Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Irene F. Marques, Carola Domènech-Panicello, Madelon L. Geurtsen, Thanh T. Hoang, Rebecca Richmond, Kristen Polinski, Lea Sirignano, Christian M. Page, Anne-Claire Binter, Todd Everson, Amber Burt, Michael Deuschle, Maria Gilles, Fabian Streit, Sunni L. Mumford, Per Magnus, Irwin K. M. Reiss, Marijn J. Vermeulen, Stephanie H. Witt, Inês Chaves, Edwina Yeung, Stephanie J. London, Mònica Guxens, Janine F. Felix

“…Three CpGs were differentially methylated in relation to maternal night shift work during pregnancy at a false discovery rate adjusted P < 0.05: cg10945885 (estimate (β) 0.38%, standard error (SE) 0.07), cg00773359 (β 0.25%, SE 0.05), and cg21836426 (β − 0.29%, SE 0.05). …”
Get full text

Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…ME/CFS patients aged 12–19 years and controls will donate biosamples of urine, blood, and peripheral blood mononuclear cells for an in-depth omics profiling analysis (whole-genome sequencing, metabolomics and quantitative proteomics) while being assessed by gold-standard clinical and neuropsychological measures. …”
Get full text

Renal Dysfunction among Ghanaians Living with Clinically Diagnosed Hypertension in the Asutifi-South District: A Cross-Sectional Descriptive Study at the St. Elizabeth Hospital, Hw... by Sylvester Yao Lokpo, James Osei-Yeboah, William K. B. A. Owiredu, Francis Abeku Ussher, Verner Ndudiri Orish, Felix Gadzeto, Paul Ntiamoah, Felix Botchway, Ivan Muanah, Romeo Asumbasiya Aduko

“…Blood pressure, weight, and creatinine were measured using standard methods. Kidney function was assessed using Cockcroft Gault (CG), Four-Variable Modification of Diet in Renal Disease (4v-MDRD) and the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. …”
Get full text

Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel... by David Cosgrave, Bairbre McNicholas, Ciara Hanley, John Robert Sheehan, Padraig Calpin, Maeve Kernan, Darragh Murphy, Alberto Alvarez‑Iglesias, John Ferguson, Camilla Giacomini, Christine Greene, Catriona Cody, Shane McGeary, Marion Murphy, Marianne Fitzgerald, Gerard Curley, Barry Dixon, Roger J. Smith, Claire Masterson, Daniel O’Toole, Frank van Haren, John G. Laffey

“…Mean age was 56.6 (SD 11.5) in the heparin group and 51.3 (SD 14.7) in the standard care group, while 60% of participants were male. …”
Get full text

Normative Values of Brainstem Auditory-Evoked Responses in Sheep by Katharina Suntinger, Adrian Dalbert, Lukas Prochazka, Milena Tegelkamp, Peter Kronen, Karina Klein, Christof Röösli, Alexander Huber, Flurin Pfiffner

“…At 100 dB SPL, the mean (±standard deviation, SD) latency of wave V was 4.35 (±0.18) ms, that of wave III was 2.44 (±0.15) ms, and that of wave I was 0.88 (±0.13) ms. …”
Get full text

Medical Students’ Tobacco Consumption Status and Experiences with Smoke-free Law Violations in Enclosed Spaces in Türkiye and Northern Cyprus by Dilek Aslan, Pınar Ay, Kervin Raymond, Özen Aşut, Gulifeiya Abuduxike, Meltem Şengelen, Duygu Çekici, Füsun Yıldız, Emine Ünal Evren, Ali Fuat Kalyoncu, Elif Dağlı

“…Descriptive statistics included frequencies, percentages, means±standard deviations, and medians (interquartile ranges). …”
Get full text

Phenolic and Iridoid Glycosides from <i>Leonurus cardiaca</i> L. and Their Effects on the α, δ, and γ Subtypes of the PPAR System—Including the Discovery of the Novel Phenylethanoi... by Kenny Kuchta, Nobuyasu Matsuura, Tung Huu Nguyen, Christian Rusch, Munekazu Iinuma, Yukihiro Shoyama, Hans Wilhelm Rauwald

