A Low-Cost Layered Double Hydroxide (LDH) Based Amperometric Sensor for the Detection of Isoproturon in Water Using Carbon Paste Modified Electrode by Herve Leclerc Tcheumi, Aude Peggy Kameni Wendji, Ignas Kenfack Tonle, Emmanuel Ngameni

“…After optimization, a linear calibration curve was obtained in the concentration range from 2 × 10−8 to 1.8 × 10−7 M, leading to a detection limit of 1 × 10−9 M (S/N = 3). The relative standard deviation for 5 identical measurements was 2.7%. …”
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DeepRetention: A Deep Learning Approach for Intron Retention Detection by Zhenpeng Wu, Jiantao Zheng, Jiashu Liu, Cuixiang Lin, Hong-Dong Li

“…Due to the lack of a gold standard dataset of IR, we first compare DeepRetention with two state-of-the-art methods, i.e. iREAD and IRFinder, on simulated RNA-seq datasets with retained introns. …”
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Study protocol of the METAPANC trial - intensified treatment in patients with local operable but oligometastatic pancreatic cancer - multimodal surgical treatment versus chemothera... by Michael Ghadimi, Uwe Pelzer, Marc G. Besselink, Jens Siveke, Ralph Telgmann, Rickmer Braren, Hanneke Wilmink, Marie Crede, Alexander Koenig, Ute Koenig, Sven Thorsten Liffers, Kai Antweiler, Bas Uijterwijk, Hanna Seppanen, Arno Nordin, Pauli Puolakkainen, Olav F. Dajani, Knut Jørgen Labori, Mia Johansson, Svein Olav Bratlie, Tim Friede, Peter Jo

“…Methods After an induction therapy with eight cyles of mFOLFIRINOX and a response assessment after four and eight cycles, patients will be randomized to either Arm 1 (perioperative mFOFIRINOX plus resection of the primary tumor with resection or ablation of all hepatic metastases) or Arm 2 (continuation of 4 cycles of the standard-of-care mFOLFIRINOX chemotherapy). This clinical trial will focus on a well-defined patient group with metastatic disease limited to the liver as the target organ, with a maximum of three metastases. …”
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Research on Innovative Apple Grading Technology Driven by Intelligent Vision and Machine Learning by Bo Han, Jingjing Zhang, Rolla Almodfer, Yingchao Wang, Wei Sun, Tao Bai, Luan Dong, Wenjing Hou

“…The proposed stem detection and apple body classification models provide innovative solutions for detection and classification tasks in automated fruit grading, offering a comprehensive and replicable research framework for standardizing image processing and feature extraction for apples and similar spherical fruit bodies.…”
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Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney... by Tazeen Hasan Jafar, Ngiap Chuan Tan, Mihir Gandhi, Sungwon Yoon, Eric Finkelstein, Peter Moey Kirm Seng, Ruiheng Ong, Anandan Gerard Thiagarajah, Bing Long Lee, Ka Chi To, Aminath Shiwaza Moosa

“…The components of the MCI are (1) nurses/service coordinators trained as health coaches for motivational conversation and CKD-specific lifestyle counseling on diet and exercise, using a hybrid follow-up approach of in-person, telephone, and secure video meetings; (2) training physicians in algorithm-based standardized management of CKD; (3) subsidy on SGLT2i medications for CKD; and (4) regular CKD case review meetings. …”
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Robot-assisted upper limb therapy for personalized rehabilitation in children with cerebral palsy: a systematic review by Daniela Cardone, David Perpetuini, Marta Di Nicola, Arcangelo Merla, Giovanni Morone, Giovanni Morone, Irene Ciancarelli, Antimo Moretti, Antimo Moretti, Francesca Gimigliano, Francesca Gimigliano, Alice Cichelli, Francesco De Flaviis, Alex Martino Cinnera, Teresa Paolucci

“…However, the limited sample size and lack of standardized and clearly reproducible protocols impose to recommend the use of robot-assisted therapy as an integration to usual rehabilitation and not as a replacement.Systematic review registrationhttps://osf.io/a78zb/.…”
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Reduction in thermal plasticity of life history traits in response to cold selection: an experimental evolution study using Drosophila melanogaster by Rishav Roy, Rishav Roy, Aradhya Chattopadhyay, Sreebes Deb Sharma, Aharna Mondal, Payel Biswas, Payel Biswas, Shampa M. Ghosh

