Development of a core measurement set for research in degenerative cervical myelopathy: a study protocol (AO Spine RECODE-DCM CMS) by Robert Chen, Angus G K McNair, Vafa Rahimi-Movaghar, Julio C Furlan, Benjamin M Davies, Oliver D Mowforth, Iwan Sadler, Bizhan Aarabi, Brian K Kwon, Michael G Fehlings, James S Harrop, Armin Curt, Ellen Sarewitz, Carl Moritz Zipser, Timothy F Boerger, Mark R N Kotter, James Milligan, Lindsay Tetreault, Danyal Khan, Keng Siang Lee, Alvaro Yanez Touzet, Ricardo Rodrigues-Pinto, James D Guest, Sukhvinder Kalsi-Ryan, Shirley Widdop

“…This protocol outlines the steps necessary for the development of a CMS for DCM research and audit.Methods and analysis The CMS will be developed in accordance with the guidance developed by the Core Outcome Measures in Effectiveness Trials and the Consensus-based Standards for the selection of health Measurement Instruments. …”
Get full text

Reducing the uncertainty in the distribution of cm-scale rock properties in the near well-bore region by Seyed Ahmad Mortazavi, Seyed Ahmad Mortazavi, Achyut Mishra, Achyut Mishra, Julie Dickinson, Julie Dickinson, Ralf R. Haese, Ralf R. Haese

“…The analysis suggests that smaller grid cell size (1 m × 1 m × 0.3 m) compared to the typical industry standard (10 m × 10 m × 2 m) significantly improves the representation of cm-scale rock properties. …”
Get full text

A global Corynebacterium diphtheriae genomic framework sheds light on current diphtheria reemergence by Hennart, Mélanie, Crestani, Chiara, Bridel, Sébastien, Armatys, Nathalie, Brémont, Sylvie, Carmi-Leroy, Annick, Landier, Annie, Passet, Virginie, Fonteneau, Laure, Vaux, Sophie, Toubiana, Julie, Badell, Edgar, Brisse, Sylvain

“…Genomic sequencing can inform on transmission routes and genotypes of concern, but currently, no standard approach exists to detect clinically important genomic features and to interpret emergence in the global C. diphtheriae population framework. …”
Get full text

Application of Machine Learning Techniques to Distinguish between Mare, Cryptomare, and Light Plains in Central Lunar South Pole−Aitken Basin by Frank C. Chuang, Matthew D. Richardson, Jennifer L. Whitten, Daniel P. Moriarty, Deborah L. Domingue

“…We apply machine learning techniques to identify and map resurfacing units in the central South Pole−Aitken (SPA) basin using three Lunar Reconnaissance Orbiter (LRO) mission data sets: 321/415 nm and 566/689 nm band reflectance ratios from Hapke photometrically standardized albedo maps and a Terrain Ruggedness Index map using the Wilson et al. method. …”
Get full text

Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer by Manoj Amrutkar, Sander Johannes Thorbjørnsen Guttorm, Anette Vefferstad Finstadsveen, Knut Jørgen Labori, Lars Eide, Helge Rootwelt, Katja Benedikte Prestø Elgstøen, Ivar P. Gladhaug, Caroline S. Verbeke

“…Neoadjuvant chemotherapy (NAT) is increasingly used for the treatment of non‐metastatic pancreatic ductal adenocarcinoma (PDAC) and is established as a standard of care for borderline resectable and locally advanced PDAC. …”
Get full text

Investigating the Effectiveness of Coal-Fired Power Plant Operations: Management, Technical and Air Pollution Aspects by Zamzam T. A. Ramly, Mohd Y. Ishak, Ahmad M. Abdullah, Marzuki Ismail, Samsuri Abdullah, Amalina Abu Mansor

“…The model indicates that verifying the standard operating procedure (SOP) is crucial for improving power generation efficiency and reducing human error (R²=0.914). …”
Get full text

