TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis by Philippe Zizzari, Ashley Castellanos-Jankiewicz, Selma Yagoub, Vincent Simon, Samantha Clark, Marlene Maître, Nathalie Dupuy, Thierry Leste-Lasserre, Delphine Gonzales, Kristina Schoonjans, Valérie S. Fénelon, Daniela Cota

“…Results: Our findings reveal that TGR5 in SF1 neurons does not play a major role in the regulation of food intake or body weight under standard chow, but it is involved in the adaptive feeding response to the acute exposure to cold or to a hypercaloric, high-fat diet, without changes in energy expenditure. …”
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Application of PDCA cycle to reduce the incidence of hemolysis in venous blood specimen (运用PDCA循环降低静脉血标本溶血率) by SHU Baozhen (舒宝珍), YU Lei (于蕾), LYU Jing (吕晶), CHEN Baili (陈百丽), XING Yumei (邢玉梅), ZHOU Jie (周洁), XU Jingjin (徐京巾)

“…Methods The PDCA cycle method was used to implement the standardized procedure of venous blood sampling, and the hemolysis rate of venous blood samples from inpatients and outpatients in the same period of 2020 and 2021 was compared and analyzed. …”
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A machine learning-based model to predict POD24 in follicular lymphoma: a study by the Chinese workshop on follicular lymphoma by Jie Zha, Qinwei Chen, Wei Zhang, Hongmei Jing, Jingjing Ye, Huanhuan Liu, Haifeng Yu, Shuhua Yi, Caixia Li, Zhong Zheng, Wei Xu, Zhifeng Li, Zhijuan Lin, Lingyan Ping, Xiaohua He, Liling Zhang, Ying Xie, Feili Chen, Xiuhua Sun, Liping Su, Huilai Zhang, Haiyan Yang, Weili Zhao, Lugui Qiu, Zhiming Li, Yuqin Song, Bing Xu

“…Key predictors of POD24 included lymphocyte-to-monocyte ratio (LMR), lactate dehydrogenase (LDH) > ULN, low hemoglobin (Hb), elevated beta-2 microglobulin (β2-MG), maximum standardized uptake value (SUVmax), and lymph node involvement. …”
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The importance of stem cells in the treatment of type 1 diabetes, type 2 diabetes and diabetes complications by Monika Kamińska, Maria Jasiewicz, Magdalena Miernik-Skrzypczak, Aleksandra Spyra, Marta Malicka, Natalia Dąbrowska, Aleksandra Kozioł, Katarzyna Moczyróg

“…While initial results are encouraging, further large-scale studies are needed to optimize protocols, assess long-term safety, and establish standardized clinical applications. …”
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Complex approach to the prevention and treatment of progressive myopia in school children by Tarutta E.P, Iomdina E.N, Tarasova N.A., Markosyan G.A., Maksimova M.V.

“…Modern approaches and the basic standards of complex treatment are reflected in the Federal recommendations «Clinical recommendation. …”
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Patient‐derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways by Katharina Bischof, Andrea Cremaschi, Lena Eroukhmanoff, Johannes Landskron, Lise‐Lotte Flage‐Larsen, Alexandra Gade, Line Bjørge, Alfonso Urbanucci, Kjetil Taskén

“…We show that the addition of AAFs to the culture media of EOC cell lines has the potential to induce resistance to standard‐of‐care drugs (SCDs). We also show that AAFs induce time‐ and concentration‐dependent activation of downstream signalling to signal transducer and activator of transcription 3 (STAT3), and concomitantly altered phosphorylation of mitogen‐activated protein kinase kinase (MEK), phosphoinositide 3‐kinase (PI3K)–protein kinase B (AKT) and nuclear factor NF‐kappa‐B (NFκB). …”
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Numerical Simulation of Surface Energy and Water Balances over a Semiarid Grassland Ecosystem in the West African Savanna by Emmanuel Quansah, Genki Katata, Matthias Mauder, Thompson Annor, Leonard K. Amekudzi, Jan Bliefernicht, Dominikus Heinzeller, Ahmed A. Balogun, Harald Kunstmann