“…We report an experimental evolution study that examined how prolonged selection at cold vs. warm temperature impacts the thermal plasticity of traits like reproductive output, body size, and body water content in Drosophila melanogaster.MethodsWe conducted the study on two sets of large, outbred fly populations: one maintained at the standard fly rearing temperature, i.e., 25°C, and another selected at cold temperature, i.e., 17°C, for 3.5 years. …”
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Proactive Maintenance and Data-Driven Optimization of Mineral Lubricating Oil in a Gas Engine Cogeneration System Extending Oil Change Intervals for Cost Savings and a Reduced Envi... by Krzysztof Pytel, Roman Filipek, Adam Kalwar, Małgorzata Piaskowska-Silarska, Wiktor Hudy, Jana Depešová, Franciszek Kurdziel

“…The findings revealed that oil change intervals could be extended by an average of 37% compared to standard schedules, thereby minimizing unnecessary maintenance downtimes, enhancing system availability, and increasing electrical and thermal energy output. …”
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Pathogenic and Genetic Characteristics of Helicobacter Pylori, and its Relationship with Drug-Resistance by Nilgün Uyduran Ünal, Adnan Barutçu, Toğrul Nagiyev, Mehmet Ağın, Tülay Kandemir, Oğuz Üsküdar, Figen Doran, Fatih Köksal, Gökhan Tümgör

“…High resistance was found against clarithromycin in the standard triple therapy regimen used in children for treating H. pylori infection.…”
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CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…BackgroundAngiogenesis is closely associated with tumor growth and metastasis, and microvascular density (MVD) is currently the clinical standard for evaluating tumor angiogenesis. Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.MethodsTumor tissue sections of 238 patients with lung adenocarcinoma (LUAD) who underwent radical surgery were retrospectively analyzed. …”
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The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study by Daniel Woo, Richard Thompson, Carl D Langefeld, Nichol McBee, Daniel Hanley, Matthew L Flaherty, Lauren Sansing, Karen Lane, Lee A Gilkerson, Achala Vagal, Nathan Walborn, Wendy Ziai, Noeleen Ostapkovich, Kevin Triene, Timothy David Howard

“…The second strategy is the current non-surgical standard of care using data from controls in MISTIE III and ENRICH and comparative data from The Ethnic/Racial Variations of ICH (ERICH) studyextended into the ERICH-Longitudinal study, which followed over 900 of ERICH cases with serial cognitive examinations. …”
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Perioperative hypothermia prevention: development of simple principles and practice recommendations using a multidisciplinary consensus-based approach by Fiona M Wood, Nicholas Ralph, Jed Duff, Judy Munday, David Sturgess, Mary-Anne Ramis

“…Objectives To develop a consensus on evidence-based principles and recommendations for perioperative hypothermia prevention in the Australian context.Design This study was informed by CAN-IMPLEMENT using the ADAPTE process: (1) formation of a multidisciplinary development team; (2) systematic search process identifying existing guidance for perioperative hypothermia prevention; (3) appraisal using the AGREE II Rigor of Development domain; (4) extraction of recommendations from guidelines meeting a quality threshold using the AGREE-REX tool; (5) review of draft principles and recommendations by multidisciplinary clinicians nationally and (6) subsequent round of discussion, drafting, reflection and revision by the original panel member team.Setting Australian perioperative departments.Participants Registered nurses, anaesthetists, surgeons and anaesthetic allied health practitioners.Results A total of 23 papers (12 guidelines, 6 evidence summaries, 3 standards, 1 best practice sheet and 1 evidence-based bundle) formed the evidence base. …”
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Evaluating food contact surface and its influence on restaurant health ratings by Saeid Fallahizadeh, Majid Majlesi, Mohammad Reza Ghalehgolab, Mohammad Hassan Sadeghi, Mohammad Reza Zarei, Alireza R. Raygan Shirazi

“…Based on these findings, training restaurant staff in personal health, food safety, and regular hygiene practices, along with routine inspections based on guidelines from inspectors, will improve restaurant health standards and help reduce foodborne illnesses.…”
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Evaluation of mental disorder related to colposcopy procedure during the COVID period: A cross-sectional study by Ilaria Bochicchio, Martina Catalano, Giovanni Deiana, Giandomenico Roviello, Pasquale Marino, Fabrizia Calenda, Alessandro R Lettini, Francesca Sanseverino

