EXtending Omalizumab Treatment Intervals in patients with Chronic spontaneous urticaria (EXOTIC): protocol of a multicentre, randomised, open-label, non-inferiority trial by Alexander Egeberg, Ditte Georgina Zhang, Christian Vestergaard, Simon Francis Thomsen, Jennifer Astrup Sørensen, Misbah Noshela Ghazanfar, Zarqa Ali, Jacob Thyssen

“…The objective of this trial is to investigate if patients with well-controlled CSU, achieved by standard treatment of 300 mg omalizumab administered subcutaneously every 4 weeks (Q4W) for 12 weeks, can maintain disease control with every 6 weeks (Q6W) dosing interval.Methods and analysis Participants who achieve an Urticaria Control Test (UCT) score ≥12 after 12 weeks on omalizumab will be randomised to 300 mg omalizumab treatment Q4W or Q6W. …”
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Horizontal and vertical optic disc rotation. The Beijing Eye Study. by Yuan Yuan Fan, Jost B Jonas, Ya Xing Wang, Chang Xi Chen, Wen Bin Wei

“…In multivariate analysis, larger optic disc rotation around the vertical axis (range:-4.90° to 41.0°) was associated (regression coefficient r:0.27) with high axial myopia (axial length ≥26.5 mm) (P<0.001;standardized regression coefficient beta beta:0.09), longer disc-fovea distance (P = 0.001;beta:0.09) and wider parapapillary beta/gamma zone (P<0.001;beta0.12). …”
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Examining the Impact of MOCK OSCE on Test Anxiety and clinical Performance of First-Term Nursing Students in the OSCE Exam by Masoumeh Fuladvandi, Shirin Ghazi, Masoumeh Abdi, Shahin Salarvand

“…Test anxiety was measured before and after the intervention using the Sarason Test Anxiety Scale, and OSCE performance scores were evaluated with standardized checklists. Data were analyzed with paired t-tests, independent t-tests, and ANOVA using SPSS version 23.Results: The results showed a significant decrease in test anxiety scores within the intervention group before and after the simulated OSCE (p<0.001, R=-0.91). …”
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Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, Helen Heneghan

“…Patients will be randomised 1:1 to receive either bariatric surgery and standard medical care or bariatric surgery and intensive goal-directed medical therapy, titrated to specific targets for glycated haemoglobin (HbA1c), blood pressure (BP) and low-density lipoproteins (LDL) cholesterol. …”
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Investigation of Shock Initiation in Covered Charges under Shock Wave and Fragment Impacts by Xingwang Chen, Jinxiang Wang, Kui Tang, Hongfei Wang, Yuanbo Li

“…Explosive initiation standards coupled with shock wave evolution characteristics were applied to specify the crucial conditions of explosive detonation. …”
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Hepatoprotective Effects of Nasturtium Officinale and Allium Polyanthum Extracts on CCL4- Induced Hepatic Damage In Albino Rats by Shkar Rzgar K.Rostam, Zana Hassan Ibrahim, Rebaz Rebwar Mala, Soran Qadir Abdul

“…The animals were fed with a standard diet and distilled water ad libitum. Except for NC, all other groups were exposed to CCl4 at every 72 hours for 3 weeks to induce hepatic damage. …”
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A comparative study of diagnostic performance of COVID-19 Reporting and Data System and computed tomography severity score in clinically suspected COVID-19 patients by Vikram Kyatham, Yarramsetty Pundari Kashudu, T.R. Nagendra, Rama Rao Piprikar, Rhidaynath A Kogekar, Rahul Bhargava

“…A binomial logistic regression analysis was performed to calculate the sensitivity, specificity, diagnostic accuracy, positive predictive value (PPV), and negative predictive value (NPV) of the two scoring systems in diagnosing COVID infection, considering RT-PCR as the reference standard. Results: A total of 400 cases were evaluated. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Within the first week after a single infusion of Acellbia or MabThera, the level of  CD19 and CD20-positive cells rapidly decreased to almost undetectable values without any obvious recovery by the end of observation (upon intergroup comparison p&gt;0.05 at all specified time points). 90% CI for the geometric mean of a Acellbia/MabThera  AUC0-t ratio fell within standard bioequivalence range 80-125% (80.1-118.2% for the ratio of AUC0-168 after a single dose). …”
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Development of a Robust UPLC Method for Simultaneous Determination of a Novel Combination of Sofosbuvir and Daclatasvir in Human Plasma: Clinical Application to Therapeutic Drug Mo... by Naser F. Al-Tannak, Ahmed Hemdan, Maya S. Eissa

“…A rapid and selective UPLC-DAD method was developed and validated for simultaneous analysis of the novel two-drug combination Darvoni® for the treatment of HCV: Sofosbuvir (SF)/Daclatasvir (DC) in human plasma using Ledipasvir as internal standard (IS) where the extraction process was conducted using automated SPE. …”
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Kiwifruit and Kiwifruit Extracts for Treatment of Constipation: A Systematic Review and Meta-Analysis by Mohamed Eltorki, Russell Leong, Elyanne M. Ratcliffe