“…The performance measure in terms of the correlation coefficient (R), centred root mean square error (RMSE), and normalized standard deviation (σ) between the simulated H and LE and their corresponding uncorrected observed values ranged between R = 0.63–0.99 and 0.83–0.94, RMSE = 0.88–1.25 and 0.88–1.92, and σ = 0.95–2.23 and 0.13–2.82 for the dry and rainy periods respectively, indicating a moderate to good model performance. …”
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The impact of the COVID-19 pandemic on HIV testing in Peru: an interrupted time series analysis from 2014 to 2022 by Robinson A. Yrene-Cubas, Jesus Perez-Castilla, Daniel E. Reynaga-Cottle, Maria José Bringas, David R. Soriano-Moreno, Daniel Fernandez-Guzman, Jose A. Gonzales-Zamora

“…Statistical analysis involved segmented regression with Newey-West standard errors, dividing each year of evaluation into four quarters. …”
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Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers by Yuki Ishikawa, Tatsuki Sugio, Kiko Shiga, Keisuke Izumi, Kazumichi Minato, Momoko Kitazawa, Sayaka Hanashiro, Ryo Takemura, Hiroyuki Uchida, Taishiro Kishimoto

“…Logistic regression analysis revealed a negative correlation between age and both PHQ-9 and PSS-10 scores (OR=0.525, 0.646). The mean and standard deviation of skin temperature showed a positive association with depressive symptoms (OR=1.687, 1.733), while normalized EDASymp showed a negative association (OR=0.564). …”
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Nutrient Formulation—A Sustainable Approach to Combat PRSV and Enhance Productivity in Papaya by Kavitha Chinnasamy, Naveen Kumar Krishnan, Moganapathi Balasubramaniam, Reena Balamurugan, Pugalendhi Lakshmanan, Kalarani M. Karuppasami, Manoranjitham S. Karuppannan, Elaiyabharathi Thiyagarajan, Senthil Alagarswamy, Saraladevi Muthusamy

“…Experiments were conducted to standardize the application time and evaluate the efficacy of nutrient formulation in enhancing yield, and to combat papaya ring spot virus (PRSV) incidence in papaya from January 2021 to December 2023 at Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, India. …”
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Evaluating the use of Uromune® autovaccine in recurrent urinary tract infections: a pilot unicenter retrospective study in Reus, Spain by Simona Iftimie, Paula Ladero-Palacio, Ana F. López-Azcona, Laia Pujol-Galarza, Antoni Pont-Salvadó, Xavier Gabaldó-Barrios, Jorge Joven, Jordi Camps, Antoni Castro, Mercè Pascual-Queralt

“…These findings suggest that Uromune® may be a promising option for managing recurrent UTIs, though controlled studies are needed to confirm its efficacy compared to standard treatments.…”
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Parent-implemented early intervention design for improving speech and language skills among Mandarin-speaking infants and toddlers with cleft lip and/or palate by Sha Lai, Li Lu, Zhongliang Zhou, Chi Shen, Binting Yang, Binting Yang, Zhanping Ren, Zhanping Ren, Siwei Ma, Siwei Ma, Siwei Ma

“…A parent-implemented early intervention was developed, including the following specific steps: health education within the hospital, 9 days of an online reading program in WeChat groups, face-to-face standardized training workshops, and individualized video feedback therapy.ConclusionWe have devised a parent-implemented early intervention to enhance speech and language abilities in Mandarin-speaking infants and toddlers with CL/P, overcoming the shortage of speech therapy services in China.…”
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Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of <i>Lactobacillus</i> Fermentation Broth in Treating Vulvovaginal Candidiasis by Huann-Cheng Horng, Jin-Wei Xu, Yi-Shan Kuo, Yu-Sin Chen, Yu-Hsuan Chiu, Kuan-Hao Tsui, Yu-Tang Tung

