1.07% and 0.63%, respectively, while those at 870 nm were 0.94% and 0.50%, respectively. …”
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