“…Eligible studies enrolled participants with constipation who were randomized to receive kiwifruit or kiwifruit extracts vs. any nonkiwifruit control. Standardized mean difference (SMD) and mean difference (MD) with confidence intervals (CI) were determined for the following outcomes: frequency of spontaneous bowel movements (SBM), abdominal pain and straining, as well as stool type as determined by the Bristol Stool Scale (BSS). …”
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Assessment of fluoride bio-accessibility in early childhood diets by Jelena Kronic, Ralph M. Duckworth, Claudio Angione, Steven M. Levy, Fatemeh Vida Zohoori

“…This study aimed to measure fluoride bio-accessibility of the dietary sources commonly consumed by children below four years of age.MethodsA total of 103 food and meal samples were purchased, prepared, and analyzed for fluoride content, subjected to a standardized static in vitro digestion procedure and subsequent determination of fluoride concentration of resultant mixtures necessary for the final fluoride bio-accessibility calculation. …”
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Seizures Following Carotid Endarterectomy: A Comprehensive Meta-Analysis of 69,479 Patients and Evidence-Based Recommendations for Perioperative Care by Kruthajn Rajesh, Helen Shen, Sonu M. M. Bhaskar

“…Future research should focus on long-term outcomes, including epilepsy, and incorporate standardized methodologies to improve data reliability and guide clinical practice.…”
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RETRACTED: The role of biofield energy treatment on psychological symptoms, mental health disorders, and stress‐related quality of life in adult subjects: A randomized controlled c... by Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal, Snehasis Jana

“…Subjects were assessed psychological questionnaire scoring using standard scale of assessment and levels of physiological biomarkers in serum were determined by parameter‐specific ELISA. …”
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A Pilot Study on the Freelisting Method Among Adolescents with Chronic Musculoskeletal Pain: Feasibility, Acceptability and Study Findings by Sabrina Gmuca, Dori Abel, Mackenzie McGill, Daneka Stryker, Eda Akpek, Whitney Eriksen, Pamela F. Weiss, Peter F. Cronholm

“…Feasibility was pre-defined as ≥85% completion. A list of ‘standardized’ freelisting terms was created, and we calculated Smith’s salience index. …”
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Protection of liver sinusoidal endothelial cells using different preservation solutions by Julia H E Houtzager, Anne-Marieke van Stalborch, Charlotte Hofstee, Thomas M van Gulik, Jaap D van Buul

“…Human umbilical vein endothelial cells (HUVECs) and LSECs were incubated in either University of Wisconsin machine perfusion solution (UW-MPS), histidine-tryptophan-ketoglutarate, or endothelial cell growth medium 2 (EGM2) (as a gold standard for cell culturing). Endothelial integrity was assessed by measurement of cellular morphology and expression of membrane proteins: PECAM-1, ICAM-1 and Fc-gamma receptor CD32b (FcΥRCD32b). …”
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Efficient Beach Litter Monitoring: Accelerated Surveys of Pollution Hotspots—A North African Case Study by Emna Ben Slimane, Mirco Haseler, Lilia Ben Abdallah, Fadhel Mhiri, Abdallah Nassour, Gerald Schernewski

“…This method significantly reduces survey time compared to the standard 100 m approach while maintaining comparable pollution metrics, offering a practical and efficient solution for areas with high litter density. …”
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An Evaluation of the Antibacterial Properties of Tormentic Acid Congener and Extracts From Callistemon viminalis on Selected ESKAPE Pathogens and Effects on Biofilm Formation by Tafadzwa Chipenzi, Genuine Baloyi, Tatenda Mudondo, Simbarashe Sithole, Godloves Fru Chi, Stanley Mukanganyama

“…The antibacterial effects were determined by the microbroth dilution method, and ciprofloxacin was used as the standard antibacterial drug. Biofilm formation and detachment assays were performed using crystal violet staining. …”
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Three-dimensional conformal radiation therapy for the osteoarthritis of knee joint: the radiobiological background, dose distribution analysis by М. V. Маkаrоvа, M. Yu. Vаlkov, D. Yu. Tretjakov

“…Osteoarthritis (OA) is the most frequent rheumatological pathology of the joints. Standard medical treatment does not always allow to stop the pain syndrome. …”
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Cost-effectiveness of the Floodlight MS app in Austria. Unlocking the mystery of costs and outcomes of a digital health application for patients with multiple sclerosis by Evelyn Walter, Matthäus Traunfellner, Franz Meyer, Christian Enzinger, Michael Guger, Christian Bsteh, Patrick Altmann, Harald Hegen, Christoph Goger, Veronika Mikl

“…This study assesses the cost-effectiveness of using the Floodlight ® MS app alongside standard-of-care (SoC) versus SoC alone in patients with relapsing-remitting MS (RRMS) from the perspective of the healthcare system. …”
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Investigation of Bacteriological Quality of Meat from Abattoir and Butcher Shops in Bishoftu, Central Ethiopia by Abebe Bersisa, Dereje Tulu, Chaluma Negera

“…The study showed that the hygienic status of the abattoir and butcher shops in the study area is poor, and the obtained results of bacterial load are higher than the acceptable limit of the standard. Therefore, the necessary strategies towards hygiene and sanitation of meat in the town should be implemented.…”
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