“…For the PPARδ experiment, all nineteen isolated constituents and GW0742 (positive control) were added to the medium of transfected COS-1 cells and further processed according to a standardized luciferase assay protocol. Only the major iridoid 7-chloro-6-desoxy-harpagide displayed significant activity in the PPARδ assay at 50 μg/mL, while the result for 100 μg/mL was higher than for the GW0742 positive control. …”
Get full text

Mapping neuro-disabilities and their dimensions among under 5 years of age children in the southern agricultural corridor of Tanzania: a preliminary baseline survey by Peter M. Chilipweli, Namanya Basinda, Paul Alikado Sabuni, Fredy Hyera, Upendojackline Liana, Titus Robert Leeyio, Elias C. Nyanza, Awerasia Vera Ngowi

“…Modified Poisson regression with robust standard errors estimated prevalence ratios (PRs) and their 95% confidence intervals (CIs).ResultsThe study included 286 mother–child pairs from four clusters: Ihemi, Kilombero, Ludewa, and Mbarali. …”
Get full text

Machine learning analysis of emerging risk factors for early-onset hypertension in the Tlalpan 2020 cohort by Mireya Martínez-García, Guadalupe O. Gutiérrez-Esparza, Guadalupe O. Gutiérrez-Esparza, Manlio F. Márquez, Manlio F. Márquez, Luis M. Amezcua-Guerra, Enrique Hernández-Lemus, Enrique Hernández-Lemus

“…Data on sociodemographic, lifestyle, anthropometric, clinical, and biochemical variables were collected through standardized questionnaires as well as clinical and laboratory assessments. …”
Get full text

How to Reliably Measure Stroke Volume Index in Pulmonary Arterial Hypertension: A Comparison of Thermodilution, Direct and Indirect Fick, and Cardiac MRI by Andrea Baccelli, Deepa Gopalan, Rachel J. Davies, Gulammehdi Haji, Wendy Gin-Sing, Luke S. Howard, Francesco Lo Giudice

“…The direct Fick (DF) method represents the gold standard for measuring it. Indirect Fick (IF) and thermodilution (TD) are simpler and widely used alternatives. …”
Get full text

Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…More than half of patients have metastases detected at diagnosis, and high-risk disease is associated with five-year survival rates of only 50–60 %. Standard therapy involves highly toxic chemotherapy, surgery, radiation, and immunotherapy, and less toxic, more specific targeted therapies are urgently needed. …”
Get full text

Effect of Plant Extract on Vase Life in Gerbera var. Pre Intenzz by B. V. Vinithbabu, S. P. Preetham, B. C. Patil, M. P. Naveen, J. S. Hiremath, G. Kirankumar, A. Prashantha

“…Among the effect of plant extract on gerbera flowers held in vase solution containing 8-HQS @ 0.8% (Standard check) recorded the longest vase life (11.54 days), cumulative uptake of vase solution (CUV) of 31.72 g days-1, cumulative transpiration loss of vase solution (CTL) of 40.86 g days-1, minimum microbial load 2.92 cfu×10-5 which was on par with Ocimum sanctum @ 5.0% recorded the longest vase life (11.00 days), CUV of 30.82 g days-1, CTL of 39.66 g days-1, minimum microbial load 3.15 cfu×10-5. …”
Get full text

Structured lactation support for mothers of very low birthweight preterm infants and establishment of human donor milk banks in German NICUs (Neo-MILK): protocol for a hybrid type... by Angela Kribs, Nicole Ernstmann, Nadine Scholten, Martin Hellmich, Antje Hammer, Eva Mildenberger, Andreas Müller, Dirk Horenkamp-Sonntag, Juliane Köberlein-Neu, Tim Ohnhäuser, Katja Matthias, Jens Ulrich Rüffer, Nicola Gabriela Dymek, Julia Jaschke, Anna Katharina Stirner, Isabella Schwab, Daniel Wiesen, Till Dresbach, Friederike Eyssel, Katharina Lugani, Anne Sunder-Plaßmann, Melanie Klein, Christoph Rupprecht

