Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals by J Sardell, S Das, K Taylor, C Stubberfield, A Malinowski, M Strivens, S Gardner

“…We then identify combinations of SNP-genotypes significantly associated with reduced disease prevalence in these high-risk protected cohorts.We discuss how actively protective combinatorial analysis generates novel insights into the genetic drivers of established disease biology and detects gene-disease associations missed by standard statistical approaches such as meta-GWAS. …”
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Segmentation of tobacco shred point cloud and 3-D measurement based on improved PointNet++ network with DTC algorithm by Yihang Wang, Haiwei Zheng, Jie Yang, Yan Wang, Li Wang, Qunfeng Niu, Qunfeng Niu

“…Meanwhile, this study also proposes a dimension transformation calculation method for calculating the three dimensions of tobacco shred.ResultsThe experimental results show that the precision and recall of the improved segmentation model increased from 84.27% and 83.63% to 95.13% and 97.68%, respectively; the relative errors of the length and width of tobacco shred were less than 5% and 7%, and the relative error of the standard gauge block thickness measurement reached 1.12%.DiscussionThis study also provides a new idea for implementing three-dimensional measurements of other flexible materials.…”
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Is Everyone Beating Around the Bush?: A Qualitative Study Examining the Status of Shared Decision-Making Between Veterans Affairs Providers and Surgical Patients in the ICU by M. Andrew Millis, MD, MPH, C. Ann Vitous, MA, MPH, Cara Ferguson, BS, Maedeh Marzoughi, BS, Erin Kim, BS, Sarah E. Bradley, PhD, MPH, CPH, Ashley Duby, MS, Pasithorn A. Suwanabol, MD, MS

“…Background:. SDM is the gold standard for decision-making in the ICU. However, it is unknown if this communication style is used in caring for critically ill surgical patients. …”
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Correlation Analysis Between Multi-Drug Resistance Phenotype and Virulence Factor Expression of Clinical <i>Pseudomonas aeruginosa</i> by Wenli Xu, Runcheng Zhou, Jingwei Pan, Zhuangcong Liu, Xuyu Huang, Yueqiao Lin, Nan Li, Kecan Chen, Wenbo Sun, Yi Deng, Anping Yang, Xin Chen

“…Exploring the characterization of virulence factor expression and its relationship with the multi-drug resistance phenotype is essential to reduce the further development of resistance as well as a high standard of infection prevention and control. A total of 50 PA isolated from clinical practice were collected. …”
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Gaseous Pollutants and Particulate Matter in Ambient Air: First Field Experiment in an Urban Mediterranean Area (Nador, Morocco) by Bouchra Oujidi, Abdelfettah Benchrif, Mounia Tahri, Fatiha Zahry, Moussa Bounakhla, Hocein Bazairi, Nadia Mhammdi, Maria Snoussi

“…On average, the particulate matter and gaseous pollutant concentrations were below the national standard limits. Two categories of PM2.5 and PM10 sources, as derived from the EF investigation, were defined as soil/crustal (Ti, Al, Mn, Sr, K, Na, Ba, and V) and anthropogenic (Ni, Cr, Cu, Zn, and Pb). …”
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Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum by Yunliang Zheng, Nana Xu, Xingjiang Hu, Qiao Zhang, Yanpeng Liu, Qingwei Zhao

“…Isotope-labeled internal standard, especially rifampicin-D8, was applied to adjust for the loss during sample treatment. …”
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Evaluation and comparison of functional and esthetic outcomes of pectoralis major myocutaneous flap with or without removal of sternocleidomastoid muscle following neck dissection... by Dhrumil Nitish Sarkar, Nitin Bhola, Anchal Agrawal

“…The quality of life reported by participants was generally favorable, with composite scores, social-emotional sub-scores, and average physical function aligning with acceptable standards. It's important to note that achieving a more substantial sample size is imperative to obtain results of greater significance and reliability.…”
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Fluocinolone acetonide 0.2 µg/day intravitreal implant in non-infectious uveitis affecting the posterior segment: EU expert user panel consensus-based clinical recommendations by Uwe Pleyer, Carlos Pavesio, Elisabetta Miserocchi, Carsten Heinz, Helen Devonport, Víctor Llorenç, Tomás Burke, Vanda Nogueira, Laurent Kodjikian, Bahram Bodaghi

“…The current consensus document addresses relevant issues related to the use of FAc implants on different types of patients with various etiologies of NIU-PS, and was conducted to standardize approaches to help specialists obtain better clinical outcomes.…”
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Factors associated with hospital length of stay in patients with thoracic hydatid cyst disease undergoing surgical intervention: a retrospective study by Reza Ershadi, Mohammadreza Salehi, Ghazal Roostaei, Niloofar Khoshnam Rad, Sara Soltanmohammadi, Hesam Amini

“…Data were collected using a standardized checklist covering demographics, medical history, clinical symptoms, laboratory findings, treatment details, surgical characteristics, and risk factors. …”
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Investigation into the Prediction of Ship Heave Motion in Complex Sea Conditions Utilizing Hybrid Neural Networks by Yuchen Liu, Xide Cheng, Kunyu Han, Zhechun Liu, Baiwei Feng

“…The data feature extraction ability of CNNs, the temporal analysis capabilities of BiLSTMs, and the dynamic adjustment function of Attention on feature weights were comprehensively utilized to predict a ship’s heave motion. Simulations of a standard container ship’s motion time series under complex sea state conditions were carried out. …”
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Prevalence, characteristics, and treatment outcome of congenital malaria in Nigeria: a systematic review by Emmanuel Kokori, Gbolahan Olatunji, Bonaventure Michael Ukoaka, Israel Charles Abraham, Rosemary Komolafe, Victor Oluwatomiwa Ajekiigbe, Ntishor Gabriel Udam, Stanley Eneh, Chidiogo Ezenwoba, Adetola Emmanuel Babalola, Oluwatobi Omoworare, Nicholas Aderinto

