ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial by R Kneen, M Lim, A Vincent, A J Pollard, W K Chong, L-M Yu, M A Iro, M Sadarangani, M Absoud, C A Clark, A Easton, V Gray, M Pike, T Solomon, L Willis

“…We describe the protocol for the first ever randomised control trial of IVIG treatment for children with all-cause encephalitis.Methods and analysis 308 children (6 months to 16 years) with a diagnosis of acute/subacute encephalitis will be recruited in ∼30 UK hospitals and randomised to receive 2 doses (1 g/kg/dose) of either IVIG or matching placebo, in addition to standard treatment. Recruitment will be over a 42-month period and follow-up of each participant will be for 12 months post randomisation. …”
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Does completion of radical hysterectomy improve oncological outcomes of women with clinical early-stage cervical cancer and intraoperative detection of nodal involvement?: protocol... by Hui Xu, Qing Liu, Yu Xu, Yi Du, Ai Zheng, Cui Hu, Ya Jia, Qianwen Zhang, Yue-Dong He, Shuang-Shuang Cui, Yong Tian, Lin Ran, Fengmei Ke

“…Methods and analysis This protocol is drafted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines, and the proposed study will be conducted in accordance with the standard guidelines of ‘Preferred Reporting Items for Systematic Reviews and Meta-Analyses’ and ‘Meta-analysis of Observational Studies in Epidemiology reporting guideline’. …”
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Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…Abstract HER2‐targeted therapy, especially the anti‐HER2 antibody trastuzumab, is standard for HER2‐positive breast cancer; however, its efficacy is limited in a subpopulation of patients. …”
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Assessing the Comparative Efficacy and Safety of Warfarin and Rivaroxaban for Cancer Associated Thrombosis: Experience From a Resource Limited Setting by Abel Tenaw Tasamma, Tsegab Alemayehu Bukate, Abdulrahim Mehadi, Bereket Tagesse Handiso, Beniam Yohannes Kassa, Eman Omer Hassen, Zekarias Seifu Ayalew, Dawit Habtie Tegegne, Gebeyehu Tessema Azibte, Tigest Abebaw Zewdie, Tinsaye Zergaw Shihur, Yonas Degelo Geremamo, Yeabsira Dessalegne Mesfin, Rediet M. Alemayehu, Amanuel Kassu Asefa, Fozia Abdela, Addisu Melkie

“…The Cox regression model was used to compare the outcome of the two groups. The baseline mean (standard deviation) age of the patients was 48.4 (15.0) and 140 (69.7%) of them were female. 41.3% of the participants had one or more comorbidities, and the most common types of cancer were gynecologic (28.9%), hematologic (21.4%), and intra‐abdominal (16.9%). …”
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Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia by Florian T. Gassert, Henriette Bast, Henriette Bast, Henriette Bast, Theresa Urban, Theresa Urban, Theresa Urban, Manuela Frank, Manuela Frank, Felix G. Gassert, Konstantin Willer, Konstantin Willer, Rafael C. Schick, Rafael C. Schick, Bernhard Renger, Thomas Koehler, Thomas Koehler, Alexandra Karrer, Andreas P. Sauter, Alexander A. Fingerle, Marcus R. Makowski, Franz Pfeiffer, Franz Pfeiffer, Franz Pfeiffer, Franz Pfeiffer, Daniela Pfeiffer, Daniela Pfeiffer

“…Using Spearman's correlation coefficient, correlation was tested between dark-field coefficient and CT-based COVID-19 index and visual total CT score as well as between the visual total dark-field score and the visual total CT score.ResultsA total of 98 participants [mean age 58 ± 14 (standard deviation) years; 59 men] were studied. The areas of signal intensity reduction observed in dark-field images showed a strong correlation with infiltrates identified on CT scans. …”
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The effect of electroslag remelting on the cleanliness of CrNiMoWMnV ultrahigh-strength steels by Ali M., Porter D., Kömi J., Heikkinen E.P., Eissa M., El Faramawy H., Mattar T.