“…By promoting a healthy vaginal microbiome, reducing inflammation, and maintaining tissue health, this probiotic-based approach presents a novel strategy for addressing VVC, particularly in cases of drug resistance or adverse reactions to standard therapies. This study underscores the potential of microbiome-modulating strategies in managing vaginal infections, paving the way for more targeted and side-effect-free VVC treatments.…”
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Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease by Haniye Ghasiyari, Mohammad Rostami-Nejad, Davar Amani, Kamran Rostami, Mohamad Amin Pourhoseingholi, Hamid Asadzadeh-Aghdaei, Mohammad Reza Zali

“…Total RNA was isolated using a standard commercial kit. The mRNA expression of TLRs was quantified by relative qPCR with β2 microglobulin (β2m) as a reference gene. …”
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Effect of the High-FODMAP Diet on Bowel Preparation for Colonoscopy: A Multicenter, Prospective Cohort Study by Peng Cheng, Ruijun Ma, Shuling Wang, Jun Fang, Zhengrong Zhong, Yu Bai, Xiangjun Meng, Zhaoshen Li

“…We recommend the consumption of nonhigh-FODMAP diet in bowel preparation as a reference standard for dietary regimen. This method was effective, flexible, referable, and well tolerated, which could help to provide patients a valuable dietary guidance in bowel preparation.…”
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Estimation of genetic parameters for reproductive traits in Korean dairy cattle by Jae-Gu Lee, Jeongwoo Seo, Mahboob Alam, Hyungjun Song, Seokhyun Lee, Joohyeon Cho, Chang-Gwon Dang, Joonho Lee

“…Methods Utilizing data from 7,596 farms and over seven million observations, we conducted quality control to rectify manual entry errors and selected traits in line with international genetic evaluation standards. Traits analyzed included heifer conception rate (HCR), interval from calving to first insemination (CF), cow conception rate (CCR), interval from first to last insemination (FL), and days open (DO). …”
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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…Sleep quality and safety will also be assessed.Ethics and dissemination The protocol for this study was approved by the Ethics Committee of Chinese PLA General Hospital (reference number S2020-337-01) and was reported according to the Standard Protocol Items: Recommendations for Interventional Trials statement. …”
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Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability by Maja Sviben, Ilijana Odak, Danijela Barić, Milena Mlakić, Ottó Horváth, Lajos Fodor, Sunčica Roca, Ivana Šagud, Irena Škorić

“…Both were much more active than the standard inhibitor galantamine against BChE. Molecular docking of the most promising inhibitor candidates, compounds <b>1</b> and <b>7</b>, revealed that stabilizing interactions between the active site residues of BChE and the ligands involve π-stacking, alkyl-π interactions, and, when the carbamate orientation allows, H-bond formation. …”
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Preparation of Chitosan Coating Loaded with Cinnamaldehyde-Tannic Acid Nano-emulsion and Its Effect on the Preservation of Chilled Meat by Xingqun DENG, Juan YOU, Ru LIU, Jirawat YONGSAWADIGUL, Tao YIN, Hong YANG

“…After 9 days of storage, the TVB-N and total bacterial count of the blank group of chilled pork were 15.07 mg/100 g and 6.36 lg CFU/g, respectively, exceeding the limit values in the Chinese National Standard (15 mg/100 g and 6 lg CFU/g). However, after 12 days of storage, the TVB-N and total bacterial count of the CS/CIN-TAs group were still lower than the limit values. …”
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A Preliminary Study to Evaluate Recovery in Environmental Microplastic Analysis by İrem Öztürk, Dilara Cinci, Fatma Nur Eraslan, Mansoor Ahmad Bhat, Eftade O. Gaga, Kadir Gedik

“…In studies focusing on the occurrence, levels, and distribution of MPs, there is a need for recovery studies since certified reference materials or standard methods have not yet been established for quality assurance in analyses. …”
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