“…VLBW infants and their mothers will receive either standard care or the Neo-MILK intervention according to the NICU’s group status. …”
Get full text

Assessment of the Heterotrophic Bacterial Contamination in Waterlines of Dental Units as a Potential Health Risk Factor in Occupational and Patient’s Exposures by Ali Shahryari, Amineh Zahed, Abdolhalim Rajabi, Maryam Shafipour, Niloufar Emrani, Hadi Rahimzadeh, Hamidreza Heidari

“…The data were analyzed using the Kruskal-Wallis and Wilcoxon signedrank tests using SPSS version 23.Results: The mean and standard deviation of bacterial contamination across all studied departments were significantly higher than the recommended limit of 500 CFU/ml (ranging from 10,250.00±8,924.28 CFU/ml for the inlet to the water tank in the pediatric department to 275,625.00±41,520.86 CFU/ml for the air-water syringe before flushing in the surgery department). …”
Get full text

Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Results In the tDCS study, of 141 participants (102 [72.3%] women; mean age 35.7 years, standard deviation 12.7), 95 completed the trial. Mean changes in the total accuracy scores from baseline to week 6 were compared across the three groups using an F-test. …”
Get full text

Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general popu... by Keita Suzuki, Hiromasa Tsujiguchi, Akinori Hara, Yumie Takeshita, Hisanori Goto, Yujiro Nakano, Reina Yamamoto, Hiroaki Takayama, Atsushi Tajima, Tatsuya Yamashita, Masao Honda, Hiroyuki Nakamura, Toshinari Takamura

“…Higher LECT2 levels positively correlated with homeostatic model assessment for insulin resistance (HOMA‐IR) values and negatively correlated with the quantitative insulin sensitivity check index (QUICKI) among all participants (HOMA‐IR; non‐standardized β (B) = 6.38, P < 0.01: QUICKI; B = −161, P < 0.01). …”
Get full text

Prevalence of piriformis syndrome and its associated risk factors among university students in Pakistan: a cross-sectional study by Hassan N Moafa, Nusrat Batool, Naila Azam, Azka Hafeez, Humaira Mehmood, Nimbal Imtiaz, Waqas A Shehzad, Asaad Saleem Malik, Ajiad Alhazmi, Manal Almalki, Almutasim B Moafa, Jobran M Moshi

“…Secondary outcome measures included the severity of PS.Results Of the total, 119 (62.6%) were female, 114 (60.0%) were between 22 and 25 years old, and 125 (65.8%) had standard body mass index. The prevalence of PS was (61.1%), whereas half suffered from severe PS, and the remaining half had mild and moderate PS. …”
Get full text

The safety and effectiveness of tDCS for epileptic patients: A systematic review and meta-analysis by Xiao-Tong Ding, Ming-Yu Hu, Chi Wang, Wei-Ye Kang, Jin-Zhao Huang, Rui-Yu Wang, Qiu-Song Shen, Hou-Ming Kan

“…Future studies should be standardized and personalized, ensure higher methodological rigor, and probe long-term effects to prove the findings further.…”
Get full text

Ellagic Acid from <i>Geranium thunbergii</i> and Antimalarial Activity of Korean Medicinal Plants by Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin-Hee Han

“…This study investigates the antimalarial potential of extracts and compounds from various plants used in traditional Korean medicine, in response to the increasing resistance of <i>Plasmodium falciparum</i> to standard treatments such as chloroquine and artemisinin. …”
Get full text

Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…Due to the limitations of microscopy as a perfect reference method, a latent class analysis (LCA) and composite reference standard (CRS) approach was used to determine the sensitivity and specificity of each test. …”
Get full text