“…Conclusions The findings highlight the need for improved diagnostic tools, standardized treatment protocols, and targeted interventions in high-burden areas. …”
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Ecological concrete by partially substitution of cement with Cameroonian corn stover ash by Martial Ngnihamye Nde, Seidou Youssoufa, Fabien Kenmogne, Merveille Meto Kuigne, Michel Mbessa, Emmanuel Yamb Bell, Didier Fokwa

“…The results of the chemical analyses carried out on the CCSA show that it contains 73.97 % of SiO2 + Al2O3 + Fe2O3, giving it a pozzolanic character in accordance with ASTM C618 standard. The mechanical behavior at an early age (0–28 days) showed a general decrease in strength for concretes containing CCSA. …”
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Determination of Organophosphorus Esters in Fall Protection Equipment by Accelerated Solvent Extraction and Solid-Phase Extraction Coupled with LC-MS/MS Detection by Haihong Li, Mingli Ye, Fangfang Wu, Xuyang Zhao, Lifeng Wang, Yili Wei, Shengyi Xie, Hairong Cui

“…Under optimized conditions, the limit of detection for the target OPEs ranged in 0.015–1.33 ng/g, with a spike recovery of 71.6%–114% and a relative standard deviation of 0.8%–11.2%. The developed method was used to analyze OPEs in fall protection equipment (safety helmets and ropes), where OPEs were all detectable. …”
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Assessment of different genotyping markers and algorithms for distinguishing Plasmodium falciparum recrudescence from reinfection in Uganda by Alex Mwesigwa, Monica Golumbeanu, Sam Jones, Sara L. Cantoreggi, Benson Musinguzi, Joaniter I. Nankabirwa, Everd Maniple Bikaitwoha, Joan N Kalyango, Charles Karamagi, Mateusz Plucinski, Samuel L. Nsobya, Christian Nsanzabana, Pauline Byakika-Kibwika

“…Discrepancies in recrudescence classification between match-counting and Bayesian algorithms highlight the need for standardized PCR correction practices.…”
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Health State Utility Values in Children and Adolescents with Disabilities: A Systematic Review by Lucy Kanya, PhD, Nana Anokye, PhD, Ahmad Hecham Alani, PharmD, Nandini Jayakumar, MSc, Jennifer M. Ryan, PhD

“…Only 2 studies used direct methods, such as time trade-off, visual analog scale, and standard gamble, whereas 29 employed generic measures (eg, EuroQol 5 Dimensions, Health Utilities Index 3) with diverse preference elicitation methods. …”
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Association between vascular endothelial growth factor and atrial fibrillation: a systematic review by Nikhil Sharma, Mahalaqua Nazli Khatib, R. Roopashree, Mandeep Kaur, Manish Srivastava, Amit Barwal, G. V. Siva Prasad, Pranchal Rajput, Rukshar Syed, Kamal Kundra, Vinamra Mittal, Muhammed Shabil, Amit Kumar, Pancham Cajla, Ganesh Bushi, Rachana Mehta, Zaid Khan, Prakasini Satapathy, Shilpa Gaidhane, Afukonyo Shidoiku Daniel, Renu Sah

“…The variability observed across studies suggests a need for standardized measurement approaches and further investigation into VEGF subtypes. …”
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From chaos to order: optimizing fecal microbiota transplantation for enhanced immune checkpoint inhibitors efficacy by Anqi Lin, Aimin Jiang, Lihaoyun Huang, Yu Li, Chunyanx Zhang, Lingxuan Zhu, Weiming Mou, Zaoqu Liu, Jian Zhang, Quan Cheng, Ting Wei, Peng Luo

“…Regulatory and ethical challenges are critically addressed, underscoring the imperative for standardized protocols and rigorous long-term safety assessments. …”
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Cochlear implantation and cognitive function in the older adult population: current state of the art and future perspectives by Tinne Vandenbroeke, Ellen Andries, Marc J.W. Lammers, Anouk Hofkens-Van den Brandt, Griet Mertens, Vincent Van Rompaey

“…Conclusion: Although there is no standardized study protocol to investigate cognition after cochlear implantation, a significant improvement in cognition is observed in the majority of studies one year after cochlear implantation. …”
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Characterization of a Novel Male Pheromone Compound in <i>Leucoptera sinuella</i> (Lepidoptera: Lyonetiidae) and Its Role in Courtship Behavior by Laura Sánchez-Aros, Abel F. O. Queiroz, Jorge Guajardo, Wilson Barros-Parada, Glenn P. Svensson, Jan Bergmann

“…Chemical microderivatization and comparisons of mass spectra and retention indices of natural compounds with synthetic standards led to the identification of two compounds: (<i>Z</i>)-3-decenyl hexanoate (the major component) and (<i>Z</i>)-3-decen-1-ol (a minor component). …”
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Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis by Changzhou Cai, Xin Song, Xueyang Chen, Weihua Zhou, Qi Jin, Shenghui Chen, Feng Ji

“…We included studies regarding the diagnosis or staging of steatosis or fibrosis by using controlled attenuation parameter (CAP) or liver stiffness measurement (LSM) measured by TE in patients with ALD or NAFLD. The reference standard of all included studies was liver biopsy. …”
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