The influence of Federal Regulations and community health indicators on community benefit spending by private nonprofit hospital in some States of the US: A retrospective longitudi... by Wael ELRAYES, David PALM, Fernando WILSON, Hongmei WANG, Jane MEZA, Robin HIGH, Valerie PACINO

“…Federal legislation in 2007 and 2010 established a standard re- porting format that allowed researchers to examine community benefit spending patterns by private nonprofit hospitals, though this continues to be an understudied subject. …”
Get full text

Screening of two efficient phosphorus-solubilizing bacteria, strain X42 (Bacillus_A_bombysepticus) and strain G62 (Bacillus velezensis) for their ability to promote Gan Nan navel o... by Wenyuan Zhao, Tao Peng, Haojie Cao, Huimin Huang, Shuijing Yu

“…Therefore, developing microbial formulations that increase soil fertility while meeting green ecological standards is highly important. Rhizobacteria promote plant growth through various mechanisms, and given the critical role of phosphorus in plant growth and development, the development and application of such microbial agents offer an effective approach to address the aforementioned issues. …”
Get full text

PFAS residue analysis in fish and fish feed by applying a modified QuEChERS method in combination with LC-HRMS detection by Ourania Koloka, Vasiliki Boti, Dimitra Hela, Triantafyllos Albanis, Ioannis Konstantinou

“…The optimized modified extraction procedure for the analysis of PFAS residues in fish feed was fully validated exhibiting recoveries between 51.1 % and 101.2 %, relative standard deviations (RSDs) < 20.7 % and LOQs between 0.03 ng/g and 0.50 ng/g. …”
Get full text

From innovation to clinic: Emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair by Rajiv Borah, Daniel Diez Clarke, Jnanendra Upadhyay, Michael G. Monaghan

“…While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). …”
Get full text

UTE MRI technical developments and applications in osteoporosis: a review by Soo Hyun Shin, Hee Dong Chae, Hee Dong Chae, Arya Suprana, Arya Suprana, Saeed Jerban, Eric Y. Chang, Eric Y. Chang, Lingyan Shi, Robert L. Sah, Jeremy H. Pettus, Gina N. Woods, Jiang Du, Jiang Du, Jiang Du

“…Bone mineral density (BMD) measurement is the current standard in assessing fracture risk; however, the majority of fractures cannot be explained by BMD alone. …”
Get full text

Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…Finally, our results demonstrated that the bioavailability of polyphenols is greater in beer than in the control standards used, supporting the future clinical application of these compounds as potential therapeutic tools in precision and translational medicine.…”
Get full text

The role of renal dual-energy computed tomography in exploring the gouty kidney: the RENODECT study by Tristan Pascart, Elie Dauphin, Chio Yokose, Charlotte Jauffret, Aurore Pacaud, Victor Laurent, Vincent Ducoulombier, Hyon K. Choi, Jean-François Budzik

“…Characteristics of patients with and without DECT-positive lesions were compared, and the DECT parameters of these lesions were measured.Results A total of 27/31 patients with had renal DECT scans and were included in the analysis (23/27 men, mean (standard deviation) 73 (9) years old, mean eGFR 45.3 mL/min/1.73 m2 (21.0), volumes of MSU in the knees and feet ranging from 0.11 to 475.0 cm3). …”
Get full text

Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Our primary outcomes include locomotor activity and prepulse inhibition measured with standardized mean differences. We will examine other behavioural readouts of relevance for psychosis as secondary outcomes, such as social interaction and cognitive function. …”
Get full text

Retinal Nerve Fiber Layer Thickness Progression after Robotic-Assisted Laparoscopic Radical Prostatectomy in Glaucoma Patients by Kazuyuki Hirooka, Kaori Ukegawa, Eri Nitta, Nobufumi Ueda, Yushi Hayashida, Hiromi Hirama, Rikiya Taoka, Yuma Sakura, Mari Yamasaki, Hiroyuki Tsunemori, Mikio Sugimoto, Yoshiaki Kiuchi