“…Thermodynamic calculations for the expected NMIs formed in the investigated steels with and without ESR were performed using FactSage 7.2 software while HSC Chemistry version 9.6.1 was used to calculate the standard Gibbs free energies (ΔG°). As a result of ESR the total impurity levels (TIL% = O% + N% + S%) and NMI contents decreased by as much as 46 % and 62 %, respectively. …”
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Advances in Radiation Protection in Oral and Dental Radiology: Pragmatic Approaches and Recent Innovations by Saiedeh Sadeghi, Nastaran Saeidi, Ali Salehi, Kamal Attari, Mohammad Ali Irani, Seyed Sasan Aryanezhad, Reza Malekzadeh, Reza Mahmoudi Anzabi

“…Digital intraoral X-ray technology has shown promising results in significantly reducing radiation exposure. To ensure standardized practices, Diagnostic Reference Levels (DRLs) have been defined for CBCT and must be established for different clinical indications. …”
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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…We have used a comprehensive food frequency questionnaire (FFQ) to evaluate dietary intake and the fatty acids quality indexes. We have employed standard methods to measure biochemical factors, anthropometrics, and physical activity levels. …”
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Evaluation of the vibration state and determination of the stress-strain state of the trash-rack structure of the hydroelectric power plants by A. S. Antonov, N. P. Karablin, K. Ju. Baud, I. V. Baklykov

“…The stresses in the metal struts do not exceed the standard values for the steel used. The performed direct measurement of vibration of structural elements demonstrated that the most dangerous frequency range is 40.30–41.75 Hz.Conclusions. …”
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improving Pain mAnagement for childreN and young people attendeD by Ambulance (PANDA): protocol for a realist review. [version 3; peer review: 2 approved, 1 approved with reservati... by Paul Leighton, Georgette Eaton, Georgie Nicholls, Kacper Sumera, Marishona Ortega, Jessica Hodgson, Michael Baliousis, Aloysius Niroshan Siriwardena, Despina Laparidou, Bill Lord, Sarah Redsell, Gregory Adam Whitley, Tatiana Bujor

“…Methods A realist review will be conducted in accordance with the Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) guidance. A five-stage approach will be adopted; 1) Developing an Initial Programme Theory (IPT): develop an IPT with key stakeholder input and evidence from informal searching; 2) Searching and screening: conduct a thorough search of relevant research databases and other literature sources and perform screening in duplicate; 3) Relevance and rigour assessment: assess documents for relevance and rigour in duplicate; 4) Extracting and organising data: code relevant data into conceptual “buckets” using qualitative data analysis software; and 5) Synthesis and Programme Theory (PT) refinement: utilise a realist logic of analysis to generate context-mechanism-outcome configurations (CMOCs) within and across conceptual “buckets”, test and refine the IPT into a realist PT. …”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…Rigorous internal validation via leave-one-out and 10-fold cross-validation yielded <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msup><mi mathvariant="normal">Q</mi><mn>2</mn></msup></semantics></math></inline-formula> values of 0.926 and 0.922, respectively, while external validation on 270 independent compounds resulted in an R² value of 0.941 with a standard deviation of 0.237. <b>Results:</b> Key molecular descriptors influencing the inhibitor potency were identified, thereby improving the interpretability of structural requirements. …”
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Detection of nontoxic BoNT/A levels in post-facial Botox injection breastmilk by Helene Gu, Zhenyu Xu, Renata Koviazina, Pengcheng Tan, Changcheng Zheng, Ferdinand Kappes, Domna G. Kotsifaki, Fangrong Shen, Anastasia Tsigkou

“…BoNT/A concentrations in samples were detected using standard Enzyme-Linked Immunosorbent Assay (ELISA), unreduced and reduced Western Blotting, confocal micro-Raman Spectroscopy, and Mass Spectrometry (LC-MS). …”
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Video Review Can Measure Surgical Robotic Skill Development in a Resident Robotic Hernia Curriculum: A Retrospective Cohort Study by Sarah B. Hays, MD, Amr I. Al Abbas, MD, Kristine Kuchta, MS, Aram Rojas, MD, Melissa Ramirez Barriga, BS, Syed Abbas Mehdi, MBBS, MPH, Stephen Haggerty, MD, H. Mason Hedberg, MD, John Linn, MD, Mark Talamonti, MD, Melissa E. Hogg, MD, MS