“…Descriptive statistics, including means, standard deviations, and frequency distributions, were calculated for each psychological variable within each time period. …”
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Small Intestinal Bacterial Overgrowth in Various Specialties of Medical Practice (Literature Review and Expert Council Resolution) by V. T. Ivashkin, V. V. Fomin, O. N. Tkacheva, O. S. Medvedev, E. A. Poluektova, D. I. Abdulganieva, S. R. Abdulkhakov, O. P. Alexeeva, S. A. Alekseenko, D. N. Andreev, A. Yu. Baranovsky, M. S. Zharkova, O. Yu. Zolnikova, K. V. Ivashkin, I. L. Kliaritskaia, N. V. Korochanskaya, S. N. Mammaev, R. V. Maslennikov, R. G. Myazin, M. V. Perekalina, A. V. Povtoreyko, A. I. Ulyanin, M. V. Fadeeva, I. B. Khlynov, V. V. Tsukanov, O. S. Shifrin

“…Today, in many regions of the Russian Federation, there are limitations for instrumental diagnosis of this disease — lack of awareness among doctors, unavailability of gas analyzers for diagnosing SIBO, lack of information about the need to diagnose SIBO in the standards of compulsory health insurance. Rifaximin is the first-line treatment due to the highest therapeutic efficacy. …”
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Diagnosis and treatment of arterial stiffness, pulmonary hypertension, diastolic cardiac dysfunction against the background of ischaemic heart disease in comorbid patients by Nadezhda N. Pribylova, Kristina O. Leonidova, Vladislav S. Pribylov, Evgeny A. Shabanov, Sergey A. Pribylov, Nikita V. Novikov

“…The study found that the addition of the combined antihypertensive drug amlodipine-perindopril to standard therapy contributed to normalization of AS, PH and BP during three months of treatment. …”
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Semiautomatic volumetry of the temporal lobes of the brain and correlation with electroencephalography results in dogs with assumed idiopathic epilepsy by Paulina Kinga Drobot, Aleksandra Banasik, Karolina Owsińska‐Schmidt, Marcin Wrzosek, Przemysław Podgórski

“…Abstract Background Lesions causing refractory epilepsy, often associated with temporal lobe epilepsy (TLE), can be undetectable on standard magnetic resonance imaging (MRI) in dogs. …”
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Effects of Flash Glucose Monitoring on Dietary Variety, Physical Activity, and Self-Care Behaviors in Patients with Diabetes by Satoshi Ida, Ryutaro Kaneko, Kanako Imataka, Kaoru Okubo, Yoshitaka Shirakura, Kentaro Azuma, Ryoko Hujiwara, Hiroka Takahashi, Kazuya Murata

“…Results showed that standard deviation and mean amplitude of glycemic excursions significantly decreased in patients with type 1 diabetes mellitus (from 71.2 (20.4) to 66.2 (17.5), P=0.033 and from 124.6 (31.9) to 108.1 (28.4), P<0.001, respectively). …”
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Recommendations for the primary prevention of atherosclerotic cardiovascular disease in primary care: a systematic guideline review by Maren Bredehorst, Ana I. González-González, Lara Schürmann, Dennis Firmansyah, Christiane Muth, Jörg Haasenritter, Veronika van der Wardt, Svetlana Puzhko

“…The recommendations also highlighted the importance of adhering to a Mediterranean-type diet, patient-centered counseling, and standardized risk assessment for patients over the age of 40.DiscussionThis review underscores the heterogeneity in primary ASCVD prevention recommendations and the importance of personalized strategies for at-risk individuals.Systematic review registrationPROSPERO, CRD42023394605, available from: https://www.crd.york.ac.uk/prospero/display_record.php?…”
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Peruvian medical residency selection: a portrayal of scores, distribution, and predictors of 28,872 applicants between 2019 and 2023 by Javier A. Flores-Cohaila, Brayan Miranda-Chavez, Cesar Copaja-Corzo, Xiomara C. Benavente-Chalco, Wagner Rios-García, Vanessa P. Moreno-Ccama, Angel Samanez-Obeso, Marco Rivarola-Hidalgo

“…The mean ENARM score was 11.69, with a pass rate of 61.6% if a standard setting was set at 11. The highest scores were seen in those who achieved scores above 13 in the ENAM and received honors in medical school, while the lowest in those who applied in the captive modality and did not take the ENAM. …”
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