“…At 1 month and 1 day before and at 1 and 2 months after the RALP operation, 10 glaucoma patients underwent standard automated perimetry and optical coherence tomography. …”
Get full text

Effects of coenzyme q10 supplementation on metabolic and reproductive outcomes in obese rats by Gisela Belén Sarrible, María Victoria Bazzano, Caterina Koutsovitis, María Guillermina Bilbao, Rodrigo Hernán Da Cuña, Melanie Neira, Julián Alberto Bartolomé, Evelin Mariel Elia

“…Wistar rats were divided into control (standard diet) and obese (CAF diet) groups. After 75 days, half of each group received oral CoQ10 (5 mg/kg) for 13 days, while the rest received a vehicle. …”
Get full text

Carboxylesterase 4A Inhibits the Malignant Biological Behavior of Nasopharyngeal Carcinoma via the PI3K/AKT Pathway by Qiaoli Chen MS, Quanxiang Hao MBBS, Yanping Yang MBBS, Limei Li PhD, Danping Li MS, Ran Zhao MS, Wanqi Wei MBBS, Lixian Deng MBBS, Jiaming Su MBBS, Ziyuan Liang MBBS, Shiyue Tang MS, Yaomin Lu MBBS, Yushan Liang PhD, Zhe Zhang PhD, Xiaoying Zhou PhD, Xue Xiao PhD, Ping Li PhD, Yi Huang PhD, Weilin Zhao PhD

“…Here, we aim to investigate the expression, cellular biological functions, and the potential underlying mechanism of CES4A in nasopharyngeal carcinoma (NPC). Method A standardized mean difference (SMD) analysis was used to analyze the dysregulation of CES4A based on the gene expression omnibus (GEO) database. qRT-PCR and immunohistochemical staining (IHC) were used to identify the mRNA and protein levels of CES4A in NPC cell lines and tissues, respectively. …”
Get full text

Alleviating small sample problem in continuous forest monitoring with remote sensing-assisted Copulas by Xinjie Cheng, Zhengyang Hou, Annika Kangas, Jean-Pierre Renaud, Hao Tang, Weisheng Zeng, Qing Xu

“…However, model-assisted estimation is largely reliant on a sample resulting from costly field surveys to meet the precision standard mandated by these instruments. While a large sample is more likely to represent the population in question and ensure meeting the prescribed precision, it is crucial to reduce costs by finding a balance between precision and sample size. …”
Get full text

Novel combination therapy for platinum-eligible patients with locally advanced or metastatic urothelial carcinoma: a systematic review and network meta-analysis by Takafumi Yanagisawa, Keiichiro Mori, Akihiro Matsukawa, Tatsushi Kawada, Satoshi Katayama, Ekaterina Laukhtina, Pawel Rajwa, Fahad Quhal, Benjamin Pradere, Wataru Fukuokaya, Kosuke Iwatani, Renate Pichler, Jeremy Yuen-Chun Teoh, Marco Moschini, Wojciech Krajewski, Jun Miki, Shahrokh F. Shariat, Takahiro Kimura, European Association of Urology–Young Academic Urologists Urothelial Carcinoma Working Group (EAU-YAU)

“…Thus, EV + pembrolizumab may become a guideline-changing standard treatment.…”
Get full text

Integrated Lung, Diaphragm and Lower Limb Muscular Ultrasound: Clinical Correlations in Geriatric Patients with Acute Respiratory Illness by Nicoletta Cerundolo, Carmine Siniscalchi, Chukwuma Okoye, Simone Scarlata, Alberto Parise, Martina Rendo, Angela Guerra, Tiziana Meschi, Antonio Nouvenne, Andrea Ticinesi

“…Diaphragm excursion, thickness, RVL thickness and CSA were measured following a standardized protocol. Frailty was assessed with the PC-FI (Primary Care-Frailty Index). …”
Get full text