“…The drills were completed by 3 attending surgeons to establish gold-standard benchmarks. Results:. In total, 20 residents started the curriculum, 19 completed all IHR drills and 17 completed all VHR drills. …”
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Anti-PL-7/PL-12 antisynthetase syndrome associated with interstitial lung disease following SARS-COV-2 infection and vaccination: A case study review by Laura García-Bravo, Ángela Villegas, Bárbara López Uceda, Anaís Mariscal, Cristina Vadillo, M Asunción Nieto Barbero, Juan Luis Rodríguez-Hermosa, Beatriz Mediero Valeros, José Carlos Plaza-Hernández, Miguel Fernández-Arquero, María Guzmán-Fulgencio, Gloria Candelas-Rodríguez, Silvia Sánchez-Ramón, Juliana Ochoa-Grullón

“…Anti-ARS autoantibodies were identified using three complementary methods: immunoblotting, western blotting (WB) and the method considered the gold standard, immunoprecipitation (IP), which ensures accurate interpretation of results. …”
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Perioperative nursing management of transcatheter edge-to-edge repair (经导管二尖瓣缘对缘修复术围手术期护理) by LIU Yuan (刘苑), LAI Jianqing (赖间清), DING Fei (丁菲), HUANG Huifen (黄惠芬)

“…The comprehensive interventions including enhanced recovery after surgery, respiratory exercise, pain control, catheter maintenance and standard health education before discharge were carried out to relieve symptoms of heart failure, improve self-care ability and quality of life of patients after transcatheter edge-to-edge repair. …”
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RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Manuel Lentzen, Srinivasan Vairavan, Marijn Muurling, Vasilis Alepopoulos, Alankar Atreya, Merce Boada, Casper de Boer, Pauline Conde, Jelena Curcic, Giovanni Frisoni, Samantha Galluzzi, Martha Therese Gjestsen, Mara Gkioka, Margarita Grammatikopoulou, Lucrezia Hausner, Chris Hinds, Ioulietta Lazarou, Alexandre de Mendonça, Spiros Nikolopoulos, Dorota Religa, Gaetano Scebba, Pieter Jelle Visser, Gayle Wittenberg, Vaibhav A. Narayan, Neva Coello, Anna-Katharine Brem, Dag Aarsland, Holger Fröhlich, on behalf of RADAR-AD

“…Methods The RADAR-AD study was designed to evaluate the accuracy and validity of multiple RMTs in detecting functional decline across various stages of AD in a real-world setting, compared to standard clinical rating scales. Our approach involved a univariate analysis using Analysis of Covariance (ANCOVA) to analyze individual features of six RMTs while adjusting for variables such as age, sex, years of education, clinical site, BMI and season. …”
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Artificial Intelligence in Cardiac Surgery: Transforming Outcomes and Shaping the Future by Vasileios Leivaditis, Eleftherios Beltsios, Athanasios Papatriantafyllou, Konstantinos Grapatsas, Francesk Mulita, Nikolaos Kontodimopoulos, Nikolaos G. Baikoussis, Levan Tchabashvili, Konstantinos Tasios, Ioannis Maroulis, Manfred Dahm, Efstratios Koletsis

“…Data extraction and quality assessment were conducted using standardized tools, and findings were synthesized narratively. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Treatment with arecagel resulted in a significant reduction in wound area compared to control and standard groups, indicating its potential in wound healing applications. …”
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Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs by Lin Wang, Jiaxi Wang, Chao Lin, Furong Wang, Xiangping Li, Wanhui Liu

“…Sitagliptin was selected as the internal standard. 0.02% formic acid aqueous solution (A) and methanol-acetonitrile (B) were used as mobile phases with gradient elution at a flow rate of 0.3 mL/min. …”
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Cardiovascular Disease and Other Competing Causes of Death in Older Kidney Cancer Patients by Yinglan Liang, Liangjia Zeng, Ruoyun Zhou, Manting Feng, Linglong Liu, Kexin Chen, Jinqi Huang, Haowen Liang, Baixin He, Binghua Zhang, Yican Ying, Yuerong Chen, Tianwang Guan, Min Yi

“…The competing risk analysis was used to produce cumulative mortality curves based on cumulative mortality for the primary outcomes by follow-up period. Utilizing the standardized mortality ratios (SMRs) and absolute excess risks (AERs), we contrasted the risk of CVD and other competing causes of death in older kidney cancer patients to that observed in the general population. …”
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